Hax1 (HCLS1 associated protein X-1) - Rat Genome Database

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Gene: Hax1 (HCLS1 associated protein X-1) Rattus norvegicus
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Symbol: Hax1
Name: HCLS1 associated protein X-1
RGD ID: 727960
Description: Enables protein domain specific binding activity. Predicted to be involved in several processes, including granulocyte colony-stimulating factor signaling pathway; positive regulation of nitrogen compound metabolic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in apical plasma membrane; clathrin-coated vesicle; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in severe congenital neutropenia 3. Orthologous to human HAX1 (HCLS1 associated protein X-1); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HAX-1; HCLS1-associated protein X-1; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; Hs1bp1; HSP1BP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,731,918 - 177,735,670 (-)NCBIGRCr8
mRatBN7.22175,434,242 - 175,437,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,434,238 - 175,437,714 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2182,580,384 - 182,584,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,602,762 - 180,606,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,203,701 - 175,207,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,330,900 - 189,333,305 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,330,902 - 189,333,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,762,955 - 208,765,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2169,373,704 - 169,377,128 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8. The anti-apoptotic protein HAX-1 is a regulator of cardiac function. Zhao W, etal., Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20776-81. doi: 10.1073/pnas.0906998106. Epub 2009 Nov 17.
Additional References at PubMed
PMID:9058808   PMID:10760273   PMID:11554782   PMID:14651853   PMID:16516414   PMID:17008324   PMID:19913549   PMID:21136158   PMID:23001182   PMID:24347163   PMID:27654581   PMID:27748880  
PMID:30309497   PMID:32958249  


Genomics

Comparative Map Data
Hax1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82177,731,918 - 177,735,670 (-)NCBIGRCr8
mRatBN7.22175,434,242 - 175,437,926 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2175,434,238 - 175,437,714 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2182,580,384 - 182,584,008 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02180,602,762 - 180,606,385 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02175,203,701 - 175,207,091 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02189,330,900 - 189,333,305 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2189,330,902 - 189,333,322 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02208,762,955 - 208,765,360 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2169,373,704 - 169,377,128 (-)NCBICelera
Cytogenetic Map2q34NCBI
HAX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381154,272,629 - 154,275,875 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1154,272,355 - 154,275,875 (+)EnsemblGRCh38hg38GRCh38
GRCh371154,245,105 - 154,248,351 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361152,511,663 - 152,514,975 (+)NCBINCBI36Build 36hg18NCBI36
Celera1127,316,760 - 127,320,072 (+)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1125,608,714 - 125,612,284 (+)NCBIHuRef
CHM1_11155,641,372 - 155,644,684 (+)NCBICHM1_1
T2T-CHM13v2.01153,409,836 - 153,413,082 (+)NCBIT2T-CHM13v2.0
Hax1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,902,753 - 89,906,023 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,902,753 - 89,906,087 (-)EnsemblGRCm39 Ensembl
GRCm38389,995,446 - 89,998,716 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,995,446 - 89,998,780 (-)EnsemblGRCm38mm10GRCm38
MGSCv37389,799,379 - 89,802,608 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36390,081,384 - 90,084,613 (-)NCBIMGSCv36mm8
Celera390,031,997 - 90,035,226 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.19NCBI
Hax1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955545816,789 - 819,667 (+)NCBIChiLan1.0ChiLan1.0
HAX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2195,558,149 - 95,561,448 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,293,380 - 95,296,608 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01129,627,564 - 129,630,920 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11133,241,077 - 133,244,431 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1133,241,077 - 133,244,431 (+)Ensemblpanpan1.1panPan2
HAX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,969,711 - 42,972,783 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,969,713 - 42,972,710 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha742,460,105 - 42,463,208 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,839,626 - 42,842,730 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,839,626 - 42,842,623 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1742,618,971 - 42,622,074 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0742,672,236 - 42,675,339 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,956,327 - 42,959,430 (-)NCBIUU_Cfam_GSD_1.0
Hax1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505824,931,036 - 24,933,940 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365803,961,441 - 3,964,322 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365803,961,433 - 3,964,322 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl495,467,632 - 95,470,290 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1495,467,629 - 95,470,972 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24104,384,708 - 104,387,371 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1209,537,544 - 9,545,214 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl209,537,525 - 9,545,299 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660388,899,738 - 8,903,169 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hax1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248853,039,256 - 3,042,362 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248853,039,711 - 3,042,702 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hax1
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:57
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000071253, ENSRNOT00000073599
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat

Markers in Region
AW743138  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.02208,764,214 - 208,764,634UniSTSRnor5.0
RGSC_v3.41758,537,056 - 58,537,309UniSTSRGSC3.4
Celera2169,375,982 - 169,376,402UniSTS
Celera1746,405,041 - 46,405,294UniSTS
Celera4151,857,489 - 151,857,743UniSTS
Cytogenetic Map17q12.1UniSTS
RH137230  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2169,373,733 - 169,373,921UniSTS
Cytogenetic Map17q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_181627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY291062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY291063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY291064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY291065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY919342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY919343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ286293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ517605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ517606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ517607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000071253   ⟹   ENSRNOP00000067159
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2175,434,245 - 175,437,376 (-)Ensembl
Rnor_6.0 Ensembl2189,330,902 - 189,333,322 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000073599   ⟹   ENSRNOP00000064877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2175,434,241 - 175,437,714 (-)Ensembl
Rnor_6.0 Ensembl2189,330,902 - 189,333,322 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076325   ⟹   ENSRNOP00000067954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2175,434,238 - 175,437,712 (-)Ensembl
Rnor_6.0 Ensembl2189,330,902 - 189,333,322 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076424   ⟹   ENSRNOP00000068480
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2189,330,902 - 189,333,015 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2189,332,215 - 189,333,279 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000076952   ⟹   ENSRNOP00000068336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2189,330,902 - 189,333,015 (-)Ensembl
RefSeq Acc Id: NM_181627   ⟹   NP_853658
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,342 (-)NCBI
mRatBN7.22175,434,242 - 175,437,666 (-)NCBI
Rnor_6.02189,330,900 - 189,333,305 (-)NCBI
Rnor_5.02208,762,955 - 208,765,360 (-)NCBI
Celera2169,373,704 - 169,377,128 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101865   ⟹   XP_038957793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,175 (-)NCBI
mRatBN7.22175,434,242 - 175,437,504 (-)NCBI
RefSeq Acc Id: XM_039101866   ⟹   XP_038957794
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,175 (-)NCBI
mRatBN7.22175,434,242 - 175,437,514 (-)NCBI
RefSeq Acc Id: XM_039101867   ⟹   XP_038957795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,409 (-)NCBI
mRatBN7.22175,434,242 - 175,437,733 (-)NCBI
RefSeq Acc Id: XM_039101868   ⟹   XP_038957796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,644 (-)NCBI
mRatBN7.22175,434,242 - 175,437,903 (-)NCBI
RefSeq Acc Id: XM_039101869   ⟹   XP_038957797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,175 (-)NCBI
mRatBN7.22175,434,242 - 175,437,511 (-)NCBI
RefSeq Acc Id: XM_039101870   ⟹   XP_038957798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,357 (-)NCBI
mRatBN7.22175,434,242 - 175,437,732 (-)NCBI
RefSeq Acc Id: XM_039101871   ⟹   XP_038957799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,409 (-)NCBI
mRatBN7.22175,434,242 - 175,437,733 (-)NCBI
RefSeq Acc Id: XM_039101872   ⟹   XP_038957800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,656 (-)NCBI
mRatBN7.22175,434,242 - 175,437,926 (-)NCBI
RefSeq Acc Id: XM_063281442   ⟹   XP_063137512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,175 (-)NCBI
RefSeq Acc Id: XM_063281443   ⟹   XP_063137513
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82177,731,918 - 177,735,670 (-)NCBI
RefSeq Acc Id: NP_853658   ⟸   NM_181627
- UniProtKB: Q7TSE7 (UniProtKB/Swiss-Prot),   Q5D1N4 (UniProtKB/Swiss-Prot),   Q5D1N3 (UniProtKB/Swiss-Prot),   Q7TSE8 (UniProtKB/Swiss-Prot),   Q7TSE9 (UniProtKB/Swiss-Prot),   A6J6I5 (UniProtKB/TrEMBL),   B8YDD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064877   ⟸   ENSRNOT00000073599
RefSeq Acc Id: ENSRNOP00000067159   ⟸   ENSRNOT00000071253
RefSeq Acc Id: ENSRNOP00000068336   ⟸   ENSRNOT00000076952
RefSeq Acc Id: ENSRNOP00000067954   ⟸   ENSRNOT00000076325
RefSeq Acc Id: ENSRNOP00000068480   ⟸   ENSRNOT00000076424
RefSeq Acc Id: XP_038957800   ⟸   XM_039101872
- Peptide Label: isoform X9
- UniProtKB: A6J6I6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957796   ⟸   XM_039101868
- Peptide Label: isoform X4
- UniProtKB: B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957799   ⟸   XM_039101871
- Peptide Label: isoform X8
- UniProtKB: B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957795   ⟸   XM_039101867
- Peptide Label: isoform X3
- UniProtKB: B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957798   ⟸   XM_039101870
- Peptide Label: isoform X7
- UniProtKB: A6J6I4 (UniProtKB/TrEMBL),   B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957794   ⟸   XM_039101866
- Peptide Label: isoform X2
- UniProtKB: B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957797   ⟸   XM_039101869
- Peptide Label: isoform X5
- UniProtKB: B8YDD0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957793   ⟸   XM_039101865
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063137513   ⟸   XM_063281443
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063137512   ⟸   XM_063281442
- Peptide Label: isoform X6

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TSE9-F1-model_v2 AlphaFold Q7TSE9 1-278 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691485
Promoter ID:EPDNEW_R2010
Type:single initiation site
Name:Hax1_2
Description:HCLS1 associated protein X-1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2011  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02189,332,911 - 189,332,971EPDNEW
RGD ID:13691502
Promoter ID:EPDNEW_R2011
Type:initiation region
Name:Hax1_1
Description:HCLS1 associated protein X-1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R2010  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02189,333,353 - 189,333,413EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727960 AgrOrtholog
BioCyc Gene G2FUF-52382 BioCyc
Ensembl Genes ENSRNOG00000045647 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055021629 UniProtKB/Swiss-Prot
  ENSRNOG00060028248 UniProtKB/Swiss-Prot
  ENSRNOG00065028381 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071253 UniProtKB/TrEMBL
  ENSRNOT00000071253.4 UniProtKB/Swiss-Prot
  ENSRNOT00000073599 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000073599.4 UniProtKB/Swiss-Prot
  ENSRNOT00000076325.2 UniProtKB/TrEMBL
  ENSRNOT00055037064 UniProtKB/Swiss-Prot
  ENSRNOT00060049313 UniProtKB/Swiss-Prot
  ENSRNOT00065048954 UniProtKB/Swiss-Prot
InterPro HAX-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 291202 ENTREZGENE
PANTHER HCLS1-ASSOCIATED PROTEIN X-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14938 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hax1 PhenoGen
PIRSF HS1-associating_X-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045647 RatGTEx
  ENSRNOG00055021629 RatGTEx
  ENSRNOG00060028248 RatGTEx
  ENSRNOG00065028381 RatGTEx
UniProt A0A096MJ14_RAT UniProtKB/TrEMBL
  A6J6I4 ENTREZGENE, UniProtKB/TrEMBL
  A6J6I5 ENTREZGENE, UniProtKB/TrEMBL
  A6J6I6 ENTREZGENE, UniProtKB/TrEMBL
  B8YDD0 ENTREZGENE, UniProtKB/TrEMBL
  B8YDD1_RAT UniProtKB/TrEMBL
  B8YDD2_RAT UniProtKB/TrEMBL
  HAX1_RAT UniProtKB/Swiss-Prot
  M0R639_RAT UniProtKB/TrEMBL
  M0RC50_RAT UniProtKB/TrEMBL
  Q1XD58_RAT UniProtKB/TrEMBL
  Q5D1N3 ENTREZGENE
  Q5D1N4 ENTREZGENE
  Q7TSE7 ENTREZGENE
  Q7TSE8 ENTREZGENE
  Q7TSE9 ENTREZGENE
UniProt Secondary Q5D1N3 UniProtKB/Swiss-Prot
  Q5D1N4 UniProtKB/Swiss-Prot
  Q7TSE7 UniProtKB/Swiss-Prot
  Q7TSE8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-20 Hax1  HCLS1 associated protein X-1  Hs1bp1  HS1 binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Hs1bp1  HS1 binding protein      Symbol and Name status set to approved 1299863 APPROVED