ABCB11 (ATP binding cassette subfamily B member 11) - Rat Genome Database

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Gene: ABCB11 (ATP binding cassette subfamily B member 11) Canis lupus familiaris
Analyze
Symbol: ABCB11
Name: ATP binding cassette subfamily B member 11
RGD ID: 12284259
Description: ENCODES a protein that exhibits ABC-type bile acid transporter activity; bile acid transmembrane transporter activity; ABC-type xenobiotic transporter activity (ortholog); INVOLVED IN bile acid and bile salt transport; canalicular bile acid transport; bile acid metabolic process (ortholog); PARTICIPATES IN statin pharmacokinetics pathway; ASSOCIATED WITH alcoholic hepatitis (ortholog); Bardet-Biedl syndrome (ortholog); benign recurrent intrahepatic cholestasis 2 (ortholog); FOUND IN plasma membrane; apical plasma membrane (ortholog); basolateral plasma membrane (ortholog); INTERACTS WITH blebbistatin
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Abcb11e; bile salt export pump; BSEP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,742,895 - 13,835,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,951,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
blebbistatin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:18985798   PMID:20398791   PMID:22301074   PMID:24643070  


Genomics

Comparative Map Data
ABCB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,742,895 - 13,835,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,951,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBIUU_Cfam_GSD_1.0
ABCB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,915,390 - 169,031,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2168,915,498 - 169,031,324 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,777,291 - 169,887,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,487,695 - 169,596,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,604,955 - 169,713,340NCBI
Celera2163,404,770 - 163,513,162 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,675,981 - 161,784,996 (-)NCBIHuRef
CHM1_12169,785,291 - 169,893,825 (-)NCBICHM1_1
T2T-CHM13v2.02169,389,027 - 169,507,061 (-)NCBIT2T-CHM13v2.0
Abcb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,958 (-)EnsemblGRCm39 Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBIMGSCv36mm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
Abcb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8374,424,620 - 74,520,646 (-)NCBIGRCr8
mRatBN7.2354,016,854 - 54,112,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,017,127 - 54,112,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,417,556 - 57,512,821 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0366,001,112 - 66,096,389 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0363,763,287 - 63,858,864 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
Abcb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,412,876 - 5,512,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,412,958 - 5,511,629 (+)NCBIChiLan1.0ChiLan1.0
ABCB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21371,579,415 - 71,699,912 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B71,594,388 - 71,714,885 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B56,199,434 - 56,311,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B173,664,518 - 173,776,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,664,518 - 173,776,379 (-)Ensemblpanpan1.1panPan2
Abcb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,017,599 - 131,107,385 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646910,521,576 - 10,599,005 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646910,521,576 - 10,599,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,402,396 - 75,486,403 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,402,296 - 75,487,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,505,249 - 84,590,184 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,458,283 - 54,575,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,459,377 - 54,575,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,979,703 - 145,077,569 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcb11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,650,772 - 6,733,195 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,653,849 - 6,733,058 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ABCB11
1160 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 32 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000019045   ⟹   ENSCAFP00000017653
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3613,746,964 - 13,823,634 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000048225   ⟹   ENSCAFP00000037796
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000091825   ⟹   ENSCAFP00000054888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3613,746,964 - 13,834,923 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036706   ⟹   ENSCAFP00845028736
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,951,309 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845036897   ⟹   ENSCAFP00845028888
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,940,004 (-)Ensembl
RefSeq Acc Id: NM_001143932   ⟹   NP_001137404
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13613,746,964 - 13,823,634 (-)NCBI
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBI
ROS_Cfam_1.03613,863,310 - 13,940,004 (-)NCBI
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBI
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBI
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038446708   ⟹   XP_038302636
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBI
RefSeq Acc Id: XM_038446709   ⟹   XP_038302637
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03613,859,241 - 13,939,995 (-)NCBI
RefSeq Acc Id: XM_038446710   ⟹   XP_038302638
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03613,859,241 - 13,914,108 (-)NCBI
RefSeq Acc Id: NP_001137404   ⟸   NM_001143932
- UniProtKB: B8K1W2 (UniProtKB/TrEMBL),   A0A8P0NPM9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000037796   ⟸   ENSCAFT00000048225
Ensembl Acc Id: ENSCAFP00000017653   ⟸   ENSCAFT00000019045
Ensembl Acc Id: ENSCAFP00000054888   ⟸   ENSCAFT00000091825
RefSeq Acc Id: XP_038302636   ⟸   XM_038446708
- Peptide Label: isoform X1
- UniProtKB: B8K1W2 (UniProtKB/Swiss-Prot),   A0A8P0NPM9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302637   ⟸   XM_038446709
- Peptide Label: isoform X2
- UniProtKB: A0A8C0JP75 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038302638   ⟸   XM_038446710
- Peptide Label: isoform X3
Ensembl Acc Id: ENSCAFP00845028888   ⟸   ENSCAFT00845036897
Ensembl Acc Id: ENSCAFP00845028736   ⟸   ENSCAFT00845036706
Protein Domains
ABC transmembrane type-1   ABC transporter


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011980 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030022858 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSCAFG00040025705 UniProtKB/TrEMBL
  ENSCAFG00805015093 UniProtKB/Swiss-Prot
  ENSCAFG00845020713 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000019045.6 UniProtKB/TrEMBL
  ENSCAFT00000048225.3 UniProtKB/TrEMBL
  ENSCAFT00030042019.1 UniProtKB/Swiss-Prot
  ENSCAFT00030042065.1 UniProtKB/TrEMBL
  ENSCAFT00030042113.1 UniProtKB/TrEMBL
  ENSCAFT00040047993.1 UniProtKB/TrEMBL
  ENSCAFT00805027499 UniProtKB/Swiss-Prot
  ENSCAFT00845036706 ENTREZGENE
  ENSCAFT00845036706.1 UniProtKB/Swiss-Prot
  ENSCAFT00845036897 ENTREZGENE
  ENSCAFT00845036897.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_1_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report cfa:488390 UniProtKB/Swiss-Prot
NCBI Gene ABCB11 ENTREZGENE
PANTHER ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-BINDING CASSETTE SUB-FAMILY B UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LP14331P UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0JP75 ENTREZGENE
  A0A8C0P5K8_CANLF UniProtKB/TrEMBL
  A0A8C0P8Y0_CANLF UniProtKB/TrEMBL
  A0A8C0Z7A3_CANLF UniProtKB/TrEMBL
  A0A8I3S214_CANLF UniProtKB/TrEMBL
  A0A8P0NPM9 ENTREZGENE, UniProtKB/TrEMBL
  ABCBB_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:37433 ENTREZGENE