Bmf (Bcl2 modifying factor) - Rat Genome Database

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Gene: Bmf (Bcl2 modifying factor) Rattus norvegicus
Analyze
Symbol: Bmf
Name: Bcl2 modifying factor
RGD ID: 628658
Description: Predicted to be involved in several processes, including negative regulation of autophagic cell death; negative regulation of autophagy; and positive regulation of cellular component organization. Predicted to act upstream of or within anoikis; negative regulation of apoptotic signaling pathway; and positive regulation of apoptotic signaling pathway. Located in acrosomal vesicle. Orthologous to human BMF (Bcl2 modifying factor); PARTICIPATES IN intrinsic apoptotic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Bcl-2 modifying factor; bcl-2-modifying factor; Bmf-pending
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,953,466 - 125,974,087 (-)NCBIGRCr8
mRatBN7.23105,499,534 - 105,520,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,173,179 - 109,193,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,768,734 - 117,789,356 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,429,111 - 115,449,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,303,515 - 110,324,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,849,170 - 116,869,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,966,652 - 104,984,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,863,079 - 104,881,180 (-)NCBI
Celera3104,419,059 - 104,437,108 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-aminopyridine  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antimycin A  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
DDT  (EXP)
deguelin  (ISO)
depsipeptide  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dichloroacetic acid  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
inulin  (ISO)
iron dichloride  (ISO)
isoprenaline  (EXP)
L-ethionine  (EXP)
leflunomide  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel dichloride  (EXP)
niclosamide  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
propionic acid  (ISO)
pyrazinecarboxamide  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Bcl-2-related protein family gene expression during oligodendroglial differentiation. Itoh T, etal., J Neurochem 2003 Jun;85(6):1500-12.
3. BH3-only proteins in apoptosis and beyond: an overview. Lomonosova E and Chinnadurai G, Oncogene. 2008 Dec;27 Suppl 1:S2-19.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Testicular expression and distribution of the rat bcl2 modifying factor in response to reduced intratesticular testosterone. Show MD, etal., Biol Reprod. 2004 Apr;70(4):1153-61. Epub 2003 Dec 10.
Additional References at PubMed
PMID:11546872   PMID:18222916   PMID:19671867   PMID:20841353   PMID:21041309   PMID:23629966   PMID:27539959   PMID:31200256   PMID:36315357  


Genomics

Comparative Map Data
Bmf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83125,953,466 - 125,974,087 (-)NCBIGRCr8
mRatBN7.23105,499,534 - 105,520,159 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3109,173,179 - 109,193,801 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03117,768,734 - 117,789,356 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03115,429,111 - 115,449,729 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03110,303,515 - 110,324,125 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03116,849,170 - 116,869,775 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43104,966,652 - 104,984,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13104,863,079 - 104,881,180 (-)NCBI
Celera3104,419,059 - 104,437,108 (-)NCBICelera
Cytogenetic Map3q35NCBI
BMF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381540,087,890 - 40,108,879 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1540,087,890 - 40,108,892 (-)EnsemblGRCh38hg38GRCh38
GRCh371540,380,091 - 40,401,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361538,167,383 - 38,188,367 (-)NCBINCBI36Build 36hg18NCBI36
Build 341538,167,385 - 38,185,931NCBI
Celera1517,145,999 - 17,167,002 (-)NCBICelera
Cytogenetic Map15q15.1NCBI
HuRef1517,223,445 - 17,244,440 (-)NCBIHuRef
CHM1_11540,499,972 - 40,520,967 (-)NCBICHM1_1
T2T-CHM13v2.01537,894,726 - 37,915,713 (-)NCBIT2T-CHM13v2.0
Bmf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392118,359,238 - 118,385,240 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2118,359,238 - 118,380,168 (-)EnsemblGRCm39 Ensembl
GRCm382118,528,757 - 118,549,686 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2118,528,757 - 118,549,687 (-)EnsemblGRCm38mm10GRCm38
MGSCv372118,354,493 - 118,375,414 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362118,220,198 - 118,241,119 (-)NCBIMGSCv36mm8
Celera2119,683,712 - 119,704,619 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map259.4NCBI
Bmf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554167,052,290 - 7,068,910 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554167,048,654 - 7,068,917 (-)NCBIChiLan1.0ChiLan1.0
BMF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21629,326,014 - 29,346,967 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11533,477,360 - 33,498,321 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01519,026,053 - 19,047,008 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11537,281,655 - 37,302,365 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1537,281,655 - 37,302,075 (-)Ensemblpanpan1.1panPan2
BMF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1307,301,000 - 7,321,949 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl307,274,174 - 7,322,034 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha307,355,731 - 7,376,675 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0307,429,431 - 7,450,406 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl307,402,587 - 7,450,406 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1307,351,934 - 7,372,873 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0307,458,286 - 7,479,257 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0307,586,431 - 7,607,394 (-)NCBIUU_Cfam_GSD_1.0
Bmf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864085,725,364 - 85,746,902 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364713,577,221 - 3,594,981 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364713,573,437 - 3,594,438 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BMF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1131,178,315 - 131,200,393 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11131,178,021 - 131,199,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
BMF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12642,893,997 - 42,915,062 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2642,894,460 - 42,915,062 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604898,040,714 - 98,061,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bmf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248047,423,547 - 7,440,014 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248047,420,003 - 7,440,012 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bmf
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:212
Count of miRNA genes:133
Interacting mature miRNAs:160
Transcripts:ENSRNOT00000010381
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3102200529115665732Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat

Markers in Region
D15S214  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23105,519,233 - 105,519,547 (+)MAPPERmRatBN7.2
Rnor_6.03110,323,212 - 110,323,527NCBIRnor6.0
Rnor_5.03116,868,867 - 116,869,182UniSTSRnor5.0
RGSC_v3.43104,983,880 - 104,984,195UniSTSRGSC3.4
Celera3104,436,198 - 104,436,551UniSTS
Cytogenetic Map3q35UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 31 19 19 19 16 34 33 11
Low 3 31 26 22 22 8 11 58 1 6 8
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010381   ⟹   ENSRNOP00000010381
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,499,538 - 105,520,145 (-)Ensembl
Rnor_6.0 Ensembl3110,306,067 - 110,324,084 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105313   ⟹   ENSRNOP00000096398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3105,499,538 - 105,517,800 (-)Ensembl
RefSeq Acc Id: NM_001401791   ⟹   NP_001388720
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,466 - 125,974,064 (-)NCBI
mRatBN7.23105,499,534 - 105,520,134 (-)NCBI
RefSeq Acc Id: NM_139258   ⟹   NP_640351
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,466 - 125,974,064 (-)NCBI
mRatBN7.23105,499,534 - 105,520,134 (-)NCBI
Rnor_6.03110,306,067 - 110,324,084 (-)NCBI
Rnor_5.03116,849,170 - 116,869,775 (-)NCBI
RGSC_v3.43104,966,652 - 104,984,752 (-)RGD
Celera3104,419,059 - 104,437,108 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234724   ⟹   XP_006234786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,974,087 (-)NCBI
mRatBN7.23105,503,224 - 105,520,159 (-)NCBI
Rnor_6.03110,307,259 - 110,324,125 (-)NCBI
Rnor_5.03116,849,170 - 116,869,775 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762079   ⟹   XP_008760301
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,974,086 (-)NCBI
mRatBN7.23105,499,534 - 105,520,159 (-)NCBI
Rnor_6.03110,303,515 - 110,324,122 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063283080   ⟹   XP_063139150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,953,467 - 125,973,891 (-)NCBI
RefSeq Acc Id: XR_005501773
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83125,969,477 - 125,974,086 (-)NCBI
mRatBN7.23105,515,550 - 105,520,159 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_640351   ⟸   NM_139258
- Peptide Label: isoform 1
- UniProtKB: A0A8L2Q4K3 (UniProtKB/TrEMBL),   A6HPB4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234786   ⟸   XM_006234724
- Peptide Label: isoform X2
- UniProtKB: A6HPB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760301   ⟸   XM_008762079
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000010381   ⟸   ENSRNOT00000010381
RefSeq Acc Id: ENSRNOP00000096398   ⟸   ENSRNOT00000105313
RefSeq Acc Id: NP_001388720   ⟸   NM_001401791
- Peptide Label: isoform 2
- UniProtKB: Q8K589 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063139150   ⟸   XM_063283080
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K589-F1-model_v2 AlphaFold Q8K589 1-185 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692310
Promoter ID:EPDNEW_R2834
Type:multiple initiation site
Name:Bmf_1
Description:Bcl2 modifying factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03110,324,078 - 110,324,138EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:628658 AgrOrtholog
BioCyc Gene G2FUF-48249 BioCyc
Ensembl Genes ENSRNOG00000007529 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010381 ENTREZGENE
  ENSRNOT00000010381.5 UniProtKB/TrEMBL
  ENSRNOT00000105313 ENTREZGENE
  ENSRNOT00000105313.1 UniProtKB/TrEMBL
InterPro BMF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:246142 UniProtKB/Swiss-Prot
NCBI Gene 246142 ENTREZGENE
PANTHER BCL-2-MODIFYING FACTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR32014 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BMF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bmf PhenoGen
RatGTEx ENSRNOG00000007529 RatGTEx
UniProt A0A8I6GLK7_RAT UniProtKB/TrEMBL
  A0A8L2Q4K3 ENTREZGENE, UniProtKB/TrEMBL
  A6HPB3 ENTREZGENE, UniProtKB/TrEMBL
  A6HPB4 ENTREZGENE, UniProtKB/TrEMBL
  BMF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bmf  Bcl2 modifying factor    Bcl-2 modifying factor  Name updated 1299863 APPROVED
2003-02-27 Bmf  Bcl-2 modifying factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains contains a BH3 domain 631874