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Gene: Fgf7 (fibroblast growth factor 7) Rattus norvegicus

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Symbol:

Fgf7

Name:

fibroblast growth factor 7

RGD ID:

61805

Description:

Enables growth factor activity; heparin binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in several processes, including ovarian follicle development; phosphatidylcholine biosynthetic process; and surfactant homeostasis. Located in extracellular space. Orthologous to human FGF7 (fibroblast growth factor 7); PARTICIPATES IN glypican signaling pathway; melanoma pathway; mitogen activated protein kinase signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2-amino-2-deoxy-D-glucopyranose; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

FGF-7; Fgf5b; fibroblast growth factor 5b; HBGF-7; heparin-binding growth factor 7; keratinocyte growth factor; Keratinocyte Growth Factor Fgf-7; Kgf; KGF/FGF7

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FGF7 (fibroblast growth factor 7)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Fgf7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Fgf7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FGF7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FGF7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fgf7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FGF7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FGF7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fgf7 (fibroblast growth factor 7)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Fgf7 (fibroblast growth factor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	FGF7 (fibroblast growth factor 7)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	fgf7 (fibroblast growth factor 7)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	bnl	Alliance	DIOPT (Ensembl Compara\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	let-756	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	fgf7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	133,734,557 - 133,786,678 (+)	NCBI		GRCr8
mRatBN7.2	3	113,280,448 - 113,333,279 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,281,283 - 113,332,929 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	117,157,853 - 117,207,039 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	125,753,368 - 125,802,554 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	123,413,729 - 123,462,917 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	118,315,859 - 118,368,464 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	118,317,761 - 118,366,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	124,840,157 - 124,892,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	113,468,427 - 113,517,538 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	113,373,999 - 113,423,111 (+)	NCBI
Celera	3	112,134,799 - 112,183,941 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	cervical squamous cell carcinoma		ISO	RGD:69203	2289084	cervical squamous cell carcinoma	RGD
Fgf7	Rat	Crohn's disease		ISO	RGD:69203	126928145	mRNA:increased expression:colon, ileum, myofibroblasts (human)	RGD
Fgf7	Rat	endometrial carcinoma		ISO	RGD:69203	2301091	mRNA:decreased expression:endometrium	RGD
Fgf7	Rat	Enterobacteriaceae Infections		ISO	RGD:62097	126928149	mRNA:increased expression:distal colon (mouse)	RGD
Fgf7	Rat	Experimental Colitis	treatment	ISO	RGD:69203	126928136	human protein in mouse model	RGD
Fgf7	Rat	Experimental Mammary Neoplasms		ISO	RGD:62097	2301094		RGD
Fgf7	Rat	Hyperplasia		ISO	RGD:62097	126928149	mRNA:increased expression:distal colon (mouse)	RGD
Fgf7	Rat	leiomyoma		ISO	RGD:69203	2301090		RGD
Fgf7	Rat	ovarian cancer		ISO	RGD:69203	2289080		RGD
Fgf7	Rat	prostate cancer		ISO	RGD:69203	2289086		RGD
Fgf7	Rat	prostatic hypertrophy		ISO	RGD:69203	2289085		RGD
Fgf7	Rat	prostatic hypertrophy	no_association	ISO	RGD:69203	2289086		RGD
Fgf7	Rat	prostatic hypertrophy		ISO	RGD:62097	2301094		RGD
Fgf7	Rat	Pseudomonas Infections	treatment	ISO	RGD:69203	126928130	human protein in rat model	RGD
Fgf7	Rat	severe acute respiratory syndrome	disease_progression	ISO	RGD:69203	5490168	mRNA:increased expression:lung (human)	RGD
Fgf7	Rat	squamous cell carcinoma		ISO	RGD:69203	2289084	cervical squamous cell carcinoma	RGD
Fgf7	Rat	ulcerative colitis		ISO	RGD:69203	126928145	mRNA:increased expression:colon, lamina propria, myofibroblasts (human)	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	Bloom syndrome		ISO	RGD:69203	8554872	ClinVar Annotator: match by term: Bloom syndrome	ClinVar	PMID:28492532
Fgf7	Rat	colorectal cancer		ISO	RGD:69203	8554872	ClinVar Annotator: match by term: Familial colorectal cancer	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	cleft lip		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17963255
Fgf7	Rat	cleft palate		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17963255
Fgf7	Rat	Gingival Hyperplasia		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:11023675
Fgf7	Rat	liver cirrhosis		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:17692400
Fgf7	Rat	Lung Injury		ISO	RGD:69203	11554173	CTD Direct Evidence: therapeutic	CTD	PMID:18385170
Fgf7	Rat	prostatic hypertrophy		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:14999240
Fgf7	Rat	pulmonary fibrosis		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:15677771
Fgf7	Rat	Reperfusion Injury		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:16526316
Fgf7	Rat	Spontaneous Abortions		ISO	RGD:69203	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:18539642

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	(S)-nicotine	multiple interactions	ISO	RGD:62097	6480464	Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein]	CTD	PMID:36868510
Fgf7	Rat	1,1-dichloroethene	increases expression	ISO	RGD:62097	6480464	vinylidene chloride results in increased expression of FGF7 mRNA	CTD	PMID:26682919
Fgf7	Rat	1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene	multiple interactions	ISO	RGD:62097	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Fgf7	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of FGF7 mRNA	CTD	PMID:30723492
Fgf7	Rat	17beta-estradiol	increases expression	ISO	RGD:69203	6480464	Estradiol results in increased expression of FGF7 mRNA; Estradiol results in increased expression of FGF7 more ...	CTD	PMID:14999240\|PMID:21098263
Fgf7	Rat	17beta-estradiol	increases expression	ISO	RGD:62097	6480464	Estradiol results in increased expression of FGF7 mRNA	CTD	PMID:19484750
Fgf7	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	RGD:62097	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Fgf7	Rat	2,2',4,4'-Tetrabromodiphenyl ether	multiple interactions	ISO	RGD:62097	6480464	[Flame Retardants results in increased abundance of 2,2',4,4'-tetrabromodiphenyl ether] which results in decreased expression of more ...	CTD	PMID:38995820
Fgf7	Rat	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:62097	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Fgf7	Rat	2,2',5,5'-tetrachlorobiphenyl	increases expression	ISO	RGD:69203	6480464	2,5,2',5'-tetrachlorobiphenyl results in increased expression of FGF7 mRNA	CTD	PMID:36804509
Fgf7	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:62097	6480464	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] more ...	CTD	PMID:16054899
Fgf7	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:62097	6480464	Tetrachlorodibenzodioxin results in increased expression of FGF7 mRNA	CTD	PMID:15034205
Fgf7	Rat	2,4,4'-trichlorobiphenyl	multiple interactions	ISO	RGD:62097	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Fgf7	Rat	2-amino-2-deoxy-D-glucopyranose	decreases expression	EXP		6480464	Glucosamine results in decreased expression of FGF7 mRNA	CTD	PMID:17109745
Fgf7	Rat	2-amino-2-deoxy-D-glucopyranose	multiple interactions	EXP		6480464	IL1B inhibits the reaction [Glucosamine results in decreased expression of FGF7 mRNA]	CTD	PMID:17109745
Fgf7	Rat	3,3',5-triiodo-L-thyronine	decreases expression	ISO	RGD:69203	6480464	Triiodothyronine results in decreased expression of FGF7 mRNA	CTD	PMID:15507505
Fgf7	Rat	3-isobutyl-1-methyl-7H-xanthine	multiple interactions	ISO	RGD:62097	6480464	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression more ...	CTD	PMID:16054899
Fgf7	Rat	3-methylcholanthrene	multiple interactions	ISO	RGD:62097	6480464	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF7 mRNA	CTD	PMID:23519560
Fgf7	Rat	5-azacytidine	decreases expression	ISO	RGD:69203	6480464	Azacitidine results in decreased expression of FGF7 mRNA	CTD	PMID:20823114
Fgf7	Rat	5-fluorouracil	decreases response to substance	ISO	RGD:69203	6480464	FGF7 protein results in decreased susceptibility to Fluorouracil; FGF7 results in decreased susceptibility to Fluorouracil	CTD	PMID:18575591
Fgf7	Rat	5-fluorouracil	multiple interactions	ISO	RGD:69203	6480464	FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Fluorouracil]; FGFR2 protein alternative form more ...	CTD	PMID:18575591
Fgf7	Rat	6-propyl-2-thiouracil	multiple interactions	ISO	RGD:62097	6480464	[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FGF7 mRNA	CTD	PMID:36706583
Fgf7	Rat	acrylamide	decreases expression	EXP		6480464	Acrylamide results in decreased expression of FGF7 mRNA	CTD	PMID:28959563
Fgf7	Rat	aldehydo-D-glucosamine	decreases expression	EXP		6480464	Glucosamine results in decreased expression of FGF7 mRNA	CTD	PMID:17109745
Fgf7	Rat	aldehydo-D-glucosamine	multiple interactions	EXP		6480464	IL1B inhibits the reaction [Glucosamine results in decreased expression of FGF7 mRNA]	CTD	PMID:17109745
Fgf7	Rat	aldehydo-D-glucose	affects transport	ISO	RGD:62097	6480464	FGF7 protein affects the transport of Glucose	CTD	PMID:12757114
Fgf7	Rat	all-trans-retinoic acid	multiple interactions	ISO	RGD:69203	6480464	[Chir 99021 co-treated with BMP4 protein co-treated with FGF10 protein co-treated with FGF7 protein co-treated more ...	CTD	PMID:35267148
Fgf7	Rat	amiodarone	increases expression	EXP		6480464	Amiodarone results in increased expression of FGF7 protein	CTD	PMID:32909452
Fgf7	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of FGF7 mRNA	CTD	PMID:16483693
Fgf7	Rat	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	ISO	RGD:69203	6480464	pyrazolanthrone inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; pyrazolanthrone inhibits more ...	CTD	PMID:15677771\|PMID:16162944
Fgf7	Rat	antirheumatic drug	increases expression	ISO	RGD:69203	6480464	Antirheumatic Agents results in increased expression of FGF7 mRNA	CTD	PMID:24449571
Fgf7	Rat	ANTU	increases expression	EXP		6480464	alpha-naphthyl thiourea results in increased expression of FGF7 mRNA	CTD	PMID:10755703
Fgf7	Rat	arabinoxylan	increases expression	ISO	RGD:69203	6480464	arabinoxylan results in increased expression of FGF7 mRNA	CTD	PMID:15678371
Fgf7	Rat	Aroclor 1254	increases expression	ISO	RGD:62097	6480464	Chlorodiphenyl (54% Chlorine) results in increased expression of FGF7 mRNA	CTD	PMID:23650126
Fgf7	Rat	arotinoid acid	multiple interactions	ISO	RGD:69203	6480464	[4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid co-treated with Chir 99021 co-treated with 3-(4-pyridyl)-1H-indole co-treated with Hydrocortisone co-treated with EGF more ...	CTD	PMID:34480604
Fgf7	Rat	arsane	decreases expression	ISO	RGD:62097	6480464	Arsenic results in decreased expression of FGF7 mRNA	CTD	PMID:19654921
Fgf7	Rat	arsenic atom	decreases expression	ISO	RGD:62097	6480464	Arsenic results in decreased expression of FGF7 mRNA	CTD	PMID:19654921
Fgf7	Rat	arsenous acid	decreases expression	ISO	RGD:69203	6480464	Arsenic Trioxide results in decreased expression of FGF7 mRNA	CTD	PMID:20458559
Fgf7	Rat	atrazine	increases expression	EXP		6480464	Atrazine results in increased expression of FGF7 mRNA	CTD	PMID:36841081
Fgf7	Rat	azathioprine	increases expression	ISO	RGD:69203	6480464	Azathioprine results in increased expression of FGF7 mRNA	CTD	PMID:19192274
Fgf7	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:62097	6480464	Benzo(a)pyrene results in decreased expression of FGF7 mRNA	CTD	PMID:15034205
Fgf7	Rat	beta-D-glucosamine	decreases expression	EXP		6480464	Glucosamine results in decreased expression of FGF7 mRNA	CTD	PMID:17109745
Fgf7	Rat	beta-D-glucosamine	multiple interactions	EXP		6480464	IL1B inhibits the reaction [Glucosamine results in decreased expression of FGF7 mRNA]	CTD	PMID:17109745
Fgf7	Rat	bis(2-chloroethyl) sulfide	decreases expression	ISO	RGD:62097	6480464	Mustard Gas results in decreased expression of FGF7 mRNA	CTD	PMID:15674843
Fgf7	Rat	bis(2-chloroethyl) sulfide	multiple interactions	ISO	RGD:69203	6480464	TNF protein affects the reaction [Mustard Gas affects the expression of FGF7 mRNA]	CTD	PMID:16173061
Fgf7	Rat	bisphenol A	increases expression	ISO	RGD:62097	6480464	bisphenol A results in increased expression of FGF7 mRNA	CTD	PMID:27022677
Fgf7	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of FGF7 mRNA	CTD	PMID:25181051
Fgf7	Rat	bleomycin A2	increases expression	ISO	RGD:62097	6480464	Bleomycin results in increased expression of FGF7 protein	CTD	PMID:30825431
Fgf7	Rat	bleomycin A2	multiple interactions	ISO	RGD:62097	6480464	Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of FGF7 protein]; lenabasum inhibits more ...	CTD	PMID:30825431
Fgf7	Rat	boric acid	increases expression	ISO	RGD:69203	6480464	boric acid results in increased expression of FGF7 protein	CTD	PMID:27206737
Fgf7	Rat	cadmium dichloride	multiple interactions	ISO	RGD:69203	6480464	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased more ...	CTD	PMID:26138014
Fgf7	Rat	cadmium dichloride	increases expression	ISO	RGD:69203	6480464	Cadmium Chloride results in increased expression of FGF7 mRNA	CTD	PMID:38568856
Fgf7	Rat	cadmium dichloride	decreases expression	ISO	RGD:69203	6480464	Cadmium Chloride results in decreased expression of FGF7 mRNA	CTD	PMID:38382870
Fgf7	Rat	cannabidiol	increases expression	ISO	RGD:69203	6480464	Cannabidiol results in increased expression of FGF7 mRNA	CTD	PMID:27918106
Fgf7	Rat	cannabidiol	multiple interactions	ISO	RGD:69203	6480464	Cannabidiol inhibits the reaction [TNF protein results in increased expression of FGF7 mRNA]	CTD	PMID:31250491
Fgf7	Rat	cannabidiol	multiple interactions	ISO	RGD:62097	6480464	Cannabidiol analog promotes the reaction [Bleomycin results in increased expression of FGF7 protein]	CTD	PMID:30825431
Fgf7	Rat	carbon nanotube	decreases expression	ISO	RGD:62097	6480464	Nanotubes, Carbon results in decreased expression of FGF7 mRNA	CTD	PMID:25554681
Fgf7	Rat	CHIR 99021	multiple interactions	ISO	RGD:69203	6480464	[4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid co-treated with Chir 99021 co-treated with 3-(4-pyridyl)-1H-indole co-treated with Hydrocortisone co-treated with EGF more ...	CTD	PMID:34480604\|PMID:35267148
Fgf7	Rat	cholesterol	multiple interactions	ISO	RGD:69203	6480464	Cholesterol inhibits the reaction [FGF7 protein results in increased expression of FAS mRNA]; Cholesterol inhibits more ...	CTD	PMID:16162944
Fgf7	Rat	cholesterol	multiple interactions	EXP		6480464	[1,2-dioleoyloxy-3-(trimethylammonium)propane co-treated with Cholesterol] results in increased expression of FGF7 protein	CTD	PMID:16034455
Fgf7	Rat	cisplatin	increases expression	ISO	RGD:62097	6480464	Cisplatin results in increased expression of FGF7 mRNA	CTD	PMID:21151649
Fgf7	Rat	cisplatin	multiple interactions	ISO	RGD:69203	6480464	[Cisplatin co-treated with Paclitaxel] results in increased expression of FGF7 mRNA	CTD	PMID:20705681
Fgf7	Rat	cortisol	multiple interactions	ISO	RGD:69203	6480464	[4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid co-treated with Chir 99021 co-treated with 3-(4-pyridyl)-1H-indole co-treated with Hydrocortisone co-treated with EGF more ...	CTD	PMID:34480604
Fgf7	Rat	coumarin	increases phosphorylation	ISO	RGD:69203	6480464	coumarin results in increased phosphorylation of FGF7 protein	CTD	PMID:35688186
Fgf7	Rat	cyclosporin A	decreases expression	ISO	RGD:69203	6480464	Cyclosporine results in decreased expression of FGF7 mRNA; Cyclosporine results in decreased expression of FGF7 more ...	CTD	PMID:15250830
Fgf7	Rat	cyclosporin A	increases expression	ISO	RGD:69203	6480464	Cyclosporine results in increased expression of FGF7 mRNA; Cyclosporine results in increased expression of FGF7 more ...	CTD	PMID:15250830
Fgf7	Rat	D-glucose	affects transport	ISO	RGD:62097	6480464	FGF7 protein affects the transport of Glucose	CTD	PMID:12757114
Fgf7	Rat	dermatan sulfate	increases activity	ISO	RGD:62097	6480464	Dermatan Sulfate analog results in increased activity of FGF7 protein	CTD	PMID:15563459
Fgf7	Rat	dexamethasone	multiple interactions	ISO	RGD:62097	6480464	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression more ...	CTD	PMID:16054899
Fgf7	Rat	diarsenic trioxide	decreases expression	ISO	RGD:69203	6480464	Arsenic Trioxide results in decreased expression of FGF7 mRNA	CTD	PMID:20458559
Fgf7	Rat	diiodine	multiple interactions	ISO	RGD:62097	6480464	[Propylthiouracil co-treated with Iodine deficiency] results in decreased expression of FGF7 mRNA	CTD	PMID:36706583
Fgf7	Rat	doxorubicin	decreases expression	EXP		6480464	Doxorubicin results in decreased expression of FGF7 mRNA	CTD	PMID:12632370
Fgf7	Rat	fluoranthene	multiple interactions	ISO	RGD:62097	6480464	[1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF7 mRNA; SB 203580 inhibits the more ...	CTD	PMID:28329830
Fgf7	Rat	geldanamycin	multiple interactions	ISO	RGD:69203	6480464	geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein]	CTD	PMID:14656992
Fgf7	Rat	geldanamycin	multiple interactions	ISO	RGD:62097	6480464	geldanamycin inhibits the reaction [ammonium trichloro(dioxoethylene-O,O'-)tellurate results in increased expression of FGF7 protein]	CTD	PMID:14656992
Fgf7	Rat	glucose	affects transport	ISO	RGD:62097	6480464	FGF7 protein affects the transport of Glucose	CTD	PMID:12757114
Fgf7	Rat	glyphosate	increases expression	EXP		6480464	Glyphosate results in increased expression of FGF7 mRNA	CTD	PMID:38314887
Fgf7	Rat	graphite	affects expression	EXP		6480464	Graphite affects the expression of FGF7 mRNA	CTD	PMID:29933104
Fgf7	Rat	heparan sulfate	affects binding	ISO	RGD:69203	6480464	Heparitin Sulfate binds to FGF7 protein	CTD	PMID:15769253
Fgf7	Rat	heparin	affects binding	EXP		6480464	[Heparin binds to FGFR2 protein alternative form] which binds to FGF7 protein	CTD	PMID:10860838
Fgf7	Rat	hyaluronic acid	increases chemical synthesis	EXP		6480464	FGF7 protein results in increased chemical synthesis of Hyaluronic Acid	CTD	PMID:14506240
Fgf7	Rat	hydrogen peroxide	decreases response to substance	ISO	RGD:69203	6480464	FGF7 protein results in decreased susceptibility to Hydrogen Peroxide	CTD	PMID:16123449
Fgf7	Rat	indometacin	multiple interactions	EXP		6480464	Indomethacin inhibits the reaction [FGF7 protein results in increased secretion of Dinoprostone]	CTD	PMID:16169897
Fgf7	Rat	L-ascorbic acid	multiple interactions	ISO	RGD:69203	6480464	[[Ascorbic Acid co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein co-treated with more ...	CTD	PMID:34480604
Fgf7	Rat	L-ascorbic acid 2-phosphate	multiple interactions	ISO	RGD:69203	6480464	[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA more ...	CTD	PMID:34480604
Fgf7	Rat	lead(0)	affects expression	ISO	RGD:69203	6480464	Lead affects the expression of FGF7 mRNA	CTD	PMID:28903495
Fgf7	Rat	lipopolysaccharide	decreases response to substance	ISO	RGD:69203	6480464	FGF7 protein results in decreased susceptibility to Lipopolysaccharides	CTD	PMID:14962112
Fgf7	Rat	lipopolysaccharide	multiple interactions	ISO	RGD:69203	6480464	[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of FGF7 mRNA	CTD	PMID:35811015
Fgf7	Rat	lipopolysaccharide	decreases expression	ISO	RGD:62097	6480464	Lipopolysaccharides results in decreased expression of FGF7 mRNA	CTD	PMID:12057914
Fgf7	Rat	lipopolysaccharide	increases expression	ISO	RGD:69203	6480464	Lipopolysaccharides results in increased expression of FGF7 mRNA; Lipopolysaccharides results in increased expression of FGF7 more ...	CTD	PMID:11842940
Fgf7	Rat	loliolide	increases expression	ISO	RGD:69203	6480464	loliolide results in increased expression of FGF7 mRNA; loliolide results in increased expression of FGF7 more ...	CTD	PMID:31601058
Fgf7	Rat	LY294002	multiple interactions	ISO	RGD:69203	6480464	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results more ...	CTD	PMID:16162944\|PMID:19661335
Fgf7	Rat	medroxyprogesterone acetate	decreases expression	ISO	RGD:69203	6480464	Medroxyprogesterone Acetate results in decreased expression of FGF7 mRNA	CTD	PMID:20843944
Fgf7	Rat	methotrexate	increases expression	ISO	RGD:69203	6480464	Methotrexate results in increased expression of FGF7 mRNA	CTD	PMID:19192274
Fgf7	Rat	N-acetyl-L-cysteine	multiple interactions	ISO	RGD:69203	6480464	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased more ...	CTD	PMID:26138014
Fgf7	Rat	N-nitrosodiethylamine	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FGF7 mRNA	CTD	PMID:20360939
Fgf7	Rat	naphthalene	multiple interactions	ISO	RGD:69203	6480464	[FGF7 protein modified form results in decreased expression of CYP2F2 mRNA] which results in decreased more ...	CTD	PMID:18385170
Fgf7	Rat	nickel atom	decreases expression	ISO	RGD:62097	6480464	Nickel results in decreased expression of FGF7 mRNA	CTD	PMID:18922574
Fgf7	Rat	nicotine	multiple interactions	ISO	RGD:62097	6480464	Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein]	CTD	PMID:36868510
Fgf7	Rat	nifedipine	increases secretion	ISO	RGD:69203	6480464	Nifedipine results in increased secretion of FGF7 protein	CTD	PMID:11023675
Fgf7	Rat	nifedipine	increases expression	ISO	RGD:69203	6480464	Nifedipine results in increased expression of FGF7 mRNA	CTD	PMID:11023675
Fgf7	Rat	nitrofen	decreases expression	EXP		6480464	nitrofen results in decreased expression of FGF7 mRNA	CTD	PMID:12861530
Fgf7	Rat	okadaic acid	decreases expression	ISO	RGD:69203	6480464	Okadaic Acid results in decreased expression of FGF7 mRNA	CTD	PMID:38832940
Fgf7	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of FGF7 mRNA	CTD	PMID:25729387
Fgf7	Rat	paclitaxel	multiple interactions	ISO	RGD:69203	6480464	[Cisplatin co-treated with Paclitaxel] results in increased expression of FGF7 mRNA	CTD	PMID:20705681
Fgf7	Rat	PCB138	multiple interactions	ISO	RGD:62097	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Fgf7	Rat	pentanal	decreases expression	ISO	RGD:69203	6480464	pentanal results in decreased expression of FGF7 mRNA	CTD	PMID:26079696
Fgf7	Rat	phenethyl caffeate	multiple interactions	EXP		6480464	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of FGF7 mRNA	CTD	PMID:20360939
Fgf7	Rat	phorbol 13-acetate 12-myristate	multiple interactions	ISO	RGD:62097	6480464	[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of FGF7 mRNA	CTD	PMID:23519560
Fgf7	Rat	pioglitazone	multiple interactions	ISO	RGD:62097	6480464	[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FGF7 mRNA	CTD	PMID:27935865
Fgf7	Rat	prostaglandin E2	increases secretion	EXP		6480464	FGF7 protein results in increased secretion of Dinoprostone	CTD	PMID:16169897
Fgf7	Rat	prostaglandin E2	multiple interactions	EXP		6480464	Indomethacin inhibits the reaction [FGF7 protein results in increased secretion of Dinoprostone]	CTD	PMID:16169897
Fgf7	Rat	quartz	increases expression	ISO	RGD:62097	6480464	Quartz results in increased expression of FGF7 protein	CTD	PMID:36868510
Fgf7	Rat	quartz	multiple interactions	ISO	RGD:62097	6480464	Nicotine promotes the reaction [Quartz results in increased expression of FGF7 protein]	CTD	PMID:36868510
Fgf7	Rat	quercetin	increases expression	ISO	RGD:69203	6480464	Quercetin results in increased expression of FGF7 mRNA	CTD	PMID:15309432
Fgf7	Rat	resveratrol	decreases expression	ISO	RGD:62097	6480464	resveratrol results in decreased expression of FGF7 mRNA	CTD	PMID:23525482
Fgf7	Rat	rotenone	decreases expression	ISO	RGD:69203	6480464	Rotenone results in decreased expression of FGF7 mRNA	CTD	PMID:37394047
Fgf7	Rat	Rutecarpine	decreases expression	ISO	RGD:69203	6480464	rutecarpine results in decreased expression of FGF7 mRNA	CTD	PMID:34955744
Fgf7	Rat	S-(1,2-dichlorovinyl)-L-cysteine	increases expression	ISO	RGD:69203	6480464	S-(1,2-dichlorovinyl)cysteine results in increased expression of FGF7 mRNA	CTD	PMID:35811015
Fgf7	Rat	S-(1,2-dichlorovinyl)-L-cysteine	multiple interactions	ISO	RGD:69203	6480464	[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of FGF7 mRNA	CTD	PMID:35811015
Fgf7	Rat	SB 203580	multiple interactions	ISO	RGD:62097	6480464	SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of FGF7 more ...	CTD	PMID:28329830
Fgf7	Rat	SB 431542	multiple interactions	ISO	RGD:69203	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with EGF protein co-treated with FGF2 protein] results in more ...	CTD	PMID:34480604
Fgf7	Rat	shikimic acid	increases expression	ISO	RGD:62097	6480464	Shikimic Acid results in increased expression of FGF7 mRNA	CTD	PMID:15265014
Fgf7	Rat	sirolimus	multiple interactions	ISO	RGD:69203	6480464	Sirolimus inhibits the reaction [TP73 protein results in increased expression of FGF7 mRNA]	CTD	PMID:21245298
Fgf7	Rat	sodium atom	increases transport	ISO	RGD:62097	6480464	FGF7 protein results in increased transport of Sodium	CTD	PMID:12757114
Fgf7	Rat	sodium aurothiomalate	increases expression	ISO	RGD:69203	6480464	Gold Sodium Thiomalate results in increased expression of FGF7 mRNA	CTD	PMID:19192274
Fgf7	Rat	sunitinib	decreases expression	ISO	RGD:69203	6480464	Sunitinib results in decreased expression of FGF7 mRNA	CTD	PMID:31533062
Fgf7	Rat	suramin	affects localization	ISO	RGD:69203	6480464	Suramin affects the localization of FGF7 protein	CTD	PMID:15733146
Fgf7	Rat	suramin	multiple interactions	ISO	RGD:69203	6480464	Suramin inhibits the reaction [FGF7 protein binds to FGFR2 protein]	CTD	PMID:15733146
Fgf7	Rat	tamoxifen	decreases response to substance	ISO	RGD:69203	6480464	FGF7 results in decreased susceptibility to Tamoxifen	CTD	PMID:18575591
Fgf7	Rat	tamoxifen	multiple interactions	ISO	RGD:69203	6480464	FGFR2 inhibits the reaction [FGF7 results in decreased susceptibility to Tamoxifen]	CTD	PMID:18575591
Fgf7	Rat	tetrachloromethane	increases expression	ISO	RGD:62097	6480464	Carbon Tetrachloride results in increased expression of FGF7 mRNA	CTD	PMID:17484886
Fgf7	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of FGF7 mRNA	CTD	PMID:17692400
Fgf7	Rat	tetraphene	increases expression	ISO	RGD:62097	6480464	benz(a)anthracene results in increased expression of FGF7 mRNA	CTD	PMID:26377693
Fgf7	Rat	thioacetamide	decreases expression	EXP		6480464	Thioacetamide results in decreased expression of FGF7 mRNA	CTD	PMID:23411599
Fgf7	Rat	titanium dioxide	increases expression	ISO	RGD:62097	6480464	titanium dioxide results in increased expression of FGF7 mRNA	CTD	PMID:35295148
Fgf7	Rat	titanium dioxide	decreases expression	ISO	RGD:69203	6480464	titanium dioxide results in decreased expression of FGF7 mRNA	CTD	PMID:34973136
Fgf7	Rat	topotecan	increases expression	EXP		6480464	Topotecan results in increased expression of FGF7 mRNA	CTD	PMID:25729387
Fgf7	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in increased expression of FGF7 mRNA	CTD	PMID:25729387
Fgf7	Rat	trichloroethene	increases expression	ISO	RGD:62097	6480464	Trichloroethylene results in increased expression of FGF7 mRNA	CTD	PMID:15363585
Fgf7	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of FGF7 mRNA	CTD	PMID:33387578
Fgf7	Rat	trimellitic anhydride	decreases expression	ISO	RGD:62097	6480464	trimellitic anhydride results in decreased expression of FGF7 mRNA	CTD	PMID:19042947
Fgf7	Rat	valproic acid	decreases methylation	ISO	RGD:69203	6480464	Valproic Acid results in decreased methylation of FGF7 gene	CTD	PMID:29154799
Fgf7	Rat	wortmannin	multiple interactions	ISO	RGD:69203	6480464	wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]	CTD	PMID:15803460
Fgf7	Rat	XAV939	multiple interactions	ISO	RGD:69203	6480464	[[ascorbate-2-phosphate co-treated with Chir 99021 co-treated with XAV939 co-treated with BMP4 protein] co-treated with [INHBA more ...	CTD	PMID:34480604

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	actin cytoskeleton organization	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	actin cytoskeleton organization	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	branching involved in salivary gland morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	branching involved in salivary gland morphogenesis	acts_upstream_of_or_within	ISO	RGD:62097	1624291	PMID:18559345	RGD	PMID:18559345
Fgf7	Rat	endothelial cell proliferation	acts_upstream_of	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	endothelial cell proliferation	acts_upstream_of	ISO	RGD:62097	1624291	PMID:14697353	RGD	PMID:14697353
Fgf7	Rat	epithelial cell proliferation	acts_upstream_of	ISO	RGD:62097	1624291	PMID:17187775	RGD	PMID:17187775
Fgf7	Rat	epithelial cell proliferation	acts_upstream_of	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	fibroblast growth factor receptor signaling pathway	acts_upstream_of_or_within	ISO	RGD:69203	1624291	UniProtKB:P21802 PMID:8663044	RGD	PMID:8663044
Fgf7	Rat	fibroblast growth factor receptor signaling pathway	acts_upstream_of_or_within	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	fibroblast growth factor receptor signaling pathway	involved_in	IBA	FB:FBgn0014135\|MGI:104723\|MGI:1099809\|MGI:1202401\|MGI:1277980\|MGI:1861377\|MGI:1891427\|MGI:95517\|MGI:99604\|PANTHER:PTN000160075\|RGD:2609\|RGD:2610\|RGD:71052\|RGD:71068\|UniProtKB:O15520\|UniProtKB:O95750\|UniProtKB:P05230\|UniProtKB:P08620\|UniProtKB:P09038\|UniProtKB:P10767\|UniProtKB:P11487\|UniProtKB:P12034\|UniProtKB:P21781\|UniProtKB:P31371\|UniProtKB:P55075\|UniProtKB:Q8AXC5\|WB:WBGene00002881	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	hair follicle morphogenesis	acts_upstream_of_or_within	ISO	RGD:62097	1624291	PMID:11098134	RGD	PMID:11098134
Fgf7	Rat	hair follicle morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	lung development	involved_in	IBA	PANTHER:PTN002608278\|RGD:61805\|UniProtKB:P21781	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	lung development		IMP		68696		RGD
Fgf7	Rat	mesenchymal cell proliferation	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	mesenchymal cell proliferation	involved_in	ISO	RGD:69203	1624291	PMID:11023837	RGD	PMID:11023837
Fgf7	Rat	myoblast proliferation	acts_upstream_of	ISO	RGD:62097	1624291	MGI:1096350 PMID:15806171	RGD	PMID:15806171
Fgf7	Rat	myoblast proliferation	acts_upstream_of	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	neurogenesis	involved_in	IBA	FB:FBgn0014135\|MGI:109178\|MGI:1099809\|MGI:1891346\|MGI:95516\|MGI:95519\|MGI:99604\|PANTHER:PTN000160075\|RGD:70891\|UniProtKB:P48800\|UniProtKB:P55075\|ZFIN:ZDB-GENE-030729-32\|ZFIN:ZDB-GENE-060427-3\|ZFIN:ZDB-GENE-980526-178\|ZFIN:ZDB-GENE-990415-72	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	ovarian follicle development		IMP		2289108	primordial to primary follicle transition	RGD
Fgf7	Rat	phosphatidylcholine biosynthetic process		IMP		68696	surfactant disaturated phosphatidylcholine DSPC synthesis	RGD
Fgf7	Rat	phospholipid biosynthetic process		IMP		68696		RGD
Fgf7	Rat	positive chemotaxis	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive chemotaxis	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	positive regulation of cell division	involved_in	IEA	UniProtKB-KW:KW-0497	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fgf7	Rat	positive regulation of cell population proliferation	acts_upstream_of_or_within	ISO	RGD:69203	1624291	UniProtKB:P21802 PMID:8663044	RGD	PMID:8663044
Fgf7	Rat	positive regulation of cell population proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of DNA-templated transcription	involved_in	ISO	RGD:62097	1624291	PMID:17394208	RGD	PMID:17394208
Fgf7	Rat	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of endothelial cell proliferation	acts_upstream_of_or_within	ISO	RGD:62097	1624291	PMID:14697353	RGD	PMID:14697353
Fgf7	Rat	positive regulation of endothelial cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of epithelial cell proliferation		IMP		2289254	mesothelial cells	RGD
Fgf7	Rat	positive regulation of epithelial cell proliferation		IDA		2289860	Dunning R3327PAP prostate tumor epithelial cells	RGD
Fgf7	Rat	positive regulation of epithelial cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of epithelial cell proliferation	acts_upstream_of_or_within	ISO	RGD:62097	1624291	PMID:17187775	RGD	PMID:17187775
Fgf7	Rat	positive regulation of epithelial cell proliferation	involved_in	IBA	MGI:95521\|PANTHER:PTN002608278\|RGD:61805\|UniProtKB:P21781	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	positive regulation of epithelial cell proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of epithelial cell proliferation	acts_upstream_of_or_within	ISO	RGD:69203	1624291	PMID:11493558	RGD	PMID:11493558
Fgf7	Rat	positive regulation of epithelial cell proliferation	involved_in	ISO	RGD:69203	1624291	PMID:15690149	RGD	PMID:15690149
Fgf7	Rat	positive regulation of epithelial cell proliferation involved in lung morphogenesis	acts_upstream_of_or_within	ISO	RGD:69203	1624291	PMID:9740653	RGD	PMID:9740653
Fgf7	Rat	positive regulation of epithelial cell proliferation involved in lung morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of keratinocyte migration	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of keratinocyte migration	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	positive regulation of keratinocyte proliferation	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of keratinocyte proliferation	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	positive regulation of MAPK cascade	involved_in	IBA	MGI:1099809\|MGI:1277980\|MGI:1861377\|MGI:1891427\|MGI:95516\|MGI:99604\|PANTHER:PTN000160075\|RGD:2609\|RGD:71068\|UniProtKB:O15520\|UniProtKB:O76093\|UniProtKB:O95750\|UniProtKB:P05230\|UniProtKB:P08620\|UniProtKB:P09038\|UniProtKB:Q9NSA1	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	positive regulation of myoblast proliferation	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	positive regulation of myoblast proliferation	acts_upstream_of_or_within	ISO	RGD:62097	1624291	MGI:1096350 PMID:15806171	RGD	PMID:15806171
Fgf7	Rat	positive regulation of peptidyl-tyrosine phosphorylation	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	protein localization to cell surface	involved_in	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	protein localization to cell surface	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	acts_upstream_of_or_within	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	acts_upstream_of_or_within	ISO	RGD:62097	1624291	PMID:18559345	RGD	PMID:18559345
Fgf7	Rat	regulation of cell migration	involved_in	IBA	MGI:1099809\|MGI:95516\|PANTHER:PTN000160075\|RGD:2610\|UniProtKB:O15520\|UniProtKB:O43320\|UniProtKB:O76093\|UniProtKB:P05230\|UniProtKB:P08620\|UniProtKB:P09038\|UniProtKB:P21781\|WB:WBGene00001185\|ZFIN:ZDB-GENE-980526-178\|ZFIN:ZDB-GENE-990415-72	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	regulation of synapse maturation	involved_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	regulation of synapse maturation	involved_in	ISO	RGD:62097	1624291	PMID:20505669	RGD	PMID:20505669
Fgf7	Rat	secretion by lung epithelial cell involved in lung growth	involved_in	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	secretion by lung epithelial cell involved in lung growth	involved_in	ISO	RGD:69203	1624291	PMID:10541313	RGD	PMID:10541313
Fgf7	Rat	surfactant homeostasis		IMP		68696		RGD

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	cytoplasm	is_active_in	IBA	MGI:109178\|MGI:109189\|MGI:1914362\|MGI:95517\|MGI:95521\|PANTHER:PTN000160075\|RGD:2608\|UniProtKB:P05230\|UniProtKB:P48800\|UniProtKB:Q92913\|WB:WBGene00002881\|ZFIN:ZDB-GENE-990415-72	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	extracellular region	located_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	extracellular region	located_in	ISO	RGD:62097	1624291	PMID:12837279	RGD	PMID:12837279
Fgf7	Rat	extracellular space		IDA		2289254		RGD
Fgf7	Rat	extracellular space	is_active_in	IBA	MGI:1099809\|MGI:1861377\|MGI:1891427\|MGI:95515\|MGI:95516\|PANTHER:PTN000160075\|RGD:2609\|RGD:61805\|RGD:620175\|RGD:620178\|UniProtKB:E1BDA6\|UniProtKB:O15520\|UniProtKB:P05230\|UniProtKB:P09038\|UniProtKB:P31371\|UniProtKB:P48800\|UniProtKB:P55075\|UniProtKB:Q9GZV9\|WB:WBGene00001185\|WB:WBGene00002881\|ZFIN:ZDB-GENE-980526-178\|ZFIN:ZDB-GENE-990415-72	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	GABA-ergic synapse	is_active_in	ISO	RGD:62097	1624291	PMID:20505669	RGD	PMID:20505669
Fgf7	Rat	GABA-ergic synapse	is_active_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	Golgi apparatus	located_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	Golgi apparatus	located_in	ISO	RGD:62097	1624291	PMID:12837279	RGD	PMID:12837279
Fgf7	Rat	postsynapse	is_active_in	ISO	RGD:62097	1624291	PMID:20505669	RGD	PMID:20505669
Fgf7	Rat	postsynapse	is_active_in	IEA	UniProtKB:P36363\|ensembl:ENSMUSP00000069681	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	chemoattractant activity	enables	ISO	RGD:69203	1624291	PMID:17449030	RGD	PMID:17449030
Fgf7	Rat	chemoattractant activity	enables	IEA	UniProtKB:P21781\|ensembl:ENSP00000267843	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Fgf7	Rat	growth factor activity		IMP		2289254		RGD
Fgf7	Rat	growth factor activity	enables	IEA	UniProtKB-KW:KW-0339	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fgf7	Rat	growth factor activity	enables	IEA	InterPro:IPR002209	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Fgf7	Rat	growth factor activity	enables	IBA	MGI:95516\|PANTHER:PTN000160075\|RGD:2605\|RGD:2610\|RGD:61805\|RGD:620129\|RGD:620165\|RGD:71068\|UniProtKB:O15520\|UniProtKB:P05230\|UniProtKB:P09038\|UniProtKB:P55075\|WB:WBGene00002881	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Fgf7	Rat	heparin binding		IDA		2289271		RGD
Fgf7	Rat	heparin binding	enables	IEA	UniProtKB-KW:KW-0358	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Fgf7	Rat	protein binding	enables	ISO	RGD:69203	1624291	UniProtKB:P21802-3 PMID:1309608	RGD	PMID:1309608
Fgf7	Rat	protein binding	enables	ISO	RGD:62097	1624291	PR:O70514 PMID:15806171	RGD	PMID:15806171
Fgf7	Rat	type 2 fibroblast growth factor receptor binding		IDA		2289271	FGFR2IIIb isoform only	RGD
Fgf7	Rat	type 2 fibroblast growth factor receptor binding	enables	IBA	PANTHER:PTN002608278\|RGD:61805	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Pathway Annotations Click to see Annotation Detail View

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	melanoma pathway		IEA		6907045		KEGG	rno:05218
Fgf7	Rat	mitogen activated protein kinase signaling pathway		IEA		6907045		KEGG	rno:04010

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Fgf7	Rat	glypican signaling pathway		ISO	RGD:69203	6484113		PID	PID:200225

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

cervical squamous cell carcinoma (ISO)

cleft lip (ISO)

cleft palate (ISO)

colorectal cancer (ISO)

Crohn's disease (ISO)

endometrial carcinoma (ISO)

Enterobacteriaceae Infections (ISO)

Experimental Colitis (ISO)

Experimental Mammary Neoplasms (ISO)

Gingival Hyperplasia (ISO)

Hyperplasia (ISO)

leiomyoma (ISO)

liver cirrhosis (ISO)

Lung Injury (ISO)

ovarian cancer (ISO)

prostate cancer (ISO)

prostatic hypertrophy (ISO)

Pseudomonas Infections (ISO)

pulmonary fibrosis (ISO)

Reperfusion Injury (ISO)

severe acute respiratory syndrome (ISO)

Spontaneous Abortions (ISO)

squamous cell carcinoma (ISO)

ulcerative colitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

3,3',5-triiodo-L-thyronine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3-methylcholanthrene (ISO)

5-azacytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (ISO)

acrylamide (EXP)

aldehydo-D-glucosamine (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antirheumatic drug (ISO)

ANTU (EXP)

arabinoxylan (ISO)

Aroclor 1254 (ISO)

arotinoid acid (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

atrazine (EXP)

azathioprine (ISO)

benzo[a]pyrene (ISO)

beta-D-glucosamine (EXP)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bleomycin A2 (ISO)

boric acid (ISO)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

CHIR 99021 (ISO)

cholesterol (EXP,ISO)

cisplatin (ISO)

cortisol (ISO)

coumarin (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

dermatan sulfate (ISO)

dexamethasone (ISO)

diarsenic trioxide (ISO)

diiodine (ISO)

doxorubicin (EXP)

fluoranthene (ISO)

geldanamycin (ISO)

glucose (ISO)

glyphosate (EXP)

graphite (EXP)

heparan sulfate (ISO)

heparin (EXP)

hyaluronic acid (EXP)

hydrogen peroxide (ISO)

indometacin (EXP)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

loliolide (ISO)

LY294002 (ISO)

medroxyprogesterone acetate (ISO)

methotrexate (ISO)

N-acetyl-L-cysteine (ISO)

N-nitrosodiethylamine (EXP)

naphthalene (ISO)

nickel atom (ISO)

nicotine (ISO)

nifedipine (ISO)

nitrofen (EXP)

okadaic acid (ISO)

oxaliplatin (EXP)

paclitaxel (ISO)

PCB138 (ISO)

pentanal (ISO)

phenethyl caffeate (EXP)

phorbol 13-acetate 12-myristate (ISO)

pioglitazone (ISO)

prostaglandin E2 (EXP)

quartz (ISO)

quercetin (ISO)

resveratrol (ISO)

rotenone (ISO)

Rutecarpine (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

shikimic acid (ISO)

sirolimus (ISO)

sodium atom (ISO)

sodium aurothiomalate (ISO)

sunitinib (ISO)

suramin (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP,ISO)

trimellitic anhydride (ISO)

valproic acid (ISO)

wortmannin (ISO)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton organization (IEA,ISO)

branching involved in salivary gland morphogenesis (IEA,ISO)

endothelial cell proliferation (IEA,ISO)

epithelial cell proliferation (IEA,ISO)

fibroblast growth factor receptor signaling pathway (IBA,IEA,ISO)

hair follicle morphogenesis (IEA,ISO)

lung development (IBA,IMP)

mesenchymal cell proliferation (IEA,ISO)

myoblast proliferation (IEA,ISO)

neurogenesis (IBA)

ovarian follicle development (IMP)

phosphatidylcholine biosynthetic process (IMP)

phospholipid biosynthetic process (IMP)

positive chemotaxis (IEA,ISO)

positive regulation of cell division (IEA)

positive regulation of cell population proliferation (IEA,ISO)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of endothelial cell proliferation (IEA,ISO)

positive regulation of epithelial cell proliferation (IBA,IDA,IEA,IMP,ISO)

positive regulation of epithelial cell proliferation involved in lung morphogenesis (IEA,ISO)

positive regulation of keratinocyte migration (IEA,ISO)

positive regulation of keratinocyte proliferation (IEA,ISO)

positive regulation of MAPK cascade (IBA)

positive regulation of myoblast proliferation (IEA,ISO)

positive regulation of peptidyl-tyrosine phosphorylation (ISO)

protein localization to cell surface (IEA,ISO)

regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling (IEA,ISO)

regulation of cell migration (IBA)

regulation of synapse maturation (IEA,ISO)

secretion by lung epithelial cell involved in lung growth (IEA,ISO)

surfactant homeostasis (IMP)

Cellular Component

cytoplasm (IBA)

extracellular region (IEA,ISO)

extracellular space (IBA,IDA)

GABA-ergic synapse (IEA,ISO)

Golgi apparatus (IEA,ISO)

postsynapse (IEA,ISO)

Molecular Function

chemoattractant activity (IEA,ISO)

growth factor activity (IBA,IEA,IMP)

heparin binding (IDA,IEA)

protein binding (ISO)

type 2 fibroblast growth factor receptor binding (IBA,IDA)

Molecular Pathway Annotations Click to see Annotation Detail View

glypican signaling pathway (ISO)

melanoma pathway (IEA)

mitogen activated protein kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	KGF and HGF are growth factors for mesothelial cells in pleural lavage fluid after intratracheal asbestos.	Adamson IY and Bakowska J, Exp Lung Res. 2001 Oct-Nov;27(7):605-16.
2.	Keratinocyte growth factor in inflammatory bowel disease. Increased mRNA transcripts in ulcerative colitis compared with Crohn's disease in biopsies and isolated mucosal myofibroblasts.	Bajaj-Elliott M, etal., Am J Pathol. 1997 Nov;151(5):1469-76.
3.	Basic fibroblast growth factor and keratinocyte growth factor over-expression in benign prostatic hyperplasia.	Boget S, etal., Farmaco. 2001 May-Jul;56(5-7):467-9.
4.	Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme.	Chelly N, etal., Endocrinology 2001 May;142(5):1814-9.
5.	Keratinocyte growth factor ameliorates dextran sodium sulfate colitis in mice.	Egger B, etal., Dig Dis Sci. 1999 Apr;44(4):836-44. doi: 10.1023/a:1026642715764.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
8.	Citrobacter rodentium infection in mice elicits a mucosal Th1 cytokine response and lesions similar to those in murine inflammatory bowel disease.	Higgins LM, etal., Infect Immun. 1999 Jun;67(6):3031-9. doi: 10.1128/IAI.67.6.3031-3039.1999.
9.	Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis.	Ishiwata T, etal., Exp Mol Pathol 2002 Dec;73(3):181-90.
10.	Keratinocyte growth factor acts as a mesenchymal factor that promotes ovarian primordial to primary follicle transition.	Kezele P, etal., Biol Reprod. 2005 Nov;73(5):967-73. Epub 2005 Jul 6.
11.	Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice.	Kitsberg DI and Leder P, Oncogene. 1996 Dec 19;13(12):2507-15.
12.	Elucidating the molecular physiopathology of acute respiratory distress syndrome in severe acute respiratory syndrome patients.	Kong SL, etal., Virus Res. 2009 Nov;145(2):260-9. Epub 2009 Jul 25.
13.	Keratinocyte growth factor expression in hormone insensitive prostate cancer.	Leung HY, etal., Oncogene. 1997 Aug 28;15(9):1115-20.
14.	Microarray study of gene expression in uterine leiomyoma.	Litovkin KV, etal., Exp Oncol. 2008 Jun;30(2):106-11.
15.	The glycine box: a determinant of specificity for fibroblast growth factor.	Luo Y, etal., Biochemistry. 1998 Nov 24;37(47):16506-15.
16.	Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma.	Manavi M, etal., Gynecol Oncol. 2007 May;105(2):418-26. Epub 2007 Feb 15.
17.	Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells.	Mason RJ, etal., J Clin Invest 2003 Jul;112(2):244-55.
18.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
19.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
20.	Angiogenesis and capillary maturation phenotypes associated with the Edpm3 locus on rat chromosome 3.	Pandey J and Wendell DL, Mamm Genome. 2006 Jan;17(1):49-57. Epub 2006 Jan 13.
21.	Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer.	Parrott JA, etal., Mol Cell Endocrinol. 2000 Sep 25;167(1-2):77-87.
22.	Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression.	Pereira CT, etal., J Surg Res. 2007 May 15;139(2):222-8. Epub 2007 Feb 9.
23.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
24.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
25.	GOA pipeline	RGD automated data pipeline
26.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
28.	Distinct patterns of expression of keratinocyte growth factor and its receptor in endometrial carcinoma.	Siegfried S, etal., Cancer. 1997 Mar 15;79(6):1166-71.
29.	Keratinocyte growth factor protects against Pseudomonas aeruginosa-induced lung injury.	Viget NB, etal., Am J Physiol Lung Cell Mol Physiol. 2000 Dec;279(6):L1199-209. doi: 10.1152/ajplung.2000.279.6.L1199.
30.	Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin.	Yan G, etal., Mol Endocrinol. 1992 Dec;6(12):2123-8.
31.	Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate.	Zhao H, etal., Biochem Biophys Res Commun 2002 Mar 29;292(2):482-91.

Additional References at PubMed

PMID:1869483	PMID:8663044	PMID:9740653	PMID:10541313	PMID:11023837	PMID:11098134	PMID:11493558	PMID:12581741	PMID:12837279	PMID:12861530	PMID:14506240	PMID:14697353
PMID:15690149	PMID:15806171	PMID:17187775	PMID:17392324	PMID:17394208	PMID:17449030	PMID:17872496	PMID:18091341	PMID:18559345	PMID:19266047	PMID:20069574	PMID:21136143
PMID:21436609	PMID:26894526	PMID:27035760	PMID:30816491	PMID:30858037	PMID:30894415	PMID:31017714	PMID:32586178	PMID:34898359

Genomics

Comparative Map Data

Fgf7
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	133,734,557 - 133,786,678 (+)	NCBI		GRCr8
mRatBN7.2	3	113,280,448 - 113,333,279 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	113,281,283 - 113,332,929 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	117,157,853 - 117,207,039 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	125,753,368 - 125,802,554 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	123,413,729 - 123,462,917 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	118,315,859 - 118,368,464 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	118,317,761 - 118,366,872 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	124,840,157 - 124,892,611 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	113,468,427 - 113,517,538 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	113,373,999 - 113,423,111 (+)	NCBI
Celera	3	112,134,799 - 112,183,941 (+)	NCBI		Celera
Cytogenetic Map	3	q36	NCBI

FGF7
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	49,423,242 - 49,488,775 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	49,423,237 - 49,488,775 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	49,715,439 - 49,780,972 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	47,502,751 - 47,566,815 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	47,502,750 - 47,566,815	NCBI
Celera	15	26,608,551 - 26,672,713 (+)	NCBI		Celera
Cytogenetic Map	15	q21.2	NCBI
HuRef	15	26,547,279 - 26,611,441 (+)	NCBI		HuRef
CHM1_1	15	49,833,504 - 49,897,659 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	47,231,591 - 47,297,131 (+)	NCBI		T2T-CHM13v2.0

Fgf7
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	125,876,578 - 125,933,105 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	125,876,578 - 125,933,105 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	126,034,658 - 126,091,185 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	126,034,658 - 126,091,185 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	125,860,394 - 125,916,921 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	125,726,225 - 125,781,966 (+)	NCBI		MGSCv36	mm8
Celera	2	127,270,998 - 127,337,627 (+)	NCBI		Celera
Cytogenetic Map	2	F1	NCBI
cM Map	2	61.76	NCBI

Fgf7
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	4,632,858 - 4,686,860 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	4,633,542 - 4,686,768 (-)	NCBI	ChiLan1.0	ChiLan1.0

FGF7
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	38,669,957 - 38,734,413 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	42,853,936 - 42,921,604 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	28,378,339 - 28,442,800 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1 Ensembl	15	46,702,119 - 46,770,163 (+)	Ensembl	panpan1.1		panPan2

FGF7
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	15,555,016 - 15,608,230 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	30	15,555,266 - 15,606,521 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	15,481,488 - 15,531,854 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	15,698,949 - 15,751,444 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	15,501,581 - 15,752,197 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	15,623,415 - 15,673,818 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	15,739,231 - 15,789,330 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	15,843,740 - 15,894,109 (+)	NCBI		UU_Cfam_GSD_1.0

Fgf7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	93,787,837 - 93,847,287 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	11,635,876 - 11,693,821 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	11,636,733 - 11,692,782 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGF7
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	122,215,882 - 122,277,750 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	122,215,878 - 122,278,705 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	135,926,619 - 135,928,879 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FGF7
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	33,802,349 - 33,867,743 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	33,802,328 - 33,867,333 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	107,261,064 - 107,330,391 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgf7
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	10,413,645 - 10,468,690 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	10,413,715 - 10,468,660 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fgf7
188 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	79
Count of miRNA genes:	73
Interacting mature miRNAs:	77
Transcripts:	ENSRNOT00000012700
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312673	Scl63	Serum cholesterol level QTL 63		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	98535255	168026850	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	70653097	121056321	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
2302373	Gluco39	Glucose level QTL 39	5.01		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	3	98535386	161695835	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	53184593	115665732	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	31172320	163586636	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	47233211	147415807	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	38192233	133483320	Rat
1582216	Bw65	Body weight QTL 65	6.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	102200529	115665732	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	29463235	118376539	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	53184593	115665732	Rat
1582219	Bw63	Body weight QTL 63	3.8	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	3	96127817	115665732	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	64655305	115665732	Rat
1581568	Rf53	Renal function QTL 53			urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	3	56395968	161299569	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	64655305	115665732	Rat
7387306	Bw124	Body weight QTL 124	3.2	0.0003	body mass (VT:0001259)	body weight (CMO:0000012)	3	84091273	129091273	Rat
1578754	Stresp16	Stress response QTL 16	4	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	3	112681431	157681431	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	61017749	121056321	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	50437504	115638231	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	73376539	118376539	Rat
8694437	Bw167	Body weight QTL 167	22.46	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	3	91797474	136797474	Rat
2302273	Gluco35	Glucose level QTL 35	5.3	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	80800231	114297550	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	59242096	157323038	Rat
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	43827364	121056321	Rat
1354611	Despr2	Despair related QTL 2	3.03	0.0028	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	3	97084464	142084464	Rat
631649	Bp123	Blood pressure QTL 123	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	89772419	134772419	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	94856903	159898684	Rat
619618	Rf3	Renal disease susceptibility QTL 3	6.5	0.001	urine albumin amount (VT:0002871)	urine albumin excretion rate to body weight ratio (CMO:0001270)	3	107693393	152693393	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	70348525	121056321	Rat
2301971	Cm71	Cardiac mass QTL 71	4.63		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	3	41874578	155617519	Rat
2312659	Slep7	Serum leptin concentration QTL 7		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	3	98535255	168026850	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2301970	Bw81	Body weight QTL 81	5.19		body mass (VT:0001259)	body weight (CMO:0000012)	3	41874578	155617519	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	78196190	146592722	Rat
631665	Bw8	Body weight QTL 8	5.5		body mass (VT:0001259)	body weight (CMO:0000012)	3	50437042	119183768	Rat
1331758	Bp207	Blood pressure QTL 207	2.848		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	112287552	135181505	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14489145	121056321	Rat
2293087	Iddm27	Insulin dependent diabetes mellitus QTL 27	2.68		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	97551417	147415807	Rat
2312670	Bw94	Body weight QTL 94		0.01	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	3	98535255	168026850	Rat
724532	Cm17	Cardiac mass QTL 17	2		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	3	95735366	140735366	Rat

Markers in Region

D3Mco11

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	3	133,753,327 - 133,753,569 (+)	Marker Load Pipeline
mRatBN7.2	3	113,299,924 - 113,300,170 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,335,462 - 118,335,705	NCBI	Rnor6.0
Rnor_5.0	3	124,859,156 - 124,859,399	UniSTS	Rnor5.0
RGSC_v3.4	3	113,486,128 - 113,486,371	UniSTS	RGSC3.4
RGSC_v3.4	3	113,486,127 - 113,486,371	RGD	RGSC3.4
RGSC_v3.1	3	113,391,700 - 113,391,944	RGD
Celera	3	112,152,539 - 112,152,780	UniSTS
Cytogenetic Map	3	q36	UniSTS

FGF7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	113,330,075 - 113,331,264 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,365,609 - 118,366,797	NCBI	Rnor6.0
Rnor_5.0	3	124,889,756 - 124,890,944	UniSTS	Rnor5.0
RGSC_v3.4	3	113,516,275 - 113,517,463	UniSTS	RGSC3.4
Celera	3	112,182,678 - 112,183,866	UniSTS
Cytogenetic Map	3	q36	UniSTS

FGF7

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	113,330,079 - 113,331,336 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	118,365,613 - 118,366,869	NCBI	Rnor6.0
Rnor_5.0	3	124,889,760 - 124,891,016	UniSTS	Rnor5.0
RGSC_v3.4	3	113,516,279 - 113,517,535	UniSTS	RGSC3.4
Celera	3	112,182,682 - 112,183,938	UniSTS
Cytogenetic Map	3	q36	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	45	98	65	64	33	25	33	6	187	93	78	44	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022182	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234903	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039104434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC139594	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF295300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LR130379	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X56551	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	X95743	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012700 ⟹ ENSRNOP00000012700

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	113,281,283 - 113,332,929 (+)	Ensembl
Rnor_6.0 Ensembl	3	118,317,761 - 118,366,872 (+)	Ensembl

RefSeq Acc Id:

NM_022182 ⟹ NP_071518

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	133,735,627 - 133,784,738 (+)	NCBI
mRatBN7.2	3	113,282,222 - 113,331,339 (+)	NCBI
Rnor_6.0	3	118,317,761 - 118,366,872 (+)	NCBI
Rnor_5.0	3	124,840,157 - 124,892,611 (+)	NCBI
RGSC_v3.4	3	113,468,427 - 113,517,538 (+)	RGD
Celera	3	112,134,799 - 112,183,941 (+)	RGD

Sequence:

show sequence

CAATCTACAATTCACAGATAGGAGGAGGCCCATGACCTAGGAGTAGCGATCAACTCAAGGTCCA
GTTCTCATTATGTTATTCATGGACACCCGGGGCACTGCTCTATAATGCGCAAATGGATACTGAC
ACGGATCCTGCCGACTCCGCTCTACAGACCGTGCTTCCACCTCGTCTGTCTTGTGGGCACCATA
TCTTTAGCTTGCAATGACATGAGTCCAGAGCAGACGGCCACGAGCGTGAACTGTTCTAGCCCCG
AGCGACACACGAGAAGTTATGACTACATGGAAGGAGGGGATATAAGGGTGAGGAGACTGTTCTG
TCGCACCCAGTGGTACCTGAGGATTGACAAACGAGGCAAAGTGAAAGGGACCCAGGAGATGAGG
AACAGCTACAACATCATGGAAATCATGACTGTGGCAGTTGGAATTGTGGCAATCAAAGGGGTGG
AAAGTGAATACTATCTTGCCATGAACAAACAAGGGGAACTCTATGCAAAGAAAGAATGCAATGA
GGATTGCAACTTCAAAGAACTGATTCTGGAAAACCATTACAACACCTCTGCATCAGCTAAATGG
ACACACAGCGGAGGGGAAATGTTCGTGGCCTTAAATCAAAAGGGGCTTCCTGTCAAAGGGAAGA
AAACGAAGAAAGAACAAAAAACGGCCCACTTTCTTCCTATGGCAATAACTTAA

hide sequence

RefSeq Acc Id:

XM_006234903 ⟹ XP_006234965

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	133,734,557 - 133,786,678 (+)	NCBI
mRatBN7.2	3	113,280,448 - 113,333,279 (+)	NCBI
Rnor_6.0	3	118,315,859 - 118,368,464 (+)	NCBI
Rnor_5.0	3	124,840,157 - 124,892,611 (+)	NCBI

Sequence:

show sequence

TGTGCATGTGTGTGTGTGTTGCAGGTACATGGAAAAGAGAATTTTAACATATGTTTTCTTAAAT
ACTCATTTAGATTGGTGATACAATGGCTCCATTCTAAATATAAAATACAATTACAATCTTGCTC
AGTACAGGATAGGCACAGACTCATTTTGGAAAGCAAAAGGGCTCTCCTATGTCCATTAGCTATT
GGCCTTACAATTACTGGATTTATCAGTTATTTTTTTTATGCTATTGCTCTCAGGGAGGCACAAG
TCAAACACCAAGGCACAAACCATTTTTCTAAAAGAATGATAGTTTTGCAAAGCATGTGTCCTTT
GTTTCTGTGAGTCGTCTGTTGGAATAAATCACAAGATGGGATGCTAAAATGACAGCACAGCACT
GGTCTGATTAGGCATGGCCATTGATTTGATACCTGAAGCAGCAGCTGGGCCACAGGGAAGTAAG
TGACTGATCCAAGGCCACATTGTTTGTTAGAATCCCAGTCTAATAAGAAACTAAGACTCACACA
CAATGGTGCACTATCTGAGAAAAGGTATGTTCTTGCCTAGGAATACCTACTCTCAGCCCTGAGC
CTGCTGCTCTAGTACTCTGAGTATGAAGGAATATGAACTTACCTCCCCAGTGTATTGTAAAGAC
CATCTAACTATTGAAAGCCCTTCTATATGTTCTAGGAAATGTTTTTCACAGACTGTACAGCTTC
TGTGCTTAAAAGGGCTAACACTTCCCTTTCTCTATGTAAGTGCTTGAGAATCAGAGGTCTGTTT
CCACAGAGCGGATGCCCACTTGTGGATTTAAACCAAAGCCGTGTCCATAGCTCCCCCTTATGAC
CACTCAACGGTACACAAGCCTTCATCTATTCCTGCTGTTTCAGACAACGAACAGCTCACTGGTT
AAGCTTTAATTGCTTCCAATGAGGTCAGCAAAGGTATTTATTGAAAATCTCTGAATAAAAGGGT
CCACGCACTCACACAAGCGCACGCGCTCACACACGGAGAAAATCCTTTTGCCTGTTGATTTATG
GAAACAATTATGATTCTGCTGGAGGACTTCTCAGCTGAGAAATAGTTTGTAGCTACAGTAGAGG
CTCAAGTTGCACCAGGCAGACAGCAGACACGGAACTCTTGTGTACCCAGCTGTTCCAAACAGAA
CAAAAGTCAAGCAGCAAATGCACGGCAGCAACTGGCCTTGTTCCGACCGGTTTCTACAAGGATA
TACCCATCAACTGTGCTCCTGAAGAAGGAATCCTCTTATTGGCATCAGAAGCTAAAAGATAAGG
TTAACAGTTTGGAAAGAGCGAGGACCTTTTCTCAAATCAATCTCCAGTTCACAGACAGGAGGAG
GCCCATGACCTAGGAGTAGCGATCAACTCAAGGTCCAGTTCTCATTATGTTATTCATGGACACC
CGGGGCACTGCTCTATAATGCGCAAATGGATACTGACACGGATCCTGCCGACTCCGCTCTACAG
ATCGTGCTTCCACCTCGTCTGTCTTGTGGGCACCATATCTTTAGCTTGCAATGACATGAGTCCA
GAGCAGACGGCCACGAGCGTGAACTGTTCTAGCCCCGAGCGACACACGAGAAGTTATGACTACA
TGGAAGGAGGGGATATAAGGGTGAGGAGACTGTTCTGTCGCACCCAGTGGTACCTGAGGATTGA
CAAACGAGGCAAAGTGAAAGGGACCCAGGAGATGAGGAACAGCTACAACATCATGGAAATCAGG
ACTGTGGCAGTTGGAATTGTGGCAATCAAAGGGGTGGAAAGTGAATACTATCTTGCCATGAACA
AAGAAGGGAAACTCTATGCAAAGAAAGAATGCAATGAGGATTGCAACTTCAAAGAACTGATTCT
GGAAAACCATTACAACACCTATGCATCAGCTAAATGGACACACAGCGGAGGGGAAATGTTCGTG
GCCTTAAATCAAAAGGGGCTTCCTGTCAAAGGGAAGAAAACGAAGAAAGAACAAAAAACGGCCC
ATTTTCTTCCCATGGCAATAACCTAAGCATACAGGGTGTTTGAGAAACCAGTTTCACTCAGCAG
GGAGATTTATTTCCAGTGGACTTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC
TCTCTCTAAGTAACCAAGAAAGGCTGGAAAACTACTGAAAAACCGATCAAGCTGGACTTGCGCA
TTTTTGTTTATTTTAAAAGACTGCATTAAAGAAAGATTTGAAGAATATACACAAAATTCAGATT
TAGTAAAAGTTGTAAAAAGTTGTAAAAGTGGTTGTACAATCATGATGTTAGTGACGTGATATTT
TTCTTAAGTTAATTTACCCTTAAGAGTATGTTAGATTTGACTATCTGATAATGAATATTTAATA
TCACTATCTGCTTATAAAATGGCTGCTATAATAATATTAATAATGCAGATGATGTTATATAAGG
TATGTCAGACCTAAAGGCTGCTGGGACGCTTTGTCAGATGATCAAGCCCCATACAAACTGTAGA
CGATGAGCAGTGTTTGAAAGCTTTCCAGAAAGAACTAAACTCCACTTCAACTCTATTCAGAAAA
GTGAATGTTCTCAACATTTTATTATAGAATACAATCTACAGGTGGTTTTACAAAATCATGCCTG
TCCTGATTAACGTGAAAAAAAATCCACTCAAATTGGAAAGGTATTGCTAACAGGATGCTTTAAA
AGTCTGTGTATGAAATAGCAATGATGATGATAATACTGCATTTCATCTTGCCACAAAGGAACAT
TTTATAATCCCTAAAAGTAAACTTCAGAAATCTTTACATTTTTTCAAGTAACATCTATCTTTTG
TATAATTCACATTTGGGAACACGACTTTCAGTAATGTTCTTCCCACAAATAATCATGCTTATTT
CCCTCTGTGATTACAGCATTAAACTCTACTTTAAGTTGTATTTGAATTTTATTGTTTTGTTATT
TAAGTTTTTGTTATTTATAAAGAAAAAAACTTAAGAAGCTGTATCTGTTTCATATGCTTTTAAT
TTCAAGGGGACAACAAACCCGTCTGGCTGCACTGCAGATGTCTCCTCCCCTGGTGGCTGACACC
AAGTCTAGCACACAACACTTGGCTAGCAAGTGCTGGATGGCAGACAAAAACGACAGGCTGCAGC
CATGCCTCCAATAGATGTCTCATAGTGAACGATACGAATATGTGGGAAAGATTTCACACAACGC
TCATGCCAATGAATTTGGATCATATAAGTAAAAGAAATCAAAGTATTTAGTGAGGACATATTTT
TGAAAGTAGGCATATTTAAAGTTAGCAATTTGATCATCTTTAGAAGTTTCTGCCATACAAAATA
TGCCAACTTTGAAATGTCAAGAGTAAAACCCCAAATAGAGGTTGTAGTCAGGGTACAGGGCCCT
AAACACCTTGAGGCTTCAGGTCAGGCCACAGATAACAGGCTTAAAAAACACATGAACTTACTCC
ATAGTTCTGCCACCAGTGGATGCTGACAGAAATGTATATATACTTATGAAGGGAAGTGCAACAT
TTATTTAAATTGTTGGTATATTAATTAATGTGATATCAACTTCATAGTGGTTGTCATTAAAGTT
TCTTTATATTACATACAA

hide sequence

RefSeq Acc Id:

XM_039104434 ⟹ XP_038960362

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	133,734,565 - 133,786,678 (+)	NCBI
mRatBN7.2	3	113,280,566 - 113,333,279 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_071518	(Get FASTA)	NCBI Sequence Viewer
	XP_006234965	(Get FASTA)	NCBI Sequence Viewer
	XP_038960362	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG31597	(Get FASTA)	NCBI Sequence Viewer
	CAA39892	(Get FASTA)	NCBI Sequence Viewer
	CAA65056	(Get FASTA)	NCBI Sequence Viewer
	EDL80082	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012700
GenBank Protein	Q02195	(Get FASTA)	NCBI Sequence Viewer
	VDK10959	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071518 ⟸ NM_022182
- Peptide Label:	precursor
- UniProtKB:	Q02195 (UniProtKB/Swiss-Prot), Q9ERN5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRKWILTRILPTPLYRPCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDI RVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIMTVAVGIVAIKGVESEYYLAMNKQGELY AKKECNEDCNFKELILENHYNTSASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMA IT hide sequence

RefSeq Acc Id:	XP_006234965 ⟸ XM_006234903
- Peptide Label:	isoform X1
- UniProtKB:	G3V775 (UniProtKB/TrEMBL), A6HPY1 (UniProtKB/TrEMBL), Q9ERN5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRKWILTRILPTPLYRSCFHLVCLVGTISLACNDMSPEQTATSVNCSSPERHTRSYDYMEGGDI RVRRLFCRTQWYLRIDKRGKVKGTQEMRNSYNIMEIRTVAVGIVAIKGVESEYYLAMNKEGKLY AKKECNEDCNFKELILENHYNTYASAKWTHSGGEMFVALNQKGLPVKGKKTKKEQKTAHFLPMA IT hide sequence

Ensembl Acc Id:

ENSRNOP00000012700 ⟸ ENSRNOT00000012700

RefSeq Acc Id:	XP_038960362 ⟸ XM_039104434
- Peptide Label:	isoform X1
- UniProtKB:	G3V775 (UniProtKB/TrEMBL), A6HPY1 (UniProtKB/TrEMBL), Q9ERN5 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q02195-F1-model_v2	AlphaFold	Q02195	1-194	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692385

Promoter ID:

EPDNEW_R2910

Type:

initiation region

Name:

Fgf7_1

Description:

fibroblast growth factor 7

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	118,317,831 - 118,317,891	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:61805	AgrOrtholog
BioCyc Gene	G2FUF-48028	BioCyc
Ensembl Genes	ENSRNOG00000009425	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000012700	ENTREZGENE
Gene3D-CATH	2.80.10.50	UniProtKB/Swiss-Prot
InterPro	Fibroblast_GF_fam	UniProtKB/Swiss-Prot
	IL1/FGF	UniProtKB/Swiss-Prot
KEGG Report	rno:29348	UniProtKB/Swiss-Prot
NCBI Gene	29348	ENTREZGENE
PANTHER	PTHR11486	UniProtKB/Swiss-Prot
Pfam	FGF	UniProtKB/Swiss-Prot
PhenoGen	Fgf7	PhenoGen
PRINTS	HBGFFGF	UniProtKB/Swiss-Prot
	IL1HBGF	UniProtKB/Swiss-Prot
PROSITE	HBGF_FGF	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009425	RatGTEx
SMART	FGF	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF50353	UniProtKB/Swiss-Prot
UniProt	A6HPY1	ENTREZGENE, UniProtKB/TrEMBL
	FGF7_RAT	UniProtKB/Swiss-Prot
	G3V775	ENTREZGENE, UniProtKB/TrEMBL
	Q02195	ENTREZGENE
	Q9ERN5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Fgf7	fibroblast growth factor 7			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed at higher levels in prostates of older animals than in younger animals	68696
gene_expression	expressed at higher levels in prostates of older animals than in younger animals	70812
gene_expression	expressed in embryonic lungs	68696
gene_expression	expressed in embryonic lungs	70812
gene_expression	produced by stromal mesenchyme-derived cells	68696
gene_expression	produced by stromal mesenchyme-derived cells	70812
gene_process	enhances glucocorticoid stimulation of fetal alveolar epithelial type II cell maturation	68696
gene_process	enhances glucocorticoid stimulation of fetal alveolar epithelial type II cell maturation	70812
gene_process	stimulates surfactant component synthesis	68696
gene_process	stimulates surfactant component synthesis	70812
gene_regulation	regulated by androgen	68696
gene_regulation	regulated by androgen	70812

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)