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Gene: Itpka (inositol-trisphosphate 3-kinase A) Rattus norvegicus
Symbol: Itpka
Name: inositol-trisphosphate 3-kinase A
RGD ID: 619950
Description: Exhibits Rac GTPase binding activity; calmodulin-dependent protein kinase activity; and inositol-1,4,5-trisphosphate 3-kinase activity. Involved in actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Localizes to dendritic spine. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; insP 3-kinase A; IP3 3-kinase A; IP3K A
Homo sapiens (human) : ITPKA (inositol-trisphosphate 3-kinase A)  HGNC  Alliance
Mus musculus (house mouse) : Itpka (inositol 1,4,5-trisphosphate 3-kinase A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpka (inositol-trisphosphate 3-kinase A)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPKA (inositol-trisphosphate 3-kinase A)
Canis lupus familiaris (dog) : ITPKA (inositol-trisphosphate 3-kinase A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpka (inositol-trisphosphate 3-kinase A)
Sus scrofa (pig) : ITPKA (inositol-trisphosphate 3-kinase A)
Chlorocebus sabaeus (African green monkey) : ITPKA (inositol-trisphosphate 3-kinase A)
Heterocephalus glaber (naked mole-rat) : Itpka (inositol-trisphosphate 3-kinase A)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.03111,545,007 - 111,553,605 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03118,093,293 - 118,102,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,257,482 - 106,266,160 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,153,909 - 106,162,588 (+)NCBI
Celera3105,636,919 - 105,645,481 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itpka
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619950
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.