Mir129-2 (microRNA 129-2) - Rat Genome Database

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Gene: Mir129-2 (microRNA 129-2) Rattus norvegicus
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Symbol: Mir129-2
Name: microRNA 129-2
RGD ID: 2325612
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Predicted to be involved in several processes, including negative regulation of blood vessel endothelial cell migration; negative regulation of vascular endothelial cell proliferation; and negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane. Orthologous to human MIR129-2 (microRNA 129-2); INTERACTS WITH atrazine; cadmium dichloride; 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione (ortholog).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-129-2; rno-mir-129-2
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,657,390 - 100,657,486 (-)NCBIGRCr8
mRatBN7.2380,202,044 - 80,202,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl380,202,044 - 80,202,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,671,967 - 83,672,063 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,271,064 - 92,271,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0390,120,483 - 90,120,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0383,137,297 - 83,137,393 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl383,137,297 - 83,137,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,837,992 - 89,838,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera379,402,824 - 79,402,920 (-)NCBICelera
Cytogenetic Map3q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14691248   PMID:15345052   PMID:16381832   PMID:17604727   PMID:17805466   PMID:20403161   PMID:32481647   PMID:33484421   PMID:35689956  


Genomics

Comparative Map Data
Mir129-2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83100,657,390 - 100,657,486 (-)NCBIGRCr8
mRatBN7.2380,202,044 - 80,202,140 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl380,202,044 - 80,202,140 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx383,671,967 - 83,672,063 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0392,271,064 - 92,271,160 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0390,120,483 - 90,120,579 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0383,137,297 - 83,137,393 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl383,137,297 - 83,137,393 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0389,837,992 - 89,838,088 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera379,402,824 - 79,402,920 (-)NCBICelera
Cytogenetic Map3q31NCBI
MIR129-2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381143,581,394 - 43,581,483 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1143,581,394 - 43,581,483 (+)EnsemblGRCh38hg38GRCh38
GRCh371143,602,944 - 43,603,033 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361143,559,519 - 43,559,608 (+)NCBINCBI36Build 36hg18NCBI36
Celera1143,749,891 - 43,749,980 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1143,313,181 - 43,313,270 (+)NCBIHuRef
CHM1_11143,602,618 - 43,602,707 (+)NCBICHM1_1
T2T-CHM13v2.01143,736,760 - 43,736,849 (+)NCBIT2T-CHM13v2.0
Mir129b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39294,071,723 - 94,071,787 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl294,071,723 - 94,071,787 (+)EnsemblGRCm39 Ensembl
GRCm38294,241,378 - 94,241,442 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl294,241,378 - 94,241,442 (+)EnsemblGRCm38mm10GRCm38
Celera295,637,949 - 95,638,013 (+)NCBICelera
Cytogenetic Map2E1NCBI
MIR129-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11826,154,534 - 26,154,596 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1826,154,534 - 26,154,596 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,841,471 - 25,841,533 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01826,776,334 - 26,776,396 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11826,285,345 - 26,285,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,931,957 - 25,932,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01826,544,065 - 26,544,127 (-)NCBIUU_Cfam_GSD_1.0
MIR129A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl218,724,213 - 18,724,304 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1218,724,220 - 18,724,299 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2220,324,630 - 20,324,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vimrno-miR-129-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:5188
Count of gene targets:3743
Count of transcripts:4039
Interacting mature miRNAs:rno-miR-129-2-3p, rno-miR-129-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)359242096157323038Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)361017749121056321Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)343827364121056321Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)378196190146592722Rat
1581568Rf53Renal function QTL 53urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)356395968161299569Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)373376539118376539Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)347233430110362260Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)36113434889115068Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)350437504115638231Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
631665Bw8Body weight QTL 85.5body mass (VT:0001259)body weight (CMO:0000012)350437042119183768Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)35378111291609953Rat
731180Bp152Blood pressure QTL 1520.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35378111291609953Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)364655305115665732Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)370348525121056321Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)364655305115665732Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system nervous system
High
Medium
Low
Below cutoff 1 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl380,202,044 - 80,202,140 (-)Ensembl
Rnor_6.0 Ensembl383,137,297 - 83,137,393 (-)Ensembl
RefSeq Acc Id: NR_031792
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83100,657,390 - 100,657,486 (-)NCBI
mRatBN7.2380,202,044 - 80,202,140 (-)NCBI
Rnor_6.0383,137,297 - 83,137,393 (-)NCBI
Rnor_5.0389,837,992 - 89,838,088 (-)NCBI
Celera379,402,824 - 79,402,920 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325612 AgrOrtholog
BioCyc Gene G2FUF-48654 BioCyc
Ensembl Genes ENSRNOG00000035542 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053665 ENTREZGENE
miRBase MI0000637 ENTREZGENE
NCBI Gene 100313984 ENTREZGENE
PhenoGen Mir129-2 PhenoGen
RatGTEx ENSRNOG00000035542 RatGTEx
RNAcentral URS000048F59D RNACentral
  URS00004E1410 RNACentral
  URS000075B975 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir129-2  microRNA 129-2  Mir129-2  microRNA mir-129-2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir129-2  microRNA mir-129-2      Symbol and Name status set to provisional 70820 PROVISIONAL