Itpka (inositol-trisphosphate 3-kinase A) - Rat Genome Database

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Pathways
Gene: Itpka (inositol-trisphosphate 3-kinase A) Rattus norvegicus
Analyze
Symbol: Itpka
Name: inositol-trisphosphate 3-kinase A
RGD ID: 619950
Description: Enables calcium/calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A); PARTICIPATES IN inositol metabolic pathway; inositol phosphate metabolic pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; insP 3-kinase A; IP3 3-kinase A; IP3K A
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,179,841 - 127,188,405 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3127,179,808 - 127,188,414 (+)EnsemblGRCr8
mRatBN7.23106,726,036 - 106,734,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3110,401,341 - 110,409,898 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,996,888 - 119,005,445 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,657,281 - 116,665,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,545,007 - 111,553,605 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)Ensemblrn6Rnor6.0
Rnor_5.03118,093,293 - 118,102,060 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43106,257,482 - 106,266,160 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,636,919 - 105,645,481 (+)NCBICelera
RGSC_v3.13106,153,909 - 106,162,588 (+)NCBI
Cytogenetic Map3q35NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dextran sulfate  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
inulin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
metacetamol  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
okadaic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytoskeleton  (IEA,ISO,ISS)
dendritic spine  (IDA)
glutamatergic synapse  (IDA,IEP,IMP)
nucleus  (IBA)
postsynaptic actin cytoskeleton  (IDA,IMP)

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and expression of a complementary DNA for inositol 1,4,5-trisphosphate 3-kinase. Choi KY, etal., Science 1990 Apr 6;248(4951):64-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
5. Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. Kim IH, etal., J Neurosci. 2009 Nov 4;29(44):14039-49. doi: 10.1523/JNEUROSCI.2483-09.2009.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Cloning and expression in Escherichia coli of a rat brain cDNA encoding a Ca2+/calmodulin-sensitive inositol 1,4,5-trisphosphate 3-kinase. Takazawa K, etal., Biochem J 1990 Nov 15;272(1):107-12.
Additional References at PubMed
PMID:7646431   PMID:8889548   PMID:10454357   PMID:12527368   PMID:15093681   PMID:15350215   PMID:15537642   PMID:19292454   PMID:19846664   PMID:20131911   PMID:22384237   PMID:22389500  
PMID:30053369  


Genomics

Comparative Map Data
Itpka
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83127,179,841 - 127,188,405 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3127,179,808 - 127,188,414 (+)EnsemblGRCr8
mRatBN7.23106,726,036 - 106,734,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3110,401,341 - 110,409,898 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03118,996,888 - 119,005,445 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03116,657,281 - 116,665,838 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03111,545,007 - 111,553,605 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)Ensemblrn6Rnor6.0
Rnor_5.03118,093,293 - 118,102,060 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43106,257,482 - 106,266,160 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3105,636,919 - 105,645,481 (+)NCBICelera
RGSC_v3.13106,153,909 - 106,162,588 (+)NCBI
Cytogenetic Map3q35NCBI
ITPKA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381541,493,874 - 41,503,551 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1541,493,393 - 41,503,551 (+)Ensemblhg38GRCh38
GRCh371541,786,072 - 41,795,749 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361539,573,414 - 39,583,039 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341539,573,413 - 39,583,037NCBI
Celera1518,554,082 - 18,563,706 (+)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1518,634,270 - 18,643,970 (+)NCBIHuRef
CHM1_11541,904,654 - 41,914,323 (+)NCBICHM1_1
T2T-CHM13v2.01539,300,037 - 39,309,713 (+)NCBIT2T-CHM13v2.0
Itpka
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392119,572,818 - 119,581,734 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2119,572,818 - 119,581,744 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm382119,742,337 - 119,751,253 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2119,742,337 - 119,751,263 (+)Ensemblmm10GRCm38
MGSCv372119,568,073 - 119,576,989 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362119,433,778 - 119,442,694 (+)NCBIMGSCv36mm8
Celera2120,898,643 - 120,907,740 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.97NCBI
Itpka
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554168,299,318 - 8,309,865 (+)Ensembl
ChiLan1.0NW_0049554168,300,059 - 8,310,225 (+)NCBIChiLan1.0ChiLan1.0
ITPKA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21630,735,096 - 30,744,968 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11534,886,349 - 34,896,201 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01520,434,532 - 20,444,389 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11538,663,857 - 38,685,172 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1538,675,600 - 38,684,779 (+)EnsemblpanPan2panpan1.1
ITPKA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1308,532,191 - 8,541,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl308,532,284 - 8,541,285 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha308,591,175 - 8,600,076 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0308,666,590 - 8,675,492 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl308,666,590 - 8,675,501 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1308,587,903 - 8,596,796 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0308,695,316 - 8,704,204 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0308,827,050 - 8,835,956 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Itpka
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864086,992,042 - 87,000,822 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364714,840,152 - 4,848,881 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364714,840,113 - 4,848,881 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPKA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1129,867,642 - 129,875,639 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11129,867,261 - 129,877,762 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21144,939,082 - 144,947,563 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ITPKA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12641,502,417 - 41,512,131 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604899,468,986 - 99,479,279 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpka
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248048,655,777 - 8,664,600 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248048,655,762 - 8,664,599 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Itpka
40 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:61
Count of miRNA genes:49
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000007247
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3122654702136118980Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3116582412136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)3104545086149545086Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3101255536134750886Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3110225882155225882Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)3125814931139636791Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3110634702155634702Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat

Markers in Region
RH130923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,734,384 - 106,734,572 (+)MAPPERmRatBN7.2
Rnor_6.03111,553,389 - 111,553,576NCBIRnor6.0
Rnor_5.03118,101,844 - 118,102,031UniSTSRnor5.0
RGSC_v3.43106,265,955 - 106,266,142UniSTSRGSC3.4
Celera3105,645,265 - 105,645,452UniSTS
RH 3.4 Map3917.7UniSTS
Cytogenetic Map3q35UniSTS
BE106366  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23106,734,718 - 106,734,882 (+)MAPPERmRatBN7.2
Rnor_6.03111,553,723 - 111,553,886NCBIRnor6.0
Rnor_5.03118,102,178 - 118,102,341UniSTSRnor5.0
RGSC_v3.43106,266,289 - 106,266,452UniSTSRGSC3.4
Celera3105,645,599 - 105,645,762UniSTS
RH 3.4 Map3921.1UniSTS
Cytogenetic Map3q35UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 67 138 91 90 59 76 59 6 324 173 11 117 70 91 31 9 9

Sequence


Ensembl Acc Id: ENSRNOT00000007247   ⟹   ENSRNOP00000007247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3127,179,808 - 127,188,414 (+)Ensembl
mRatBN7.2 Ensembl3106,726,036 - 106,734,600 (+)Ensembl
Rnor_6.0 Ensembl3111,545,007 - 111,553,604 (+)Ensembl
RefSeq Acc Id: NM_031045   ⟹   NP_112307
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,179,841 - 127,188,405 (+)NCBI
mRatBN7.23106,726,036 - 106,734,601 (+)NCBI
Rnor_6.03111,545,007 - 111,553,605 (+)NCBI
Rnor_5.03118,093,293 - 118,102,060 (+)NCBI
RGSC_v3.43106,257,482 - 106,266,160 (+)RGD
Celera3105,636,919 - 105,645,481 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039105917   ⟹   XP_038961845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83127,180,810 - 127,188,395 (+)NCBI
mRatBN7.23106,726,744 - 106,734,593 (+)NCBI
Protein Sequences
Protein RefSeqs NP_112307 (Get FASTA)   NCBI Sequence Viewer  
  XP_038961845 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41457 (Get FASTA)   NCBI Sequence Viewer  
  CAA40248 (Get FASTA)   NCBI Sequence Viewer  
  EDL79923 (Get FASTA)   NCBI Sequence Viewer  
  EDL79924 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007247
  ENSRNOP00000007247.1
GenBank Protein P17105 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_112307   ⟸   NM_031045
- UniProtKB: P17105 (UniProtKB/Swiss-Prot),   A6HPH2 (UniProtKB/TrEMBL),   A6HPH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007247   ⟸   ENSRNOT00000007247
RefSeq Acc Id: XP_038961845   ⟸   XM_039105917
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P17105-F1-model_v2 AlphaFold P17105 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692335
Promoter ID:EPDNEW_R2858
Type:initiation region
Name:Itpka_1
Description:inositol-trisphosphate 3-kinase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03111,544,998 - 111,545,058EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619950 AgrOrtholog
BioCyc Gene G2FUF-48192 BioCyc
BioCyc Pathway PWY-6361 [1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)] BioCyc
  PWY-6362 [1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)] BioCyc
  PWY-6364 [D-myo-inositol (1,3,4)-trisphosphate biosynthesis] BioCyc
BioCyc Pathway Image PWY-6361 BioCyc
  PWY-6362 BioCyc
  PWY-6364 BioCyc
Ensembl Genes ENSRNOG00000005284 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007247 ENTREZGENE
  ENSRNOT00000007247.4 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.470.160 UniProtKB/Swiss-Prot
InterPro IPK UniProtKB/Swiss-Prot
  IPK_sf UniProtKB/Swiss-Prot
KEGG Report rno:81677 UniProtKB/Swiss-Prot
NCBI Gene 81677 ENTREZGENE
PANTHER INOSITOL-TRISPHOSPHATE 3-KINASE A UniProtKB/Swiss-Prot
  PTHR12400 UniProtKB/Swiss-Prot
Pfam IPK UniProtKB/Swiss-Prot
PhenoGen Itpka PhenoGen
RatGTEx ENSRNOG00000005284 RatGTEx
Superfamily-SCOP SAICAR synthase-like UniProtKB/Swiss-Prot
UniProt A6HPH2 ENTREZGENE, UniProtKB/TrEMBL
  A6HPH3 ENTREZGENE, UniProtKB/TrEMBL
  IP3KA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-02 Itpka  inositol-trisphosphate 3-kinase A  Itpka  inositol 1,4,5-trisphosphate 3-kinase A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Itpka  inositol 1,4,5-trisphosphate 3-kinase A    inositol 1,4,5-triphosphate 3-kinase  Name updated 1299863 APPROVED
2002-08-07 Itpka  inositol 1,4,5-triphosphate 3-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains calmodulin-binding site and six regions with amino acid compositions (PEST regions) common to proteins that are susceptible to calpain 633125
gene_regulation activity stimulated by Ca2+ in the presence of calmodulin 633124