Bdnf (brain-derived neurotrophic factor) - Rat Genome Database

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Gene: Bdnf (brain-derived neurotrophic factor) Rattus norvegicus
Symbol: Bdnf
Name: brain-derived neurotrophic factor
RGD ID: 2202
Description: Enables neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and regulation of neuronal synaptic plasticity. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; Huntington's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Brain derived neurothrophic factor; brain derived neurotrophic factor; MGC105254
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Bdnfem1Sage  
Genetic Models: SD-Bdnfem1Sage+/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2396,165,042 - 96,215,621 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl396,165,042 - 96,215,615 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx399,726,226 - 99,776,801 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03108,325,184 - 108,375,759 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03106,087,694 - 106,138,272 (+)NCBIRnor_WKY
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
alcohol use disorder  (IEP)
alopecia  (ISO)
Alzheimer's disease  (IEP,IMP,ISO)
amnestic disorder  (ISO)
amphetamine abuse  (ISO)
Amyloid Plaques  (ISO)
anxiety disorder  (IEP)
asthma  (ISO)
Ataxia  (ISO)
atopic dermatitis  (ISO)
attention deficit hyperactivity disorder  (IEP)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bacterial meningitis  (IEP,ISO)
bipolar disorder  (ISO)
Body Weight  (ISO)
Brain Injuries  (IEP,ISO)
brain ischemia  (ISO)
Cerebral Hemorrhage  (ISO)
Chronic Pain  (IEP)
Cocaine-Related Disorders  (IMP,ISO)
cognitive disorder  (ISO)
colitis  (ISO)
color blindness  (ISO)
congenital central hypoventilation syndrome  (ISO)
cystitis  (IEP,IMP)
Deafness  (ISO)
depressive disorder  (IEP,ISO)
Diabetic Nephropathies  (IMP)
diabetic neuropathy  (IMP)
diabetic retinopathy  (IEP)
Drug Eruptions  (ISO)
epilepsy  (ISO)
epilepsy with generalized tonic-clonic seizures  (ISO)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Diabetes Mellitus  (IEP)
focal epilepsy  (ISO)
Frontotemporal Lobar Degeneration  (ISO)
genetic disease  (ISO)
glaucoma  (IDA,IEP,ISO)
Gliosis  (ISO)
Hearing Loss  (IEP)
Hearing Loss, Noise-Induced  (IEP,ISO)
heroin dependence  (ISO)
Huntington's disease  (ISO)
Hyperalgesia  (IDA,IEP,IMP,ISO)
Hyperoxia  (IEP)
hypertensive encephalopathy  (IEP)
hypothyroidism  (IEP)
Hypoxia  (ISO)
Inflammation  (IEP,ISO)
inner ear disease  (ISO)
intellectual disability  (ISO)
intermediate coronary syndrome  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Displacement  (IEP)
irritable bowel syndrome  (ISO)
keratoconus  (ISO)
Leukoencephalopathies  (IEP)
low tension glaucoma  (ISO)
major depressive disorder  (ISO)
Memory Disorders  (ISO)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (IEP)
morbid obesity  (ISO)
multiple sclerosis  (ISO)
Nasal Polyps  (ISO)
neovascular inflammatory vitreoretinopathy  (ISO)
Nerve Degeneration  (IEP,ISO)
Nerve Injuries  (IEP)
nervous system disease  (ISO)
nicotine dependence  (ISO)
obesity  (ISO)
obsessive-compulsive disorder  (ISO)
obstructive sleep apnea  (ISO)
Optic Nerve Injuries  (IEP,ISO)
Pain  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (ISO)
Peripheral Nerve Injuries  (IEP,ISO)
post-traumatic stress disorder  (ISO)
Presbycusis  (IEP)
primary open angle glaucoma  (ISO)
psychotic disorder  (ISO)
pulmonary fibrosis  (ISO)
pulmonary sarcoidosis  (ISO)
Radiation Injuries  (IEP)
Referred Pain  (IMP)
Reperfusion Injury  (IEP)
Respiration Disorders  (ISO)
Respiratory Tract Infections  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (IDA,ISO)
rhinitis  (IEP,ISO)
schizophrenia  (ISO)
sciatic neuropathy  (IDA,IEP)
Seasonal Allergic Rhinitis  (ISO)
sensorineural hearing loss  (ISO)
Sjogren's syndrome  (ISO)
Sleep Deprivation  (IEP)
Spinal Cord Injuries  (IDA,IEP,ISO)
Spinal Cord Reperfusion Injury  (IEP)
status epilepticus  (IMP,ISO)
Stomach Neoplasms  (ISO)
systemic scleroderma  (ISO)
Tinnitus  (IEP,ISO)
Tobacco Use Disorder  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vascular dementia  (IEP)
Visceral Pain  (ISO)
withdrawal disorder  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(20S)-ginsenoside Rg3  (ISO)
(R)-salsolinol  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-3,5-dihydroxyphenylglycine  (ISO)
(S)-amphetamine  (EXP,ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
13,14-dihydro-Delta(12)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-hexanedione  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (EXP)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-nitropropanoic acid  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (EXP)
4-hydroxynon-2-enal  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP)
5-methoxypsoralen  (ISO)
6-anilino-5,8-quinolinedione  (ISO)
6-Cyano-7-nitroquinoxaline-2,3-dione  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
[6]-Shogaol  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
agathisflavone  (EXP)
agmatine  (ISO)
agomelatine  (EXP,ISO)
alcohol  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
alpha-pinene  (EXP)
alpha-Solamarine  (ISO)
AM-251  (ISO)
amantadine  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP)
arachidonic acid  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsanilic acid  (EXP)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Asiaticoside  (EXP)
Atractylone  (ISO)
atrazine  (EXP,ISO)
Bardoxolone methyl  (ISO)
Bay-K-8644  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
bromocriptine  (ISO)
bucladesine  (ISO)
bupivacaine  (ISO)
buprenorphine  (EXP)
Butylparaben  (EXP)
C60 fullerene  (EXP)
cabergoline  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calcitriol  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon dioxide  (EXP)
carbon monoxide  (EXP)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorohydrocarbon  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (ISO)
cisplatin  (EXP,ISO)
Citreoviridin  (ISO)
clofibrate  (ISO)
clopidogrel  (ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP,ISO)
creatine  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (EXP)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cypermethrin  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dantrolene  (ISO)
decabromodiphenyl ether  (EXP,ISO)
deguelin  (ISO)
dermatan sulfate  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP,ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroactinidiolide  (ISO)
diisopropyl fluorophosphate  (EXP)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dizocilpine maleate  (EXP)
donepezil hydrochloride  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
echinacoside  (EXP)
elemental selenium  (EXP)
endosulfan  (EXP)
enzacamene  (EXP)
epoxiconazole  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
excitatory amino acid agonist  (EXP)
fenvalerate  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (EXP)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
Fusaric acid  (EXP)
galactose  (ISO)
gallic acid  (ISO)
gallocatechin  (ISO)
gamma-aminobutyric acid  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (ISO)
gingerol  (ISO)
glycidol  (EXP)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
haloperidol  (EXP,ISO)
herbicide  (EXP)
heroin  (EXP,ISO)
hydrogen peroxide  (ISO)
ifosfamide  (EXP)
imipramine  (EXP,ISO)
inulin  (ISO)
kainic acid  (EXP)
ketamine  (EXP,ISO)
ketanserin  (EXP)
KT 5823  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamotrigine  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
lovastatin  (EXP)
LY294002  (ISO)
lycopene  (EXP,ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (EXP,ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methyl beta-cyclodextrin  (ISO)
methyl methanesulfonate  (ISO)
methylglyoxal  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
mevastatin  (ISO)
mifepristone  (EXP,ISO)
morin  (EXP)
morphine  (EXP,ISO)
muscimol  (EXP)
N-acetyl-L-cysteine  (ISO)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-methyl-N-nitrosourea  (EXP)
naproxen  (EXP)
nicardipine  (EXP)
nickel atom  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (EXP)
nimodipine  (ISO)
nitric oxide  (ISO)
Nonylphenol  (EXP,ISO)
ochratoxin A  (EXP)
olanzapine  (EXP,ISO)
ouabain  (EXP)
Oxadiazon  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
paclitaxel  (EXP)
paliperidone palmitate  (EXP)
panaxydol  (EXP)
papaverine  (EXP)
paracetamol  (EXP,ISO)
paraldehyde  (EXP)
paraquat  (EXP,ISO)
parathion-methyl  (EXP)
paroxetine  (ISO)
pentetrazol  (EXP,ISO)
pentobarbital  (EXP)
perchlorate  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
permethrin  (EXP,ISO)
peroxynitrous acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (EXP)
picrotoxin  (EXP,ISO)
pioglitazone  (ISO)
poly(I:C)  (EXP,ISO)
potassium atom  (EXP,ISO)
potassium chloride  (ISO)
potassium chromate  (ISO)
prasugrel hydrochloride  (EXP)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
propanal  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quercetin  (ISO)
quetiapine fumarate  (EXP)
quinolinic acid  (EXP)
reserpine  (EXP,ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
risperidone  (EXP,ISO)
ritanserin  (EXP)
rivastigmine  (EXP)
rolipram  (EXP)
romidepsin  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
salvianolic acid B  (ISO)
saxagliptin  (EXP)
SB 431542  (ISO)
scopolamine  (EXP,ISO)
selenium atom  (EXP)
serotonin  (EXP,ISO)
sertraline  (ISO)
sevoflurane  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sirolimus  (ISO)
SKF-96365 hydrochloride  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Soman  (EXP)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sumatriptan  (EXP)
tacrine  (ISO)
tacrolimus hydrate  (EXP)
tadalafil  (ISO)
tamibarotene  (EXP,ISO)
tamoxifen  (ISO)
taurine  (EXP,ISO)
telmisartan  (ISO)
tert-butyl hydroperoxide  (ISO)
Testosterone propionate  (EXP)
tetrodotoxin  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
toluene  (ISO)
topiramate  (EXP)
torcetrapib  (ISO)
tranylcypromine  (EXP)
triacsin C  (ISO)
triazolam  (ISO)
triazophos  (EXP)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
undecane  (EXP)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
veratridine  (EXP,ISO)
vinclozolin  (EXP)
VX nerve agent  (ISO)
wortmannin  (EXP,ISO)
xenon atom  (EXP)
xenon(0)  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zolpidem  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon extension  (ISO)
axon guidance  (ISO)
axon target recognition  (ISO)
behavioral fear response  (ISO)
behavioral response to cocaine  (IMP)
cellular response to nerve growth factor stimulus  (IEP)
cellular response to norepinephrine stimulus  (IEP)
cellular response to potassium ion  (IEP)
cellular response to tumor necrosis factor  (IEP)
chronic inflammatory response  (IEP)
circadian rhythm  (ISO)
cognition  (IEP)
collateral sprouting  (IEA,ISO)
conditioned place preference  (IMP)
dendrite development  (ISO)
dendrite extension  (ISO)
excitatory postsynaptic potential  (IMP)
fear response  (ISO)
feeding behavior  (ISO)
gamma-aminobutyric acid signaling pathway  (ISO)
glutamate secretion  (ISO)
inhibitory postsynaptic potential  (ISO)
inner ear development  (ISO)
learning  (IMP)
learning or memory  (ISO)
mechanoreceptor differentiation  (ISO)
memory  (IBA)
mitochondrial electron transport, NADH to ubiquinone  (IMP)
modulation of chemical synaptic transmission  (IBA)
negative regulation of apoptotic process  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of myotube differentiation  (IMP)
negative regulation of neuroblast proliferation  (ISO)
negative regulation of neuron apoptotic process  (IBA,ISO)
negative regulation of programmed cell death  (ISO)
negative regulation of striated muscle tissue development  (IMP)
negative regulation of synaptic transmission, GABAergic  (ISO)
nerve development  (IBA,ISO)
nerve growth factor signaling pathway  (IBA)
nervous system development  (IDA)
neuron apoptotic process  (ISO)
neuron differentiation  (TAS)
neuron projection extension  (IDA)
neuron projection morphogenesis  (IBA)
neuron recognition  (ISO)
peptidyl-serine phosphorylation  (ISO)
peripheral nervous system development  (IBA)
positive regulation of axon extension  (ISO)
positive regulation of collateral sprouting  (IBA,IEA,ISO)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of glucocorticoid receptor signaling pathway  (IDA)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of neuron differentiation  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of peptidyl-serine phosphorylation  (IBA,IGI,ISO)
positive regulation of receptor binding  (IDA,IEA,ISO)
positive regulation of synapse assembly  (IEA,ISO)
regeneration  (IDA)
regulation of axon extension  (IMP)
regulation of collateral sprouting  (ISO)
regulation of long-term neuronal synaptic plasticity  (IDA)
regulation of neuron apoptotic process  (ISO)
regulation of neuron differentiation  (IBA)
regulation of retinal cell programmed cell death  (ISO)
regulation of short-term neuronal synaptic plasticity  (IDA)
regulation of synaptic plasticity  (ISO)
response to activity  (IEP)
response to anesthetic  (IEP)
response to auditory stimulus  (IEP)
response to electrical stimulus  (IEP)
response to food  (IEP)
response to hormone  (IEP)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
response to L-glutamate  (IEP)
response to light intensity  (IEP)
response to light stimulus  (IEP)
response to nerve growth factor  (IEP)
response to nutrient levels  (IEP)
response to potassium ion  (IEP)
response to tumor necrosis factor  (IEP)
response to vitamin A  (IEP)
response to xenobiotic stimulus  (IEP,ISO)
retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission  (ISO)
signal transduction  (IEA)
synapse assembly  (IEA,ISO)
taste bud development  (ISO)
trans-synaptic signaling by BDNF, modulating synaptic transmission  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
ureteric bud development  (ISO)

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Mouse and rat BDNF gene structure and expression revisited. Aid T, etal., J Neurosci Res. 2007 Feb 15;85(3):525-35.
2. Relationship between Sonic hedgehog protein, brain-derived neurotrophic factor and oxidative stress in autism spectrum disorders. Al-Ayadhi LY, Neurochem Res. 2012 Feb;37(2):394-400. doi: 10.1007/s11064-011-0624-x. Epub 2011 Oct 9.
3. BDNF-triggered events in the rat hippocampus are required for both short- and long-term memory formation. Alonso M, etal., Hippocampus 2002;12(4):551-60.
4. Genetic variation in BDNF is associated with allergic asthma and allergic rhinitis in an ethnic Chinese population in Singapore. Andiappan AK, etal., Cytokine. 2011 Nov;56(2):218-23. doi: 10.1016/j.cyto.2011.05.008. Epub 2011 Jun 30.
5. Temporal and spatial differences in expression of TrkB isoforms in rat retina during constant light exposure. Asai N, etal., Exp Eye Res. 2007 Sep;85(3):346-55. Epub 2007 Jun 15.
6. Patterns of expression of brain-derived neurotrophic factor and tyrosine kinase B mRNAs and distribution and ultrastructural localization of their proteins in the visual pathway of the adult rat. Avwenagha O, etal., Neuroscience. 2006 Jul 7;140(3):913-28. Epub 2006 Apr 19.
7. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Baker-Herman TL, etal., Nat Neurosci. 2004 Jan;7(1):48-55. Epub 2003 Dec 14.
8. Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. Balkowiec A and Katz DM, J Neurosci 2002 Dec 1;22(23):10399-407.
9. Activity-dependent release of endogenous brain-derived neurotrophic factor from primary sensory neurons detected by ELISA in situ. Balkowiec A and Katz DM, J Neurosci. 2000 Oct 1;20(19):7417-23.
10. Evaluation of the brain-derived neurotrophic factor, nerve growth factor and memory in adult rats survivors of the neonatal meningitis by Streptococcus agalactiae. Barichello T, etal., Brain Res Bull. 2013 Mar;92:56-9. doi: 10.1016/j.brainresbull.2012.05.014. Epub 2012 Jun 7.
11. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
12. A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4. Bian WJ, etal., Dev Neurobiol. 2015 Aug;75(8):805-22. doi: 10.1002/dneu.22250. Epub 2014 Dec 1.
13. Brain-derived neurotrophic factor gene variants and Alzheimer disease: an association study in an Alzheimer disease Italian population. Boiocchi C, etal., Rejuvenation Res. 2013 Feb;16(1):57-66. doi: 10.1089/rej.2012.1381.
14. The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced hippocampus perfusion in frontotemporal lobar degeneration. Borroni B, etal., J Alzheimers Dis. 2012;31(2):243-51. doi: 10.3233/JAD-2012-120226.
15. Calcitonin gene-related peptide enhances release of native brain-derived neurotrophic factor from trigeminal ganglion neurons. Buldyrev I, etal., J Neurochem. 2006 Dec;99(5):1338-50. Epub 2006 Oct 25.
16. Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. Burbach GJ, etal., J Neurosci. 2004 Mar 10;24(10):2421-30.
17. Brain-derived neurotrophic factor is an anterograde survival factor in the rat visual system. Caleo M, etal., Curr Biol. 2000 Oct 5;10(19):1155-61.
18. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. Cao XH, etal., J Neurochem. 2010 Sep 1;114(5):1460-75. Epub 2010 Jun 24.
19. Lumbar transplant of neurons genetically modified to secrete brain-derived neurotrophic factor attenuates allodynia and hyperalgesia after sciatic nerve constriction. Cejas PJ, etal., Pain. 2000 May;86(1-2):195-210.
20. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, etal., Arch Physiol Biochem. 2001 Oct;109(4):357-60.
21. Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats. Chen H and Weber AJ, Brain Res. 2004 Jun 11;1011(1):99-106.
22. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. Cho SR, etal., J Clin Invest. 2007 Oct;117(10):2889-902.
23. Expression of neurotrophic factors and their receptors in keratoconic cornea. Chung ES, etal., Curr Eye Res. 2013 Jul;38(7):743-50. doi: 10.3109/02713683.2013.774421. Epub 2013 Mar 14.
24. The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease. Chuu JY, etal., J Alzheimers Dis. 2006 Mar;9(1):43-9.
25. Mucosal expression of nerve growth factor and brain-derived neurotrophic factor in chronic rhinosinusitis. Coffey CS, etal., Am J Rhinol Allergy. 2009 Nov-Dec;23(6):571-4.
26. Involvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats. Constandil L, etal., Brain Res Bull. 2011 Nov 25;86(5-6):454-9. doi: 10.1016/j.brainresbull.2011.08.008. Epub 2011 Aug 16.
27. SNPs in neurotrophin system genes and Alzheimer's disease in an Italian population. Cozza A, etal., J Alzheimers Dis. 2008 Sep;15(1):61-70.
28. Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model. Cruz Duarte P, etal., Exp Neurol. 2012 Apr;234(2):466-81. doi: 10.1016/j.expneurol.2012.01.021. Epub 2012 Jan 27.
29. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. Danzer SC, etal., J Neurosci 2002 Nov 15;22(22):9754-63.
30. Cortical expression of brain derived neurotrophic factor and type-1 cannabinoid receptor after striatal excitotoxic lesions. De March Z, etal., Neuroscience. 2008 Mar 27;152(3):734-40. doi: 10.1016/j.neuroscience.2007.11.044. Epub 2007 Dec 8.
31. Laser therapy and pain-related behavior after injury of the inferior alveolar nerve: possible involvement of neurotrophins. de Oliveira Martins D, etal., J Neurotrauma. 2013 Mar 15;30(6):480-6. doi: 10.1089/neu.2012.2603. Epub 2013 Mar 20.
32. Total and Mitochondrial Nitrosative Stress, Decreased Brain-Derived Neurotrophic Factor (BDNF) Levels and Glutamate Uptake, and Evidence of Endoplasmic Reticulum Stress in the Hippocampus of Vitamin A-Treated Rats. de Oliveira MR, etal., Neurochem Res. 2010 Dec 28.
33. Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memory. Del Arco A, etal., Behav Brain Res. 2011 Jan 1;216(1):136-45. Epub 2010 Jul 22.
34. [Effects of chaihu shugan powder on the behavior and expressions of BDNF and TrkB in the hippocampus, amygdala, and the frontal lobe in rat model of depression]. Deng Y, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2011 Oct;31(10):1373-8.
35. Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Di Polo A, etal., Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3978-83.
36. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Dolotov OV, etal., Brain Res. 2006 Oct 30;1117(1):54-60. Epub 2006 Sep 22.
37. Early reactions of brain-derived neurotrophic factor in plasma (pBDNF) and outcome to acute antidepressant treatment in patients with Major Depression. Dreimuller N, etal., Neuropharmacology. 2012 Jan;62(1):264-9. doi: 10.1016/j.neuropharm.2011.07.017. Epub 2011 Jul 22.
38. Differential correlation of serum BDNF and microRNA content in rats with rapid or late onset of heavy alcohol use. Ehinger Y, etal., Addict Biol. 2020 Mar 5:e12890. doi: 10.1111/adb.12890.
39. Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease. Ejiri J, etal., Circulation. 2005 Oct 4;112(14):2114-20. Epub 2005 Sep 26.
40. Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. Erickson JT, etal., J Neurosci. 1996 Sep 1;16(17):5361-71.
41. Brain-derived neurotrophic factor and nerve growth factor correlate with T-cell activation in primary Sjogren's syndrome. Fauchais AL, etal., Scand J Rheumatol. 2009 Jan-Feb;38(1):50-7. doi: 10.1080/03009740802378832.
42. Brain-derived neurotrophic factor, acting at the spinal cord level, participates in bladder hyperactivity and referred pain during chronic bladder inflammation. Frias B, etal., Neuroscience. 2013 Mar 27;234:88-102. doi: 10.1016/j.neuroscience.2012.12.044. Epub 2013 Jan 8.
43. Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma. Fu QL, etal., Neuroscience. 2009 Aug 18;162(2):375-82. doi: 10.1016/j.neuroscience.2009.04.075. Epub 2009 May 5.
44. Axonal protection by brain-derived neurotrophic factor associated with CREB phosphorylation in tumor necrosis factor-alpha-induced optic nerve degeneration. Fujino H, etal., Acta Neuropathol. 2009 Jan;117(1):75-84. doi: 10.1007/s00401-008-0440-9. Epub 2008 Oct 1.
45. BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice. Fukui H, etal., Sci Rep. 2012;2:838. doi: 10.1038/srep00838. Epub 2012 Nov 12.
46. Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model. Fukuoka T, etal., J Neurosci. 2001 Jul 1;21(13):4891-900.
47. Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells. Gao H, etal., Arch Ophthalmol. 2002 Jun;120(6):797-803.
48. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
49. Brain-derived neurotrophic factor gene delivery to muller glia preserves structure and function of light-damaged photoreceptors. Gauthier R, etal., Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3383-92.
50. Brain-derived neurotrophic factor as a biomarker in primary open-angle glaucoma. Ghaffariyeh A, etal., Optom Vis Sci. 2011 Jan;88(1):80-5. doi: 10.1097/OPX.0b013e3181fc329f.
51. Brain-derived neurotrophic factor in patients with normal-tension glaucoma. Ghaffariyeh A, etal., Optometry. 2009 Nov;80(11):635-8. doi: 10.1016/j.optm.2008.09.014.
52. Expression and localisation of BDNF, NT4 and TrkB in proliferative vitreoretinopathy. Ghazi-Nouri SM, etal., Exp Eye Res. 2008 May;86(5):819-27. doi: 10.1016/j.exer.2008.02.010. Epub 2008 Mar 2.
53. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
54. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Goodman LJ, etal., Mol Cell Neurosci. 1996 Mar;7(3):222-38.
55. Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus. Goto F, etal., Neurosci Lett. 2012 Feb 29;510(2):73-7. doi: 10.1016/j.neulet.2012.01.001. Epub 2012 Jan 17.
56. Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity. Griesbach GS, etal., J Neurotrauma 2002 Jul;19(7):803-14.
57. Cell type-specific regulation of brain-derived neurotrophic factor in states of allergic inflammation. Groneberg DA, etal., Clin Exp Allergy. 2007 Sep;37(9):1386-91.
58. Spinal brain-derived neurotrophic factor (BDNF) produces hyperalgesia in normal mice while antisense directed against either BDNF or trkB, prevent inflammation-induced hyperalgesia. Groth R and Aanonsen L, Pain. 2002 Nov;100(1-2):171-81.
59. TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders. Gupta VK, etal., Int J Mol Sci. 2013 May 13;14(5):10122-42. doi: 10.3390/ijms140510122.
60. Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Hall D, etal., Am J Hum Genet 2003 Aug;73(2):370-6. Epub 2003 Jun 27.
61. Association of brain-derived neurotrophic factor (BDNF) haploinsufficiency with lower adaptive behaviour and reduced cognitive functioning in WAGR/11p13 deletion syndrome. Han JC, etal., Cortex. 2013 Nov-Dec;49(10):2700-10. doi: 10.1016/j.cortex.2013.02.009. Epub 2013 Feb 19.
62. Transplantation of BDNF-secreting mesenchymal stem cells provides neuroprotection in chronically hypertensive rat eyes. Harper MM, etal., Invest Ophthalmol Vis Sci. 2011 Jun 23;52(7):4506-15. doi: 10.1167/iovs.11-7346.
63. Treadmill exercise ameliorates disturbance of spatial learning ability in scopolamine-induced amnesia rats. Heo YM, etal., J Exerc Rehabil. 2014 Jun 30;10(3):155-61. doi: 10.12965/jer.140110. eCollection 2014 Jun.
64. Variation in the BDNF and NGFB genes in German atopic dermatitis patients. Hoffjan S, etal., Mol Cell Probes. 2009 Feb;23(1):35-8. doi: 10.1016/j.mcp.2008.10.005. Epub 2008 Nov 11.
65. A study of the cough reflex in idiopathic pulmonary fibrosis. Hope-Gill BD, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):995-1002. Epub 2003 Aug 13.
66. Altered histone acetylation at glutamate receptor 2 and brain-derived neurotrophic factor genes is an early event triggered by status epilepticus. Huang Y, etal., J Neurosci 2002 Oct 1;22(19):8422-8.
67. Brain-derived neurotrophic factor is upregulated in rats with chronic pancreatitis and mediates pain behavior. Hughes MS, etal., Pancreas. 2011 May;40(4):551-6. doi: 10.1097/MPA.0b013e318214fb77.
68. Brain-derived neurotrophic factor promotes adaptive plasticity within the spinal cord and mediates the beneficial effects of controllable stimulation. Huie JR, etal., Neuroscience. 2012 Jan 3;200:74-90. doi: 10.1016/j.neuroscience.2011.10.028. Epub 2011 Oct 25.
69. Serial changes in bladder, locomotion, and levels of neurotrophic factors in rats with spinal cord contusion. Hyun JK, etal., J Neurotrauma. 2009 Oct;26(10):1773-82.
70. 4-Methylcatechol prevents derangements of brain-derived neurotrophic factor and TrkB-related signaling in anterior cingulate cortex in chronic pain with depression-like behavior. Ishikawa K, etal., Neuroreport. 2014 Mar 5;25(4):226-32. doi: 10.1097/WNR.0000000000000072.
71. Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats. Jeong HI, etal., J Exerc Rehabil. 2014 Jun 30;10(3):162-7. doi: 10.12965/jer.140111. eCollection 2014 Jun.
72. Forced running exercise attenuates hippocampal neurogenesis impairment and the neurocognitive deficits induced by whole-brain irradiation via the BDNF-mediated pathway. Ji JF, etal., Biochem Biophys Res Commun. 2014 Jan 10;443(2):646-51. doi: 10.1016/j.bbrc.2013.12.031. Epub 2013 Dec 11.
73. Protective effect against ischemia and light damage of iris pigment epithelial cells transfected with the BDNF gene. Kano T, etal., Invest Ophthalmol Vis Sci. 2002 Dec;43(12):3744-53.
74. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
75. Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. Kerr BJ, etal., J Neurosci. 1999 Jun 15;19(12):5138-48.
76. Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation. Khundakar AA and Zetterstrom TS, Brain Res. 2006 Aug 23;1106(1):12-20. Epub 2006 Jul 13.
77. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Krabbe KS, etal., Diabetologia. 2007 Feb;50(2):431-8. Epub 2006 Dec 7.
78. BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. Kramer F, etal., J Neurooncol. 2010 May;98(1):31-9. doi: 10.1007/s11060-009-0063-6. Epub 2009 Nov 25.
79. BDNF diminishes caspase-2 but not c-Jun immunoreactivity of neurons in retinal ganglion cell layer after transient ischemia. Kurokawa T, etal., Invest Ophthalmol Vis Sci. 1999 Nov;40(12):3006-11.
80. Brain-derived neurotrophic factor signaling rewrites the glucocorticoid transcriptome via glucocorticoid receptor phosphorylation. Lambert WM, etal., Mol Cell Biol. 2013 Sep;33(18):3700-14. doi: 10.1128/MCB.00150-13. Epub 2013 Jul 22.
81. Brain-derived neurotrophic factor promotes cochlear spiral ganglion cell survival and function in deafened, developing cats. Leake PA, etal., J Comp Neurol. 2011 Jun 1;519(8):1526-45. doi: 10.1002/cne.22582.
82. Human neural stem cells genetically modified to overexpress brain-derived neurotrophic factor promote functional recovery and neuroprotection in a mouse stroke model. Lee HJ, etal., J Neurosci Res. 2010 Nov 15;88(15):3282-94.
83. Hypertension downregulates the expression of brain-derived neurotrophic factor in the ischemia-vulnerable hippocampal CA1 and cortical areas after carotid artery occlusion. Lee TH, etal., Brain Res. 2006 Oct 20;1116(1):31-8. Epub 2006 Sep 7.
84. Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats. Li L, etal., Neurotox Res. 2006 Jun;9(4):269-83.
85. [Expression of BDNF and trk B in the cochleas of the aged rats]. Li Y, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Oct;20(19):894-5.
86. Serum nerve grow factor and brain-derived neurotrophic factor profiles in Sjogren's syndrome concomitant with interstitial lung disease. Li YJ, etal., Clin Rheumatol. 2014 Apr 2.
87. Up-regulation of dorsal root ganglia BDNF and trkB receptor in inflammatory pain: an in vivo and in vitro study. Lin YT, etal., J Neuroinflammation. 2011 Sep 30;8:126. doi: 10.1186/1742-2094-8-126.
88. Serum neurotrophin profile in systemic sclerosis. Lise MC, etal., PLoS One. 2010 Nov 9;5(11):e13918.
89. The neuroprotective effects of Tanshinone IIA are associated with induced nuclear translocation of TORC1 and upregulated expression of TORC1, pCREB and BDNF in the acute stage of ischemic stroke. Liu L, etal., Brain Res Bull. 2010 May 31;82(3-4):228-33. Epub 2010 Apr 24.
90. Platelet and plasma BDNF in lower respiratory tract infections of the adult. Lommatzsch M, etal., Respir Med. 2007 Jul;101(7):1493-9. Epub 2007 Feb 20.
91. General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Lu LX, etal., Apoptosis. 2006 Sep;11(9):1603-15.
92. Brain-derived neurotrophic factor gene polymorphisms and serum levels in Chinese atopic dermatitis patients. Ma L, etal., J Eur Acad Dermatol Venereol. 2009 Nov;23(11):1277-81. doi: 10.1111/j.1468-3083.2009.03308.x. Epub 2009 Jun 1.
93. Single-cell characterization of retrograde signaling by brain-derived neurotrophic factor. Magby JP, etal., J Neurosci. 2006 Dec 27;26(52):13531-6.
94. Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. Maisonpierre PC, etal., Genomics 1991 Jul;10(3):558-68.
95. Huperzine A ameliorates cognitive deficits in streptozotocin-induced diabetic rats. Mao XY, etal., Int J Mol Sci. 2014 May 5;15(5):7667-83. doi: 10.3390/ijms15057667.
96. BDNF increases rat brain mitochondrial respiratory coupling at complex I, but not complex II. Markham A, etal., Eur J Neurosci 2004 Sep;20(5):1189-96.
97. GABA-glutamate interaction in the control of BDNF expression in hypothalamic neurons. Marmigere F, etal., Neurochem Int 2003 Mar;42(4):353-8.
98. The expression of mitogen-activated protein kinases and brain-derived neurotrophic factor in inferior colliculi after acoustic trauma. Meltser I and Canlon B, Neurobiol Dis. 2010 Oct;40(1):325-30. doi: 10.1016/j.nbd.2010.06.006. Epub 2010 Jun 18.
99. Differential activation of mitogen-activated protein kinases and brain-derived neurotrophic factor after temporary or permanent damage to a sensory system. Meltser I, etal., Neuroscience. 2010 Feb 17;165(4):1439-46. doi: 10.1016/j.neuroscience.2009.11.025. Epub 2009 Nov 21.
100. The anterogradely transported BDNF promotes retinal axon remodeling during eye specific segregation within the LGN. Menna E, etal., Mol Cell Neurosci. 2003 Dec;24(4):972-83.
101. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
102. Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease. Michalski B and Fahnestock M, Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):148-54.
103. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Miller R, etal., Brain Res 2002 Sep 20;950(1-2):137-47.
104. Transplants of fibroblasts expressing BDNF and NT-3 promote recovery of bladder and hindlimb function following spinal contusion injury in rats. Mitsui T, etal., Exp Neurol. 2005 Aug;194(2):410-31.
105. Taste disturbance after stapes surgery--clinical and experimental study. Miuchi S, etal., Acta Otolaryngol Suppl. 2009 Jun;(562):71-8.
106. BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. Mousavi K and Jasmin BJ, J Neurosci. 2006 May 24;26(21):5739-49.
107. Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma. Muller GC, etal., Clin Exp Allergy. 2010 Dec;40(12):1755-9. doi: 10.1111/j.1365-2222.2010.03618.x. Epub 2010 Sep 28.
108. Comparison of the effects of HGF, BDNF, CT-1, CNTF, and the branchial arches on the growth of embryonic cranial motor neurons. Naeem A, etal., J Neurobiol 2002 May;51(2):101-14.
109. Brain-derived neurotrophic factor regulates surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid receptors by enhancing the N-ethylmaleimide-sensitive factor/GluR2 interaction in developing neocortical neurons. Narisawa-Saito M, etal., J Biol Chem. 2002 Oct 25;277(43):40901-10. Epub 2002 Jul 18.
110. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
111. The influence of inhalative corticosteroids on circulating Nerve Growth Factor, Brain-Derived Neurotrophic Factor and Neurotrophin-3 in allergic asthmatics. Noga O, etal., Clin Exp Allergy. 2001 Dec;31(12):1906-12.
112. The production, storage and release of the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 by human peripheral eosinophils in allergics and non-allergics. Noga O, etal., Clin Exp Allergy. 2003 May;33(5):649-54.
113. Rapid increase of NGF, BDNF and NT-3 mRNAs in inflamed bladder. Oddiah D, etal., Neuroreport. 1998 May 11;9(7):1455-8.
114. Increased expression of brain-derived neurotrophic factor preserves retinal function and slows cell death from rhodopsin mutation or oxidative damage. Okoye G, etal., J Neurosci. 2003 May 15;23(10):4164-72.
115. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
116. Immunoreactivity of brain-derived neurotrophic factor in rat dorsal root ganglion and spinal cord dorsal horn following exposure to herniated nucleus pulposus. Onda A, etal., Neurosci Lett. 2003 Nov 27;352(1):49-52.
117. Brain-derived nerve factor and neurotrophins in androgenetic alopecia. Panchaprateep R, etal., Br J Dermatol. 2011 Nov;165(5):997-1002. doi: 10.1111/j.1365-2133.2011.10514.x. Epub 2011 Sep 29.
118. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Pandey GN, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 May 30;34(4):645-51. Epub 2010 Mar 20.
119. Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors. Pandey SC, etal., J Neurosci. 2006 Aug 9;26(32):8320-31.
120. Midazolam reverses salicylate-induced changes in brain-derived neurotrophic factor and arg3.1 expression: implications for tinnitus perception and auditory plasticity. Panford-Walsh R, etal., Mol Pharmacol. 2008 Sep;74(3):595-604. doi: 10.1124/mol.108.046375. Epub 2008 Jun 4.
121. Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model. Paradiso B, etal., Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7191-6. Epub 2009 Apr 6.
122. Reduced expression of brain-derived neurotrophic factor protein in Parkinson's disease substantia nigra. Parain K, etal., Neuroreport. 1999 Feb 25;10(3):557-61.
123. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Pease ME, etal., Invest Ophthalmol Vis Sci. 2000 Mar;41(3):764-74.
124. Inhaled NO prevents hyperoxia-induced white matter damage in neonatal rats. Pham H, etal., Exp Neurol. 2014 Feb;252:114-23. doi: 10.1016/j.expneurol.2013.11.025. Epub 2013 Dec 7.
125. 17alpha-Oestradiol-induced neuroprotection in the brain of spontaneously hypertensive rats. Pietranera L, etal., J Neuroendocrinol. 2014 May;26(5):310-20. doi: 10.1111/jne.12151.
126. Sequestration of brain derived nerve factor by intravenous delivery of TrkB-Ig2 reduces bladder overactivity and noxious input in animals with chronic cystitis. Pinto R, etal., Neuroscience. 2010 Mar 31;166(3):907-16. Epub 2010 Jan 15.
127. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
128. Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in Stargazer mutant mice. Qiao X, etal., J Neurosci. 1998 Sep 1;18(17):6990-9.
129. Antidepressive effect of sodium valproate involving suppression of corticotropin-releasing factor expression and elevation of BDNF expression in rats exposed to chronic unpredicted stress. Qiu HM, etal., Neuroreport. 2014 Mar 5;25(4):205-10. doi: 10.1097/WNR.0000000000000054.
130. Circulating levels of brain-derived neurotrophic factor correlate with disease severity in the intrinsic type of atopic dermatitis. Raap U, etal., Allergy. 2006 Dec;61(12):1416-8.
131. Modulation of neurotrophin and neurotrophin receptor expression in nasal mucosa after nasal allergen provocation in allergic rhinitis. Raap U, etal., Allergy. 2008 Apr;63(4):468-75. Epub 2008 Feb 11.
132. n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism. Rao JS, etal., Mol Psychiatry. 2007 Jan;12(1):36-46. Epub 2006 Sep 19.
133. GOA pipeline RGD automated data pipeline
134. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
135. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
136. Neurotrophin system activation in bronchoalveolar lavage fluid immune cells in pulmonary sarcoidosis. Ricci A, etal., Sarcoidosis Vasc Diffuse Lung Dis. 2005 Oct;22(3):186-94.
137. Chronic caloric restriction reduces tissue damage and improves spatial memory in a rat model of traumatic brain injury. Rich NJ, etal., J Neurosci Res. 2010 Oct;88(13):2933-9.
138. Repeated co-treatment with fluoxetine and amantadine induces brain-derived neurotrophic factor gene expression in rats. Rogoz Z, etal., Pharmacol Rep. 2008 Nov-Dec;60(6):817-26.
139. Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria. Rossing K, etal., Clin Exp Allergy. 2011 Oct;41(10):1392-9. doi: 10.1111/j.1365-2222.2011.03795.x. Epub 2011 Jun 16.
140. Impact of Changes in Neurotrophic Supplementation on Development of Alzheimer's Disease-Like Pathology in Oxys Rats. Rudnitskaya EA, etal., Biochemistry (Mosc). 2017 Mar;82(3):318-329. doi: 10.1134/S0006297917030105.
141. Up-regulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B-dependent mechanisms. Rumajogee P, etal., J Neurochem 2002 Dec;83(6):1525-8.
142. Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise. Russo-Neustadt AA, etal., Neuropsychopharmacology. 2004 Dec;29(12):2189-99.
143. Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats. Saadati H, etal., Regul Pept. 2014 Nov;194-195:11-5. doi: 10.1016/j.regpep.2014.11.004. Epub 2014 Nov 20.
144. No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease. Saarela MS, etal., Folia Neuropathol. 2006;44(1):12-6.
145. Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice. Saito A, etal., Environ Toxicol. 2011 Jun;26(3):224-32. doi: 10.1002/tox.20547.
146. Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia. Sakr HF, etal., J Physiol Pharmacol. 2014 Feb;65(1):41-53.
147. Involvement of brain-derived neurotrophic factor in early retinal neuropathy of streptozotocin-induced diabetes in rats: therapeutic potential of brain-derived neurotrophic factor for dopaminergic amacrine cells. Seki M, etal., Diabetes. 2004 Sep;53(9):2412-9.
148. Muller Cells as a source of brain-derived neurotrophic factor in the retina: noradrenaline upregulates brain-derived neurotrophic factor levels in cultured rat Muller cells. Seki M, etal., Neurochem Res. 2005 Sep;30(9):1163-70.
149. Association between Val66Met polymorphism of Brain-Derived Neurotrophic Factor (BDNF) gene and a deficiency of colour vision in alcohol-dependent male patients. Sery O, etal., Neurosci Lett. 2011 Jul 25;499(3):154-7. doi: 10.1016/j.neulet.2011.05.038. Epub 2011 May 26.
150. Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer's disease rats. Sim YJ J Exerc Rehabil. 2014 Apr 30;10(2):81-8. doi: 10.12965/jer.140102. eCollection 2014 Apr.
151. Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain. Snigdha S, etal., J Mol Neurosci. 2010 Sep 18.
152. Reduced cocaine-seeking behavior in heterozygous BDNF knockout rats. St Laurent R, etal., Neurosci Lett. 2013 Jun 7;544:94-9. doi: 10.1016/j.neulet.2013.03.050. Epub 2013 Apr 9.
153. Regulation of brain-derived neurotrophic factor (BDNF) during sleep apnoea treatment. Staats R, etal., Thorax. 2005 Aug;60(8):688-92.
154. Effects of perinatal hypothyroidism on regulation of reelin and brain-derived neurotrophic factor gene expression in rat hippocampus: Role of DNA methylation and histone acetylation. Sui L and Li BM, Steroids. 2010 Dec;75(12):988-97. Epub 2010 Jun 19.
155. Administration of thyroid hormone increases reelin and brain-derived neurotrophic factor expression in rat hippocampus in vivo. Sui L, etal., Brain Res. 2010 Feb 8;1313:9-24. Epub 2009 Dec 16.
156. Comparison of the capability of GDNF, BDNF, or both, to protect nigrostriatal neurons in a rat model of Parkinson's disease. Sun M, etal., Brain Res. 2005 Aug 9;1052(2):119-29.
157. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic children. Szczepankiewicz A, etal., Pediatr Allergy Immunol. 2007 Jun;18(4):293-7.
158. REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation. Tabuchi A, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):415-20.
159. Extension of optic nerve fibers on genetically modified cells producing brain-derived neurotrophic factor. Takahashi JB, etal., Neurosci Lett. 1993 Jan 4;149(1):83-6.
160. Tinnitus behavior and hearing function correlate with the reciprocal expression patterns of BDNF and Arg3.1/arc in auditory neurons following acoustic trauma. Tan J, etal., Neuroscience. 2007 Mar 16;145(2):715-26. Epub 2007 Feb 1.
161. [Expression of BDNF mRNA in nasal mucosa with allergic rhinitis rat model]. Tao F, etal., Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2010 Mar;24(5):224-6.
162. Tooth pulp inflammation increases brain-derived neurotrophic factor expression in rodent trigeminal ganglion neurons. Tarsa L, etal., Neuroscience. 2010 Jun 2;167(4):1205-15. Epub 2010 Mar 9.
163. Increased expression of BDNF and proliferation of dentate granule cells after bacterial meningitis. Tauber SC, etal., J Neuropathol Exp Neurol. 2005 Sep;64(9):806-15.
164. Glutamate stimulates neurotrophin expression in cultured Muller cells. Taylor S, etal., Brain Res Mol Brain Res. 2003 Mar 17;111(1-2):189-97.
165. Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment. Tender GC, etal., Spine J. 2010 Aug;10(8):715-20. Epub 2010 May 7.
166. Substrate-mediated nanoparticle/gene delivery to MSC spheroids and their applications in peripheral nerve regeneration. Tseng TC and Hsu SH, Biomaterials. 2014 Mar;35(9):2630-41. doi: 10.1016/j.biomaterials.2013.12.021. Epub 2014 Jan 2.
167. Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet. Tyagi E, etal., Neurobiol Dis. 2015 Jan;73:307-18. doi: 10.1016/j.nbd.2014.09.014. Epub 2014 Oct 2.
168. Epigenetic regulation of BDNF expression in the primary sensory neurons after peripheral nerve injury: implications in the development of neuropathic pain. Uchida H, etal., Neuroscience. 2013 Jun 14;240:147-54. doi: 10.1016/j.neuroscience.2013.02.053. Epub 2013 Mar 4.
169. Brain-derived neurotrophic factor facilitates TrkB down-regulation and neuronal injury after status epilepticus in the rat hippocampus. Unsain N, etal., J Neurochem. 2009 Oct;111(2):428-40. Epub 2009 Aug 17.
170. Combined effects of chronic nicotine and acute virus exposure on neurotrophin expression in rat lung. Urrego F, etal., Pediatr Pulmonol. 2009 Nov;44(11):1075-84.
171. Impact of sound exposure and aging on brain-derived neurotrophic factor and tyrosine kinase B receptors levels in dorsal cochlear nucleus 80 days following sound exposure. Wang H, etal., Neuroscience. 2011 Jan 13;172:453-9. Epub 2010 Oct 27.
172. TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. Wang X, etal., Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5751-8. Epub 2010 Jun 16.
173. Supplement zinc as an effective treatment for spinal cord ischemia/reperfusion injury in rats. Wang Y, etal., Brain Res. 2014 Jan 30;1545:45-53. doi: 10.1016/j.brainres.2013.12.015. Epub 2013 Dec 19.
174. Effects of Zuogui Pill () and Yougui Pill () on the expression of brain-derived neurotrophic factor and cyclic adenosine monophosphate/protein kinase A signaling transduction pathways of axonal regeneration in model rats with experimental autoimmune encephalomyelitis. Wang YZ, etal., Chin J Integr Med. 2014 Jan;20(1):24-30. doi: 10.1007/s11655-012-1236-2. Epub 2012 Dec 3.
175. Idiopathic congenital central hypoventilation syndrome: evaluation of brain-derived neurotrophic factor genomic DNA sequence variation. Weese-Mayer DE, etal., Am J Med Genet 2002 Feb 1;107(4):306-10.
176. Paradoxical role of BDNF: BDNF+/- retinas are protected against light damage-mediated stress. Wilson RB, etal., Invest Ophthalmol Vis Sci. 2007 Jun;48(6):2877-86.
177. A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor. Wu A, etal., Neuroscience. 2003;119(2):365-75.
178. Effects of corticotrophin on pain behavior and BDNF, CRF levels in frontal cortex of rats suffering from chronic pain. Xu HW, etal., Acta Pharmacol Sin. 2000 Jul;21(7):600-4.
179. [Effects of proBDNF on cell proliferation and differentiation in hippocampal dentate gyrus in Alzheimer' disease rat model]. Xu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2010 May 18;90(19):1353-6.
180. Involvement of a spinal brain-derived neurotrophic factor/full-length TrkB pathway in the development of nerve injury-induced thermal hyperalgesia in mice. Yajima Y, etal., Brain Res. 2002 Dec 27;958(2):338-46.
181. The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut. Yang J, etal., Eur J Pain. 2010 Jul;14(6):574-9. doi: 10.1016/j.ejpain.2009.10.007. Epub 2009 Nov 20.
182. Hyperoxia enhances brain-derived neurotrophic factor and tyrosine kinase B receptor expression in peribronchial smooth muscle of neonatal rats. Yao Q, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L307-14. Epub 2005 Apr 8.
183. Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis. Yoshimura S, etal., Mult Scler. 2010 Oct;16(10):1178-88. Epub 2010 Jul 23.
184. Brain-derived neurotrophic factor contributes to abdominal pain in irritable bowel syndrome. Yu YB, etal., Gut. 2012 May;61(5):685-94. doi: 10.1136/gutjnl-2011-300265. Epub 2011 Oct 13.
185. Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice. Zajac MS, etal., Hippocampus. 2010 May;20(5):621-36. doi: 10.1002/hipo.20658.
186. The effect of BDNF gene variants on asthma in German children. Zeilinger S, etal., Allergy. 2009 Dec;64(12):1790-4.
187. Gingerol ameliorates neuronal damage induced by hypoxia-reoxygenation via the miR-210/brain-derived neurotrophic factor axis. Zhai Y, etal., Kaohsiung J Med Sci. 2022 Apr;38(4):367-377. doi: 10.1002/kjm2.12486. Epub 2021 Dec 28.
188. PTSD risk is associated with BDNF Val66Met and BDNF overexpression. Zhang L, etal., Mol Psychiatry. 2014 Jan;19(1):8-10. doi: 10.1038/mp.2012.180. Epub 2013 Jan 15.
189. Chronic antidepressant administration alleviates frontal and hippocampal BDNF deficits in CUMS rat. Zhang Y, etal., Brain Res. 2010 Dec 17;1366:141-8. Epub 2010 Oct 1.
190. Overexpression of BDNF increases excitability of the lumbar spinal network and leads to robust early locomotor recovery in completely spinalized rats. Ziemlinska E, etal., PLoS One. 2014 Feb 14;9(2):e88833. doi: 10.1371/journal.pone.0088833. eCollection 2014.
191. Systematic assessment of BDNF and its receptor levels in human cortices affected by Huntington's disease. Zuccato C, etal., Brain Pathol. 2008 Apr;18(2):225-38. Epub 2007 Dec 17.
192. Lack of brain-derived neurotrophic factor hampers inner hair cell synapse physiology, but protects against noise-induced hearing loss. Zuccotti A, etal., J Neurosci. 2012 Jun 20;32(25):8545-53. doi: 10.1523/JNEUROSCI.1247-12.2012.
Additional References at PubMed
PMID:1446835   PMID:1966766   PMID:2025430   PMID:7605630   PMID:7854051   PMID:8461137   PMID:8861722   PMID:8889548   PMID:10908605   PMID:11214319   PMID:11389170   PMID:11483592  
PMID:11729324   PMID:11747369   PMID:11852178   PMID:11860475   PMID:11860494   PMID:12044449   PMID:12049326   PMID:12069900   PMID:12093587   PMID:12106019   PMID:12114522   PMID:12124432  
PMID:12140784   PMID:12142569   PMID:12358730   PMID:12376548   PMID:12424260   PMID:12429205   PMID:12477932   PMID:12499861   PMID:12586427   PMID:12610654   PMID:12640007   PMID:12742641  
PMID:12742653   PMID:12796784   PMID:12798291   PMID:12805282   PMID:12821376   PMID:12842309   PMID:12843275   PMID:12890780   PMID:12904469   PMID:12914971   PMID:12941963   PMID:12956715  
PMID:14507972   PMID:14535953   PMID:14552902   PMID:14574682   PMID:14593183   PMID:14597197   PMID:14598299   PMID:14615046   PMID:14622147   PMID:14668298   PMID:14693917   PMID:14715936  
PMID:14736076   PMID:14999078   PMID:15014133   PMID:15038999   PMID:15073322   PMID:15079864   PMID:15123022   PMID:15123340   PMID:15140465   PMID:15157993   PMID:15193526   PMID:15231696  
PMID:15238431   PMID:15242649   PMID:15249684   PMID:15282290   PMID:15341182   PMID:15341601   PMID:15341606   PMID:15342202   PMID:15376326   PMID:15379998   PMID:15384067   PMID:15464571  
PMID:15465029   PMID:15489334   PMID:15518646   PMID:15525761   PMID:15533311   PMID:15548637   PMID:15591144   PMID:15659589   PMID:15698628   PMID:15698637   PMID:15703301   PMID:15704182  
PMID:15707984   PMID:15722062   PMID:15737745   PMID:15738070   PMID:15844198   PMID:15862959   PMID:15869495   PMID:15896913   PMID:15968642   PMID:15979572   PMID:16018995   PMID:16159102  
PMID:16175575   PMID:16181428   PMID:16206279   PMID:16252072   PMID:16277604   PMID:16330218   PMID:16355225   PMID:16376315   PMID:16377431   PMID:16399679   PMID:16413508   PMID:16510129  
PMID:16513266   PMID:16516892   PMID:16522641   PMID:16530518   PMID:16604191   PMID:16631934   PMID:16650607   PMID:16652337   PMID:16682819   PMID:16754670   PMID:16769156   PMID:16781670  
PMID:16819522   PMID:16901909   PMID:16904263   PMID:16938627   PMID:16957779   PMID:17003042   PMID:17005865   PMID:17022948   PMID:17064361   PMID:17072373   PMID:17161541   PMID:17164818  
PMID:17194538   PMID:17197100   PMID:17224407   PMID:17267564   PMID:17330943   PMID:17421024   PMID:17442827   PMID:17445226   PMID:17445239   PMID:17456785   PMID:17460894   PMID:17463054  
PMID:17467122   PMID:17494704   PMID:17506495   PMID:17506860   PMID:17512913   PMID:17515814   PMID:17524360   PMID:17556103   PMID:17561822   PMID:17569735   PMID:17610355   PMID:17626221  
PMID:17630209   PMID:17639782   PMID:17647101   PMID:17651427   PMID:17685400   PMID:17688944   PMID:17762522   PMID:17764660   PMID:17765576   PMID:17828499   PMID:17828750   PMID:17852404  
PMID:17854778   PMID:17885772   PMID:17893397   PMID:17898207   PMID:17912701   PMID:17921868   PMID:17923424   PMID:17950272   PMID:17959796   PMID:17974009   PMID:17997277   PMID:18021756  
PMID:18052976   PMID:18191115   PMID:18194437   PMID:18219447   PMID:18242714   PMID:18262500   PMID:18289509   PMID:18301726   PMID:18304740   PMID:18309046   PMID:18338800   PMID:18339694  
PMID:18353280   PMID:18373519   PMID:18381242   PMID:18395922   PMID:18398848   PMID:18420184   PMID:18432062   PMID:18445109   PMID:18445478   PMID:18450779   PMID:18474605   PMID:18496748  
PMID:18515408   PMID:18538870   PMID:18539944   PMID:18544182   PMID:18547240   PMID:18563704   PMID:18571429   PMID:18573344   PMID:18585459   PMID:18586239   PMID:18596175   PMID:18604298  
PMID:18625328   PMID:18635195   PMID:18636983   PMID:18637202   PMID:18655199   PMID:18680554   PMID:18685070   PMID:18728191   PMID:18766297   PMID:18813339   PMID:18852301   PMID:18923034  
PMID:18937073   PMID:18957307   PMID:18973595   PMID:18992724   PMID:19036963   PMID:19046371   PMID:19059263   PMID:19072257   PMID:19083991   PMID:19094092   PMID:19124536   PMID:19126684  
PMID:19147841   PMID:19150054   PMID:19150437   PMID:19164786   PMID:19175406   PMID:19179431   PMID:19181453   PMID:19181454   PMID:19183490   PMID:19188859   PMID:19190544   PMID:19217433  
PMID:19222557   PMID:19267952   PMID:19295157   PMID:19295451   PMID:19321768   PMID:19332029   PMID:19339597   PMID:19344636   PMID:19368814   PMID:19387610   PMID:19418263   PMID:19418634  
PMID:19424097   PMID:19437410   PMID:19448629   PMID:19524026   PMID:19524560   PMID:19530223   PMID:19546592   PMID:19547753   PMID:19555673   PMID:19555760   PMID:19558709   PMID:19570026  
PMID:19662538   PMID:19665523   PMID:19702335   PMID:19726361   PMID:19726638   PMID:19755135   PMID:19796445   PMID:19805324   PMID:19818836   PMID:19822210   PMID:19837135   PMID:19864562  
PMID:19880806   PMID:19893098   PMID:19906967   PMID:19923273   PMID:19925812   PMID:19937808   PMID:19959385   PMID:19965374   PMID:20029969   PMID:20029971   PMID:20034565   PMID:20047714  
PMID:20083190   PMID:20087891   PMID:20138132   PMID:20164202   PMID:20170723   PMID:20172535   PMID:20176405   PMID:20186743   PMID:20206238   PMID:20219632   PMID:20220070   PMID:20222154  
PMID:20226152   PMID:20232397   PMID:20335141   PMID:20392195   PMID:20398635   PMID:20405200   PMID:20407211   PMID:20410295   PMID:20427644   PMID:20452683   PMID:20522777   PMID:20535563  
PMID:20580927   PMID:20601027   PMID:20603120   PMID:20614233   PMID:20615547   PMID:20625416   PMID:20635439   PMID:20639200   PMID:20643185   PMID:20644345   PMID:20648648   PMID:20649532  
PMID:20649843   PMID:20708057   PMID:20708081   PMID:20711185   PMID:20722975   PMID:20728493   PMID:20731656   PMID:20814019   PMID:20838921   PMID:20848610   PMID:20854252   PMID:20890994  
PMID:20946939   PMID:21034794   PMID:21044076   PMID:21074587   PMID:21082236   PMID:21098478   PMID:21134422   PMID:21172615   PMID:21198979   PMID:21210848   PMID:21225335   PMID:21248226  
PMID:21254300   PMID:21255015   PMID:21269288   PMID:21306736   PMID:21307245   PMID:21307800   PMID:21334417   PMID:21335064   PMID:21338685   PMID:21349227   PMID:21357693   PMID:21420441  
PMID:21430148   PMID:21436126   PMID:21474450   PMID:21515660   PMID:21525862   PMID:21527636   PMID:21530554   PMID:21540781   PMID:21562951   PMID:21656118   PMID:21690335   PMID:21723373  
PMID:21730062   PMID:21756773   PMID:21756980   PMID:21767606   PMID:21792677   PMID:21801814   PMID:21803120   PMID:21835234   PMID:21839142   PMID:21839807   PMID:21856381   PMID:21861389  
PMID:21865474   PMID:21890320   PMID:21907460   PMID:21945647   PMID:21946312   PMID:22024546   PMID:22027236   PMID:22044922   PMID:22050733   PMID:22069327   PMID:22128191   PMID:22134693  
PMID:22174809   PMID:22178325   PMID:22178659   PMID:22193444   PMID:22195050   PMID:22209827   PMID:22223265   PMID:22227452   PMID:22234237   PMID:22244747   PMID:22253429   PMID:22265241  
PMID:22272355   PMID:22280975   PMID:22306205   PMID:22345308   PMID:22374757   PMID:22410736   PMID:22426107   PMID:22428625   PMID:22442695   PMID:22469747   PMID:22499464   PMID:22500633  
PMID:22510533   PMID:22515203   PMID:22521816   PMID:22527999   PMID:22553040   PMID:22561407   PMID:22573254   PMID:22573708   PMID:22649026   PMID:22650038   PMID:22650039   PMID:22650040  
PMID:22650041   PMID:22650043   PMID:22672085   PMID:22678720   PMID:22730318   PMID:22778217   PMID:22796076   PMID:22841916   PMID:22847550   PMID:22848609   PMID:22886995   PMID:22917619  
PMID:22930524   PMID:22936723   PMID:22959240   PMID:23017014   PMID:23035088   PMID:23056528   PMID:23058367   PMID:23080167   PMID:23086941   PMID:23134146   PMID:23157205   PMID:23160045  
PMID:23168995   PMID:23179587   PMID:23185000   PMID:23189980   PMID:23219910   PMID:23237316   PMID:23255148   PMID:23261589   PMID:23271640   PMID:23274899   PMID:23326507   PMID:23337714  
PMID:23337936   PMID:23349925   PMID:23367482   PMID:23376487   PMID:23392678   PMID:23432085   PMID:23436435   PMID:23439217   PMID:23512738   PMID:23531843   PMID:23534605   PMID:23550026  
PMID:23564488   PMID:23588198   PMID:23599427   PMID:23643896   PMID:23700463   PMID:23704876   PMID:23715956   PMID:23749289   PMID:23762244   PMID:23770418   PMID:23785138   PMID:23811393  
PMID:23825410   PMID:23842743   PMID:23870838   PMID:23918351   PMID:23942837   PMID:23949197   PMID:23963709   PMID:23993653   PMID:23999152   PMID:24006456   PMID:24021607   PMID:24035762  
PMID:24076087   PMID:24092446   PMID:24103311   PMID:24114393   PMID:24127005   PMID:24157309   PMID:24201284   PMID:24244357   PMID:24280707   PMID:24302729   PMID:24303055   PMID:24316448  
PMID:24321407   PMID:24345682   PMID:24361450   PMID:24365909   PMID:24372023   PMID:24378336   PMID:24401942   PMID:24431454   PMID:24440750   PMID:24465591   PMID:24503120   PMID:24573299  
PMID:24625911   PMID:24709620   PMID:24714156   PMID:24747049   PMID:24747659   PMID:24753016   PMID:24802968   PMID:24811179   PMID:24839168   PMID:24917666   PMID:24921856   PMID:24934279  
PMID:24965890   PMID:24966334   PMID:24968020   PMID:24978397   PMID:24978930   PMID:24993297   PMID:25010399   PMID:25011012   PMID:25052557   PMID:25055143   PMID:25059794   PMID:25082546  
PMID:25087780   PMID:25110093   PMID:25143381   PMID:25182413   PMID:25203492   PMID:25209292   PMID:25226925   PMID:25231482   PMID:25241777   PMID:25282819   PMID:25392083   PMID:25424467  
PMID:25444867   PMID:25445195   PMID:25449846   PMID:25451258   PMID:25453757   PMID:25481360   PMID:25519736   PMID:25527489   PMID:25542970   PMID:25555929   PMID:25559382   PMID:25568287  
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PMID:26163515   PMID:26166726   PMID:26189832   PMID:26198255   PMID:26200505   PMID:26211445   PMID:26239042   PMID:26239616   PMID:26291061   PMID:26339375   PMID:26368940   PMID:26388293  
PMID:26391661   PMID:26396035   PMID:26398857   PMID:26449489   PMID:26459016   PMID:26469350   PMID:26471218   PMID:26554621   PMID:26571801   PMID:26586578   PMID:26630405   PMID:26659122  
PMID:26676568   PMID:26682524   PMID:26691781   PMID:26700412   PMID:26708520   PMID:26712630   PMID:26794594   PMID:26802511   PMID:26820887   PMID:26844865   PMID:26861177   PMID:26877199  
PMID:26881097   PMID:26888068   PMID:26926964   PMID:26941165   PMID:26960058   PMID:27006395   PMID:27010597   PMID:27013094   PMID:27028464   PMID:27085775   PMID:27094192   PMID:27132084  
PMID:27137405   PMID:27151332   PMID:27154426   PMID:27181637   PMID:27252349   PMID:27267245   PMID:27270670   PMID:27306412   PMID:27310873   PMID:27329329   PMID:27381812   PMID:27435421  
PMID:27474832   PMID:27503312   PMID:27521083   PMID:27550421   PMID:27569259   PMID:27597545   PMID:27611779   PMID:27624937   PMID:27639585   PMID:27683907   PMID:27693383   PMID:27727393  
PMID:27744091   PMID:27771283   PMID:27830679   PMID:27832087   PMID:27857218   PMID:27874237   PMID:27913431   PMID:27914953   PMID:27926876   PMID:28072837   PMID:28078614   PMID:28119091  
PMID:28145853   PMID:28238708   PMID:28254195   PMID:28258626   PMID:28261618   PMID:28281382   PMID:28306606   PMID:28330827   PMID:28420943   PMID:28440877   PMID:28445707   PMID:28492549  
PMID:28524001   PMID:28598964   PMID:28600519   PMID:28622174   PMID:28634074   PMID:28640008   PMID:28663119   PMID:28698933   PMID:28711394   PMID:28767193   PMID:28770018   PMID:28821448  
PMID:28829495   PMID:28854337   PMID:28855298   PMID:28857460   PMID:28865749   PMID:28890399   PMID:28965325   PMID:29075579   PMID:29098710   PMID:29126980   PMID:29263199   PMID:29288061  
PMID:29305263   PMID:29353374   PMID:29380665   PMID:29401579   PMID:29420916   PMID:29425916   PMID:29499310   PMID:29540150   PMID:29545098   PMID:29611441   PMID:29621970   PMID:29648487  
PMID:29704115   PMID:29773102   PMID:29777700   PMID:29781158   PMID:29800645   PMID:29802680   PMID:29911174   PMID:30001178   PMID:30024334   PMID:30076998   PMID:30100066   PMID:30102916  
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PMID:30483749   PMID:30503681   PMID:30548775   PMID:30550948   PMID:30569121   PMID:30639279   PMID:30680641   PMID:30695408   PMID:30710509   PMID:30741614   PMID:30761261   PMID:30851317  
PMID:30940563   PMID:30956976   PMID:31014242   PMID:31017891   PMID:31114979   PMID:31134851   PMID:31213568   PMID:31219215   PMID:31281833   PMID:31327126   PMID:31329835   PMID:31412259  
PMID:31415765   PMID:31449911   PMID:31492038   PMID:31524100   PMID:31539886   PMID:31557760   PMID:31577916   PMID:31694441   PMID:31770584   PMID:31773433   PMID:31828524   PMID:31883222  
PMID:31883511   PMID:31915257   PMID:31922368   PMID:31960229   PMID:31973999   PMID:31982414   PMID:32027953   PMID:32043504   PMID:32120967   PMID:32179157   PMID:32189593   PMID:32193501  
PMID:32214273   PMID:32219700   PMID:32222405   PMID:32323597   PMID:32417176   PMID:32445041   PMID:32488870   PMID:32505509   PMID:32507324   PMID:32585251   PMID:32588398   PMID:32671697  
PMID:32681810   PMID:32738378   PMID:32770453   PMID:32787648   PMID:32820184   PMID:32822705   PMID:33075004   PMID:33103739   PMID:33147870   PMID:33148515   PMID:33204065   PMID:33206632  
PMID:33245480   PMID:33290797   PMID:33359781   PMID:33436052   PMID:33560226   PMID:33577886   PMID:33649977   PMID:33745752   PMID:33763156   PMID:33874962   PMID:33961393   PMID:33982757  
PMID:34008409   PMID:34061025   PMID:34068707   PMID:34086671   PMID:34101873   PMID:34102241   PMID:34192516   PMID:34225593   PMID:34274327   PMID:34295224   PMID:34299002   PMID:34328517  
PMID:34348149   PMID:34374467   PMID:34374900   PMID:34454019   PMID:34497360   PMID:34529365   PMID:34536437   PMID:34543287   PMID:34619155   PMID:34695541   PMID:34700232   PMID:34743976  
PMID:34869766   PMID:34907761   PMID:34929632   PMID:34937120   PMID:34948299   PMID:34960080   PMID:35013359   PMID:35059698   PMID:35216241   PMID:35256586   PMID:35293071   PMID:35439934  
PMID:35481944   PMID:35557046   PMID:35596908   PMID:35644274   PMID:35769142   PMID:35806000   PMID:35820831   PMID:35921478   PMID:36041572   PMID:36233065   PMID:36316156   PMID:36375307  
PMID:36499323   PMID:36567651   PMID:36649932   PMID:36674499   PMID:36736275   PMID:36884028   PMID:36902428   PMID:36988364  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2396,165,042 - 96,215,621 (+)NCBImRatBN7.2