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Gene: Gchfr (GTP cyclohydrolase I feedback regulator) Rattus norvegicus
Symbol: Gchfr
Name: GTP cyclohydrolase I feedback regulator
Description: Exhibits several functions, including GTP cyclohydrolase binding activity; GTP-dependent protein binding activity; and amino acid binding activity. Involved in negative regulation of GTP cyclohydrolase I activity and protein-containing complex assembly. Localizes to the protein-containing complex. Orthologous to human GCHFR (GTP cyclohydrolase I feedback regulator); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: GFRP; GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein; MGC108604; p35
Homo sapiens (human) : GCHFR (GTP cyclohydrolase I feedback regulator)  HGNC  Alliance
Mus musculus (house mouse) : Gchfr (GTP cyclohydrolase I feedback regulator)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gchfr (GTP cyclohydrolase I feedback regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : GCHFR (GTP cyclohydrolase I feedback regulator)
Canis lupus familiaris (dog) : GCHFR (GTP cyclohydrolase I feedback regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gchfr (GTP cyclohydrolase I feedback regulator)
Sus scrofa (pig) : GCHFR (GTP cyclohydrolase I feedback regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03110,975,923 - 110,979,957 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,975,923 - 110,979,957 (+)Ensembl
Rnor_5.03117,526,561 - 117,530,595 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,683,288 - 105,687,349 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13105,579,715 - 105,583,776 (+)NCBI
Celera3105,071,083 - 105,075,117 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gchfr
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621746
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.