Plcb2 (phospholipase C, beta 2) - Rat Genome Database

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Gene: Plcb2 (phospholipase C, beta 2) Rattus norvegicus
Analyze
Symbol: Plcb2
Name: phospholipase C, beta 2
RGD ID: 621004
Description: Enables G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Located in Golgi apparatus; cytosol; and plasma membrane. Part of G-protein beta/gamma-subunit complex. Orthologous to human PLCB2 (phospholipase C beta 2); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2; phospholipase C beta 2; phospholipase C-beta-2; PKC beta II; PLC-beta-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,683,676 - 105,704,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,357,684 - 109,377,152 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03117,953,248 - 117,972,712 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03115,613,610 - 115,633,075 (-)NCBIRnor_WKY
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Celera3104,599,222 - 104,618,601 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Identification of phospholipase C beta isoforms and their location in cultured vascular smooth muscle cells of pig, human and rat. Blayney L, etal., Cardiovasc Res. 1998 Dec;40(3):564-72.
2. Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding--how many ways can you activate an enzyme? Drin G and Scarlata S, Cell Signal. 2007 Jul;19(7):1383-92. Epub 2007 Apr 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Subcellular localization of phospholipase C isoforms in vascular smooth muscle. LaBelle EF, etal., Biochim Biophys Acta. 2002 Aug 8;1583(3):273-8.
7. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Li Z, etal., Science 2000 Feb 11;287(5455):1046-9.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Regulation of phosphoinositide-specific phospholipase C. Rhee SG Annu Rev Biochem. 2001;70:281-312.
15. Identification of a phospholipase C beta subtype in rat taste cells. Rossler P, etal., Eur J Cell Biol 1998 Nov;77(3):253-61.
16. Differential association of the pleckstrin homology domains of phospholipases C-beta 1, C-beta 2, and C-delta 1 with lipid bilayers and the beta gamma subunits of heterotrimeric G proteins. Wang T, etal., Biochemistry. 1999 Feb 2;38(5):1517-24.
17. Evidence for the involvement of a phospholipase C--protein kinase C signaling pathway in insulin stimulated glucose transport in skeletal muscle. Wright DC, etal., Life Sci 2003 May 23;73(1):61-71.
18. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways. Zhang Y, etal., Cell 2003 Feb 7;112(3):293-301.
Additional References at PubMed
PMID:8454637   PMID:8519600   PMID:15759003   PMID:18820027   PMID:20393598   PMID:21606356   PMID:23010799   PMID:23625927  


Genomics

Comparative Map Data
Plcb2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23105,683,676 - 105,704,384 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,357,684 - 109,377,152 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03117,953,248 - 117,972,712 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03115,613,610 - 115,633,075 (-)NCBIRnor_WKY
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Celera3104,599,222 - 104,618,601 (-)NCBICelera
Cytogenetic Map3q35NCBI
PLCB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,284,256 - 40,307,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1540,278,176 - 40,307,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371540,580,110 - 40,600,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,367,390 - 38,387,466 (-)NCBINCBI36Build 36hg18NCBI36
Build 341538,367,401 - 38,387,330NCBI
Celera1517,346,090 - 17,366,157 (-)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,423,058 - 17,443,532 (-)NCBIHuRef
CHM1_11540,700,041 - 40,720,115 (-)NCBICHM1_1
T2T-CHM13v2.01538,094,812 - 38,114,815 (-)NCBIT2T-CHM13v2.0
Plcb2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,535,484 - 118,559,140 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,537,998 - 118,558,919 (-)EnsemblGRCm39 Ensembl
GRCm382118,705,003 - 118,728,661 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,707,517 - 118,728,438 (-)EnsemblGRCm38mm10GRCm38
MGSCv372118,533,253 - 118,554,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,398,958 - 118,419,879 (-)NCBIMGSCv36mm8
Celera2119,861,823 - 119,882,734 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.43NCBI
Plcb2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,218,417 - 7,240,739 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,221,326 - 7,240,743 (-)NCBIChiLan1.0ChiLan1.0
PLCB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11537,476,699 - 37,496,813 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,476,699 - 37,496,813 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01519,218,329 - 19,241,977 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PLCB2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,472,208 - 7,493,106 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,472,413 - 7,492,801 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,526,161 - 7,547,075 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,598,044 - 7,618,970 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,594,683 - 7,619,120 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,522,589 - 7,543,490 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,628,543 - 7,649,438 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,757,123 - 7,778,226 (-)NCBIUU_Cfam_GSD_1.0
Plcb2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,908,907 - 85,928,377 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,756,970 - 3,776,392 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364713,756,978 - 3,776,452 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLCB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,005,408 - 131,028,689 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,005,408 - 131,031,864 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21146,286,447 - 146,302,118 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PLCB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,706,462 - 42,727,516 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,707,625 - 42,727,145 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,236,858 - 98,257,092 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Plcb2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,591,844 - 7,612,645 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,593,956 - 7,612,860 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Plcb2
53 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

Markers in Region
Plcb2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,690,184 - 105,690,850 (+)MAPPERmRatBN7.2
Rnor_6.03110,503,144 - 110,503,809NCBIRnor6.0
Rnor_5.03117,044,015 - 117,044,680UniSTSRnor5.0
Celera3104,604,484 - 104,605,149UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 11 8
Low 2 35 55 39 8 39 8 10 64 32 31 3 8
Below cutoff 8 2 2 2 1 10 3 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001837051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AJ011035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ120506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB877226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB895860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC934635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC953269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000078037   ⟹   ENSRNOP00000070903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)Ensembl
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105616   ⟹   ENSRNOP00000086367
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,684,815 - 105,704,302 (-)Ensembl
RefSeq Acc Id: NM_053478   ⟹   NP_445930
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,684,815 - 105,704,302 (-)NCBI
Rnor_6.03110,497,760 - 110,517,261 (-)NCBI
Rnor_5.03117,038,677 - 117,058,132 (-)NCBI
RGSC_v3.43105,203,524 - 105,223,342 (-)RGD
Celera3104,599,222 - 104,618,601 (-)RGD
Sequence:
RefSeq Acc Id: XM_039105996   ⟹   XP_038961924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,683,676 - 105,693,492 (-)NCBI
RefSeq Acc Id: XM_039105997   ⟹   XP_038961925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,693,589 - 105,704,384 (-)NCBI
RefSeq Acc Id: XR_001837051
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,687,709 - 105,704,384 (-)NCBI
Rnor_6.03110,500,719 - 110,517,563 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005501996
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23105,691,708 - 105,704,384 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_445930   ⟸   NM_053478
- UniProtKB: O89040 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070903   ⟸   ENSRNOT00000078037
RefSeq Acc Id: XP_038961924   ⟸   XM_039105996
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038961925   ⟸   XM_039105997
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086367   ⟸   ENSRNOT00000105616
Protein Domains
C2   PI-PLC X-box   PI-PLC Y-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89040-F1-model_v2 AlphaFold O89040 1-1183 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621004 AgrOrtholog
BioCyc Gene G2FUF-48241 BioCyc
BioCyc Pathway PWY-6351 [D-myo-inositol (1,4,5)-trisphosphate biosynthesis] BioCyc
  PWY-6367 [D-myo-inositol-5-phosphate metabolism] BioCyc
  PWY-8052 [2-arachidonoylglycerol biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000058337 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000070903 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOP00000086367.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000078037 ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOT00000105616.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.190 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C2_Ca-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  Phospholipase_C_EF-hand-like UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_C UniProtKB/Swiss-Prot
  Phospholipase_C_Pinositol-sp_Y UniProtKB/Swiss-Prot
  PI-PLC_fam UniProtKB/TrEMBL
  PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_PH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC_EF-hand-like UniProtKB/TrEMBL
  PLipase_C_PInositol-sp_X_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLipase_C_Pinositol-sp_Y UniProtKB/TrEMBL
KEGG Report rno:85240 UniProtKB/Swiss-Prot
NCBI Gene 85240 ENTREZGENE
PANTHER PTHR10336 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10336:SF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_14 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI-PLC-Y UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLC-beta_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plcb2 PhenoGen
PIRSF PLC-beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS PHPHLIPASEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PIPLC_X_DOMAIN UniProtKB/Swiss-Prot
  PIPLC_Y_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50004 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PLCXc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLCYc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PLC-like_Pdiesterase_TIM-brl UniProtKB/Swiss-Prot
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49562 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51695 UniProtKB/TrEMBL
UniProt A0A0G2JZ43_RAT UniProtKB/TrEMBL
  A0A8I6GEV3_RAT UniProtKB/TrEMBL
  O89040 ENTREZGENE, UniProtKB/Swiss-Prot
  Q45QJ6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Plcb2  phospholipase C, beta 2    phospholipase C beta 2  Name updated 1299863 APPROVED
2002-08-07 Plcb2  phospholipase C beta 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed exclusively in a subset of taste receptor cells of circumvallate papillae 729588