Ano3 (anoctamin 3) - Rat Genome Database

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Gene: Ano3 (anoctamin 3) Rattus norvegicus
Symbol: Ano3
Name: anoctamin 3
RGD ID: 1308873
Description: Predicted to enable chloride channel activity and phospholipid scramblase activity. Involved in detection of mechanical stimulus and detection of temperature stimulus. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in dystonia 24. Orthologous to human ANO3 (anoctamin 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: anoctamin-3; LOC311287; Tmem16c; transmembrane protein 16C
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ano3Tn(sb-T2/Bart3)2.307Mcwi  
Genetic Models: F344-Ano3Tn(sb-T2/Bart3)2.307Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83117,690,242 - 118,004,695 (-)NCBIGRCr8
mRatBN7.2397,235,671 - 97,550,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl397,238,354 - 97,550,154 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03101,843,516 - 102,203,368 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,840,630 - 102,151,489 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03108,441,370 - 108,751,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4396,123,925 - 96,237,157 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1396,018,606 - 96,401,781 (-)NCBI
Celera396,244,306 - 96,609,033 (-)NCBICelera
Cytogenetic Map3q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. TMEM16C facilitates Na(+)-activated K+ currents in rat sensory neurons and regulates pain processing. Huang F, etal., Nat Neurosci. 2013 Sep;16(9):1284-90. doi: 10.1038/nn.3468. Epub 2013 Jul 21.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:21984732   PMID:23532839   PMID:33972431  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr83117,690,242 - 118,004,695 (-)NCBIGRCr8
mRatBN7.2397,235,671 - 97,550,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl397,238,354 - 97,550,154 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03101,843,516 - 102,203,368 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3101,840,630 - 102,151,489 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03108,441,370 - 108,751,911 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4396,123,925 - 96,237,157 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1396,018,606 - 96,401,781 (-)NCBI
Celera396,244,306 - 96,609,033 (-)NCBICelera
Cytogenetic Map3q34NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381126,188,808 - 26,663,289 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1126,188,842 - 26,663,289 (+)EnsemblGRCh38hg38GRCh38
GRCh371126,210,355 - 26,684,836 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361126,310,254 - 26,641,412 (+)NCBINCBI36Build 36hg18NCBI36
Build 341126,309,546 - 26,641,411NCBI
Celera1126,498,680 - 26,830,111 (+)NCBICelera
Cytogenetic Map11p14.3-p14.2NCBI
HuRef1126,049,842 - 26,381,695 (+)NCBIHuRef
CHM1_11126,352,915 - 26,683,853 (+)NCBICHM1_1
T2T-CHM13v2.01126,329,688 - 26,803,844 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392110,485,546 - 110,780,854 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2110,485,546 - 110,781,268 (-)EnsemblGRCm39 Ensembl
GRCm382110,655,201 - 110,950,391 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2110,655,201 - 110,950,923 (-)EnsemblGRCm38mm10GRCm38
MGSCv372110,498,297 - 110,790,401 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera2111,811,420 - 112,117,515 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map256.75NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554765,813,071 - 6,060,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554765,702,888 - 6,060,545 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2928,531,536 - 28,865,020 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11128,532,042 - 28,865,368 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01126,287,123 - 26,618,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,188,895 - 26,519,646 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,047,200 - 26,519,646 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12147,046,020 - 47,416,360 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2147,045,978 - 47,410,908 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2146,531,987 - 46,908,223 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02148,182,161 - 48,557,461 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2148,182,107 - 48,553,681 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12147,168,753 - 47,544,204 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02147,335,086 - 47,707,198 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02147,920,278 - 48,293,168 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494737,282,558 - 37,557,680 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365406,439,990 - 6,712,283 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365406,437,362 - 6,712,433 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl233,618,005 - 33,905,069 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1233,618,740 - 34,048,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2236,222,904 - 36,708,472 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1138,423,719 - 38,889,088 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl138,422,204 - 38,755,319 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038135,743,996 - 136,210,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462476616,340,630 - 16,605,724 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476616,340,636 - 16,605,724 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ano3
1567 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:32
Interacting mature miRNAs:38
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)396127817102200699Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2397,551,417 - 97,551,561 (+)MAPPERmRatBN7.2
Rnor_6.03102,152,812 - 102,152,955NCBIRnor6.0
Rnor_5.03108,753,156 - 108,753,299UniSTSRnor5.0
RGSC_v3.4396,506,774 - 96,506,917UniSTSRGSC3.4
RGSC_v3.4396,506,745 - 96,507,062RGDRGSC3.4
RGSC_v3.1396,403,202 - 96,403,345RGD
Celera396,557,569 - 96,557,712UniSTS
RH 3.4 Map3759.8RGD
RH 3.4 Map3759.8UniSTS
RH 2.0 Map3516.8RGD
SHRSP x BN Map349.5398RGD
Cytogenetic Map3q33-q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2397,298,165 - 97,298,391 (+)MAPPERmRatBN7.2
Rnor_6.03101,902,509 - 101,902,734NCBIRnor6.0
Rnor_5.03108,500,649 - 108,500,874UniSTSRnor5.0
RGSC_v3.4396,185,024 - 96,185,250RGDRGSC3.4
RGSC_v3.4396,185,025 - 96,185,250UniSTSRGSC3.4
RGSC_v3.1396,081,452 - 96,081,678RGD
Celera396,305,776 - 96,306,001UniSTS
Cytogenetic Map3q33-q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2397,237,031 - 97,237,221 (+)MAPPERmRatBN7.2
Rnor_6.03101,842,002 - 101,842,191NCBIRnor6.0
Rnor_5.03108,439,856 - 108,440,045UniSTSRnor5.0
RGSC_v3.4396,122,652 - 96,122,841UniSTSRGSC3.4
Celera396,245,658 - 96,245,847UniSTS
RH 3.4 Map3759.7UniSTS
Cytogenetic Map3q33-q34UniSTS

Genetic Models
This gene Ano3 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 23
Low 1 10 8 8 51 16
Below cutoff 1 26 15 9 4 9 3 3 20 21 5 3


RefSeq Acc Id: ENSRNOT00000006349   ⟹   ENSRNOP00000006349
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl397,238,354 - 97,550,154 (-)Ensembl
Rnor_6.0 Ensembl3101,840,630 - 102,151,489 (-)Ensembl
RefSeq Acc Id: XM_039106460   ⟹   XP_038962388
Rat AssemblyChrPosition (strand)Source
GRCr83117,690,242 - 118,004,695 (-)NCBI
mRatBN7.2397,235,671 - 97,550,090 (-)NCBI
RefSeq Acc Id: XM_039106461   ⟹   XP_038962389
Rat AssemblyChrPosition (strand)Source
GRCr83117,690,242 - 117,885,147 (-)NCBI
mRatBN7.2397,235,671 - 97,430,603 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001417331 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962388 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962389 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006349
RefSeq Acc Id: ENSRNOP00000006349   ⟸   ENSRNOT00000006349
RefSeq Acc Id: XP_038962388   ⟸   XM_039106460
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962389   ⟸   XM_039106461
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M0A0-F1-model_v2 AlphaFold F1M0A0 1-972 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308873 AgrOrtholog
BioCyc Gene G2FUF-48462 BioCyc
Ensembl Genes ENSRNOG00000004731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006349.7 UniProtKB/TrEMBL
InterPro Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
  Anoctamin_TM UniProtKB/TrEMBL
  PTHR12308:SF16 UniProtKB/TrEMBL
Pfam Anoct_dimer UniProtKB/TrEMBL
  Anoctamin UniProtKB/TrEMBL
PhenoGen Ano3 PhenoGen
RatGTEx ENSRNOG00000004731 RatGTEx

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tmem16c  transmembrane protein 16C   Tmem16c_predicted  transmembrane protein 16C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tmem16c_predicted  transmembrane protein 16C (predicted)      Symbol and Name status set to approved 70820 APPROVED