Capn3 (calpain 3) - Rat Genome Database
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Gene: Capn3 (calpain 3) Rattus norvegicus
Analyze
Symbol: Capn3
Name: calpain 3
RGD ID: 2269
Description: Exhibits several functions, including calcium-dependent cysteine-type endopeptidase activity; enzyme binding activity; and titin binding activity. Involved in several processes, including response to calcium ion; response to muscle activity; and sodium-dependent self proteolysis. Localizes to T-tubule; Z disc; and nucleus. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; and muscular dystrophy. Orthologous to human CAPN3 (calpain 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: calcium-activated neutral proteinase 3; calpain L3; calpain p94; calpain-3; CANP 3; Lp82; Lp84; Lp85; muscle-specific calcium-activated neutral protease 3; p94
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23107,407,518 - 107,457,858 (+)NCBI
Rnor_6.0 Ensembl3112,228,720 - 112,278,408 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03112,227,486 - 112,278,408 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03118,776,357 - 118,825,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,946,878 - 106,998,274 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,843,308 - 106,894,702 (+)NCBI
Celera3106,315,875 - 106,366,640 (+)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-dependent self proteolysis  (IEA,ISO,ISS)
cellular response to calcium ion  (IEA,ISO,ISS)
cellular response to salt stress  (IEA,ISO,ISS)
G1 to G0 transition involved in cell differentiation  (IEA,ISO)
muscle structure development  (ISO,ISS)
myofibril assembly  (ISO,ISS)
negative regulation of apoptotic process  (IBA,IEA,ISO,ISS)
negative regulation of protein sumoylation  (IEA,ISO,ISS)
negative regulation of skeletal muscle cell differentiation  (ISO)
negative regulation of transcription, DNA-templated  (IEA,ISO,ISS)
positive regulation of NF-kappaB transcription factor activity  (IEA,ISO,ISS)
positive regulation of proteolysis  (IEA,ISO,ISS)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO,ISS)
positive regulation of satellite cell activation involved in skeletal muscle regeneration  (IEA,ISO,ISS)
positive regulation of transcription, DNA-templated  (IEA,ISO,ISS)
programmed cell death  (IEA,ISO)
protein catabolic process  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein localization to membrane  (IEA,ISO,ISS)
protein-containing complex assembly  (IEA,ISO,ISS)
proteolysis  (IBA,IDA,IEA,ISO,TAS)
regulation of catalytic activity  (IEA,ISO,ISS)
regulation of I-kappaB kinase/NF-kappaB signaling  (IEA,ISO,ISS)
regulation of myoblast differentiation  (IEA,ISO)
response to calcium ion  (IDA)
response to drug  (IEP)
response to muscle activity  (IDA)
sarcomere organization  (IEA,ISO,ISS)
self proteolysis  (IDA,ISO)
sodium-dependent self proteolysis  (IDA)

Cellular Component
cytoplasm  (IBA,IDA,IEA,ISO)
cytosol  (IEA,ISO,ISS)
myofibril  (IDA)
nucleus  (IDA,IEA,ISO)
plasma membrane  (IDA,IEA,ISO,ISS)
protein-containing complex  (IEA,ISO,ISS)
T-tubule  (IDA)
Z disc  (IDA)

Molecular Function

References

References - curated
1. Busquets S, etal., Biochim Biophys Acta. 2000 Jun 1;1475(1):5-9.
2. Fukiage C, etal., J Biol Chem. 2002 Jun 7;277(23):20678-85. Epub 2002 Mar 19.
3. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. GOA data from the GO Consortium
5. Guyon JR, etal., Muscle Nerve. 2003 Oct;28(4):472-83.
6. Konig N, etal., J Chem Neuroanat 2003 Feb;25(2):129-36.
7. Kramerova I, etal., Hum Mol Genet. 2008 Nov 1;17(21):3271-80. doi: 10.1093/hmg/ddn223. Epub 2008 Aug 1.
8. Ma H, etal., Exp Eye Res 1998 Aug;67(2):221-9.
9. Ma H, etal., Invest Ophthalmol Vis Sci 1998 Feb;39(2):454-61.
10. Marcilhac A, etal., Int J Biochem Cell Biol. 2006;38(12):2128-40. Epub 2006 Jul 5.
11. MGD data from the GO Consortium
12. Miyabara EH, etal., Cell Tissue Res. 2005 Mar;319(3):479-89. Epub 2005 Jan 27.
13. Murphy RM and Lamb GD, J Biol Chem. 2009 Mar 20;284(12):7811-9. doi: 10.1074/jbc.M808655200. Epub 2009 Jan 14.
14. NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. OMIM Disease Annotation Pipeline
16. Ono Y, etal., J Biol Chem. 2010 Jul 23;285(30):22986-98. doi: 10.1074/jbc.M110.126946. Epub 2010 May 11.
17. RGD automated data pipeline
18. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. RGD automated import pipeline for gene-chemical interactions
20. Richard I, etal., Am J Hum Genet. 1997 May;60(5):1128-38.
21. Sorimachi H, etal., J Biol Chem 1989 Nov 25;264(33):20106-11.
22. Tagawa K, etal., Hum Mol Genet 2000 May 22;9(9):1393-402.
Additional References at PubMed
PMID:9642272   PMID:11120559   PMID:12482600   PMID:12658553   PMID:15138196   PMID:16107503   PMID:16857710   PMID:18073330   PMID:18310072   PMID:19295178   PMID:19386580   PMID:19556129  
PMID:20139084   PMID:20694146   PMID:23300487   PMID:23357851   PMID:26569227   PMID:29783071  


Genomics

Comparative Map Data
Capn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23107,407,518 - 107,457,858 (+)NCBI
Rnor_6.0 Ensembl3112,228,720 - 112,278,408 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03112,227,486 - 112,278,408 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03118,776,357 - 118,825,812 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43106,946,878 - 106,998,274 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13106,843,308 - 106,894,702 (+)NCBI
Celera3106,315,875 - 106,366,640 (+)NCBICelera
Cytogenetic Map3q35NCBI
CAPN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1542,359,500 - 42,412,318 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1542,359,498 - 42,412,949 (+)EnsemblGRCh38hg38GRCh38
GRCh381542,359,501 - 42,412,317 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371542,651,699 - 42,704,515 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361540,427,593 - 40,491,807 (+)NCBINCBI36hg18NCBI36
Build 341540,427,592 - 40,491,807NCBI
Celera1519,408,011 - 19,472,224 (+)NCBI
Cytogenetic Map15q15.1NCBI
HuRef1519,499,872 - 19,552,636 (+)NCBIHuRef
CHM1_11542,770,186 - 42,823,000 (+)NCBICHM1_1
Capn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392120,294,074 - 120,335,400 (+)NCBIGRCm39mm39
GRCm39 Ensembl2120,294,053 - 120,335,399 (+)Ensembl
GRCm382120,463,593 - 120,504,919 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2120,456,019 - 120,504,913 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl2120,463,572 - 120,504,918 (+)EnsemblGRCm38mm10GRCm38
MGSCv372120,289,329 - 120,330,655 (+)NCBIGRCm37mm9NCBIm37
MGSCv362120,155,314 - 120,195,940 (+)NCBImm8
Celera2121,617,948 - 121,659,023 (+)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.31NCBI
Capn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554169,070,399 - 9,117,794 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554169,070,479 - 9,121,099 (+)NCBIChiLan1.0ChiLan1.0
LOC100984344
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11539,458,400 - 39,528,820 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1539,476,302 - 39,528,820 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01521,227,371 - 21,372,406 (+)NCBIMhudiblu_PPA_v0panPan3
CAPN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1309,329,190 - 9,384,622 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl309,329,015 - 9,383,772 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha309,387,300 - 9,442,600 (+)NCBI
ROS_Cfam_1.0309,464,173 - 9,519,888 (+)NCBI
UMICH_Zoey_3.1309,384,166 - 9,439,578 (+)NCBI
UNSW_CanFamBas_1.0309,489,492 - 9,545,424 (+)NCBI
UU_Cfam_GSD_1.0309,623,343 - 9,678,674 (+)NCBI
Capn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_ltri_2NW_02440864087,819,711 - 87,863,585 (+)NCBI
SpeTri2.0NW_0049364715,667,839 - 5,711,822 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CAPN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1128,960,121 - 129,013,547 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11128,960,117 - 129,013,508 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21143,852,337 - 143,905,767 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q15-q17NCBI
CAPN3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12640,568,320 - 40,657,443 (-)NCBI
ChlSab1.1 Ensembl2640,568,885 - 40,625,597 (-)Ensembl
Capn3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248049,473,075 - 9,512,643 (+)NCBI

Position Markers
D3Rat261  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,232,846 - 112,233,058NCBIRnor6.0
Rnor_5.03118,780,585 - 118,780,797UniSTSRnor5.0
RGSC_v3.43106,951,512 - 106,951,725RGDRGSC3.4
RGSC_v3.43106,951,513 - 106,951,725UniSTSRGSC3.4
RGSC_v3.13106,847,940 - 106,848,153RGD
Celera3106,319,855 - 106,320,067UniSTS
SHRSP x BN Map352.8698UniSTS
SHRSP x BN Map352.8698RGD
Cytogenetic Map3q35UniSTS
RH130533  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,278,066 - 112,278,262NCBIRnor6.0
Rnor_5.03118,825,470 - 118,825,666UniSTSRnor5.0
RGSC_v3.43106,997,932 - 106,998,128UniSTSRGSC3.4
Celera3106,366,298 - 106,366,494UniSTS
RH 3.4 Map3940.1UniSTS
Cytogenetic Map3q35UniSTS
RH130699  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,226,671 - 112,226,857NCBIRnor6.0
Rnor_5.03118,774,410 - 118,774,596UniSTSRnor5.0
RGSC_v3.43106,944,931 - 106,945,117UniSTSRGSC3.4
Celera3106,313,928 - 106,314,114UniSTS
RH 3.4 Map3939.7UniSTS
Cytogenetic Map3q35UniSTS
RH94578  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q35UniSTS
Capn3  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,228,953 - 112,229,127NCBIRnor6.0
Rnor_5.03118,776,692 - 118,776,866UniSTSRnor5.0
RGSC_v3.43106,947,213 - 106,947,387UniSTSRGSC3.4
Celera3106,316,210 - 106,316,384UniSTS
Cytogenetic Map3q35UniSTS
GDB:595526  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,228,855 - 112,229,295NCBIRnor6.0
Rnor_5.03118,776,594 - 118,777,034UniSTSRnor5.0
RGSC_v3.43106,947,115 - 106,947,555UniSTSRGSC3.4
Celera3106,316,112 - 106,316,552UniSTS
Cytogenetic Map3q35UniSTS
SKM-CALPOV  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,228,850 - 112,229,107NCBIRnor6.0
Rnor_5.03118,776,589 - 118,776,846UniSTSRnor5.0
RGSC_v3.43106,947,110 - 106,947,367UniSTSRGSC3.4
Celera3106,316,107 - 106,316,364UniSTS
Cytogenetic Map3q35UniSTS
CANP3SKM  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03112,263,884 - 112,264,781NCBIRnor6.0
Rnor_5.03118,811,288 - 118,812,185UniSTSRnor5.0
RGSC_v3.43106,983,750 - 106,984,647UniSTSRGSC3.4
Celera3106,352,115 - 106,353,012UniSTS
Cytogenetic Map3q35UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)366711607119830094Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)366711607119830094Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)383817637119509260Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)3100730984119830094Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
1582216Bw65Body weight QTL 656.3body mass (VT:0001259)body weight (CMO:0000012)3106900427119830094Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:56
Count of miRNA genes:53
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000011761
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 11 8
Low 18 23 16 17 16 63 3 31 11
Below cutoff 3 25 27 18 2 18 11 32 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_017117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF052540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF061726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF173834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF184950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U96367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000011761   ⟹   ENSRNOP00000011761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3112,228,919 - 112,278,038 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079079   ⟹   ENSRNOP00000069651
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3112,228,720 - 112,278,022 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080533   ⟹   ENSRNOP00000071494
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3112,242,270 - 112,278,408 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082876   ⟹   ENSRNOP00000075081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3112,242,326 - 112,278,401 (+)Ensembl
RefSeq Acc Id: NM_017117   ⟹   NP_058813
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,407,838 - 107,457,858 (+)NCBI
Rnor_6.03112,228,618 - 112,278,408 (+)NCBI
Rnor_5.03118,776,357 - 118,825,812 (+)NCBI
RGSC_v3.43106,946,878 - 106,998,274 (+)RGD
Celera3106,315,875 - 106,366,640 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234728   ⟹   XP_006234790
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,421,308 - 107,457,856 (+)NCBI
Rnor_6.03112,242,243 - 112,278,406 (+)NCBI
Rnor_5.03118,776,357 - 118,825,812 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234729   ⟹   XP_006234791
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,421,264 - 107,457,856 (+)NCBI
Rnor_6.03112,242,247 - 112,278,406 (+)NCBI
Rnor_5.03118,776,357 - 118,825,812 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762080   ⟹   XP_008760302
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03112,227,486 - 112,278,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762081   ⟹   XP_008760303
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,407,522 - 107,457,856 (+)NCBI
Rnor_6.03112,227,487 - 112,278,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591508   ⟹   XP_017446997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03112,242,246 - 112,278,406 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039104419   ⟹   XP_038960347
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,407,521 - 107,457,856 (+)NCBI
RefSeq Acc Id: XM_039104420   ⟹   XP_038960348
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,421,308 - 107,457,856 (+)NCBI
RefSeq Acc Id: XM_039104421   ⟹   XP_038960349
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,407,518 - 107,457,856 (+)NCBI
RefSeq Acc Id: XM_039104422   ⟹   XP_038960350
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23107,421,266 - 107,457,856 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058813   ⟸   NM_017117
- Sequence:
RefSeq Acc Id: XP_006234791   ⟸   XM_006234729
- Peptide Label: isoform X4
- UniProtKB: O70482 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234790   ⟸   XM_006234728
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K9P9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760302   ⟸   XM_008762080
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008760303   ⟸   XM_008762081
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017446997   ⟸   XM_017591508
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000075081   ⟸   ENSRNOT00000082876
RefSeq Acc Id: ENSRNOP00000069651   ⟸   ENSRNOT00000079079
RefSeq Acc Id: ENSRNOP00000071494   ⟸   ENSRNOT00000080533
RefSeq Acc Id: ENSRNOP00000011761   ⟸   ENSRNOT00000011761
RefSeq Acc Id: XP_038960349   ⟸   XM_039104421
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038960347   ⟸   XM_039104419
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038960350   ⟸   XM_039104422
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038960348   ⟸   XM_039104420
- Peptide Label: isoform X5
Protein Domains
Calpain catalytic   EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2269 AgrOrtholog
Ensembl Genes ENSRNOG00000008609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011761 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000069651 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071494 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075081 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011761 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079079 UniProtKB/TrEMBL
  ENSRNOT00000080533 UniProtKB/TrEMBL
  ENSRNOT00000082876 UniProtKB/TrEMBL
InterPro C2_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_cysteine_protease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_domain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calpain_III_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAPN3/9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C2_calpain_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29155 UniProtKB/Swiss-Prot
NCBI Gene 29155 ENTREZGENE
PANTHER PTHR10183:SF329 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Capn3 PhenoGen
PRINTS CALPAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CALPAIN_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART calpain_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CysPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49758 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JVX0_RAT UniProtKB/TrEMBL
  A0A0G2K9P9 ENTREZGENE, UniProtKB/TrEMBL
  CAN3_RAT UniProtKB/Swiss-Prot
  F1LSQ2_RAT UniProtKB/TrEMBL
  O08702_RAT UniProtKB/TrEMBL
  O70482 ENTREZGENE, UniProtKB/TrEMBL
  P16259 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Capn3  calpain 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the muscle, forebrain, in the corpus callosum and in the dentate gyrus of the brain 634694
gene_expression p94 isoform expressed only in skeletal muscle, not expressed in heart or in smooth muscle 69795
gene_expression Lp84 isoform expressed exclusively in lens of eye 1299839
gene_function calcium-dependent protease 634694
gene_function Lp82 isoform exhibits calcium-activated protease activity 1299852
gene_process may be involved in astrocyte plasticity and/or motility 634694
gene_process Lp82 isoform may contribute to proteolysis of lens crystallin proteins in both normal development and in cataract formation 1299852
gene_transcript alternatively spliced into p94 or Lp82 isoforms via usage of alternative exon 1 and deletions of IS1 and IS2 regions 1299839