Wt1 (WT1 transcription factor) - Rat Genome Database
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Gene: Wt1 (WT1 transcription factor) Rattus norvegicus
Analyze
Symbol: Wt1
Name: WT1 transcription factor
RGD ID: 3974
Description: Exhibits sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Localizes to nucleus. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor); INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 3,7-dihydropurine-6-thione.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Wilms tumor 1; Wilms tumor protein homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
Cytogenetic Map3q33NCBI
RH 3.4 Map3720.19RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,7-dihydropurine-6-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
acetic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (ISO)
Butylbenzyl phthalate  (EXP)
caffeine  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
chloroprene  (EXP)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (EXP)
crocidolite asbestos  (ISO)
curcumin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP,ISO)
dieldrin  (EXP)
diethyl phthalate  (EXP)
diisobutyl phthalate  (EXP)
diisononyl phthalate  (EXP)
dioxygen  (ISO)
diuron  (EXP)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
ethanol  (EXP)
flavonoids  (EXP)
formaldehyde  (EXP)
fulvestrant  (ISO)
furan  (EXP)
genistein  (EXP)
gentamycin  (EXP)
Indeno[1,2,3-cd]pyrene  (ISO)
losartan  (ISO)
malathion  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercaptopurine  (EXP)
methapyrilene  (ISO)
nickel subsulfide  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
Pachymic acid  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
resmethrin  (ISO)
rosuvastatin calcium  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
spironolactone  (EXP)
staurosporine  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vitamin E  (EXP)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adrenal cortex formation  (ISO,ISS)
adrenal gland development  (ISO,ISS)
apoptotic process  (ISO)
branching involved in ureteric bud morphogenesis  (ISO,ISS)
camera-type eye development  (ISO,ISS)
cardiac muscle cell fate commitment  (ISO)
cellular response to cAMP  (ISO)
cellular response to gonadotropin stimulus  (ISO,ISS)
diaphragm development  (ISO,ISS)
epithelial cell differentiation  (ISO,ISS)
flagellated sperm motility  (ISO)
germ cell development  (ISO,ISS)
glomerular basement membrane development  (ISO,ISS)
glomerular visceral epithelial cell development  (ISO)
glomerular visceral epithelial cell differentiation  (ISO,ISS)
glomerulus development  (ISO,ISS)
gonad development  (ISO,ISS)
heart development  (ISO,ISS)
kidney development  (ISO)
male genitalia development  (ISO,ISS)
male gonad development  (ISO)
mesenchymal to epithelial transition  (ISO,ISS)
mesonephros development  (ISO)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric epithelium development  (ISO)
metanephric mesenchyme development  (ISO,ISS)
metanephric S-shaped body morphogenesis  (ISO,ISS)
metanephros development  (ISO)
negative regulation of apoptotic process  (IBA,ISO,ISS)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (IBA,ISO,ISS)
negative regulation of female gonad development  (ISO,ISS)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
negative regulation of metanephric glomerular mesangial cell proliferation  (ISO,ISS)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO,ISS)
negative regulation of translation  (ISO,ISS)
positive regulation of apoptotic process  (ISO,ISS)
positive regulation of DNA methylation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of heart growth  (ISO,ISS)
positive regulation of male gonad development  (ISO,ISS)
positive regulation of metanephric ureteric bud development  (ISO,ISS)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (IMP,ISO)
positive regulation of transcription, DNA-templated  (IDA,ISO,ISS)
posterior mesonephric tubule development  (ISO,ISS)
regulation of animal organ formation  (ISO,ISS)
regulation of gene expression  (ISO)
regulation of transcription by RNA polymerase II  (IBA,ISO,ISS)
regulation of transcription, DNA-templated  (IEA,ISO,ISS)
RNA splicing  (ISO,ISS)
seminiferous tubule development  (ISO)
Sertoli cell development  (ISO)
sex determination  (ISO,ISS)
single fertilization  (ISO)
spermatogenesis  (ISO)
thorax and anterior abdomen determination  (ISO,ISS)
tissue development  (ISO,ISS)
ureteric bud development  (ISO,ISS)
vasculogenesis  (ISO,ISS)
visceral serous pericardium development  (ISO,ISS)

Cellular Component
chromatin  (IBA)
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
nuclear speck  (IEA,ISO,ISS)
nucleolus  (IEA)
nucleoplasm  (ISO,ISS)
nucleus  (IDA,ISO)

References

Additional References at PubMed
PMID:1332065   PMID:1662794   PMID:7585606   PMID:7588596   PMID:7720589   PMID:7856737   PMID:7926762   PMID:8119964   PMID:8132626   PMID:8306891   PMID:8395349   PMID:8530339  
PMID:8889548   PMID:9118800   PMID:9178767   PMID:9765217   PMID:9784496   PMID:9815658   PMID:9927198   PMID:10077614   PMID:10101119   PMID:10322633   PMID:11278547   PMID:11509181  
PMID:11889045   PMID:11912180   PMID:12151099   PMID:12609742   PMID:12665546   PMID:12738801   PMID:12802290   PMID:14678822   PMID:14681305   PMID:14701728   PMID:15063178   PMID:15518539  
PMID:15520190   PMID:15716344   PMID:15961562   PMID:16264195   PMID:16338327   PMID:16418481   PMID:16467207   PMID:16934801   PMID:17430890   PMID:17457373   PMID:17537799   PMID:17848411  
PMID:18496514   PMID:18618131   PMID:19050011   PMID:19205749   PMID:19301398   PMID:19457926   PMID:21072664   PMID:21390327   PMID:21443142   PMID:21654746   PMID:21719793   PMID:21778682  
PMID:22431408   PMID:23042785   PMID:23107969   PMID:23229934   PMID:25258363   PMID:27009470   PMID:28315733   PMID:29025062   PMID:30242881  


Genomics

Comparative Map Data
Wt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0395,133,221 - 95,180,574 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03101,756,056 - 101,802,601 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4390,529,704 - 90,577,280 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1390,463,925 - 90,472,651 (+)NCBI
Celera390,623,287 - 90,669,803 (+)NCBICelera
Cytogenetic Map3q33NCBI
RH 3.4 Map3720.19RGD
WT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1132,387,775 - 32,435,564 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1132,387,775 - 32,435,885 (-)EnsemblGRCh38hg38GRCh38
GRCh381132,387,775 - 32,435,539 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371132,408,789 - 32,457,104 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361132,365,901 - 32,413,663 (-)NCBINCBI36hg18NCBI36
Build 341132,365,896 - 32,413,653NCBI
Celera1132,556,060 - 32,603,819 (-)NCBI
Cytogenetic Map11p13NCBI
HuRef1132,104,249 - 32,152,010 (-)NCBIHuRef
CHM1_11132,409,251 - 32,457,017 (-)NCBICHM1_1
Wt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392104,956,874 - 105,003,959 (+)NCBIGRCm39mm39
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBImm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E3NCBI
cM Map255.06NCBI
Wt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,464,616 - 10,504,473 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,464,688 - 10,504,473 (-)NCBIChiLan1.0ChiLan1.0
WT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11132,238,720 - 32,282,879 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,238,720 - 32,287,249 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01132,349,807 - 32,398,494 (-)NCBIMhudiblu_PPA_v0panPan3
WT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1835,103,934 - 35,148,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11835,099,660 - 35,148,767 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Wt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365335,411,949 - 5,459,693 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl228,411,794 - 28,456,003 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1228,411,467 - 28,456,007 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2230,902,160 - 30,946,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap2p14-q11NCBI
WT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1132,750,300 - 32,801,832 (+)NCBI
Wt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476620,899,546 - 20,937,084 (-)NCBI

Position Markers
D3Rat26  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0395,176,716 - 95,176,874NCBIRnor6.0
Rnor_5.03101,798,743 - 101,798,901UniSTSRnor5.0
RGSC_v3.4390,573,422 - 90,573,580UniSTSRGSC3.4
RGSC_v3.4390,573,349 - 90,573,782RGDRGSC3.4
RGSC_v3.1390,469,850 - 90,470,008RGD
Celera390,665,945 - 90,666,103UniSTS
Cytogenetic Map3q32UniSTS
RH 3.4 Map3724.0RGD
RH 3.4 Map3724.0UniSTS
RH 2.0 Map3471.1RGD
SHRSP x BN Map347.2698RGD
RH142234  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q32UniSTS
RH 3.4 Map3720.19UniSTS
GDB:371639  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0395,133,828 - 95,133,992NCBIRnor6.0
Rnor_5.03101,756,608 - 101,756,772UniSTSRnor5.0
RGSC_v3.4390,529,819 - 90,529,983UniSTSRGSC3.4
Celera390,623,402 - 90,623,566UniSTS
Cytogenetic Map3q32UniSTS
GDB:371627  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0395,133,254 - 95,133,462NCBIRnor6.0
Rnor_5.03101,756,034 - 101,756,242UniSTSRnor5.0
RGSC_v3.4390,529,245 - 90,529,453UniSTSRGSC3.4
Celera390,622,828 - 90,623,036UniSTS
Cytogenetic Map3q32UniSTS
PMC186395P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0395,132,785 - 95,132,906NCBIRnor6.0
Rnor_5.03101,755,565 - 101,755,686UniSTSRnor5.0
RGSC_v3.4390,528,776 - 90,528,897UniSTSRGSC3.4
Celera390,622,359 - 90,622,480UniSTS
Cytogenetic Map3q32UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)310639528127023997Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)330114912123700444Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333477354108914061Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)334394121103141944Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)343295930108914061Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)345406058127023997Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)348562146115249962Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)351821836124513579Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)351822008120917851Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)354630948119830094Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)354630948119830094Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35524527695176874Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35524527695176874Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)356735995101735995Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)362922868127023997Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)366711607119830094Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)366711607119830094Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)372672290127023997Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)372973445127023997Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)378700444123700444Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)383817637119509260Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:268
Count of miRNA genes:100
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000017591, ENSRNOT00000067940
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 6 6 6 6 26 40
Low 17 37 26 8 26 2 9 1 11
Below cutoff 3 14 9 5 9 6 6 36 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000067940   ⟹   ENSRNOP00000060038
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl395,133,713 - 95,180,564 (+)Ensembl
RefSeq Acc Id: NM_031534   ⟹   NP_113722
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,713 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
RGSC_v3.4390,529,704 - 90,577,280 (+)RGD
Celera390,623,287 - 90,669,803 (+)RGD
Sequence:
RefSeq Acc Id: XM_006234620   ⟹   XP_006234682
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,320 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234621   ⟹   XP_006234683
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,222 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006234622   ⟹   XP_006234684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,221 - 95,180,574 (+)NCBI
Rnor_5.03101,756,056 - 101,802,601 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591476   ⟹   XP_017446965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,134,173 - 95,180,574 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017591477   ⟹   XP_017446966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,134,173 - 95,180,574 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_113722   ⟸   NM_031534
- UniProtKB: P49952 (UniProtKB/Swiss-Prot),   D3ZJ55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234683   ⟸   XM_006234621
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006234684   ⟸   XM_006234622
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006234682   ⟸   XM_006234620
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017446965   ⟸   XM_017591476
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017446966   ⟸   XM_017591477
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000060038   ⟸   ENSRNOT00000067940
Protein Domains
C2H2-type

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692271
Promoter ID:EPDNEW_R2793
Type:single initiation site
Name:AABR07053172_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,206 - 95,133,266EPDNEW
RGD ID:13692269
Promoter ID:EPDNEW_R2794
Type:single initiation site
Name:Wt1_1
Description:Wilms tumor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0395,133,803 - 95,133,863EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3974 AgrOrtholog
Ensembl Genes ENSRNOG00000013074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000060038 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067940 ENTREZGENE, UniProtKB/TrEMBL
InterPro Wilms_tumour UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wilms_tumour_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24883 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24883 ENTREZGENE
PANTHER PTHR23235:SF49 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wt1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.92531 ENTREZGENE
UniProt D3ZJ55 ENTREZGENE, UniProtKB/TrEMBL
  P49952 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Wt1  WT1 transcription factor  Wt1  Wilms tumor 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Wt1  Wilms tumor 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease involved in the development of Wilms tumor 61791
gene_expression mRNA expressed in kidney glomeruli, testis, spinal chord and area postrema in the brain 730080
gene_function transcriptional factor that interacts with TCC repeats in epidermal growth factor 61791
gene_physical_interaction binds to TCC repeat sequences of epidermal growth factor promoter 727305
gene_process involved in the nerve growth factor-induced down regulation of EGF receptor 61791