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Gene: Bdnf (brain-derived neurotrophic factor) Rattus norvegicus
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Symbol: Bdnf
Name: brain-derived neurotrophic factor
RGD ID: 2202
Description: Exhibits neurotrophin TRKB receptor binding activity. Involved in several processes, including behavioral response to cocaine; cellular response to norepinephrine stimulus; and generation of neurons. Localizes to several cellular components, including mitochondrial crista; perikaryon; and synaptic vesicle. Used to study Alzheimer's disease; cystitis; eye disease (multiple); neuropathy (multiple); and status epilepticus. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; hypertensive encephalopathy; middle cerebral artery infarction; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; Huntington's disease pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (-)-epigallocatechin 3-gallate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Brain derived neurothrophic factor; brain derived neurotrophic factor; MGC105254
Orthologs:
Homo sapiens (human) : BDNF (brain derived neurotrophic factor)  HGNC  Alliance
Mus musculus (house mouse) : Bdnf (brain derived neurotrophic factor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bdnf (brain derived neurotrophic factor)
Pan paniscus (bonobo/pygmy chimpanzee) : BDNF (brain derived neurotrophic factor)
Canis lupus familiaris (dog) : BDNF (brain derived neurotrophic factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bdnf (brain derived neurotrophic factor)
Sus scrofa (pig) : BDNF (brain derived neurotrophic factor)
Chlorocebus sabaeus (African green monkey) : BDNF (brain derived neurotrophic factor)
Heterocephalus glaber (naked mole-rat) : Bdnf (brain derived neurotrophic factor)
more info ...
Allele / Splice: Bdnfem1Sage  
Genetic Models: SD-Bdnfem1Sage
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03100,768,637 - 100,819,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3100,768,637 - 100,819,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03107,371,329 - 107,421,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera395,191,318 - 95,241,949 (+)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Strain Sequence Variants (Rnor 6.0)