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Gene: Plcb2 (phospholipase C, beta 2) Rattus norvegicus
Symbol: Plcb2
Name: phospholipase C, beta 2
RGD ID: 621004
Description: Exhibits G-protein beta/gamma-subunit complex binding activity; phosphatidylinositol phospholipase C activity; and phospholipid binding activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste and phospholipase C-activating G protein-coupled receptor signaling pathway. Localizes to several cellular components, including G-protein beta/gamma-subunit complex; Golgi apparatus; and cytosol. Orthologous to human PLCB2 (phospholipase C beta 2); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2; phospholipase C beta 2; phospholipase C-beta-2; PKC beta II; PLC-beta-2
Homo sapiens (human) : PLCB2 (phospholipase C beta 2)  HGNC  Alliance
Mus musculus (house mouse) : Plcb2 (phospholipase C, beta 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcb2 (phospholipase C beta 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCB2 (phospholipase C beta 2)
Canis lupus familiaris (dog) : PLCB2 (phospholipase C beta 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcb2 (phospholipase C beta 2)
Sus scrofa (pig) : PLCB2 (phospholipase C beta 2)
Chlorocebus sabaeus (African green monkey) : PLCB2 (phospholipase C beta 2)
Heterocephalus glaber (naked mole-rat) : Plcb2 (phospholipase C beta 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03110,497,760 - 110,517,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,498,114 - 110,517,163 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03117,038,677 - 117,058,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43105,203,524 - 105,223,342 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13105,099,951 - 105,119,770 (-)NCBI
Celera3104,599,222 - 104,618,601 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Plcb2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621004
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.