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Gene: Plcb2 (phospholipase C, beta 2) Rattus norvegicus

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Symbol:

Plcb2

Name:

phospholipase C, beta 2

RGD ID:

621004

Description:

Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (phospholipase C beta 2); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2; phospholipase C beta 2; phospholipase C-beta-2; PKC beta II; PLC-beta-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLCB2 (phospholipase C beta 2)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Plcb2 (phospholipase C, beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Plcb2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLCB2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLCB2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Plcb2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLCB2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLCB2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Plcb2 (phospholipase C beta 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PLCB2 (phospholipase C beta 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Plcb2 (phospholipase C, beta 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	plcb2 (phospholipase C, beta 2)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	PLC1	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	Plc21C	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	plc-2	Alliance	DIOPT (OMA\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	plcb2	Alliance	DIOPT (OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,134,925 - 126,158,303 (-)	NCBI		GRCr8
mRatBN7.2	3	105,683,676 - 105,704,384 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	105,684,815 - 105,704,302 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	109,357,684 - 109,377,152 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	117,953,248 - 117,972,712 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	115,613,610 - 115,633,075 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,497,760 - 110,517,563 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,498,114 - 110,517,163 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,038,677 - 117,058,132 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,203,524 - 105,223,342 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	105,099,951 - 105,119,770 (-)	NCBI
Celera	3	104,599,222 - 104,618,601 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

Moebius syndrome (ISO)

mosaic variegated aneuploidy syndrome 1 (ISO)

thrombocytopenia (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (EXP)

all-trans-retinoic acid (ISO)

allethrin (EXP)

ammonium chloride (EXP)

antirheumatic drug (ISO)

apocynin (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP,ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

cisplatin (ISO)

Cuprizon (EXP)

cyhalothrin (EXP)

cypermethrin (EXP)

cytarabine (ISO)

D-glucose (EXP)

daidzein (EXP)

dapsone (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

diquat (ISO)

doxorubicin (ISO)

edelfosine (ISO)

ethanol (ISO)

fenvalerate (EXP)

fonofos (ISO)

FR900359 (ISO)

fulvestrant (ISO)

furan (EXP)

glucose (EXP)

glyphosate (EXP)

lidocaine (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-methyl-4-phenylpyridinium (ISO)

nitrates (EXP)

ozone (ISO)

paraquat (ISO)

parathion (ISO)

phorbol 13-acetate 12-myristate (ISO)

pyrethrins (EXP)

quercitrin (ISO)

serpentine asbestos (ISO)

silicon dioxide (EXP)

sodium arsenite (ISO)

streptozocin (EXP)

sunitinib (ISO)

terbufos (ISO)

testosterone (EXP,ISO)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

tungsten (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

detection of chemical stimulus involved in sensory perception of bitter taste (IDA,IMP)

G protein-coupled receptor signaling pathway (IBA)

intracellular signal transduction (IEA)

lipid catabolic process (IEA)

phosphatidylinositol metabolic process (IBA,IEA,ISO,ISS)

phosphatidylinositol-mediated signaling (IBA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IDA,IEA,ISO)

release of sequestered calcium ion into cytosol (IBA)

sensory perception of bitter taste (IEA,ISO)

Cellular Component

cytoplasm (IBA,ISO)

G-protein beta/gamma-subunit complex (IDA)

neuronal dense core vesicle (IEA,ISO)

Molecular Function

calcium ion binding (IEA)

G-protein beta/gamma-subunit complex binding (IDA)

phosphatidylinositol phospholipase C activity (IBA,IEA,IMP,ISO,ISS)

phospholipase C activity (IMP)

phospholipid binding (IDA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of phospholipase C beta isoforms and their location in cultured vascular smooth muscle cells of pig, human and rat.	Blayney L, etal., Cardiovasc Res. 1998 Dec;40(3):564-72.
2.	Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme?	Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
6.	Subcellular localization of phospholipase C isoforms in vascular smooth muscle.	LaBelle EF, etal., Biochim Biophys Acta. 2002 Aug 8;1583(3):273-8.
7.	Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction.	Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Regulation of phosphoinositide-specific phospholipase C.	Rhee SG Annu Rev Biochem. 2001;70:281-312.
15.	Identification of a phospholipase C beta subtype in rat taste cells.	Rossler P, etal., Eur J Cell Biol 1998 Nov;77(3):253-61.
16.	Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins.	Wang T, etal., Biochemistry. 1999 Feb 2;38(5):1517-24.
17.	Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle.	Wright DC, etal., Life Sci 2003 May 23;73(1):61-71.
18.	Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.	Zhang Y, etal., Cell 2003 Feb 7;112(3):293-301.

Additional References at PubMed

PMID:8454637	PMID:8519600	PMID:15759003	PMID:18820027	PMID:20393598	PMID:21606356	PMID:23010799	PMID:23625927	PMID:36934663

Genomics

Comparative Map Data

Plcb2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	126,134,925 - 126,158,303 (-)	NCBI		GRCr8
mRatBN7.2	3	105,683,676 - 105,704,384 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	105,684,815 - 105,704,302 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	109,357,684 - 109,377,152 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	117,953,248 - 117,972,712 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	115,613,610 - 115,633,075 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	110,497,760 - 110,517,563 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	110,498,114 - 110,517,163 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	117,038,677 - 117,058,132 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	105,203,524 - 105,223,342 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	105,099,951 - 105,119,770 (-)	NCBI
Celera	3	104,599,222 - 104,618,601 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

PLCB2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	40,284,256 - 40,307,935 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	40,278,176 - 40,307,935 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	40,580,110 - 40,600,136 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	38,367,390 - 38,387,466 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	38,367,401 - 38,387,330	NCBI
Celera	15	17,346,090 - 17,366,157 (-)	NCBI		Celera
Cytogenetic Map	15	q15.1	NCBI
HuRef	15	17,423,058 - 17,443,532 (-)	NCBI		HuRef
CHM1_1	15	40,700,041 - 40,720,115 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	38,091,173 - 38,114,815 (-)	NCBI		T2T-CHM13v2.0

Plcb2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	118,535,484 - 118,559,140 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	118,537,998 - 118,558,919 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	118,705,003 - 118,728,661 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	118,707,517 - 118,728,438 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	118,533,253 - 118,554,174 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	118,398,958 - 118,419,879 (-)	NCBI		MGSCv36	mm8
Celera	2	119,861,823 - 119,882,734 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.43	NCBI

Plcb2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	7,218,417 - 7,240,739 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	7,221,326 - 7,240,743 (-)	NCBI	ChiLan1.0	ChiLan1.0

PLCB2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	29,518,245 - 29,541,893 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	33,669,673 - 33,693,337 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	19,218,329 - 19,241,977 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	37,476,699 - 37,496,813 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	37,476,699 - 37,496,813 (-)	Ensembl	panpan1.1		panPan2

PLCB2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	7,472,208 - 7,493,106 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	7,472,413 - 7,492,801 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	7,526,161 - 7,547,075 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	7,598,044 - 7,618,970 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	7,594,683 - 7,619,120 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	7,522,589 - 7,543,490 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	7,628,543 - 7,649,438 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	7,757,123 - 7,778,226 (-)	NCBI		UU_Cfam_GSD_1.0

Plcb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	85,908,907 - 85,928,377 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	3,756,970 - 3,776,392 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	3,756,978 - 3,776,452 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLCB2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	131,005,408 - 131,028,689 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	131,005,408 - 131,031,864 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	146,286,447 - 146,302,118 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLCB2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	42,706,462 - 42,727,516 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	42,707,625 - 42,727,145 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	98,236,858 - 98,257,092 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plcb2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	7,591,844 - 7,612,645 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	7,593,956 - 7,612,860 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Plcb2
75 total Variants

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	84091273	129091273	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

Plcb2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	126,144,103 - 126,144,769 (+)	Marker Load Pipeline
mRatBN7.2	3	105,690,184 - 105,690,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	110,503,144 - 110,503,809	NCBI	Rnor6.0
Rnor_5.0	3	117,044,015 - 117,044,680	UniSTS	Rnor5.0
Celera	3	104,604,484 - 104,605,149	UniSTS
Cytogenetic Map	3	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053478	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592081	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592082	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039105997	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284735	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_001837051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010064706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AJ011035	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ120505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ120506	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB877226	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB895860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC934635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC953269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000078037 ⟹ ENSRNOP00000070903

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	105,684,815 - 105,704,302 (-)	Ensembl
Rnor_6.0 Ensembl	3	110,498,114 - 110,517,163 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000105616 ⟹ ENSRNOP00000086367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	105,684,815 - 105,704,302 (-)	Ensembl

RefSeq Acc Id:

NM_053478 ⟹ NP_445930

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,138,736 - 126,158,221 (-)	NCBI
mRatBN7.2	3	105,684,815 - 105,704,302 (-)	NCBI
Rnor_6.0	3	110,497,760 - 110,517,261 (-)	NCBI
Rnor_5.0	3	117,038,677 - 117,058,132 (-)	NCBI
RGSC_v3.4	3	105,203,524 - 105,223,342 (-)	RGD
Celera	3	104,599,222 - 104,618,601 (-)	RGD

Sequence:

show sequence

CCCAGCCTAGCTTCCCCTCCAGTTCCCCTCCTTCCTTCTCTCCTCCTGTCCACTGGAGAGGTTT
GCCCAACCTCTGCAAAGAGGGACAATTGACATCATGTCTTTGCTCAACCCTGTCCTGTTGCCCC
CTAAGGTGAAGGCATATCTGAGCCAAGGGGAGCGCTTCATCAAGTGGGACGATGAAACCTCAAT
AGCCTCCCCTGTTATCCTTCGGGTGGATCCCAAGGGCTATTACTTATACTGGACACATCAAAGT
AAGGAGATGGAATTTCTGGATGTCACGAGCATCCGAGACACTCGCTTTGGGAAGTTTGCCAAGA
TACCCAAGAGCCAGAAACTCCGGGAGGTATTCAACATGGACTTTCCAGACAACCACTTCCTGCT
GAAAACATTCACAGTGGTATCCGGCCCGGACATGGTGGGCCTCACCTTCCACAATTTTGTCTCT
TACAAGGAGAACGTAGGCAAGGATTGGGCTGAGGATGTACTGGCTCTGGCCAAACACCCAATGA
CAGCCAATGCTTCTCGAAGCACATTCCTAGACAAGATCCTGGTGAAGCTTAAAATGCAGCTGAG
CCCTGAAGGGAAGATCCCTGTGAAGAATTTTTTCCAGATGTTTCCTGCCGATCGCAAACGTGTA
GAAGCTGCCCTCAGTGCCTGTCACCTTGCAAAAGGCAAGAATGATGCTATCAATCCCGAGGACT
TCCCAGAATCTGTGTACAAGAGCTTCCTCATGAGCCTCTGTCCTCGGCCAGAAATTGATGAGAT
CTTCACTTCTTATCATGCTAAAGCCAAACCCTACATGACCAAGGAGCACCTGACCAAATTCATC
AATCAGAAGCAACGAGACCCTCGACTCAATTCCTTGCTGTTCCCACCAGCCCGGCCTGAGCAGG
TGCAGGCGCTCATTGACAAGTACGAGCCCAGCGGCATCAATGTGCAGAGGGGCCAACTGTCACC
AGAGGGCATGGTCTGGTTTCTCTGTGGACCAGAGAACAGTGTCCTGGCCCATGATACTCTGCGG
ATCCACCAAGACATGACACAGCCTCTGAATCACTACTTCATCAACTCCTCACACAACACTTACC
TGACAGCTGGCCAGTTTTCAGGCCCTTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTATCTGG
CTGCCGTTGTGTAGAATTAGATTGTTGGAAAGGAAAGCCCCCCGACGAAGAACCCATCATCACC
CACGGCTTCACTATGACCACAGATATCTTGTTCAAGGAAGCAGTCGAAGCCATTGCAGAAAGTG
CCTTTAAGACCTCCCCATATCCTGTCATCCTGTCATTTGAAAACCACGTGGACTCACCCCGCCA
ACAGGCTAAGATGGCCGAGTACTGCCGGACCATGTTTGGAGAGACCTTGCTCACAGAGCCCCTG
GAAAACTTTCCTCTGAAACCTGGCATGCCTCTGCCTAGCCCTGAGGACCTCCGGGGCAAGATCC
TCATTAAGAATAAGAAGAACCAGTTTTCTGGGCCAGCATCCCCCAACAAGAAGCCTGATGGGGT
GTCTGAGGGCGGCTTCCCATCTAGTGTCCCTGTAGAAGAGGACACGGGGTGGACTGCTGAGGAC
CGGACTGAGGTGGAGGAGGGAGAGGAGGAGGAGGAGGTGGAAGAAGAGGAAGAGGAGGAGTCAG
GAAACCTGGATGAAGAAGAAATTAAGAAGATGCAGTCTGATGAGGGCACAGCAGGCTTGGAGGT
GACAGCTTATGAGGAAATGTCCAGCCTTGTCAATTACATCCAGCCCACCAAGTTTATCTCCTTC
GAGTTCTCTGCACAGAAGAACAGGAGTTACCTTGTCTCTTCCTTCACGGAGCTCAAGGCCTACG
AGCTGCTCTCCAAGGCCTCCATGCAGTTTGTGGACTATAATAAACGCCAGATGAGCCGCGTGTA
CCCCAAGGGCACGCGCATGGACTCTTCCAACTACATGCCCCAGATGTTCTGGAATGCCGGATGT
CAGATGGTTGCCCTCAATTTCCAGACAATGGATCTGCCCATGCAGCAGAACATGGCACTGTTTG
AGTTCAACGGGCAGAGTGGCTACCTCCTAAAGCACGAGTTCATGCGCAGGCAGGACAAGCAGTT
CAACCCCTTCTCGGTGGACCGCATTGATGTGGTGGTTGCCACTACCCTTTCCATTACGGTCATC
TCTGGGCAGTTCCTGTCAGAGCGCAGTGTGCGCACCTATGTGGAAGTAGAACTGTTTGGCCTCC
CAGGGGACCCCAAGAGGCGCTATCGTACCAAGCTGTCACCTACTGCTAACTCCATCAATCCTGT
CTGGAAGGAGGAACCCTTCATTTTTGAGAAGATCTTGGTGCCTGAGCTGGCCTCCCTCAGGATA
GCTGTAATGGAAGAAGGCGGCAAATTTATTGGACATCGCATCATCCCCATCAATGCCTTACATT
CCGGATACCACCATCTGTGCCTGCGCAGTGAGAGCAACATGCCTCTCACCATGCCTGCTCTCTT
CGTCTTCCTGGAGATGAAGGACTATGTACCTGACACGTGGGCAGATCTTACTGTGGCTCTTGCC
AACCCCATCAAGTACTTCAGTGCCCATGATAAGAAGTCTGTGAAGCTCAAAGAAGTGACAGGAA
GTCTGCCTGAGAAGCTCTTCTCTGGGATTCCTGTTGCCAGCCAGTCCAACGGGGCTCCAGTCTC
CGCAGGCAATGGGTCAACAGCGCCTGGGACCAAGGCCAAGGAGGAAGCTACGAAGGAAGTGGCA
GAGCCACAGACCACTAGCTTGGAAGAGCTGCGGGAGCTGAAGGGCGTGGTGAAGCTGCAGCGGA
GACATGAGAAGGAGCTTCGAGAGCTGGAGCGGCGTGGAGCCCGGCGCTGGGAGGAGCTGCTGCA
GCGTGGCGCTGCACAGCTAGCGGAGCTCCAGGACCCAGCAGCAAGCTGCAAGCTCCGCCCGGGC
AAGGGCTCCCGCAAGAAGAGGATCGTGCCCTGTGAGGAGACCATCGTGGTGCCTAGGGAGGTCC
TCGAGGGACCGGACCCCCGCGTGCAGGATCTGAAGGACAGGCTGGAGCAGGAGCTGCAGCAGCA
AGGCGAGGAGCAGTACCGCTCTGTCCTCAAGCGTAAGGAGCAGCACGTGACCGAGCAAATCGCC
AAGATGATGGAGCTGGCCAGAGAGAAACAGGCTGCTGAACTCAAGAGCTTCAAGGAGACCTCGG
AAACTGACACCAAAGAGATGAAGAAAAAACTGGAGGCCAAAAGGCTGGAGCGGATCCAAGCCAT
GACCAAAGTCACCACAGACAAGGTGGCCCAGGAGAGGCTCAAGAGAGAAATTAACAACTCCCAC
ATCCAGGAGGTGGTGCAGGCTGTCAAGCAGATGACAGAGACCCTGGAGCGTCACCAGGAGAAGC
TGGAAGAGAAGCAGACAGCCTGCCTGGAGCAGATCCAGGCAATGGAAAAGCAGTTCCAGGAGAA
GGCGCTGGCAGAGTATGAGGCCAAGATGAAGGGCCTGGAGGCTGAAGTAAAGGAGTCAATGCGG
GCTTGCTTCAAGGCCTGCTTCCCCACGGAAGCAGAAGAGAAGCCTGAGAGGCCCTGTGAGGCCT
CTGAGGAGTCGTGTCCACAGGAGCCACTTGTGAACAAGACAGACACTCAGGAGAGCCGCCTCTG
AATGCCAGCATCTCACTCCGACATTTTAGCAAGGATATCCACGCCTTTCTCCTCGGGAGAAAAG
GACCTTATTACTCTGGGGCTGTGGGAGCCTGGGGCTGCTTGGCTGCCGCAGCCCCGCTTCTCAG
CCACATAAGGCAGAAATGGGAGACCATTGGGGCAAGAGCCCCATGGAACCCGAGTCTTTTCTAA
GCTGGCTTCTTCTGTCGTCCCACCTGTAGTGCCATATACTTATTGAAGGCAAAGGAATATGGAC
CAAGAGAGAGGAAATTGGGTCCTGGTCTCCCTCTGCCTTTCCTAACATACATGCAGGGGCTCTC
ACTTGGAGCTCCGTTCCTTTCCTGGATGCTT

hide sequence

RefSeq Acc Id:

XM_039105997 ⟹ XP_038961925

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,147,508 - 126,158,303 (-)	NCBI
mRatBN7.2	3	105,693,589 - 105,704,384 (-)	NCBI

RefSeq Acc Id:

XM_063284733 ⟹ XP_063140803

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,134,925 - 126,158,303 (-)	NCBI

RefSeq Acc Id:

XM_063284734 ⟹ XP_063140804

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,134,925 - 126,156,475 (-)	NCBI

RefSeq Acc Id:

XM_063284735 ⟹ XP_063140805

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,134,925 - 126,147,419 (-)	NCBI

RefSeq Acc Id:

XR_001837051

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,141,629 - 126,158,303 (-)	NCBI
mRatBN7.2	3	105,687,709 - 105,704,384 (-)	NCBI
Rnor_6.0	3	110,500,719 - 110,517,563 (-)	NCBI

Sequence:

show sequence

CTAGTTCCAACACTTCCAAAACTCATAGCCTGCCCCTCCATTCACAGCAGCCCAGAGAGGGAAG
CCCAGAGCAGGAAGTGCTGAGGCAGGGGGTGGGGAGGGACTCCCAGGAGGGGAGCCCAGCCCCT
TGGGCAGAAACAGCCGTAGCAGCCCCCACTTCGGGTGGGGGCGGAGGCTGATTTACAAGGCAGA
TCAACTGGGCCTCTGCCTGAAGCTCTGAGTCCTGCTACCGGCTACTGCCACCCTGTAGGCTATA
AGAGTACCCCGACTTCCGGACCAGTTCTGGGCGGGTGCCATGTGAGCCCAGCCTAGCTTCCCCT
CCAGTTCACCCTCCTTCCTTCTCTCCTCCTGTCCACTGGAGAGGTTTGCCCAACCTCTGCAAAG
AGGGACAATTGACATCATGTCTTTGCTCAACCCTGTCCTGTTGCCCCCTAAGGTGAAGGCATAT
CTGAGCCAAGGGGAGCGCTTCATCAAGTGGGACGATGAAACCTCAATAGCCTCCCCTGTTATCC
TTCGGGTGGATCCCAAGGGCTATTACTTATACTGGACACATCAAAGTAAGGAGATGGAATTTCT
GGATGTCACGAGCATCCGAGACACTCGCTTTGGGAAGTTTGCCAAGATACCCAAGAGCCAGAAA
CTCCGGGAGGTATTCAACATGGACTTTCCAGACAACCACTTCCTGCTGAAAACATTCACAGTGG
TATCCGGCCCGGACATGGTGGGCCTCACCTTCCACAATTTTGTCTCTTACAAGGAGAACGTAGG
CAAGGATTGGGCTGAGGATGTACTGGCTCTGGCCAAACACCCAATGACAGCCAATGCTTCTCGA
AGCACATTCCTAGACAAGATCCTGGTGAAGCTTAAAATGCAGCTGAGCCCTGAAGGGAAGATCC
CTGTGAAGAATTTTTTCCAGATGTTTCCTGCCGATCGCAAACGTGTAGAAGCTGCCCTCAGTGC
CTGTCACCTTGCAAAAGGCAAGAATGATGCTATCAATCCCGAGGACTTCCCAGAATCTGTGTAC
AAGAGCTTCCTCATGAGCCTCTGTCCTCGGCCAGAAATTGATGAGATCTTCACTTCTTATCATG
CTAAAGCCAAACCCTACATGACCAAGGAGCACCTGACCAAATTCATCAATCAGAAGCAACGAGA
CCCTCGACTCAATTCCTTGCTGTTCCCACCAGCCCGGCCTGAGCAGGTGCAGGCGCTCATTGAC
AAGTACGAGCCCAGCGGCATCAATGTGCAGAGGGGCCAACTGTCACCAGAGGGCATGGTCTGGT
TTCTCTGTGGACCAGAGAACAGTGTCCTGGCCCATGATACTCTGCGGATCCACCAAGACATGAC
ACAGCCTCTGAATCACTACTTCATCAACTCCTCACACAACACCTACCTGACAGCTGGCCAGTTT
TCAGGCCCTTCCTCGGCTGAGATGTACCGCCAGGTGCTGCTATCTGGCTGCCGTTGTGTAGAAT
TAGATTGTTGGAAAGGAAAGCCCCCCGACGAAGAACCCATCATCACCCACGGCTTCACTATGAC
CACAGATATCTTGTTCAAGGAAGCAGTCGAAGCCATTGCAGAAAGTGCCTTTAAGACCTCCCCA
TATCCTGTCATCCTGTCATTTGAAAACCACGTGGACTCACCCCGCCAACAGGCTAAGATGGCCG
AGTACTGCCGGACCATGTTTGGAGAGACCTTGCTCACAGAGCCCCTGGAAAACTTTCCTCTGAA
ACCTGGCATGCCTCTGCCTAGCCCTGAGGACCTCCGGGGCAAGATCCTCATTAAGAATAAGAAG
AACCAGTTTTCTGGGCCAGCATCCCCCAACAAGAAGCCTGATGGGGTGTCTGAGGGCGGCTTCC
CATCTAGTGTCCCTGTAGAAGAGGACACGGGGTGGACTGCTGAGGACCGGACTGAGGTGGAGGA
GGGAGAGGAGGAGGAGGAGGTGGAAGAAGAGGAAGAGGAGGAGTCAGGAAACCTGGATGAAGAA
GAAATTAAGAAGATGCAGTCTGATGAGGGCACAGCAGGCTTGGAGGTGACAGCTTATGAGGAAA
TGTCCAGCCTTGTCAATTACATCCAGCCCACCAAGTTTATCTCCTTCGAGTTCTCTGCACAGAA
GAACAGGAGTTACCTTGTCTCTTCCTTCACGGAGCTCAAGGCCTACGAGCTGCTCTCCAAGGCC
TCCATGCAGTTTGTGGACTATAATAAACGCCAGATGAGCCGCGTGTACCCCAAGGGCACGCGCA
TGGACTCTTCCAACTACATGCCCCAGATGTTCTGGAATGCCGGATGTCAGATGGTTGCCCTCAA
TTTCCAGACAATGGATCTGCCCATGCAGCAGAACATGGCACTGTTTGAGTTCAACGGGCAGAGT
GGCTACCTCCTAAAGCACGAGTTCATGCGCAGGCAGGACAAGCAGTTCAACCCCTTCTCGGTGG
ACCGCATTGATGTGGTGGTTGCCACTACCCTTTCCATTACGGTCATCTCTGGGCAGTTCCTGTC
AGAGCGCAGTGTGCGCACCTATGTGGAAGTAGAACTGTTTGGCCTCCCAGGGGACCCCAAGAGG
CGCTATCGTACCAAGCTGTCACCTACTGCTAACTCCATCAATCCTGTCTGGAAGGAGGAACCCT
TCATTTTTGAGAAGATCTTGGTGCCTGAGCTGGCCTCCCTCAGGATAGCTGTAATGGAAGAAGG
CGGCAAATTTATTGGACATCGCATCATCCCCATCAATGCCTTACATTCCGGATACCACCATCTG
TGCCTGCGCAGTGAGAGCAACATGCCTCTCACCATGCCTGCTCTCTTCGTCTTCCTGGAGATGA
AGGACTATGTACCTGACACGTGGGCAGATCTTACTGTGGCTCTTGCCAACCCCATCAAGTACTT
CAGTGCCCATGATAAGAAGTCTGTGAAGCTCAAAGAAGTGACAGGAAGTCTGCCTGAGAAGCTC
TTCTCTGGGATTCCTGTTGCCAGCCAGTCCAACGGGGCTCCAGTCTCCGCAGGCAATGGGTCAA
CAGGAACCAAACTGAGGTGCCTCCAAGGCACCTGACAGTCCAGCCCTGTGCTCTTACAGCGCCT
GGGACCAAGGCCAAGGAGGAAGCTACGAAGGAAGTGGCAGAGCCACAGACCACTAGCTTGGAAG
AGCTGCGGGAGCTGAAGGGCGTGGTGAAGCT

hide sequence

RefSeq Acc Id:

XR_005501996

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,145,623 - 126,158,303 (-)	NCBI
mRatBN7.2	3	105,691,708 - 105,704,384 (-)	NCBI

RefSeq Acc Id:

XR_010064706

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	126,141,629 - 126,158,303 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_445930	(Get FASTA)	NCBI Sequence Viewer
	XP_038961925	(Get FASTA)	NCBI Sequence Viewer
	XP_063140803	(Get FASTA)	NCBI Sequence Viewer
	XP_063140804	(Get FASTA)	NCBI Sequence Viewer
	XP_063140805	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAZ23844	(Get FASTA)	NCBI Sequence Viewer
	AAZ23845	(Get FASTA)	NCBI Sequence Viewer
	CAA09465	(Get FASTA)	NCBI Sequence Viewer
	CBF62962	(Get FASTA)	NCBI Sequence Viewer
	CBF74725	(Get FASTA)	NCBI Sequence Viewer
	CBU87838	(Get FASTA)	NCBI Sequence Viewer
	CBU96785	(Get FASTA)	NCBI Sequence Viewer
	EDL79869	(Get FASTA)	NCBI Sequence Viewer
	EDL79870	(Get FASTA)	NCBI Sequence Viewer
	EDL79871	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000070903
	ENSRNOP00000070903.2
	ENSRNOP00000086367.1
	ENSRNOP00055003057
	ENSRNOP00060033278
	ENSRNOP00065031775
GenBank Protein	O89040	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445930 ⟸ NM_053478

- UniProtKB:

O89040 (UniProtKB/Swiss-Prot), A0A0G2JZ43 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSI
RDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAE
DVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAK
GKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNS
LLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNH
YFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILF
KEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPL
PSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEE
EVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYL
VSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMD
LPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVR
TYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIG
HRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDK
KSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELR
ELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPC
EETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQA
AELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQM
TETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEA
EEKPERPCEASEESCPQEPLVNKTDTQESRL

hide sequence

Ensembl Acc Id:

ENSRNOP00000070903 ⟸ ENSRNOT00000078037

RefSeq Acc Id:	XP_038961925 ⟸ XM_039105997
- Peptide Label:	isoform X4

Ensembl Acc Id:

ENSRNOP00000086367 ⟸ ENSRNOT00000105616

RefSeq Acc Id:	XP_063140803 ⟸ XM_063284733
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JZ43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140804 ⟸ XM_063284734
- Peptide Label:	isoform X2
- UniProtKB:	A0A0G2JZ43 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063140805 ⟸ XM_063284735
- Peptide Label:	isoform X3
- UniProtKB:	A6HPB8 (UniProtKB/TrEMBL)

Protein Domains

C2 Phosphatidylinositol-specific phospholipase C X PI-PLC X-box PI-PLC Y-box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O89040-F1-model_v2	AlphaFold	O89040	1-1183	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621004	AgrOrtholog
BioCyc Gene	G2FUF-48241	BioCyc
BioCyc Pathway	PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis]	BioCyc
	PWY-6367 [D-myo-inositol-5-phosphate metabolism]	BioCyc
	PWY-8052 [2-arachidonoylglycerol biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-6351	BioCyc
	PWY-6367	BioCyc
	PWY-8052	BioCyc
Ensembl Genes	ENSRNOG00000058337	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055002548	UniProtKB/Swiss-Prot
	ENSRNOG00060023267	UniProtKB/Swiss-Prot
	ENSRNOG00065022861	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000078037	UniProtKB/TrEMBL
	ENSRNOT00000078037.2	UniProtKB/Swiss-Prot
	ENSRNOT00000105616.1	UniProtKB/TrEMBL
	ENSRNOT00055004053	UniProtKB/Swiss-Prot
	ENSRNOT00060040306	UniProtKB/Swiss-Prot
	ENSRNOT00065039121	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1230.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.240	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.20.20.190	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C2_Ca-dep	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
	Phospholipase_C_Pinositol-sp_C	UniProtKB/Swiss-Prot
	Phospholipase_C_Pinositol-sp_Y	UniProtKB/Swiss-Prot
	PI-PLC_fam	UniProtKB/TrEMBL
	PLC-beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-beta2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-beta_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-beta_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-beta_PH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC_EF-hand-like	UniProtKB/TrEMBL
	PLCB1-4-like_EFh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLCbeta2_EF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_C_PInositol-sp_X_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLipase_C_Pinositol-sp_Y	UniProtKB/TrEMBL
KEGG Report	rno:85240	UniProtKB/Swiss-Prot
NCBI Gene	85240	ENTREZGENE
PANTHER	PTHR10336	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10336:SF10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	EF-hand_like	UniProtKB/TrEMBL
	PF00168	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH_14	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PI-PLC-X	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PI-PLC-Y	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-beta_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLCB1-4-like_EFh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Plcb2	PhenoGen
PIRSF	PLC-beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	PHPHLIPASEC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PIPLC_X_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PIPLC_Y_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PS50004	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000058337	RatGTEx
	ENSRNOG00055002548	RatGTEx
	ENSRNOG00060023267	RatGTEx
	ENSRNOG00065022861	RatGTEx
SMART	PLCXc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLCYc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00239	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	C-terminal domain of PLC-beta	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PH domain-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/Swiss-Prot
	SSF47473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF49562	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF51695	UniProtKB/TrEMBL
UniProt	A0A0G2JZ43	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6GEV3_RAT	UniProtKB/TrEMBL
	A6HPB8	ENTREZGENE, UniProtKB/TrEMBL
	A6HPB9_RAT	UniProtKB/TrEMBL
	A6HPC0_RAT	UniProtKB/TrEMBL
	O89040	ENTREZGENE, UniProtKB/Swiss-Prot
	Q45QJ6_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Plcb2	phospholipase C, beta 2		phospholipase C beta 2	Name updated	1299863	APPROVED
2002-08-07	Plcb2	phospholipase C beta 2			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed exclusively in a subset of taste receptor cells of circumvallate papillae	729588

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

RGD Manual Annotations

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

BioCyc Pathways