Itpka (inositol-trisphosphate 3-kinase A) - Rat Genome Database

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Gene: Itpka (inositol-trisphosphate 3-kinase A) Rattus norvegicus
Analyze
Symbol: Itpka
Name: inositol-trisphosphate 3-kinase A
RGD ID: 619950
Description: Enables calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; insP 3-kinase A; IP3 3-kinase A; IP3K A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23106,726,036 - 106,734,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,401,341 - 110,409,898 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03118,996,888 - 119,005,445 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03116,657,281 - 116,665,838 (+)NCBIRnor_WKY
Rnor_6.03111,545,007 - 111,553,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,093,293 - 118,102,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,257,482 - 106,266,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13106,153,909 - 106,162,588 (+)NCBI
Celera3105,636,919 - 105,645,481 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a complementary DNA for inositol 1,4,5-trisphosphate 3-kinase. Choi KY, etal., Science 1990 Apr 6;248(4951):64-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. Kim IH, etal., J Neurosci. 2009 Nov 4;29(44):14039-49. doi: 10.1523/JNEUROSCI.2483-09.2009.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase. Takazawa K, etal., Biochem J 1990 Nov 15;272(1):107-12.
Additional References at PubMed
PMID:7646431   PMID:8889548   PMID:10454357   PMID:12527368   PMID:15093681   PMID:15350215   PMID:15537642   PMID:19292454   PMID:19846664   PMID:20131911   PMID:22384237   PMID:22389500  
PMID:30053369  


Genomics

Comparative Map Data
Itpka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23106,726,036 - 106,734,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3110,401,341 - 110,409,898 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03118,996,888 - 119,005,445 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03116,657,281 - 116,665,838 (+)NCBIRnor_WKY
Rnor_6.03111,545,007 - 111,553,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,093,293 - 118,102,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,257,482 - 106,266,160 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13106,153,909 - 106,162,588 (+)NCBI
Celera3105,636,919 - 105,645,481 (+)NCBICelera
Cytogenetic Map3q35NCBI
ITPKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381541,493,874 - 41,503,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1541,493,393 - 41,503,551 (+)EnsemblGRCh38hg38GRCh38
GRCh371541,786,072 - 41,795,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,573,414 - 39,583,039 (+)NCBINCBI36Build 36hg18NCBI36
Build 341539,573,413 - 39,583,037NCBI
Celera1518,554,082 - 18,563,706 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,634,270 - 18,643,970 (+)NCBIHuRef
CHM1_11541,904,654 - 41,914,323 (+)NCBICHM1_1
T2T-CHM13v2.01539,300,037 - 39,309,713 (+)NCBIT2T-CHM13v2.0
Itpka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,572,818 - 119,581,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,572,818 - 119,581,744 (+)EnsemblGRCm39 Ensembl
GRCm382119,742,337 - 119,751,253 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,742,337 - 119,751,263 (+)EnsemblGRCm38mm10GRCm38
MGSCv372119,568,073 - 119,576,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362119,433,778 - 119,442,694 (+)NCBIMGSCv36mm8
Celera2120,898,643 - 120,907,740 (+)NCBICelera
Cytogenetic Map2E5NCBI
Itpka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554168,299,318 - 8,309,865 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554168,300,059 - 8,310,225 (+)NCBIChiLan1.0ChiLan1.0
ITPKA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11538,663,857 - 38,685,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,675,600 - 38,684,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01520,434,532 - 20,444,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ITPKA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,532,191 - 8,541,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,532,284 - 8,541,285 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha308,591,175 - 8,600,076 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0308,666,590 - 8,675,492 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,666,590 - 8,675,501 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,587,903 - 8,596,796 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,695,316 - 8,704,204 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,827,050 - 8,835,956 (+)NCBIUU_Cfam_GSD_1.0
Itpka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,992,042 - 87,000,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,840,152 - 4,848,881 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364714,840,113 - 4,848,881 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1129,867,642 - 129,875,639 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11129,867,261 - 129,877,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21144,939,082 - 144,947,563 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12641,502,417 - 41,512,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604899,468,986 - 99,479,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,655,777 - 8,664,600 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248048,655,762 - 8,664,599 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itpka
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:49
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000007247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat

Markers in Region
RH130923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,734,384 - 106,734,572 (+)MAPPERmRatBN7.2
Rnor_6.03111,553,389 - 111,553,576NCBIRnor6.0
Rnor_5.03118,101,844 - 118,102,031UniSTSRnor5.0
RGSC_v3.43106,265,955 - 106,266,142UniSTSRGSC3.4
Celera3105,645,265 - 105,645,452UniSTS
RH 3.4 Map3917.7UniSTS
Cytogenetic Map3q35UniSTS
BE106366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,734,718 - 106,734,882 (+)MAPPERmRatBN7.2
Rnor_6.03111,553,723 - 111,553,886NCBIRnor6.0
Rnor_5.03118,102,178 - 118,102,341UniSTSRnor5.0
RGSC_v3.43106,266,289 - 106,266,452UniSTSRGSC3.4
Celera3105,645,599 - 105,645,762UniSTS
RH 3.4 Map3921.1UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 25 7
Low 1 28 57 41 11 41 32 25 34 11
Below cutoff 15 8 6 7 15 10 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007247   ⟹   ENSRNOP00000007247
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)Ensembl
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)Ensembl
RefSeq Acc Id: NM_031045   ⟹   NP_112307
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23106,726,036 - 106,734,601 (+)NCBI
Rnor_6.03111,545,007 - 111,553,605 (+)NCBI
Rnor_5.03118,093,293 - 118,102,060 (+)NCBI
RGSC_v3.43106,257,482 - 106,266,160 (+)RGD
Celera3105,636,919 - 105,645,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105917   ⟹   XP_038961845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23106,726,744 - 106,734,593 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_112307   ⟸   NM_031045
- UniProtKB: P17105 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007247   ⟸   ENSRNOT00000007247
RefSeq Acc Id: XP_038961845   ⟸   XM_039105917
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17105-F1-model_v2 AlphaFold P17105 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692335
Promoter ID:EPDNEW_R2858
Type:initiation region
Name:Itpka_1
Description:inositol-trisphosphate 3-kinase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,544,998 - 111,545,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619950 AgrOrtholog
BioCyc Gene G2FUF-48192 BioCyc
BioCyc Pathway PWY-6361 [1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)] BioCyc
  PWY-6362 [1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)] BioCyc
  PWY-6364 [D-myo-inositol (1,3,4)-trisphosphate biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000005284 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000007247 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007247 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.470.160 UniProtKB/Swiss-Prot
InterPro IPK UniProtKB/Swiss-Prot
  IPK_sf UniProtKB/Swiss-Prot
KEGG Report rno:81677 UniProtKB/Swiss-Prot
NCBI Gene 81677 ENTREZGENE
PANTHER PTHR12400 UniProtKB/Swiss-Prot
Pfam IPK UniProtKB/Swiss-Prot
PhenoGen Itpka PhenoGen
UniProt IP3KA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpka  inositol-trisphosphate 3-kinase A  Itpka  inositol 1,4,5-trisphosphate 3-kinase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Itpka  inositol 1,4,5-trisphosphate 3-kinase A    inositol 1,4,5-triphosphate 3-kinase  Name updated 1299863 APPROVED
2002-08-07 Itpka  inositol 1,4,5-triphosphate 3-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains calmodulin-binding site and six regions with amino acid compositions (PEST regions) common to proteins that are susceptible to calpain 633125
gene_regulation activity stimulated by Ca2+ in the presence of calmodulin 633124