Rasgrp1 (RAS guanyl releasing protein 1) - Rat Genome Database

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Gene: Rasgrp1 (RAS guanyl releasing protein 1) Rattus norvegicus
Analyze
Symbol: Rasgrp1
Name: RAS guanyl releasing protein 1
RGD ID: 3539
Description: Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of lymphocyte differentiation. Predicted to act upstream of or within several processes, including mast cell degranulation; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and vesicle transport along microtubule. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEF1; calDAG-GEFII; RAS guanyl releasing protein; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; Rasgrp
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83124,624,039 - 124,684,079 (-)NCBIGRCr8
mRatBN7.23104,168,549 - 104,230,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3104,170,013 - 104,230,056 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3107,820,175 - 107,880,225 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03116,415,684 - 116,475,744 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,076,078 - 114,136,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03108,984,029 - 109,044,420 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3108,984,029 - 109,044,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03115,539,782 - 115,600,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43103,371,879 - 103,433,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13103,268,306 - 103,329,438 (-)NCBI
Celera3103,097,991 - 103,157,871 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
calcidiol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
delta-tocotrienol  (ISO)
dexamethasone  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
GW 4064  (ISO)
haloperidol  (EXP)
hydroxychloroquine  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
Mesaconitine  (EXP)
methamphetamine  (EXP)
methotrexate  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
pentanal  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
quercetin  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
thioacetamide  (EXP)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Ebinu JO, etal., Science 1998 May 15;280(5366):1082-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Kawasaki H, etal., Proc Natl Acad Sci U S A 1998 Oct 27;95(22):13278-83.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat. Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:10807788   PMID:11017103   PMID:12845332   PMID:14532295   PMID:15064353   PMID:15899849   PMID:17190838   PMID:19933860   PMID:21957144   PMID:21968647   PMID:23908768   PMID:27776107  
PMID:29155103  


Genomics

Comparative Map Data
Rasgrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83124,624,039 - 124,684,079 (-)NCBIGRCr8
mRatBN7.23104,168,549 - 104,230,107 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3104,170,013 - 104,230,056 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3107,820,175 - 107,880,225 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03116,415,684 - 116,475,744 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03114,076,078 - 114,136,139 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03108,984,029 - 109,044,420 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3108,984,029 - 109,044,420 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03115,539,782 - 115,600,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43103,371,879 - 103,433,010 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13103,268,306 - 103,329,438 (-)NCBI
Celera3103,097,991 - 103,157,871 (-)NCBICelera
Cytogenetic Map3q35NCBI
RASGRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381538,488,103 - 38,564,814 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1538,488,103 - 38,565,575 (-)EnsemblGRCh38hg38GRCh38
GRCh371538,780,304 - 38,857,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361536,567,596 - 36,644,224 (-)NCBINCBI36Build 36hg18NCBI36
Build 341536,567,597 - 36,644,224NCBI
Celera1515,547,460 - 15,623,931 (-)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1515,624,949 - 15,701,560 (-)NCBIHuRef
CHM1_11538,899,429 - 38,976,151 (-)NCBICHM1_1
T2T-CHM13v2.01536,293,389 - 36,370,106 (-)NCBIT2T-CHM13v2.0
Rasgrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392117,110,464 - 117,173,358 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2117,110,474 - 117,173,482 (-)EnsemblGRCm39 Ensembl
GRCm382117,279,983 - 117,342,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2117,279,993 - 117,343,001 (-)EnsemblGRCm38mm10GRCm38
MGSCv372117,105,729 - 117,168,613 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362116,971,434 - 117,034,318 (-)NCBIMGSCv36mm8
Celera2118,408,657 - 118,471,539 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.19NCBI
Rasgrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554165,494,030 - 5,561,614 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554165,494,030 - 5,561,608 (-)NCBIChiLan1.0ChiLan1.0
RASGRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21627,718,510 - 27,793,906 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11531,869,704 - 31,945,133 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01517,417,684 - 17,494,333 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11535,672,893 - 35,749,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1535,675,348 - 35,750,315 (-)Ensemblpanpan1.1panPan2
RASGRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1305,840,901 - 5,914,804 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl305,841,738 - 5,914,810 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha305,895,306 - 5,970,092 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0305,964,791 - 6,039,684 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl305,964,193 - 6,039,699 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1305,890,270 - 5,965,004 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0305,989,611 - 6,064,493 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0306,124,968 - 6,199,850 (-)NCBIUU_Cfam_GSD_1.0
Rasgrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864084,305,783 - 84,374,676 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364712,153,880 - 2,222,229 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364712,152,231 - 2,222,260 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1132,702,541 - 132,786,532 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11132,702,495 - 132,786,536 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21148,187,586 - 148,271,567 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12644,405,007 - 44,483,291 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604896,442,505 - 96,519,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248045,690,400 - 5,763,288 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248045,691,011 - 5,763,314 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasgrp1
230 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:157
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000007687
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat

Markers in Region
D3Got61  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23104,205,496 - 104,205,741 (+)MAPPERmRatBN7.2
Rnor_6.03109,019,847 - 109,020,091NCBIRnor6.0
Rnor_5.03115,575,600 - 115,575,844UniSTSRnor5.0
RGSC_v3.43103,407,356 - 103,407,601RGDRGSC3.4
RGSC_v3.43103,407,357 - 103,407,601UniSTSRGSC3.4
RGSC_v3.13103,303,785 - 103,304,029RGD
Celera3103,133,407 - 103,133,651UniSTS
RH 3.4 Map3787.9RGD
RH 3.4 Map3787.9UniSTS
Cytogenetic Map3q34-q35UniSTS
D3Wox41  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23104,170,078 - 104,170,330 (+)MAPPERmRatBN7.2
Rnor_6.03108,984,095 - 108,984,344NCBIRnor6.0
Rnor_5.03115,539,848 - 115,540,097UniSTSRnor5.0
RGSC_v3.43103,371,945 - 103,372,194UniSTSRGSC3.4
Celera3103,098,057 - 103,098,302UniSTS
Cytogenetic Map3q34-q35UniSTS
BF412005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23104,227,771 - 104,227,874 (+)MAPPERmRatBN7.2
Rnor_6.03109,042,136 - 109,042,238NCBIRnor6.0
Rnor_5.03115,597,986 - 115,598,088UniSTSRnor5.0
RGSC_v3.43103,430,726 - 103,430,828UniSTSRGSC3.4
Celera3103,155,583 - 103,155,685UniSTS
RH 3.4 Map3787.7UniSTS
Cytogenetic Map3q34-q35UniSTS
AU048142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23104,188,455 - 104,188,557 (+)MAPPERmRatBN7.2
Rnor_6.03109,002,808 - 109,002,909NCBIRnor6.0
Rnor_5.03115,558,561 - 115,558,662UniSTSRnor5.0
RGSC_v3.43103,390,318 - 103,390,419UniSTSRGSC3.4
Celera3103,116,394 - 103,116,495UniSTS
Cytogenetic Map3q34-q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000007687   ⟹   ENSRNOP00000007687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3104,170,013 - 104,230,056 (-)Ensembl
Rnor_6.0 Ensembl3108,984,029 - 109,044,420 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104283   ⟹   ENSRNOP00000090995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3104,171,220 - 104,230,056 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000111941   ⟹   ENSRNOP00000080984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3104,171,220 - 104,230,056 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114112   ⟹   ENSRNOP00000094823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3104,170,013 - 104,193,499 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114986   ⟹   ENSRNOP00000088046
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3104,170,013 - 104,230,056 (-)Ensembl
RefSeq Acc Id: NM_019211   ⟹   NP_062084
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83124,624,039 - 124,684,079 (-)NCBI
mRatBN7.23104,170,013 - 104,230,056 (-)NCBI
Rnor_6.03108,984,029 - 109,044,420 (-)NCBI
Rnor_5.03115,539,782 - 115,600,270 (-)NCBI
RGSC_v3.43103,371,879 - 103,433,010 (-)RGD
Celera3103,097,991 - 103,157,871 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_062084 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC40137 (Get FASTA)   NCBI Sequence Viewer  
  AAC79700 (Get FASTA)   NCBI Sequence Viewer  
  EDL79846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007687.5
  ENSRNOP00000080984.1
  ENSRNOP00000088046.1
  ENSRNOP00000090995.1
  ENSRNOP00000094823.1
GenBank Protein Q9R1K8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062084   ⟸   NM_019211
- UniProtKB: O88469 (UniProtKB/Swiss-Prot),   Q9R1K8 (UniProtKB/Swiss-Prot),   A6HP95 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007687   ⟸   ENSRNOT00000007687
Ensembl Acc Id: ENSRNOP00000088046   ⟸   ENSRNOT00000114986
Ensembl Acc Id: ENSRNOP00000080984   ⟸   ENSRNOT00000111941
Ensembl Acc Id: ENSRNOP00000094823   ⟸   ENSRNOT00000114112
Ensembl Acc Id: ENSRNOP00000090995   ⟸   ENSRNOT00000104283
Protein Domains
EF-hand   N-terminal Ras-GEF   Phorbol-ester/DAG-type   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9R1K8-F1-model_v2 AlphaFold Q9R1K8 1-795 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692305
Promoter ID:EPDNEW_R2829
Type:multiple initiation site
Name:Rasgrp1_1
Description:RAS guanyl releasing protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03109,044,432 - 109,044,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3539 AgrOrtholog
BioCyc Gene G2FUF-48275 BioCyc
Ensembl Genes ENSRNOG00000005404 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007687.5 UniProtKB/TrEMBL
  ENSRNOT00000104283.1 UniProtKB/TrEMBL
  ENSRNOT00000111941.1 UniProtKB/TrEMBL
  ENSRNOT00000114112.1 UniProtKB/TrEMBL
  ENSRNOT00000114986.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.60.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.250.2730 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C1-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAG/PE-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29434 UniProtKB/Swiss-Prot
NCBI Gene 29434 ENTREZGENE
PANTHER PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS GUANYL-RELEASING PROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rasgrp1 PhenoGen
PRINTS DAGPEDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005404 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57889 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC234472
UniProt A0A8I5ZR13_RAT UniProtKB/TrEMBL
  A0A8I6ADN9_RAT UniProtKB/TrEMBL
  A0A8I6GFR9_RAT UniProtKB/TrEMBL
  A0A8I6GLC0_RAT UniProtKB/TrEMBL
  A0A8L2Q3E3_RAT UniProtKB/TrEMBL
  A6HP95 ENTREZGENE, UniProtKB/TrEMBL
  GRP1_RAT UniProtKB/Swiss-Prot
  O88469 ENTREZGENE
  Q9R1K8 ENTREZGENE
UniProt Secondary O88469 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Rasgrp1  RAS guanyl releasing protein 1  Rasgrp1  RAS guanyl releasing protein 1 (calcium and DAG-regulated)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Rasgrp1  RAS guanyl releasing protein 1 (calcium and DAG-regulated)  Rasgrp1  RAS guanyl releasing protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Rasgrp1  RAS guanyl releasing protein 1      Name updated 70584 APPROVED
2001-12-06 Rasgrp1  RAS guanyl releasing protein 1      Symbol updated to reflect Human and Mouse nomenclature 69665 APPROVED