Rasgrp1 (RAS guanyl releasing protein 1)

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Gene: Rasgrp1 (RAS guanyl releasing protein 1) Rattus norvegicus

Analyze

Symbol:

Rasgrp1

Name:

RAS guanyl releasing protein 1

RGD ID:

3539

Description:

Predicted to enable several functions, including cation binding activity; diacylglycerol binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including positive regulation of cytokine production; positive regulation of intracellular signal transduction; and positive regulation of lymphocyte differentiation. Predicted to act upstream of or within several processes, including mast cell degranulation; regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and vesicle transport along microtubule. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 64. Orthologous to human RASGRP1 (RAS guanyl releasing protein 1); PARTICIPATES IN mitogen activated protein kinase signaling pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

calcium and DAG-regulated guanine nucleotide exchange factor II; CalDAG-GEF1; calDAG-GEFII; RAS guanyl releasing protein; RAS guanyl releasing protein 1 (calcium and DAG-regulated); RAS guanyl-releasing protein 1; Rasgrp

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASGRP1 (RAS guanyl releasing protein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Rasgrp1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasgrp1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASGRP1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASGRP1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasgrp1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASGRP1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASGRP1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasgrp1 (RAS guanyl releasing protein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	RASGRP1 (RAS guanyl releasing protein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Rasgrp1 (RAS guanyl releasing protein 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rgef-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rasgrp1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	104,168,549 - 104,230,107 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	104,170,013 - 104,230,056 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	107,820,175 - 107,880,225 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	116,415,684 - 116,475,744 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	114,076,078 - 114,136,139 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	108,984,029 - 109,044,420 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	108,984,029 - 109,044,420 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	115,539,782 - 115,600,270 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	103,371,879 - 103,433,010 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	103,268,306 - 103,329,438 (-)	NCBI
Celera	3	103,097,991 - 103,157,871 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Bloom syndrome (ISO)

colorectal cancer (ISO)

endometriosis (ISO)

genetic disease (ISO)

immunodeficiency 64 (ISO)

Legius Syndrome (ISO)

rheumatoid arthritis (ISO)

schizophrenia (ISO)

systemic lupus erythematosus (ISO,ISS)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-butoxyethanol (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

afimoxifene (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

amphotericin B (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

avobenzone (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

calcidiol (EXP)

cannabidiol (EXP)

carbon nanotube (ISO)

chloroprene (ISO)

chlorpyrifos (EXP,ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

delta-tocotrienol (ISO)

dexamethasone (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

ethanol (ISO)

folic acid (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

GW 4064 (ISO)

haloperidol (EXP)

hydroxychloroquine (ISO)

indometacin (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

methamphetamine (EXP)

methotrexate (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

mifepristone (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

O-methyleugenol (ISO)

ochratoxin A (ISO)

oxidopamine (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

PCB138 (ISO)

pentanal (ISO)

pentane-2,3-dione (EXP)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

potassium chromate (ISO)

progesterone (ISO)

propanal (ISO)

quercetin (ISO)

raloxifene (ISO)

resveratrol (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulfasalazine (ISO)

sunitinib (ISO)

tamoxifen (ISO)

taurine (ISO)

thioacetamide (EXP)

tributylstannane (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

B cell activation (ISO)

B cell proliferation (IEA,ISO)

cell differentiation (IEA)

inflammatory response to antigenic stimulus (IEA,ISO)

mast cell degranulation (IEA,ISO)

natural killer cell activation (IEA,ISO)

positive regulation of ERK1 and ERK2 cascade (IEA,ISO)

positive regulation of granulocyte macrophage colony-stimulating factor production (IEA,ISO)

positive regulation of JNK cascade (IEA,ISO)

positive regulation of natural killer cell activation (ISO)

positive regulation of natural killer cell differentiation (IEA,ISO)

positive regulation of natural killer cell mediated cytotoxicity (IEA,ISO)

positive regulation of protein phosphorylation (IEA,ISO)

positive regulation of Ras protein signal transduction (IEA,ISO)

positive regulation of T cell differentiation in thymus (IEA,ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

positive regulation of type II interferon production (IEA,ISO)

Ras protein signal transduction (IBA)

regulation of ERK1 and ERK2 cascade (ISO)

regulation of p38MAPK cascade (ISO)

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA,ISO)

secretory granule localization (IEA,ISO)

small GTPase mediated signal transduction (IEA)

T cell activation (ISO)

T cell proliferation (IEA,ISO)

vesicle transport along microtubule (IEA,ISO)

Cellular Component

cytosol (IEA,ISO)

endoplasmic reticulum membrane (IEA)

Golgi apparatus (IEA,ISO)

Golgi membrane (IEA)

plasma membrane (IBA,IEA,ISO)

Molecular Function

calcium ion binding (IEA,ISO)

diacylglycerol binding (IEA,ISO)

guanyl-nucleotide exchange factor activity (IBA,IEA,ISO,TAS)

identical protein binding (IEA,ISO)

phosphatidylcholine binding (IEA,ISO)

zinc ion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mitogen activated protein kinase signaling pathway (IEA)

T cell receptor signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs.	Ebinu JO, etal., Science 1998 May 15;280(5366):1082-6.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia.	Kawasaki H, etal., Proc Natl Acad Sci U S A 1998 Oct 27;95(22):13278-83.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
8.	GOA pipeline	RGD automated data pipeline
9.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	Localization of 54 rat genes, and definition of new synteny groups conserved in the human and the rat.	Szpirer C, etal., Mamm Genome 2000 Sep;11(9):729-35
12.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10807788	PMID:11017103	PMID:12845332	PMID:14532295	PMID:15064353	PMID:15899849	PMID:17190838	PMID:19933860	PMID:21957144	PMID:21968647	PMID:23908768	PMID:27776107
PMID:29155103

Genomics

Comparative Map Data

Rasgrp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	104,168,549 - 104,230,107 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	104,170,013 - 104,230,056 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	107,820,175 - 107,880,225 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	116,415,684 - 116,475,744 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	114,076,078 - 114,136,139 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	108,984,029 - 109,044,420 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	108,984,029 - 109,044,420 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	115,539,782 - 115,600,270 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	103,371,879 - 103,433,010 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	103,268,306 - 103,329,438 (-)	NCBI
Celera	3	103,097,991 - 103,157,871 (-)	NCBI		Celera
Cytogenetic Map	3	q35	NCBI

RASGRP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	38,488,103 - 38,564,814 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	38,488,103 - 38,565,575 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	38,780,304 - 38,857,015 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	36,567,596 - 36,644,224 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	36,567,597 - 36,644,224	NCBI
Celera	15	15,547,460 - 15,623,931 (-)	NCBI		Celera
Cytogenetic Map	15	q14	NCBI
HuRef	15	15,624,949 - 15,701,560 (-)	NCBI		HuRef
CHM1_1	15	38,899,429 - 38,976,151 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	36,293,389 - 36,370,106 (-)	NCBI		T2T-CHM13v2.0

Rasgrp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	117,110,464 - 117,173,358 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	117,110,474 - 117,173,482 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	117,279,983 - 117,342,877 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	117,279,993 - 117,343,001 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	117,105,729 - 117,168,613 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	116,971,434 - 117,034,318 (-)	NCBI		MGSCv36	mm8
Celera	2	118,408,657 - 118,471,539 (-)	NCBI		Celera
Cytogenetic Map	2	E5	NCBI
cM Map	2	59.19	NCBI

Rasgrp1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	5,494,030 - 5,561,614 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	5,494,030 - 5,561,608 (-)	NCBI	ChiLan1.0	ChiLan1.0

RASGRP1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	15	31,869,704 - 31,945,133 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	17,417,684 - 17,494,333 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	35,672,893 - 35,749,621 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	35,675,348 - 35,750,315 (-)	Ensembl	panpan1.1		panPan2

RASGRP1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	5,840,901 - 5,914,804 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	5,841,738 - 5,914,810 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	5,895,306 - 5,970,092 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	5,964,791 - 6,039,684 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	5,964,193 - 6,039,699 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	5,890,270 - 5,965,004 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	5,989,611 - 6,064,493 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	6,124,968 - 6,199,850 (-)	NCBI		UU_Cfam_GSD_1.0

Rasgrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	84,305,783 - 84,374,676 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	2,153,880 - 2,222,229 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936471	2,152,231 - 2,222,260 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASGRP1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	132,702,541 - 132,786,532 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	132,702,495 - 132,786,536 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	148,187,586 - 148,271,567 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASGRP1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	44,405,007 - 44,483,291 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	96,442,505 - 96,519,691 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasgrp1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624804	5,690,400 - 5,763,288 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624804	5,691,011 - 5,763,314 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Rasgrp1
198 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	246
Count of miRNA genes:	157
Interacting mature miRNAs:	180
Transcripts:	ENSRNOT00000007687
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	47233430	110362260	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat

Markers in Region

D3Got61

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	104,205,496 - 104,205,741 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	109,019,847 - 109,020,091	NCBI	Rnor6.0
Rnor_5.0	3	115,575,600 - 115,575,844	UniSTS	Rnor5.0
RGSC_v3.4	3	103,407,356 - 103,407,601	RGD	RGSC3.4
RGSC_v3.4	3	103,407,357 - 103,407,601	UniSTS	RGSC3.4
RGSC_v3.1	3	103,303,785 - 103,304,029	RGD
Celera	3	103,133,407 - 103,133,651	UniSTS
RH 3.4 Map	3	787.9	RGD
RH 3.4 Map	3	787.9	UniSTS
Cytogenetic Map	3	q34-q35	UniSTS

D3Wox41

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	104,170,078 - 104,170,330 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	108,984,095 - 108,984,344	NCBI	Rnor6.0
Rnor_5.0	3	115,539,848 - 115,540,097	UniSTS	Rnor5.0
RGSC_v3.4	3	103,371,945 - 103,372,194	UniSTS	RGSC3.4
Celera	3	103,098,057 - 103,098,302	UniSTS
Cytogenetic Map	3	q34-q35	UniSTS

BF412005

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	104,227,771 - 104,227,874 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	109,042,136 - 109,042,238	NCBI	Rnor6.0
Rnor_5.0	3	115,597,986 - 115,598,088	UniSTS	Rnor5.0
RGSC_v3.4	3	103,430,726 - 103,430,828	UniSTS	RGSC3.4
Celera	3	103,155,583 - 103,155,685	UniSTS
RH 3.4 Map	3	787.7	UniSTS
Cytogenetic Map	3	q34-q35	UniSTS

AU048142

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	104,188,455 - 104,188,557 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	109,002,808 - 109,002,909	NCBI	Rnor6.0
Rnor_5.0	3	115,558,561 - 115,558,662	UniSTS	Rnor5.0
RGSC_v3.4	3	103,390,318 - 103,390,419	UniSTS	RGSC3.4
Celera	3	103,116,394 - 103,116,495	UniSTS
Cytogenetic Map	3	q34-q35	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	12	8		19				45		7	2
Low	1	30	43	35		35	8	9	29	35	34	9	8
Below cutoff		1	6	6		6		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104440	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF060819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF081196	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000007687 ⟹ ENSRNOP00000007687

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	104,170,013 - 104,230,056 (-)	Ensembl
Rnor_6.0 Ensembl	3	108,984,029 - 109,044,420 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000104283 ⟹ ENSRNOP00000090995

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	104,171,220 - 104,230,056 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111941 ⟹ ENSRNOP00000080984

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	104,171,220 - 104,230,056 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114112 ⟹ ENSRNOP00000094823

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	104,170,013 - 104,193,499 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000114986 ⟹ ENSRNOP00000088046

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	104,170,013 - 104,230,056 (-)	Ensembl

RefSeq Acc Id:

NM_019211 ⟹ NP_062084

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	104,170,013 - 104,230,056 (-)	NCBI
Rnor_6.0	3	108,984,029 - 109,044,420 (-)	NCBI
Rnor_5.0	3	115,539,782 - 115,600,270 (-)	NCBI
RGSC_v3.4	3	103,371,879 - 103,433,010 (-)	RGD
Celera	3	103,097,991 - 103,157,871 (-)	RGD

Sequence:

show sequence

GCGCCTGGGTCGGCTCGCCGGGCTCCGAGAGTGGCCGGCTCCGGGCTGCGAGGGCCGGCGGCGG
CCGAGGGATGCGCCGCTCCCGGCCGAGCCGATCCCACCGCTCCAGGTGAGACGGCTCCAGGGGC
GCAGAGAGCCGCGGCCATGGGAACCCTGGGCAAGGCGAGAGAGGCTCCGCGGAAACCTTGCCAT
GGCTCCAGAGCTGGCCCCAAAGGAAGACTAGAGGCCAAATCAACCAACAGTCCTCTCCCTGCCC
AGCCCAGCTTGGCCCAGATCACCCAGTTCCGAATGATGGTGTCCCTGGGACATCTGGCCAAAGG
AGCCAGCCTGGATGATCTTATTGACAGCTGCATTCAATCTTTCGATGCAGATGGAAACCTGTGT
CGAAGTAACCAGCTGTTACAAGTCATGCTAACCATGCACCGAATCATCATCTCCTCGGCCGAGC
TGCTGCAAAAACTCATGAATCTATATAAGGACGCCCTGGAAAAGAATTCTCCAGGAATTTGCTT
GAAGATCTGCTATTTTGTCAGGTATTGGATAACAGAATTCTGGATCATGTTCAAAATGGATGCC
AGCTTGACCAGCACCATGGAAGAGTTTCAGGACCTGGTGAAAGCCAATGGTGAGGAGTCCCACT
GCCACCTCATCGACACGACACAAATTAATTCTCGAGACTGGTCCAGGAAACTGACTCAGAGGAT
AAAATCAAATACCAGCAAGAAGCGGAAAGTGTCCCTGCTGTTTGACCATCTTGAACCTGAAGAA
CTGTCTGAACACCTCACCTACCTTGAGTTCAAGTCCTTCCGACGGATATCTTTCTCTGATTATC
AGAATTACCTTGTAAACAGCTGCGTAAAGGAGAACCCCACCATGGAGCGGTCCATTGCCCTGTG
CAATGGCATCTCCCAGTGGGTACAACTGATGGTTCTCAGCCGTCCCACCCCACAGCTCCGGGCA
GAGGTCTTCATCAAGTTCATCCATGTGGCTCAGAAGCTCCACCAGCTACAGAACTTCAACACGC
TAATGGCTGTGATCGGGGGACTGTGTCACAGCTCCATCTCCAGGCTCAAGGAGACAAGTTCACA
TGTCCCACATGAGATCAATAAGGTTCTGGGTGAGATGACTGAACTGCTGTCCTCCTGCAGAAAC
TATGACAACTACAGGCGAGCCTATGGTGAGTGCACCCACTTCAAAATCCCCATACTGGGTGTGC
ACCTCAAGGACCTCATATCCCTATATGAAGCCATGCCTGACTACCTGGAAGACGGGAAGGTGAA
TGTCCAAAAGCTCCTGGCCCTTTACAATCACATCAATGAGTTGGTCCAGCTGCAGGACGTGGCC
CCACCATTGGATGCCAACAAGGACCTGGTGCACCTGCTGACGTTATCCCTGGATCTATACTACA
CCGAAGATGAAATCTATGAGCTTTCCTACGCCCGTGAACCAAGGAACCACAGGGCCCCGCCACT
GACACCTTCGAAGCCACCAGTTGTAGTGGACTGGGCCTCTGGAGTGTCTCCCAAACCTGACCCG
AAGACCATCAGCAAACACGTCCAAAGGATGGTGGATTCTGTCTTTAAGAACTATGATCTCGACC
AGGATGGATATATCTCTCAGGAGGAGTTTGAAAAGATTGCTGCGAGCTTTCCATTTTCCTTCTG
TGTGATGGACAAAGATAGGGAGGGCCTCATCAGCAGAGACGAGATCACAGCCTACTTCATGAGG
GCCAGCTCCATCTATTCCAAGCTGGGCCTAGGCTTTCCACACAACTTTCAAGAGACCACTTACC
TGAAGCCCACCTTCTGTGACAACTGTGCTGGCTTTCTCTGGGGTGTGATCAAGCAAGGCTATCG
CTGTAAAGACTGTGGGATGAACTGCCACAAACAGTGCAAAGACCTGGTAGTGTTTGAGTGCAAG
AAACGATCCAAGAGCCCGGCGGTATCCACAGAAAACATCAGCTCTGTGGTGCCAATGTCCACTC
TTTGTCCACTGGGAACCAAAGATCTGCTCCATGCACCCGAAGAAGGATCTTTCATTTTCCAGAA
TGGAGAGGTTGTGGACCACAGTGAGGAGAGCAAGGATAGGACCATCATGCTCTTGGGCGTATCC
TCACAGAAAATTTCAGTTCGGCTGAAGAGGACTGTTGCCCACAAGACCACCCAGACAGAATCAT
TTCCTTGGGTTGGCGGCGAGATGCCCCCTGGTCACTTTGTGCTGACTTCTCCAAGAAAGTCAGC
ACAAGGGGCTCTTTATGTGCACAGTCCAGCATCTCCGTGCCCCAGCCCAGCACTGGTCCGGAAG
CGGGCATTCGTCAAGTGGGAGAACAAAGAGTCCCTTATCAAACCAAAACCAGAGCTTCACCTCA
GGCTCCGGACCTACCAAGAACTGGAACAGGAGGTAAATACCCTGAGGGCAGATAACGATGCTCT
GAAGATCCAGCTGAAGTATGCACAGAAACAAATAGAATCCCTGCAGCTTGGCAAAAGCAATCAC
GTCTTAGCACAGATGGACCACGGTGATGGTACTTAATCCAGAAATTCAAGGAACAGAATCTGCA
GACGGGTTTACTGGGATCTCACTTCAAAACTGATTGCAGAGGTTCAGCAACTTTAGACTGATTG
ACTTTTAAAGGGCAGAGATAGCCACTGTTATTGGTGTCCTTGGTTTTTTCCCTAACTGTCTTTA
ATGTGAGTCGTGGGTTTTCAGTCAGTTGAGTAAAAGGGAAGAAAAGTTCCAGCATGTAAAACAC
TGAGCAGTCATATTCTAACCTTTTCTTTCTTTTACTGAAACCAATACCAAACATGTGCTAAAAT
AAGAGTATAGTTTCCTGACAGTGTCTCAGGCAGCCTGCTTTACTGATTCGCACTTAGATAAAGA
GCCCCTGGTGAATCAATTTGCTGCCTTCCCCAGGGTTTCTGCAAACTGGGAGTTACTTTGTTCT
ACCCGAAAACCTGCTCATAATGGAAACAATACCCTAAAAGTGGTGACTTTGACATGCCTGCATT
GTTTGTGAAGCTGATCCCTACCTTATTCACTACCTCAGATCTCAAGAGCCTCTTTCCCTGTCCT
TTACTTGCCCCCTATTTCCTCCCTTGCTTGTAGGCACATCAGCATATCTACCTAGAAGTGACCT
CCTAGAGATGTAGCCTGTGTTTAAATCCAGAGCTTCTTAATTGAACTTGACATTGTCTGATTGC
AGGCCAACTTATAGCTCTAGGTCTTAGTCATTATGAAATACAAAATAAAACTACCCATAATCAT
CAATTACCATGTCATACACAGAACTCATTATCTAAGTCAAACGACGTAAACACGCCTGTCCAGA
TAGTCTTTCTTTAGTGGATAGAATTAACAATCTGTGACCTTTTAAAAGACATGGTCTGTGAACA
GTGTTTAGTTCTTCACGTTCTAGTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCT
CTCTCTCTCAAGTAAACTATCGTAAGGTCCTCTTTTGAACTGAATCTGTGCTTAAAATTGTCTT
CACTTTTATTATCTACAAATAAGCTATGGGAGGCGATGGCTTTAACAGCTGACAGCATTTACCT
ATGTGTAGAATATGTGTATATAGTATCAGGCATGCATGGA

hide sequence

RefSeq Acc Id:

XM_039104440 ⟹ XP_038960368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	104,168,549 - 104,230,107 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062084	(Get FASTA)	NCBI Sequence Viewer
	XP_038960368	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC40137	(Get FASTA)	NCBI Sequence Viewer
	AAC79700	(Get FASTA)	NCBI Sequence Viewer
	EDL79846	(Get FASTA)	NCBI Sequence Viewer
	Q9R1K8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_062084 ⟸ NM_019211

- UniProtKB:

O88469 (UniProtKB/Swiss-Prot), Q9R1K8 (UniProtKB/Swiss-Prot), A6HP95 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGTLGKAREAPRKPCHGSRAGPKGRLEAKSTNSPLPAQPSLAQITQFRMMVSLGHLAKGASLDD
LIDSCIQSFDADGNLCRSNQLLQVMLTMHRIIISSAELLQKLMNLYKDALEKNSPGICLKICYF
VRYWITEFWIMFKMDASLTSTMEEFQDLVKANGEESHCHLIDTTQINSRDWSRKLTQRIKSNTS
KKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQ
WVQLMVLSRPTPQLRAEVFIKFIHVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEI
NKVLGEMTELLSSCRNYDNYRRAYGECTHFKIPILGVHLKDLISLYEAMPDYLEDGKVNVQKLL
ALYNHINELVQLQDVAPPLDANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHRAPPLTPSKP
PVVVDWASGVSPKPDPKTISKHVQRMVDSVFKNYDLDQDGYISQEEFEKIAASFPFSFCVMDKD
REGLISRDEITAYFMRASSIYSKLGLGFPHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCG
MNCHKQCKDLVVFECKKRSKSPAVSTENISSVVPMSTLCPLGTKDLLHAPEEGSFIFQNGEVVD
HSEESKDRTIMLLGVSSQKISVRLKRTVAHKTTQTESFPWVGGEMPPGHFVLTSPRKSAQGALY
VHSPASPCPSPALVRKRAFVKWENKESLIKPKPELHLRLRTYQELEQEVNTLRADNDALKIQLK
YAQKQIESLQLGKSNHVLAQMDHGDGT

hide sequence

RefSeq Acc Id:

ENSRNOP00000007687 ⟸ ENSRNOT00000007687

RefSeq Acc Id:	XP_038960368 ⟸ XM_039104440
- Peptide Label:	isoform X1
- UniProtKB:	A6HP95 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000088046 ⟸ ENSRNOT00000114986

RefSeq Acc Id:

ENSRNOP00000080984 ⟸ ENSRNOT00000111941

RefSeq Acc Id:

ENSRNOP00000094823 ⟸ ENSRNOT00000114112

RefSeq Acc Id:

ENSRNOP00000090995 ⟸ ENSRNOT00000104283

Protein Domains

EF-hand N-terminal Ras-GEF Phorbol-ester/DAG-type Ras-GEF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9R1K8-F1-model_v2	AlphaFold	Q9R1K8	1-795	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:3539	AgrOrtholog
BioCyc Gene	G2FUF-48275	BioCyc
Ensembl Genes	ENSRNOG00000005404	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000007687	ENTREZGENE
	ENSRNOP00000007687.5	UniProtKB/TrEMBL
	ENSRNOP00000080984.1	UniProtKB/TrEMBL
	ENSRNOP00000088046.1	UniProtKB/TrEMBL
	ENSRNOP00000090995.1	UniProtKB/TrEMBL
	ENSRNOP00000094823.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000007687	ENTREZGENE
	ENSRNOT00000007687.5	UniProtKB/TrEMBL
	ENSRNOT00000104283.1	UniProtKB/TrEMBL
	ENSRNOT00000111941.1	UniProtKB/TrEMBL
	ENSRNOT00000114112.1	UniProtKB/TrEMBL
	ENSRNOT00000114986.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.840.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.30.60.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	6.10.250.2730	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C1-like_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DAG/PE-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand-dom_pair	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_Hand_1_Ca_BS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PE/DAG-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ras-like_GEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ras-like_Gua-exchang_fac_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ras_GEF_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RASGEF_cat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RASGEF_cat_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29434	UniProtKB/Swiss-Prot
NCBI Gene	29434	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RAS GUANYL-RELEASING PROTEIN 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	C1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF-hand_5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGEF_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Rasgrp1	PhenoGen
PRINTS	DAGPEDOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	EF_HAND_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	EF_HAND_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RASGEF_CAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RASGEF_NTER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DAG_PE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	EFh	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGEF	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RasGEFN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00109	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48366	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF57889	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC234472
UniProt	A0A8I5ZR13_RAT	UniProtKB/TrEMBL
	A0A8I6ADN9_RAT	UniProtKB/TrEMBL
	A0A8I6GFR9_RAT	UniProtKB/TrEMBL
	A0A8I6GLC0_RAT	UniProtKB/TrEMBL
	A0A8L2Q3E3_RAT	UniProtKB/TrEMBL
	A6HP95	ENTREZGENE, UniProtKB/TrEMBL
	GRP1_RAT	UniProtKB/Swiss-Prot
	O88469	ENTREZGENE
	Q9R1K8	ENTREZGENE
UniProt Secondary	O88469	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-01-27	Rasgrp1	RAS guanyl releasing protein 1	Rasgrp1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Rasgrp1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	Rasgrp1	RAS guanyl releasing protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Rasgrp1	RAS guanyl releasing protein 1			Name updated	70584	APPROVED
2001-12-06	Rasgrp1	RAS guanyl releasing protein 1			Symbol updated to reflect Human and Mouse nomenclature	69665	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)