Mybpc3 (myosin binding protein C3) - Rat Genome Database

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Gene: Mybpc3 (myosin binding protein C3) Rattus norvegicus
Symbol: Mybpc3
Name: myosin binding protein C3
RGD ID: 1305950
Description: Predicted to enable identical protein binding activity and myosin heavy chain binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction and regulation of striated muscle contraction. Located in striated muscle myosin thick filament. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1MM; familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH acetamide; amphetamine; bisphenol A.
Type: protein-coding
Previously known as: C-protein, cardiac muscle isoform; cardiac MyBP-C; LOC295929; myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
Animal Disease Models  (ISO)
arrhythmogenic right ventricular cardiomyopathy  (ISO)
arrhythmogenic right ventricular dysplasia 1  (ISO)
Brugada syndrome  (ISO)
cardiac amyloidosis  (ISO)
cardiac arrest  (ISO)
Cardiac Conduction Defect  (ISO)
Cardiomegaly  (ISO)
cardiomyopathy  (ISO)
catecholaminergic polymorphic ventricular tachycardia  (ISO)
catecholaminergic polymorphic ventricular tachycardia 1  (ISO)
congenital disorder of glycosylation type IIc  (ISO)
dilated cardiomyopathy  (ISO)
dilated cardiomyopathy 1A  (ISO)
dilated cardiomyopathy 1B  (ISO)
dilated cardiomyopathy 1H  (ISO)
dilated cardiomyopathy 1I  (ISO)
dilated cardiomyopathy 1MM  (ISO)
Dilated Cardiomyopathy with Left Ventricular Noncompaction  (ISO)
Dyspnea  (ISO)
Familial Amyloid Polyneuropathies  (ISO)
familial hypertrophic cardiomyopathy  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
genetic disease  (ISO)
Heart Block  (ISO)
Hirschsprung's disease  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 1  (ISO)
hypertrophic cardiomyopathy 4  (ISO,ISS)
intellectual disability  (ISO)
Isolated Noncompaction of the Ventricular Myocardium  (ISO)
Left Ventricular Hypertrophy  (ISO)
left ventricular noncompaction  (ISO)
Left Ventricular Noncompaction 1  (ISO)
long QT syndrome  (ISO)
neuropathy  (ISO)
nuclear type mitochondrial complex I deficiency 20  (ISO)
Paroxysmal Atrial Fibrillation  (ISO)
peripheral nervous system disease  (ISO)
Sudden Cardiac Death  (ISO)
Sudden Death  (ISO)
sudden infant death syndrome  (ISO)
Sudden Unexpected Nocturnal Death Syndrome  (ISO)
Tachycardia  (ISO)
transthyretin amyloidosis  (ISO)
Ventricular Premature Complexes  (ISO)
Wolff-Parkinson-White syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Functional and spectroscopic studies of a familial hypertrophic cardiomyopathy mutation in Motif X of cardiac myosin binding protein-C. Brown LJ, etal., Eur Biophys J. 2002 Sep;31(5):400-8. Epub 2002 Jun 25.
2. Organization and sequence of human cardiac myosin binding protein C gene (MYBPC3) and identification of mutations predicted to produce truncated proteins in familial hypertrophic cardiomyopathy. Carrier L, etal., Circ Res. 1997 Mar;80(3):427-34.
3. Hypertrophic cardiomyopathy linked to homozygosity for a new mutation in the myosin-binding protein C gene (A627V) suggests a dosage effect. Garcia-Castro M, etal., Int J Cardiol. 2005 Jul 20;102(3):501-7. Epub 2004 Sep 23.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Mutations in the cardiac myosin-binding protein C gene are the predominant cause of familial hypertrophic cardiomyopathy in eastern Finland. Jaaskelainen P, etal., J Mol Med. 2002 Jul;80(7):412-22. Epub 2002 Apr 11.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. Niimura H, etal., N Engl J Med. 1998 Apr 30;338(18):1248-57.
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. Infantile restrictive cardiomyopathy resulting from a mutation in the cardiac troponin T gene. Peddy SB, etal., Pediatrics. 2006 May;117(5):1830-3.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy. Van Driest SL, etal., J Am Coll Cardiol. 2004 Nov 2;44(9):1903-10.
17. MYBPC3 polymorphism is a modifier for expression of cardiac hypertrophy in patients with hypertrophic cardiomyopathy. Wang P, etal., Biochem Biophys Res Commun. 2005 Apr 8;329(2):796-9.
18. Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle. Weisberg A and Winegrad S, Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8999-9003.
Additional References at PubMed
PMID:7493025   PMID:8618961   PMID:9784245   PMID:10024460   PMID:10532952   PMID:10545522   PMID:11815426   PMID:14500336   PMID:15059932   PMID:15472117   PMID:16224063   PMID:16380103  
PMID:16754800   PMID:17075052   PMID:17192269   PMID:17254601   PMID:18201573   PMID:19850579   PMID:21971072   PMID:22527638   PMID:22982234   PMID:25512492   PMID:25583989   PMID:25771144  
PMID:26316108   PMID:27233767   PMID:28315668   PMID:29470978   PMID:30082313   PMID:31308242   PMID:35352799  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8397,550,974 - 97,569,216 (+)NCBIGRCr8
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,573,681 - 80,591,786 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,172,692 - 89,190,793 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,023,927 - 87,042,063 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381147,331,406 - 47,352,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,331,406 - 47,352,702 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,352,957 - 47,374,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,309,533 - 47,330,829 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,309,526 - 47,330,798NCBI
Celera1147,492,237 - 47,513,531 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,052,045 - 47,073,383 (-)NCBIHuRef
CHM1_11147,352,197 - 47,373,500 (-)NCBICHM1_1
T2T-CHM13v2.01147,488,226 - 47,509,533 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39290,948,459 - 90,966,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,948,489 - 90,966,861 (+)EnsemblGRCm39 Ensembl
GRCm38291,118,114 - 91,136,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,118,144 - 91,136,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,958,301 - 90,976,673 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,919,009 - 90,937,348 (+)NCBIMGSCv36mm8
Celera292,502,890 - 92,521,291 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2949,532,715 - 49,553,783 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,552,509 - 49,573,577 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,277,799 - 47,299,102 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,830,605 - 47,851,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,831,087 - 47,851,849 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11842,271,159 - 42,288,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,271,724 - 42,289,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,000,886 - 41,017,318 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,926,187 - 42,943,245 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,926,235 - 43,024,307 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,412,622 - 42,429,047 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,967,840 - 41,984,282 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,697,140 - 42,713,582 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494719,759,573 - 19,778,450 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,871,410 - 1,889,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,871,194 - 1,890,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl215,247,340 - 15,270,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1117,964,581 - 17,986,351 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl117,963,706 - 17,985,758 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038115,266,096 - 115,286,419 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247671,406,587 - 1,420,436 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,406,563 - 1,420,778 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Mybpc3
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:139
Interacting mature miRNAs:153
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,111,683 - 77,112,044 (+)MAPPERmRatBN7.2
Rnor_6.0379,957,009 - 79,957,369NCBIRnor6.0
Rnor_5.0386,665,762 - 86,666,122UniSTSRnor5.0
RGSC_v3.4375,495,029 - 75,495,389UniSTSRGSC3.4
Celera376,319,966 - 76,320,326UniSTS
Cytogenetic Map3q24UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 17
Medium 26 3 8
Low 28 14 16 14 7 8 16 7 18 3 7
Below cutoff 2 12 10 3 10 1 2 11 23 13 1


RefSeq Acc Id: ENSRNOT00000016652   ⟹   ENSRNOP00000016652
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)Ensembl
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104096   ⟹   ENSRNOP00000081300
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,095,741 - 77,113,405 (+)Ensembl
RefSeq Acc Id: NM_001106490   ⟹   NP_001099960
Rat AssemblyChrPosition (strand)Source
GRCr8397,551,061 - 97,569,216 (+)NCBI
mRatBN7.2377,095,252 - 77,113,405 (+)NCBI
Rnor_6.0379,940,561 - 79,958,730 (+)NCBI
Rnor_5.0386,649,264 - 86,667,484 (+)NCBI
RGSC_v3.4375,478,579 - 75,496,750 (+)RGD
Celera376,303,526 - 76,321,687 (+)RGD
RefSeq Acc Id: XM_063283293   ⟹   XP_063139363
Rat AssemblyChrPosition (strand)Source
GRCr8397,550,974 - 97,569,213 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099960 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139363 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL79508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016652
GenBank Protein P56741 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001099960   ⟸   NM_001106490
- UniProtKB: P56741 (UniProtKB/Swiss-Prot),   A0A8I5ZRN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016652   ⟸   ENSRNOT00000016652
RefSeq Acc Id: ENSRNOP00000081300   ⟸   ENSRNOT00000104096
RefSeq Acc Id: XP_063139363   ⟸   XM_063283293
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZRN0 (UniProtKB/TrEMBL),   A0A8L2Q868 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P56741-F1-model_v2 AlphaFold P56741 1-1274 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692207
Promoter ID:EPDNEW_R2732
Type:single initiation site
Description:myosin binding protein C, cardiac
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,940,542 - 79,940,602EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305950 AgrOrtholog
BioCyc Gene G2FUF-48748 BioCyc
Ensembl Genes ENSRNOG00000012307 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016652 ENTREZGENE
  ENSRNOT00000016652.7 UniProtKB/TrEMBL
  ENSRNOT00000104096.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MyBP-C_THB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:295929 UniProtKB/Swiss-Prot
  TITIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mybpc3 PhenoGen
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012307 RatGTEx
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Mybpc3  myosin binding protein C3  Mybpc3  myosin binding protein C, cardiac  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mybpc3  myosin binding protein C, cardiac   Mybpc3_predicted  myosin binding protein C, cardiac (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mybpc3_predicted  myosin binding protein C, cardiac (predicted)      Symbol and Name status set to approved 70820 APPROVED