Ivd (isovaleryl-CoA dehydrogenase) - Rat Genome Database

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Gene: Ivd (isovaleryl-CoA dehydrogenase) Rattus norvegicus
Analyze
Symbol: Ivd
Name: isovaleryl-CoA dehydrogenase
RGD ID: 2936
Description: Enables identical protein binding activity and isovaleryl-CoA dehydrogenase activity. Involved in L-leucine catabolic process. Located in mitochondrial matrix and mitochondrial membrane. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and isovaleric acidemia. Orthologous to human IVD (isovaleryl-CoA dehydrogenase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: butyryl-CoA dehydrogenase; isovaleryl coenzyme A dehydrogenase; isovaleryl-CoA dehydrogenase, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,305,584 - 126,326,016 (+)NCBIGRCr8
mRatBN7.23105,851,710 - 105,872,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,851,683 - 105,872,575 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,524,766 - 109,545,235 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,120,320 - 118,140,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,780,686 - 115,801,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,669,355 - 110,689,789 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,669,312 - 110,690,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,207,292 - 117,227,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,374,429 - 105,394,861 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,270,846 - 105,291,661 (+)NCBI
Celera3104,765,745 - 104,785,979 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dexrazoxane  (ISO)
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
clobetasol  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
lead diacetate  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP,ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
PhIP  (EXP)
phlorizin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
Propiverine  (EXP)
resveratrol  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Purification and characterization of isovaleryl coenzyme A dehydrogenase from rat liver mitochondria. Ikeda Y and Tanaka K, J Biol Chem. 1983 Jan 25;258(2):1077-85.
4. Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Ikeda Y, etal., Arch Biochem Biophys. 1987 Feb 1;252(2):662-74.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Molecular cloning and nucleotide sequence of cDNAs encoding the precursors of rat long chain acyl-coenzyme A, short chain acyl-coenzyme A, and isovaleryl-coenzyme A dehydrogenases. Sequence homology of four enzymes of the acyl-CoA dehydrogenase family. Matsubara Y, etal., J Biol Chem 1989 Sep 25;264(27):16321-31.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Exon skipping in IVD RNA processing in isovaleric acidemia caused by point mutations in the coding region of the IVD gene. Vockley J, etal., Am J Hum Genet 2000 Feb;66(2):356-67.
17. Molecular characterization of four different classes of mutations in the isovaleryl-CoA dehydrogenase gene responsible for isovaleric acidemia. Vockley J, etal., Am J Hum Genet. 1991 Jul;49(1):147-57.
Additional References at PubMed
PMID:3446585   PMID:3597357   PMID:7640268   PMID:9214289   PMID:12477932   PMID:14651853   PMID:15489334   PMID:18614015   PMID:23474214   PMID:25931508   PMID:26316108  


Genomics

Comparative Map Data
Ivd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83126,305,584 - 126,326,016 (+)NCBIGRCr8
mRatBN7.23105,851,710 - 105,872,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,851,683 - 105,872,575 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,524,766 - 109,545,235 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,120,320 - 118,140,785 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,780,686 - 115,801,150 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,669,355 - 110,689,789 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,669,312 - 110,690,173 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,207,292 - 117,227,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,374,429 - 105,394,861 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,270,846 - 105,291,661 (+)NCBI
Celera3104,765,745 - 104,785,979 (+)NCBICelera
Cytogenetic Map3q35NCBI
IVD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,405,795 - 40,435,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,405,485 - 40,435,947 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,697,996 - 40,728,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,484,978 - 38,498,355 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,484,977 - 38,498,355NCBI
Celera1517,463,670 - 17,479,493 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,541,064 - 17,556,886 (+)NCBIHuRef
CHM1_11540,817,565 - 40,833,386 (+)NCBICHM1_1
T2T-CHM13v2.01538,212,996 - 38,243,333 (+)NCBIT2T-CHM13v2.0
Ivd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,692,475 - 118,713,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,692,435 - 118,713,390 (+)EnsemblGRCm39 Ensembl
GRCm382118,861,959 - 118,882,909 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,861,954 - 118,882,909 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,687,736 - 118,707,093 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,553,441 - 118,572,798 (+)NCBIMGSCv36mm8
Celera2120,013,107 - 120,032,696 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.64NCBI
Ivd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,327,557 - 7,346,027 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,327,557 - 7,341,533 (+)NCBIChiLan1.0ChiLan1.0
IVD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,642,102 - 29,672,428 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,793,458 - 33,823,800 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,342,283 - 19,372,465 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,596,455 - 37,626,708 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,596,688 - 37,609,902 (+)Ensemblpanpan1.1panPan2
IVD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,584,122 - 7,594,599 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,584,086 - 7,594,150 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,637,893 - 7,648,417 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,709,948 - 7,720,478 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,688,665 - 7,720,482 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,634,265 - 7,644,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,740,300 - 7,750,859 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,869,140 - 7,879,708 (+)NCBIUU_Cfam_GSD_1.0
Ivd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,023,008 - 86,036,677 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,871,148 - 3,885,241 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,871,152 - 3,883,521 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IVD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1130,893,984 - 130,910,586 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11130,896,488 - 130,910,582 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21145,981,544 - 145,995,640 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IVD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,592,387 - 42,605,931 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,589,709 - 42,606,199 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,364,384 - 98,377,989 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ivd
94 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:81
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000013829
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
D3Wox27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,871,874 - 105,872,003 (+)MAPPERmRatBN7.2
Rnor_6.03110,689,520 - 110,689,648NCBIRnor6.0
Rnor_5.03117,227,457 - 117,227,585UniSTSRnor5.0
RGSC_v3.43105,394,591 - 105,394,720RGDRGSC3.4
RGSC_v3.43105,394,592 - 105,394,720UniSTSRGSC3.4
RGSC_v3.13105,291,019 - 105,291,148RGD
Celera3104,785,710 - 104,785,838UniSTS
RH 3.4 Map3913.79UniSTS
RH 3.4 Map3913.79RGD
RH 2.0 Map3590.1RGD
Cytogenetic Map3q35UniSTS
D3Arb26  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,871,832 - 105,872,056 (+)MAPPERmRatBN7.2
Rnor_6.03110,689,478 - 110,689,701NCBIRnor6.0
Rnor_5.03117,227,415 - 117,227,638UniSTSRnor5.0
RGSC_v3.43105,394,549 - 105,394,773RGDRGSC3.4
RGSC_v3.43105,394,550 - 105,394,773UniSTSRGSC3.4
RGSC_v3.13105,290,977 - 105,291,201RGD
Celera3104,785,668 - 104,785,891UniSTS
Cytogenetic Map3q35UniSTS
AI463340  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,872,163 - 105,872,340 (+)MAPPERmRatBN7.2
Rnor_6.03110,689,809 - 110,689,985NCBIRnor6.0
Rnor_5.03117,227,746 - 117,227,922UniSTSRnor5.0
RGSC_v3.43105,394,881 - 105,395,057UniSTSRGSC3.4
Celera3104,785,999 - 104,786,175UniSTS
Cytogenetic Map3q35UniSTS
AU048627  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,867,494 - 105,867,607 (+)MAPPERmRatBN7.2
Rnor_6.03110,685,139 - 110,685,251NCBIRnor6.0
Rnor_5.03117,223,076 - 117,223,188UniSTSRnor5.0
RGSC_v3.43105,390,213 - 105,390,325UniSTSRGSC3.4
Celera3104,781,332 - 104,781,444UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000013829   ⟹   ENSRNOP00000013829
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,851,683 - 105,872,535 (+)Ensembl
Rnor_6.0 Ensembl3110,669,312 - 110,690,173 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103671   ⟹   ENSRNOP00000086985
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,851,688 - 105,872,514 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107497   ⟹   ENSRNOP00000078431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,851,683 - 105,872,575 (+)Ensembl
RefSeq Acc Id: NM_012592   ⟹   NP_036724
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83126,305,584 - 126,326,016 (+)NCBI
mRatBN7.23105,851,710 - 105,872,144 (+)NCBI
Rnor_6.03110,669,355 - 110,689,789 (+)NCBI
Rnor_5.03117,207,292 - 117,227,726 (+)NCBI
RGSC_v3.43105,374,429 - 105,394,861 (+)RGD
Celera3104,765,745 - 104,785,979 (+)RGD
Sequence:
RefSeq Acc Id: NP_036724   ⟸   NM_012592
- Peptide Label: precursor
- UniProtKB: P12007 (UniProtKB/Swiss-Prot),   A6HPD3 (UniProtKB/TrEMBL),   A0A8I6A3D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000013829   ⟸   ENSRNOT00000013829
RefSeq Acc Id: ENSRNOP00000078431   ⟸   ENSRNOT00000107497
RefSeq Acc Id: ENSRNOP00000086985   ⟸   ENSRNOT00000103671
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12007-F1-model_v2 AlphaFold P12007 1-424 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692314
Promoter ID:EPDNEW_R2839
Type:multiple initiation site
Name:Ivd_1
Description:isovaleryl-CoA dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,669,337 - 110,669,397EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2936 AgrOrtholog
BioCyc Gene G2FUF-48227 BioCyc
BioCyc Pathway LEU-DEG2-PWY [L-leucine degradation I] BioCyc
BioCyc Pathway Image LEU-DEG2-PWY BioCyc
Ensembl Genes ENSRNOG00000009421 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055002697 UniProtKB/Swiss-Prot
  ENSRNOG00060025127 UniProtKB/Swiss-Prot
  ENSRNOG00065023036 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000013829 ENTREZGENE
  ENSRNOT00000013829.6 UniProtKB/Swiss-Prot
  ENSRNOT00000103671.1 UniProtKB/TrEMBL
  ENSRNOT00000107497.1 UniProtKB/TrEMBL
  ENSRNOT00055004286 UniProtKB/Swiss-Prot
  ENSRNOT00060043516 UniProtKB/Swiss-Prot
  ENSRNOT00065039414 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.540.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7193077 IMAGE-MGC_LOAD
InterPro Acyl-CoA_DH_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IVD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24513 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93591 IMAGE-MGC_LOAD
NCBI Gene 24513 ENTREZGENE
PANTHER ACYL-COA DEHYDROGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ivd PhenoGen
PROSITE ACYL_COA_DH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYL_COA_DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009421 RatGTEx
  ENSRNOG00055002697 RatGTEx
  ENSRNOG00060025127 RatGTEx
  ENSRNOG00065023036 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56645 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC204526
UniProt A0A8I5ZKU7_RAT UniProtKB/TrEMBL
  A0A8I6A3D0 ENTREZGENE, UniProtKB/TrEMBL
  A6HPD2_RAT UniProtKB/TrEMBL
  A6HPD3 ENTREZGENE, UniProtKB/TrEMBL
  IVD_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Ivd  isovaleryl-CoA dehydrogenase  Ivd  isovaleryl coenzyme A dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ivd  Isovaleryl Coenzyme A dehydrogenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the mitochondrial matrix 631718
gene_function catalyzes alpha, beta-dehydroganation of acyl-CoA esters 631718
gene_transcript homotetrameric flavoprotein 40-45 kDa in size 631718