Chrm5 (cholinergic receptor, muscarinic 5) - Rat Genome Database

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Gene: Chrm5 (cholinergic receptor, muscarinic 5) Rattus norvegicus
Symbol: Chrm5
Name: cholinergic receptor, muscarinic 5
RGD ID: 620027
Description: Enables G protein-coupled acetylcholine receptor activity. Involved in regulation of phosphatidylinositol dephosphorylation. Predicted to be located in postsynaptic membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Orthologous to human CHRM5 (cholinergic receptor muscarinic 5); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphaq protein family; G protein mediated signaling pathway via Galphaq family; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: muscarinic acetylcholine receptor M5
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2399,284,846 - 99,337,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3102,911,743 - 102,964,081 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03111,510,739 - 111,563,079 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03109,207,281 - 109,259,678 (-)NCBIRnor_WKY
Rnor_6.03103,966,451 - 104,018,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03110,560,292 - 110,632,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4398,326,809 - 98,378,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1398,223,400 - 98,274,959 (-)NCBI
Celera398,270,221 - 98,321,572 (-)NCBICelera
Cytogenetic Map3q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Molecular cloning and expression of a fifth muscarinic acetylcholine receptor. Liao CF, etal., J Biol Chem 1989 May 5;264(13):7328-37.
3. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. Muscarinic signaling in the brain. Thiele A Annu Rev Neurosci. 2013 Jul 8;36:271-94. doi: 10.1146/annurev-neuro-062012-170433.
9. Radiation hybrid mapping of five muscarinic acetylcholine receptor subtype genes in Rattus norvegicus. Tseng J, etal., Hear Res 2002 Dec;174(1-2):86-92.
Additional References at PubMed
PMID:2380182   PMID:3272174   PMID:11756520   PMID:18246091   PMID:18443764   PMID:19160866   PMID:22095037   PMID:23504804   PMID:24866457  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2399,284,846 - 99,337,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3102,911,743 - 102,964,081 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03111,510,739 - 111,563,079 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03109,207,281 - 109,259,678 (-)NCBIRnor_WKY
Rnor_6.03103,966,451 - 104,018,815 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03110,560,292 - 110,632,938 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4398,326,809 - 98,378,531 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1398,223,400 - 98,274,959 (-)NCBI
Celera398,270,221 - 98,321,572 (-)NCBICelera
Cytogenetic Map3q35NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381533,968,497 - 34,067,458 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1533,968,497 - 34,067,458 (+)EnsemblGRCh38hg38GRCh38
GRCh371534,260,698 - 34,359,659 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361532,097,720 - 32,144,579 (+)NCBINCBI36Build 36hg18NCBI36
Build 341532,097,719 - 32,144,579NCBI
Celera1511,064,121 - 11,160,334 (+)NCBICelera
Cytogenetic Map15q14NCBI
HuRef1511,124,408 - 11,221,244 (+)NCBIHuRef
CHM1_11534,379,045 - 34,475,247 (+)NCBICHM1_1
T2T-CHM13v2.01531,766,653 - 31,865,649 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392112,309,078 - 112,365,491 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2112,309,516 - 112,311,114 (-)EnsemblGRCm39 Ensembl
GRCm382112,478,733 - 112,536,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2112,479,171 - 112,480,769 (-)EnsemblGRCm38mm10GRCm38
MGSCv372112,319,229 - 112,320,974 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362112,280,010 - 112,281,608 (-)NCBIMGSCv36mm8
Celera2113,630,348 - 113,632,093 (-)NCBICelera
Cytogenetic Map2E3NCBI
cM Map257.02NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955416526,755 - 528,353 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955416526,718 - 528,353 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11531,315,839 - 31,408,563 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1531,406,198 - 31,407,796 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01512,478,656 - 12,575,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.130988,764 - 1,074,599 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl30990,208 - 991,806 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha301,033,732 - 1,118,973 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0301,086,979 - 1,172,509 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl301,088,172 - 1,089,832 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1301,033,678 - 1,119,068 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0301,132,741 - 1,218,246 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0301,260,343 - 1,345,796 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440864079,539,375 - 79,618,606 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366732,608,003 - 2,609,624 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049366732,607,906 - 2,610,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl780,427,360 - 80,428,963 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1780,423,768 - 80,429,187 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2786,417,799 - 86,503,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12648,842,021 - 48,940,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2648,842,779 - 48,844,377 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604892,061,214 - 92,063,631 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624804255,505 - 257,103 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624804252,437 - 334,457 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Chrm5
193 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:138
Count of miRNA genes:106
Interacting mature miRNAs:118
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
2302273Gluco35Glucose level QTL 355.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)380800231114297550Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)389772419134772419Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)391797474136797474Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)394856903159898684Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)395735366140735366Rat
1582252Sual1Serum uric acid level QTL 13.40.0123blood uric acid amount (VT:0010302)blood uric acid level (CMO:0000501)396127817102200699Rat
1582219Bw63Body weight QTL 633.80.001body mass (VT:0001259)body weight (CMO:0000012)396127817115665732Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)397084464142084464Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)397551417147415807Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)398535386161695835Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,300,139 - 99,300,344 (+)MAPPERmRatBN7.2
Rnor_6.03103,981,744 - 103,981,948NCBIRnor6.0
Rnor_5.03110,575,585 - 110,575,789UniSTSRnor5.0
RGSC_v3.4398,342,016 - 98,342,325RGDRGSC3.4
RGSC_v3.4398,342,103 - 98,342,307UniSTSRGSC3.4
RGSC_v3.1398,238,531 - 98,238,735RGD
Celera398,285,514 - 98,285,718UniSTS
RH 3.4 Map3857.1RGD
RH 3.4 Map3857.1UniSTS
Cytogenetic Map3q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,285,763 - 99,285,993 (+)MAPPERmRatBN7.2
Rnor_6.03103,967,369 - 103,967,598NCBIRnor6.0
Rnor_5.03110,561,210 - 110,561,439UniSTSRnor5.0
RGSC_v3.4398,327,727 - 98,327,956UniSTSRGSC3.4
Celera398,271,139 - 98,271,368UniSTS
Cytogenetic Map3q34UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2399,285,375 - 99,286,294 (+)MAPPERmRatBN7.2
Rnor_6.03103,966,981 - 103,967,899NCBIRnor6.0
Rnor_5.03110,560,822 - 110,561,740UniSTSRnor5.0
Celera398,270,751 - 98,271,669UniSTS
Cytogenetic Map3q34UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Low 30 24 8 16 8 2 2 52 7 9 8 2
Below cutoff 2 11 6 6 3 6 6 7 14 1 18 2 6


Reference Sequences
RefSeq Acc Id: ENSRNOT00000008387   ⟹   ENSRNOP00000008387
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl399,284,846 - 99,337,252 (-)Ensembl
Rnor_6.0 Ensembl3103,966,451 - 104,018,861 (-)Ensembl
RefSeq Acc Id: NM_017362   ⟹   NP_059058
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.2399,284,846 - 99,337,252 (-)NCBI
Rnor_6.03103,966,451 - 104,018,815 (-)NCBI
Rnor_5.03110,560,292 - 110,632,938 (-)NCBI
RGSC_v3.4398,326,809 - 98,378,531 (-)RGD
Celera398,270,221 - 98,321,572 (-)RGD
Protein Sequences
Protein RefSeqs NP_059058 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA40658 (Get FASTA)   NCBI Sequence Viewer  
  AAA41572 (Get FASTA)   NCBI Sequence Viewer  
  EDL79805 (Get FASTA)   NCBI Sequence Viewer  
  P08911 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_059058   ⟸   NM_017362
- UniProtKB: P08911 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008387   ⟸   ENSRNOT00000008387

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P08911-F1-model_v2 AlphaFold P08911 1-531 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620027 AgrOrtholog
BioCyc Gene G2FUF-48385 BioCyc
Ensembl Genes ENSRNOG00000006397 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000008387 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000008387 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Musac_Ach_M5_rcpt UniProtKB/Swiss-Prot
  Musac_Ach_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:53949 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Chrm5 PhenoGen
  MUSCARINICR UniProtKB/Swiss-Prot
  MUSCRINICM5R UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt ACM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Chrm5  cholinergic receptor, muscarinic 5    muscarinic acetylcholine receptor M5  Name updated 1299863 APPROVED
2002-08-07 Chrm5  muscarinic acetylcholine receptor M5      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 531 amino acids 724743