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Gene: ABCB11 (ATP binding cassette subfamily B member 11) Homo sapiens
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Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
RGD ID: 730944
Description: Exhibits ATPase-coupled bile acid transmembrane transporter activity; ATPase-coupled xenobiotic transmembrane transporter activity; and canalicular bile acid transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; drug export; and drug transmembrane transport. Localizes to apical plasma membrane and cell surface. Implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC member 16, MDR/TAP subfamily; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; bile salt export pump; BRIC2; BSEP; PFIC-2; PFIC2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGP
Orthologs:
Mus musculus (house mouse) : Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11)  MGI  Alliance
Rattus norvegicus (Norway rat) : Abcb11 (ATP binding cassette subfamily B member 11)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Abcb11 (ATP binding cassette subfamily B member 11)
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB11 (ATP binding cassette subfamily B member 11)
Canis lupus familiaris (dog) : ABCB11 (ATP binding cassette subfamily B member 11)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb11 (ATP binding cassette subfamily B member 11)
Sus scrofa (pig) : ABCB11 (ATP binding cassette subfamily B member 11)
Chlorocebus sabaeus (African green monkey) : ABCB11 (ATP binding cassette subfamily B member 11)
Heterocephalus glaber (naked mole-rat) : Abcb11 (ATP binding cassette subfamily B member 11)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2168,915,498 - 169,031,324 (-)EnsemblGRCh38hg38GRCh38
GRCh382168,915,468 - 169,031,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,779,336 - 169,887,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,487,695 - 169,596,079 (-)NCBINCBI36hg18NCBI36
Build 342169,604,955 - 169,713,340NCBI
Celera2163,404,770 - 163,513,162 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,675,981 - 161,784,996 (-)NCBIHuRef
CHM1_12169,785,291 - 169,893,825 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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