Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) - Rat Genome Database

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Gene: Eif2ak4 (eukaryotic translation initiation factor 2 alpha kinase 4) Rattus norvegicus
Analyze
Symbol: Eif2ak4
Name: eukaryotic translation initiation factor 2 alpha kinase 4
RGD ID: 1311439
Description: Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity and tRNA binding activity. Involved in positive regulation of protein phosphorylation. Predicted to be active in cytosol and nucleus. Biomarker of pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease 2. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; hepatitis C pathway; influenza A pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: eIF-2-alpha kinase GCN2; eukaryotic translation initiation factor 2-alpha kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Eif2ak4em1  
Genetic Models: SD-Eif2ak4em1
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,810,207 - 125,895,574 (+)NCBIGRCr8
mRatBN7.23105,356,261 - 105,441,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,356,261 - 105,441,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,022,930 - 109,108,350 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,618,459 - 117,703,890 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,278,837 - 115,364,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,159,624 - 110,245,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,159,708 - 110,249,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,705,333 - 116,791,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,870,871 - 104,875,529 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,716,669 - 104,802,714 (+)NCBI
Celera3104,273,489 - 104,358,836 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to amino acid starvation  (IEA,ISO)
cellular response to cold  (IEA,ISO)
cellular response to starvation  (ISO)
cellular response to UV  (ISO)
chromatin remodeling  (IEA)
DNA damage checkpoint signaling  (IEA)
eiF2alpha phosphorylation in response to endoplasmic reticulum stress  (IEA,ISO)
endoplasmic reticulum unfolded protein response  (ISO)
GCN2-mediated signaling  (IEA,ISO,ISS)
learning  (ISO,ISS)
long-term memory  (ISO,ISS)
negative regulation by host of viral genome replication  (ISO,ISS)
negative regulation of CREB transcription factor activity  (ISO,ISS)
negative regulation of cytoplasmic translational initiation in response to stress  (IBA)
negative regulation of neuron differentiation  (ISO)
negative regulation of translation  (ISO)
negative regulation of translational initiation  (ISO,ISS)
negative regulation of translational initiation in response to stress  (ISO)
neuron projection extension  (ISO)
positive regulation of adaptive immune response  (ISO)
positive regulation of defense response to virus by host  (ISO,ISS)
positive regulation of gene expression  (ISO)
positive regulation of long-term synaptic potentiation  (ISO,ISS)
positive regulation of protein phosphorylation  (IMP)
positive regulation of translational initiation in response to starvation  (ISO,ISS)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO,ISS)
regulation of cytoplasmic translational initiation in response to stress  (ISO)
regulation of feeding behavior  (ISO)
regulation of translational initiation  (ISO)
regulation of translational initiation by eIF2 alpha phosphorylation  (IEA,ISO,ISS)
regulation of translational initiation in response to stress  (ISO)
response to endoplasmic reticulum stress  (ISO)
T cell activation involved in immune response  (ISO)
viral translation  (ISO,ISS)

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10504407   PMID:10655230   PMID:11106749   PMID:12176355   PMID:12947022   PMID:14729979   PMID:15937339   PMID:16054071   PMID:16121183   PMID:16176978   PMID:16601681  
PMID:18996085   PMID:23447528   PMID:24310610   PMID:24333428   PMID:25329545   PMID:26102367   PMID:36476191   PMID:36852942  


Genomics

Comparative Map Data
Eif2ak4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,810,207 - 125,895,574 (+)NCBIGRCr8
mRatBN7.23105,356,261 - 105,441,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,356,261 - 105,441,630 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,022,930 - 109,108,350 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,618,459 - 117,703,890 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,278,837 - 115,364,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,159,624 - 110,245,382 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,159,708 - 110,249,217 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,705,333 - 116,791,037 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,870,871 - 104,875,529 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,716,669 - 104,802,714 (+)NCBI
Celera3104,273,489 - 104,358,836 (+)NCBICelera
Cytogenetic Map3q35NCBI
EIF2AK4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381539,934,115 - 40,035,591 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1539,934,115 - 40,035,591 (+)EnsemblGRCh38hg38GRCh38
GRCh371540,226,316 - 40,327,792 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,013,639 - 38,115,089 (+)NCBINCBI36Build 36hg18NCBI36
Build 341538,033,406 - 38,115,083NCBI
Celera1516,989,625 - 17,091,096 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,070,557 - 17,171,948 (+)NCBIHuRef
CHM1_11540,345,975 - 40,447,471 (+)NCBICHM1_1
T2T-CHM13v2.01537,739,435 - 37,840,931 (+)NCBIT2T-CHM13v2.0
Eif2ak4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,219,065 - 118,305,715 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,219,099 - 118,305,715 (+)EnsemblGRCm39 Ensembl
GRCm382118,388,583 - 118,475,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,388,618 - 118,475,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv372118,214,353 - 118,300,970 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,080,058 - 118,166,674 (+)NCBIMGSCv36mm8
Celera2119,539,566 - 119,626,375 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Eif2ak4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554166,897,848 - 7,009,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554166,897,897 - 7,005,602 (+)NCBIChiLan1.0ChiLan1.0
EIF2AK4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,171,788 - 29,273,327 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,323,160 - 33,424,672 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01518,871,867 - 18,973,380 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,128,000 - 37,229,216 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,120,044 - 37,229,211 (+)Ensemblpanpan1.1panPan2
EIF2AK4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,144,727 - 7,248,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,144,570 - 7,248,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,199,521 - 7,302,773 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,271,731 - 7,376,532 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1307,195,772 - 7,298,966 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,301,246 - 7,405,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,430,444 - 7,533,631 (+)NCBIUU_Cfam_GSD_1.0
Eif2ak4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,575,724 - 85,679,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,423,813 - 3,526,913 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,423,792 - 3,527,089 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EIF2AK4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,245,466 - 131,355,226 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,244,818 - 131,355,240 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,476,415 - 146,493,038 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EIF2AK4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,966,095 - 43,072,083 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,962,447 - 43,072,001 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604897,883,347 - 97,988,989 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eif2ak4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,262,163 - 7,376,267 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,262,195 - 7,371,506 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eif2ak4
433 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:218
Count of miRNA genes:160
Interacting mature miRNAs:181
Transcripts:ENSRNOT00000009222
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
RH140887  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,440,464 - 105,441,499 (+)MAPPERmRatBN7.2
Rnor_6.03110,244,217 - 110,245,251NCBIRnor6.0
Rnor_5.03116,789,872 - 116,790,906UniSTSRnor5.0
RGSC_v3.43104,905,123 - 104,906,157UniSTSRGSC3.4
Celera3104,357,671 - 104,358,705UniSTS
Cytogenetic Map3q35UniSTS


Genetic Models
This gene Eif2ak4 is modified in the following models/strains:
SD-Eif2ak4em1    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009222   ⟹   ENSRNOP00000009222
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,356,261 - 105,441,630 (+)Ensembl
Rnor_6.0 Ensembl3110,159,708 - 110,249,217 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103360   ⟹   ENSRNOP00000076860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,367,222 - 105,441,630 (+)Ensembl
RefSeq Acc Id: NM_001105744   ⟹   NP_001099214
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,810,207 - 125,895,574 (+)NCBI
mRatBN7.23105,356,261 - 105,441,630 (+)NCBI
Rnor_6.03110,159,624 - 110,245,382 (+)NCBI
Rnor_5.03116,705,333 - 116,791,037 (+)NCBI
RGSC_v3.43104,870,871 - 104,875,529 (+)RGD
Celera3104,273,489 - 104,358,836 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099214 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D4A7V9 (Get FASTA)   NCBI Sequence Viewer  
  EDL79857 (Get FASTA)   NCBI Sequence Viewer  
  EDL79858 (Get FASTA)   NCBI Sequence Viewer  
  EDL79859 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009222.7
  ENSRNOP00000076860.1
RefSeq Acc Id: NP_001099214   ⟸   NM_001105744
- UniProtKB: D4A7V9 (UniProtKB/Swiss-Prot),   A0A8L2Q433 (UniProtKB/TrEMBL),   A6HPA6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009222   ⟸   ENSRNOT00000009222
Ensembl Acc Id: ENSRNOP00000076860   ⟸   ENSRNOT00000103360
Protein Domains
Protein kinase   RWD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A7V9-F1-model_v2 AlphaFold D4A7V9 1-1649 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692308
Promoter ID:EPDNEW_R2832
Type:multiple initiation site
Name:Eif2ak4_1
Description:eukaryotic translation initiation factor 2 alpha kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,159,667 - 110,159,727EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311439 AgrOrtholog
BioCyc Gene G2FUF-48255 BioCyc
Ensembl Genes ENSRNOG00000006027 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009222.8 UniProtKB/TrEMBL
  ENSRNOT00000103360.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro aa-tRNA-synth_II/BPL/LPL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anticodon-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CC_SR_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Gcn2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HisRS-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HisRS-related_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114859 UniProtKB/TrEMBL
NCBI Gene 114859 ENTREZGENE
PANTHER EIF-2-ALPHA KINASE GCN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HGTP_anticodon2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  tRNA-synt_His UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eif2ak4 PhenoGen
PIRSF Ser/Thr_PK_GCN2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006027 RatGTEx
SMART RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55681 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y0V7_RAT UniProtKB/TrEMBL
  A0A8L2Q433 ENTREZGENE, UniProtKB/TrEMBL
  A6HPA6 ENTREZGENE, UniProtKB/TrEMBL
  D4A7V9 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Eif2ak4  eukaryotic translation initiation factor 2 alpha kinase 4   Eif2ak4_predicted  eukaryotic translation initiation factor 2 alpha kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eif2ak4_predicted  eukaryotic translation initiation factor 2 alpha kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED