Mybpc3 (myosin binding protein C3) - Rat Genome Database

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Gene: Mybpc3 (myosin binding protein C3) Rattus norvegicus
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Symbol: Mybpc3
Name: myosin binding protein C3
RGD ID: 1305950
Description: Predicted to enable identical protein binding activity and myosin heavy chain binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction and regulation of striated muscle contraction. Located in striated muscle myosin thick filament. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 4. Orthologous to human MYBPC3 (myosin binding protein C3); PARTICIPATES IN dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH acetamide; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-protein, cardiac muscle isoform; cardiac MyBP-C; LOC295929; myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)Ensembl
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:7493025   PMID:8618961   PMID:9784245   PMID:10024460   PMID:10532952   PMID:10545522   PMID:11815426   PMID:14500336   PMID:15059932   PMID:15472117   PMID:16224063   PMID:16380103  
PMID:16754800   PMID:17075052   PMID:17192269   PMID:17254601   PMID:18201573   PMID:19850579   PMID:21971072   PMID:22527638   PMID:22982234   PMID:25512492   PMID:25583989   PMID:25771144  
PMID:26316108   PMID:27233767   PMID:28315668   PMID:29470978   PMID:30082313   PMID:31308242  


Genomics

Comparative Map Data
Mybpc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2377,095,165 - 77,113,406 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl377,095,252 - 77,113,405 (+)Ensembl
Rnor_6.0379,940,509 - 79,958,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,940,561 - 79,958,730 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,649,264 - 86,667,484 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,478,579 - 75,496,750 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1375,375,715 - 75,394,374 (+)NCBI
Celera376,303,526 - 76,321,687 (+)NCBICelera
Cytogenetic Map3q24NCBI
MYBPC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1147,331,406 - 47,352,702 (-)EnsemblGRCh38hg38GRCh38
GRCh381147,331,406 - 47,352,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371147,352,957 - 47,374,253 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,309,533 - 47,330,829 (-)NCBINCBI36hg18NCBI36
Build 341147,309,526 - 47,330,798NCBI
Celera1147,492,237 - 47,513,531 (-)NCBI
Cytogenetic Map11p11.2NCBI
HuRef1147,052,045 - 47,073,383 (-)NCBIHuRef
CHM1_11147,352,197 - 47,373,500 (-)NCBICHM1_1
Mybpc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,948,459 - 90,966,861 (+)NCBIGRCm39mm39
GRCm39 Ensembl290,948,489 - 90,966,861 (+)Ensembl
GRCm38291,118,114 - 91,136,516 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,118,144 - 91,136,516 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,958,301 - 90,976,673 (+)NCBIGRCm37mm9NCBIm37
MGSCv36290,919,009 - 90,937,348 (+)NCBImm8
Celera292,502,890 - 92,521,291 (+)NCBICelera
Cytogenetic Map2E1NCBI
Mybpc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422888,589 - 901,725 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422888,529 - 902,074 (+)NCBIChiLan1.0ChiLan1.0
MYBPC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11147,830,605 - 47,851,909 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,831,087 - 47,851,849 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01147,277,799 - 47,299,102 (-)NCBIMhudiblu_PPA_v0panPan3
MYBPC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,271,159 - 42,288,782 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1842,271,724 - 42,289,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1841,000,886 - 41,017,318 (+)NCBI
ROS_Cfam_1.01842,926,187 - 42,943,245 (+)NCBI
UMICH_Zoey_3.11842,412,622 - 42,429,047 (+)NCBI
UNSW_CanFamBas_1.01841,967,840 - 41,984,282 (+)NCBI
UU_Cfam_GSD_1.01842,697,140 - 42,713,582 (+)NCBI
Mybpc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,759,573 - 19,778,450 (+)NCBI
SpeTri2.0NW_0049365621,871,194 - 1,890,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYBPC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,247,539 - 15,270,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,247,679 - 15,269,714 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,454,543 - 16,476,408 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MYBPC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,964,581 - 17,986,351 (+)NCBI
ChlSab1.1 Ensembl117,963,706 - 17,985,758 (+)Ensembl
Vero_WHO_p1.0NW_023666038115,266,096 - 115,286,419 (+)NCBI
Mybpc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247671,406,563 - 1,420,778 (+)NCBI

Position Markers
PMC181559P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,111,683 - 77,112,044 (+)MAPPERmRatBN7.2
Rnor_6.0379,957,009 - 79,957,369NCBIRnor6.0
Rnor_5.0386,665,762 - 86,666,122UniSTSRnor5.0
RGSC_v3.4375,495,029 - 75,495,389UniSTSRGSC3.4
Celera376,319,966 - 76,320,326UniSTS
Cytogenetic Map3q24UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight