Spint1 (serine peptidase inhibitor, Kunitz type 1)

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Gene: Spint1 (serine peptidase inhibitor, Kunitz type 1) Rattus norvegicus

Analyze

Symbol:

Spint1

Name:

serine peptidase inhibitor, Kunitz type 1

RGD ID:

1303138

Description:

Exhibits serine-type endopeptidase inhibitor activity. Involved in cellular response to BMP stimulus; negative regulation of neural precursor cell proliferation; and positive regulation of glial cell differentiation. Localizes to plasma membrane. Biomarker of liver cirrhosis. Orthologous to human SPINT1 (serine peptidase inhibitor, Kunitz type 1); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

HAI-1; hepatocyte growth factor activator inhibitor 1; hepatocyte growth factor activator inhibitor-1; kunitz-type protease inhibitor 1; serine protease inhibitor, Kunitz type 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	105,654,093 - 105,666,772 (+)	NCBI
Celera	3	105,144,668 - 105,157,338 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

biliary atresia (ISO)

breast cancer (ISO)

cholestasis (ISO)

Colorectal Neoplasms (ISO)

ichthyosis (ISO)

liver cirrhosis (IEP)

ovarian cancer (ISO)

primary biliary cholangitis (ISO)

prostate carcinoma (ISO)

stomach carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (EXP)

aldrin (ISO)

all-trans-retinoic acid (ISO)

Aroclor 1254 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butan-1-ol (ISO)

choline (ISO)

cisplatin (ISO)

diarsenic trioxide (ISO)

dibenz[a,h]anthracene (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

folic acid (ISO)

hydralazine (ISO)

L-methionine (ISO)

N-ethyl-N-nitrosourea (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

PCB138 (EXP,ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

thioacetamide (EXP)

topotecan (EXP)

tributylstannane (ISO)

trichostatin A (ISO)

triclosan (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in labyrinthine layer morphogenesis (ISO)

cellular response to BMP stimulus (IEP)

embryonic placenta development (ISO)

extracellular matrix organization (ISO)

negative regulation of endopeptidase activity (IEA)

negative regulation of neural precursor cell proliferation (IMP)

neural tube closure (ISO)

placenta blood vessel development (ISO)

positive regulation of glial cell differentiation (IMP)

Cellular Component

integral component of membrane (IEA)

plasma membrane (IDA,ISO)

Molecular Function

protein binding (ISO)

serine-type endopeptidase inhibitor activity (IMP)

References

References - curated


1.	Huang HP, etal., Hepatology. 2012 Jan;55(1):161-72. doi: 10.1002/hep.24657. Epub 2011 Nov 16.
2.	Kaido T, etal., Hepatogastroenterology. 2004 Mar-Apr;51(56):547-51.
3.	Kirchhofer D, etal., J Biol Chem 2003 Sep 19;278(38):36341-9. Epub 2003 Jun 18.
4.	Koivuniemi R, etal., PLoS One. 2013;8(2):e56117. doi: 10.1371/journal.pone.0056117. Epub 2013 Feb 7.
5.	Kojima K, etal., J Biol Chem. 2008 Feb 1;283(5):2478-87. Epub 2007 Nov 29.
6.	MGD data from the GO Consortium
7.	Nagaike K, etal., Am J Pathol. 2008 Nov;173(5):1464-75. doi: 10.2353/ajpath.2008.071142. Epub 2008 Oct 2.
8.	Oberst MD, etal., Clin Cancer Res. 2002 Apr;8(4):1101-7.
9.	Parr C, etal., Clin Cancer Res. 2004 Jan 1;10(1 Pt 1):202-11.
10.	RGD automated data pipeline
11.	RGD automated import pipeline for gene-chemical interactions
12.	Saleem M, etal., Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):217-27.
13.	Vogel LK, etal., BMC Cancer. 2006 Jul 4;6:176.
14.	Yamada T, etal., Exp Neurol. 1998 Sep;153(1):60-4.
15.	Zeng L, etal., World J Gastroenterol. 2005 Oct 21;11(39):6202-7.

Additional References at PubMed

PMID:12477932	PMID:15669920	PMID:15964823	PMID:16502470	PMID:17174946	PMID:19592578	PMID:20682770	PMID:23376485	PMID:23533145	PMID:25758223

Genomics

Comparative Map Data

Spint1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	105,654,093 - 105,666,772 (+)	NCBI
Celera	3	105,144,668 - 105,157,338 (+)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

SPINT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	15	40,844,018 - 40,858,207 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	15	40,844,048 - 40,858,207 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	15	41,136,246 - 41,149,853 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,923,538 - 38,937,145 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	15	17,904,155 - 17,917,761 (+)	NCBI
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,956,043 - 17,998,087 (+)	NCBI		HuRef
CHM1_1	15	41,254,190 - 41,267,796 (+)	NCBI		CHM1_1

Spint1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	119,067,841 - 119,080,016 (+)	NCBI	GRCm39		mm39
GRCm38	2	119,237,360 - 119,249,535 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	119,237,362 - 119,249,527 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	119,063,096 - 119,075,250 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	118,928,918 - 118,940,633 (+)	NCBI			mm8
Celera	2	120,387,921 - 120,400,196 (+)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI

Spint1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,715,536 - 7,729,158 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	7,715,536 - 7,728,759 (+)	NCBI	ChiLan1.0	ChiLan1.0

SPINT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	15	38,036,638 - 38,050,303 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	38,036,638 - 38,050,303 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	15	19,786,621 - 19,800,297 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

SPINT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	30	7,975,235 - 7,988,339 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	30	7,976,094 - 7,989,019 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Spint1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936471	4,238,883 - 4,251,291 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	130,458,909 - 130,473,783 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	130,458,909 - 130,473,791 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	145,616,937 - 145,631,763 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINT1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,136,749 - 42,150,125 (-)	NCBI
ChlSab1.1 Ensembl	26	42,134,536 - 42,150,118 (-)	Ensembl

Spint1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624804	8,092,700 - 8,105,478 (+)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	39248391	140271184	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	43295930	163640485	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	43295930	163640485	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	45406058	127023997	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	45406058	177699992	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	48561928	155263151	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	48562146	115249962	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	51821836	124513579	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	51822008	120917851	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	54630948	119830094	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	54630948	119830094	Rat
1581568	Rf53	Renal function QTL 53			total urine protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	58204463	170534769	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	61241033	165369047	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	62922868	127023997	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	66711607	119830094	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	66711607	119830094	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	72672290	127023997	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	72973445	127023997	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	78700444	123700444	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	total urine protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	81136227	154416635	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	83817637	119509260	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	88910015	133910015	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	94788365	139788365	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	97009185	142009185	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	99465522	168732722	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	100730984	119830094	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	101058963	146058963	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	102152812	155263151	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	102466149	147466149	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	103141814	176418101	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	103141814	176418101	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	103141814	176418101	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	103141944	170934860	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	106900427	119830094	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	98
Count of miRNA genes:	81
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000017223
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	4	19	18	9	18			2	35	16	11
Low		23	28	19	10	19	3	4	72		25		3
Below cutoff		16	10	4		4	5	7					5

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001004265	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234763	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01024609	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB154834	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC132987	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225954	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017223 ⟹ ENSRNOP00000017223

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	111,049,315 - 111,061,990 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000088870 ⟹ ENSRNOP00000069737

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	111,049,118 - 111,062,011 (+)	Ensembl

RefSeq Acc Id:

NM_001004265 ⟹ NP_001004265

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	111,049,315 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI
RGSC_v3.4	3	105,757,666 - 105,770,345 (+)	RGD
Celera	3	105,144,668 - 105,157,338 (+)	RGD

Sequence:

show sequence

GAGCTCCCGAGCGGTGCTCTGCCCGACGTCGGGTTCGAGTGTGCGTGGACGGATAGGCCCGCGT
GCGCCTGCTCGTTCCCAGTGCCCCGCGCCACTACCCGAGCTGATCAGGTGCGTCTCTTGTGTCT
CCTCCCCTCTCAGGTCACAAGCACCCTCGGAACCCAGAGGCCCGCACTGTGAAGGTGACTCCCG
CCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATGGCGGCCCGCCGCCTGGCGCAGGCCAG
CATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTGGTCTCCAGGGCACTGAGACCGAGCTG
CCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTGCTTGAACCGCTTTACCAGCGGGGTGC
CGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAACGGGGCCACCTTCCTGGGTTCCCCGAC
GGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCACCACCCAAAACTGTAACCTGGCGCTG
GTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTCTGCCTGCTTCCTCATGAACTGCCTGT
ATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGACGGCTTCATCAACTATCTTACCCAAGA
TCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCTTTGGAGGTTCCCGGATCCCTCGAATC
TGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCCCCTGGTACTGAGAGATGCAGACAACA
CAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGTGTTAAGAGAAACCATCCAGAAGAAGT
TGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCCAACTGACAAGAACCGACTCAGACCAG
CTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAACTGCCGAGCAGACGGAAGATTATTGCC
TCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTCCCACGCTGGTACTATGACCCCAAGGA
ACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAGGCAACAAGAACAACTACCTTCGTGAG
GAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAATCTCACCTAAAAGGCATCATCCAGTGT
GCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGCAATGGCTGCTGTATCGACGGCTTCCT
GGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCGATGAGGCCACTTGTGAAAAATATAGC
AGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAGTGACAAAGGGTACTGTGCAGAGCTGC
CAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGGTATTACAACCCATTCAGTGAACGCTG
TGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGAACAACTTTGAGAAGGAACAGCAGTGT
CTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTTCGGTCTTCGGAGGGAAAGCTCCGTTC
CCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTGCTGGCCGTCTGCATCATAGTGGTCTT
GACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAAAGAACTTCCACAGCCCCCTGCACCAA
CCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCACTGAGGACACAGAGCACCTGGTCTATA
ATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGCCAGTCTCACCAGGTTCTGTCTTAAGA
CAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCTTTCTACCTCTTCCTGGGCATACTTAC
TCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGACTCTCAGCTGCACTCAGGCCAGTTCT
GGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTGAGCCAGGAATACTATACATAGAAGGA
CCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTCATCTTGTTCAAAGCTGCCTGCCCCCA
TCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCAGAAGCCACACACTGCCTTCCACGATG
TCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGCTTTGTAGTTTATGCTGTAAATAATTG
CTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTGTGTATGGTCACCCTCAGTGCTCTACA
CGGCACCACAAATTACATTAAATTAAAGAATAAAATGTTGTGTTTGTCCAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006234763 ⟹ XP_006234825

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	111,049,132 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI

Sequence:

show sequence

AGAAACTAGGGAGCGGGGAAGAGGCAGCCAATCGTCCGCGCACCCAGAGCCGAGCGGAAGCCGG
GCGGGATCTTCGGCGGGCCCACCCCGTTCACCTGCGCAGGTCACAAGCACCCTCGGAACCCAGA
GGCCCGCACTGTGAAGGTGACTCCCGCCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATG
GCGGCCCGCCGCCTGGCGCAGGCCAGCATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTG
GTCTCCAGGGCACTGAGACCGAGCTGCCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTG
CTTGAACCGCTTTACCAGCGGGGTGCCGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAAC
GGGGCCACCTTCCTGGGTTCCCCGACGGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCA
CCACCCAAAACTGTAACCTGGCGCTGGTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTC
TGCCTGCTTCCTCATGAACTGCCTGTATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGAC
GGCTTCATCAACTATCTTACCCAAGATCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCT
TTGGAGGTTCCCGGATCCCTCGAATCTGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCC
CCTGGTACTGAGAGATGCAGACAACACAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGT
GTTAAGAGAAACCATCCAGAAGAAGTTGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCC
AACTGACAAGAACCGACTCAGACCAGCTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAAC
TGCCGAGCAGACGGAAGATTATTGCCTCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTC
CCACGCTGGTACTATGACCCCAAGGAACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAG
GCAACAAGAACAACTACCTTCGTGAGGAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAAT
CTCACCTAAAAGGCATCATCCAGTGTGCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGC
AATGGCTGCTGTATCGACGGCTTCCTGGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCG
ATGAGGCCACTTGTGAAAAATATAGCAGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAG
TGACAAAGGGTACTGTGCAGAGCTGCCAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGG
TATTACAACCCATTCAGTGAACGCTGTGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGA
ACAACTTTGAGAAGGAACAGCAGTGTCTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTT
CGGTCTTCGGAGGGAAAGCTCCGTTCCCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTG
CTGGCCGTCTGCATCATAGTGGTCTTGACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAA
AGAACTTCCACAGCCCCCTGCACCAACCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCAC
TGAGGACACAGAGCACCTGGTCTATAATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGC
CAGTCTCACCAGGTTCTGTCTTAAGACAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCT
TTCTACCTCTTCCTGGGCATACTTACTCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGA
CTCTCAGCTGCACTCAGGCCAGTTCTGGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTG
AGCCAGGAATACTATACATAGAAGGACCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTC
ATCTTGTTCAAAGCTGCCTGCCCCCATCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCA
GAAGCCACACACTGCCTTCCACGATGTCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGC
TTTGTAGTTTATGCTGTAAATAATTGCTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTG
TGTATGGTCACCCTCAGTGCTCTACACGGCACCACAAATTACATTAAATTAAAGAATAAAATGT
TGTGTTTGTCCA

hide sequence

RefSeq Acc Id:

XM_006234764 ⟹ XP_006234826

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	111,049,230 - 111,061,991 (+)	NCBI
Rnor_5.0	3	117,599,717 - 117,612,635 (+)	NCBI

Sequence:

show sequence

CGCAGGTAGCCTGGGCGGACGGTAGGCGGAGGCCCAGCGGGGTCCGAGCGTGTTTGGCGGACAT
CCGCTCTGTGTTGGGGTCACAAGCACCCTCGGAACCCAGAGGCCCGCACTGTGAAGGTGACTCC
CGCCTTGGGGAGGAGGGCGACGGCCCCTGGGAGCACGATGGCGGCCCGCCGCCTGGCGCAGGCC
AGCATCTCTACGGTCTGCGTATGGCTCCTTTGCGCGCTTGGTCTCCAGGGCACTGAGACCGAGC
TGCCGTCCGCACCCCCTGAGTTTTCCGGGGGAGCCGCCTGCTTGAACCGCTTTACCAGCGGGGT
GCCGGCTTTTGTGTTGGACACCGAAGCTTCAGTCAGCAACGGGGCCACCTTCCTGGGTTCCCCG
ACGGTGCACCGCGGCTGGGACTGCGTGCGTGCCTGCTGCACCACCCAAAACTGTAACCTGGCGC
TGGTGGAGCTGCAGCCGGACGGAGGCGAGGACGCCATCTCTGCCTGCTTCCTCATGAACTGCCT
GTATGAGCAGAACTTCGTGTGCAAATTCGCTCCGAAGGACGGCTTCATCAACTATCTTACCCAA
GATCTTTACAACTCCTACCGCGAGCTGCGAACTCGAGGCTTTGGAGGTTCCCGGATCCCTCGAA
TCTGGATGGGCATAGACTTGAAGGTGCAGCTGCAGAAGCCCCTGGTACTGAGAGATGCAGACAA
CACAGACTGGCATCTACTGCAAGGTGACCAAGATGTCAGTGTTAAGAGAAACCATCCAGAAGAA
GTTGAGCTGTGGGGACTTAAGGAGGGAACCTACCTGTTCCAACTGACAAGAACCGACTCAGACC
AGCTAGAGGAAACAGTCAACCTGACTATCACCGTGCTAACTGCCGAGCAGACGGAAGATTATTG
CCTCGCATCCTACAAGGTGGGCCGCTGCCGGGGCTCCTTCCCACGCTGGTACTATGACCCCAAG
GAACAGATCTGCAAAAGTTTCACTTTTGGAGGTTGCCTAGGCAACAAGAACAACTACCTTCGTG
AGGAAGAGTGCATGCTAGCCTGCAAGGATGTGAAAGGAATCTCACCTAAAAGGCATCATCCAGT
GTGCACCGGCAGCTGCCATAGCACGCAGTTCCAGTGCAGCAATGGCTGCTGTATCGACGGCTTC
CTGGAGTGTGATGACACGCCTGACTGCCCTGATGGCTCCGATGAGGCCACTTGTGAAAAATATA
GCAGCGGCTTTGATGAACTTCAGAGTATCCACTTCCTCAGTGACAAAGGGTACTGTGCAGAGCT
GCCAGACACTGGATTTTGCAAGGAGAACATCCCACGCTGGTATTACAACCCATTCAGTGAACGC
TGTGCCCGCTTCACCTATGGTGGTTGCTACGGGAACAAGAACAACTTTGAGAAGGAACAGCAGT
GTCTTGAGTCCTGTCGTGGCATCTCCAAGAAGGATGTGTTCGGTCTTCGGAGGGAAAGCTCCGT
TCCCAGTGCAGGCTCTGTGGAGGTAGCTATTGCTGTATTGCTGGCCGTCTGCATCATAGTGGTC
TTGACCATCCTGGGCTACTGTTTCTTCAAGAACCAAAAAAAGAACTTCCACAGCCCCCTGCACC
AACCACCTCCCACACCAGCCAGCTCCACTGTTTCCACCACTGAGGACACAGAGCACCTGGTCTA
TAATCACACAACCCAGCCTCTCTGAGCCTGGGACTCTTGCCAGTCTCACCAGGTTCTGTCTTAA
GACAGAAGCCAGACCTGGGAAAACTTGGGGACCAGAATCTTTCTACCTCTTCCTGGGCATACTT
ACTCTGTCTCAGGAGACAGATCTCTGGGCCTCTCAGAGGACTCTCAGCTGCACTCAGGCCAGTT
CTGGAGAAGGCCCAGGAGTCTGGGAGAAGCAACAGCCTTGAGCCAGGAATACTATACATAGAAG
GACCTGCTTATCCAGGAGCCAGAGGAAGTTTGTGTTTTTCATCTTGTTCAAAGCTGCCTGCCCC
CATCCAATGACGCTAGGGCCGTGAGTGGAGTCGGAGGCCAGAAGCCACACACTGCCTTCCACGA
TGTCCTCCACTCTGCACAGGCCTGCACTGAAGGACATGGCTTTGTAGTTTATGCTGTAAATAAT
TGCTTTTGGGGCCCCAGGGTCATAGCTCAGTGGTAGCGTGTGTATGGTCACCCTCAGTGCTCTA
CACGGCACCACAAATTACATTAAATTAAAGAATAAAATGTTGTGTTTGTCCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001004265	(Get FASTA)	NCBI Sequence Viewer
	XP_006234825	(Get FASTA)	NCBI Sequence Viewer
	XP_006234826	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97253	(Get FASTA)	NCBI Sequence Viewer
	BAD23971	(Get FASTA)	NCBI Sequence Viewer
	EDL79898	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001004265 ⟸ NM_001004265
- Peptide Label:	precursor
- UniProtKB:	Q4V8Q2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL hide sequence

RefSeq Acc Id:	XP_006234825 ⟸ XM_006234763
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8Q2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL hide sequence

RefSeq Acc Id:	XP_006234826 ⟸ XM_006234764
- Peptide Label:	isoform X1
- UniProtKB:	Q4V8Q2 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAARRLAQASISTVCVWLLCALGLQGTETELPSAPPEFSGGAACLNRFTSGVPAFVLDTEASVS NGATFLGSPTVHRGWDCVRACCTTQNCNLALVELQPDGGEDAISACFLMNCLYEQNFVCKFAPK DGFINYLTQDLYNSYRELRTRGFGGSRIPRIWMGIDLKVQLQKPLVLRDADNTDWHLLQGDQDV SVKRNHPEEVELWGLKEGTYLFQLTRTDSDQLEETVNLTITVLTAEQTEDYCLASYKVGRCRGS FPRWYYDPKEQICKSFTFGGCLGNKNNYLREEECMLACKDVKGISPKRHHPVCTGSCHSTQFQC SNGCCIDGFLECDDTPDCPDGSDEATCEKYSSGFDELQSIHFLSDKGYCAELPDTGFCKENIPR WYYNPFSERCARFTYGGCYGNKNNFEKEQQCLESCRGISKKDVFGLRRESSVPSAGSVEVAIAV LLAVCIIVVLTILGYCFFKNQKKNFHSPLHQPPPTPASSTVSTTEDTEHLVYNHTTQPL hide sequence

RefSeq Acc Id:

ENSRNOP00000017223 ⟸ ENSRNOT00000017223

RefSeq Acc Id:

ENSRNOP00000069737 ⟸ ENSRNOT00000088870

Protein Domains

BPTI/Kunitz inhibitor MANSC

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1303138	AgrOrtholog
Ensembl Genes	ENSRNOG00000012811	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017223	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000069737	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017223	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000088870	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	4.10.400.10	UniProtKB/TrEMBL
	4.10.410.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7459422	IMAGE-MGC_LOAD
InterPro	Ig-like_fold	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	LDL_receptor-like_sf	UniProtKB/TrEMBL
	LDLR_class-A_CS	UniProtKB/TrEMBL
	LDLR_classA_rpt	UniProtKB/TrEMBL
	MANSC	UniProtKB/TrEMBL
	MANSC_N	UniProtKB/TrEMBL
	Prot_inh_Kunz-m	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
	Spint1	UniProtKB/TrEMBL
KEGG Report	rno:311331	UniProtKB/TrEMBL
MGC_CLONE	MGC:114209	IMAGE-MGC_LOAD
NCBI Gene	311331	ENTREZGENE
PANTHER	PTHR46750	UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/TrEMBL
	Ldl_recept_a	UniProtKB/TrEMBL
	MANEC	UniProtKB/TrEMBL
PhenoGen	Spint1	PhenoGen
PRINTS	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
	LDLRA_1	UniProtKB/TrEMBL
	LDLRA_2	UniProtKB/TrEMBL
	MANSC	UniProtKB/TrEMBL
SMART	LDLa	UniProtKB/TrEMBL
	MANEC	UniProtKB/TrEMBL
	SM00131	UniProtKB/TrEMBL
Superfamily-SCOP	LDL_rcpt_classA_cys-rich	UniProtKB/TrEMBL
	Prot_inh_Kunz-m	UniProtKB/TrEMBL
UniGene	Rn.44189	ENTREZGENE
UniProt	Q4V8Q2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-09-18	Spint1	serine peptidase inhibitor, Kunitz type 1	Spint1	serine protease inhibitor, Kunitz type 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Spint1	serine peptidase inhibitor, Kunitz type 1		hepatocyte growth factor activator inhibitor 1	Name updated	1299863	APPROVED
2005-02-14	Spint1	hepatocyte growth factor activator inhibitor 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)