Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) - Rat Genome Database

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Gene: Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) Mus musculus
Analyze
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
RGD ID: 730945
MGI Page MGI
Description: Exhibits canalicular bile acid transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; lipid homeostasis; and regulation of lipid metabolic process. Localizes to apical part of cell; intercellular canaliculus; and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC1; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; Bs; Bsep; Lit; Lith1; PFI; PFIC2; PGY; PGY4; sister of P-glycoprotein; SPGP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,960 (-)Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBImm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-glucosiduronic acid  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
acadesine  (ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
alpha-linolenic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amprenavir  (ISO)
angelicin  (ISO)
ANTIMYCIN  (ISO)
arachidonic acid  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atropine  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benziodarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
bosentan  (ISO)
bromfenac  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcein am  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cefaclor  (ISO)
cefalotin  (EXP)
celecoxib  (ISO)
cerivastatin  (ISO)
cetirizine  (EXP)
cetrorelix  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlordiazepoxide  (ISO)
chloroform  (ISO)
chlorohydrocarbon  (ISO)
chlorpromazine  (ISO)
cholate  (ISO)
cholesterol  (EXP)
cholic acid  (EXP,ISO)
choline  (EXP)
chrysophanol  (ISO)
ciglitazone  (ISO)
cinnarizine  (ISO)
ciprofibrate  (EXP)
cisapride  (ISO)
clarithromycin  (ISO)
clofazimine  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
cloxacillin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
danazol  (ISO)
DDE  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydroergotamine  (ISO)
dioscin  (ISO)
dioxygen  (EXP)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (EXP,ISO)
doxycycline  (ISO)
drospirenone  (ISO)
drotaverine  (ISO)
efavirenz  (ISO)
emodin  (EXP,ISO)
enilconazole  (EXP)
epoxiconazole  (ISO)
ergocristine  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
etoricoxib  (ISO)
everolimus  (ISO)
ezetimibe  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
finasteride  (ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
fluvoxamine  (ISO)
folic acid  (EXP)
furan  (EXP,ISO)
fusidic acid  (ISO)
gallocatechin  (ISO)
gefitinib  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (ISO)
glimepiride  (ISO)
glipizide  (ISO)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
Goe 6976  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
ibuprofen  (EXP)
iloperidone  (ISO)
imipenem hydrate  (EXP)
indinavir  (ISO)
indocyanine green  (ISO)
indometacin  (ISO)
irbesartan  (ISO)
isoniazide  (ISO)
Isradipine  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
kynurenic acid  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
latanoprost  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
lopinavir  (ISO)
Loratadine  (ISO)
losartan  (ISO)
lovastatin  (ISO)
Maprotiline  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methoxsalen  (ISO)
methylisothiazolinone  (ISO)
methyltestosterone  (ISO)
Mibefradil  (ISO)
midazolam  (ISO)
Midecamycin  (ISO)
mifepristone  (EXP,ISO)
MK 571  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-nitrosodiethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
neomycin  (EXP)
neratinib  (ISO)
Nicardipine  (ISO)
nifedipine  (ISO)
nitrendipine  (ISO)
nitrofurantoin  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oxybutynin  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
pazopanib  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phalloidin  (ISO)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (EXP)
physcion  (ISO)
Pilsicainide hydrochloride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
posaconazole  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
primidone  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
ranolazine  (ISO)
Repaglinide  (ISO)
reserpine  (ISO)
rifabutin  (ISO)
rifampicin  (ISO)
rifamycin SV  (EXP)
rifapentine  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (ISO)
Salidroside  (EXP)
saquinavir  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silibinin  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
sorafenib  (ISO)
soybean oil  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
stigmasterol  (EXP)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfinpyrazone  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tasosartan  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurodeoxycholic acid  (EXP,ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
telithromycin  (ISO)
telmisartan  (ISO)
Temsirolimus  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
ticlopidine  (ISO)
tinidazole  (ISO)
tipranavir  (ISO)
tolcapone  (ISO)
Tolvaptan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
valrubicin  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (EXP,ISO)
wortmannin  (ISO)
Yangonin  (EXP)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Besheer T, etal., Turk J Gastroenterol. 2018 May;29(3):299-307. doi: 10.5152/tjg.2018.17570.
2. Chen R, etal., Sci Rep. 2016 Jun 13;6:27750. doi: 10.1038/srep27750.
3. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
4. Cusato J, etal., J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. doi: 10.1093/jac/dkx237.
5. Fuchs CD, etal., J Hepatol. 2017 Jan;66(1):95-101. doi: 10.1016/j.jhep.2016.08.017. Epub 2016 Sep 1.
6. Henkel AS, etal., Gastroenterology. 2011 Oct;141(4):1404-11, 1411.e1-2. doi: 10.1053/j.gastro.2011.06.062. Epub 2011 Jul 2.
7. Hirano M, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.
8. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
9. Marrone J, etal., IUBMB Life. 2017 Dec;69(12):978-984. doi: 10.1002/iub.1689. Epub 2017 Oct 31.
10. MGD and Homologene mouse data transfer
11. MGD data from the GO Consortium
12. MGD IEA
13. Monte MJ, etal., Clin Sci (Lond). 2005 Aug;109(2):199-207.
14. M├╝llenbach R, etal., BMC Gastroenterol. 2012 Jun 8;12:63. doi: 10.1186/1471-230X-12-63.
15. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. OMIM Disease Annotation Pipeline
17. Pawlikowska L, etal., J Hepatol. 2010 Jul;53(1):170-8. doi: 10.1016/j.jhep.2010.01.034. Epub 2010 Apr 13.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Stindt J, etal., Liver Int. 2013 Nov;33(10):1527-35. doi: 10.1111/liv.12217. Epub 2013 Jun 12.
23. Strautnieks SS, etal., Nat Genet. 1998 Nov;20(3):233-8.
24. Takahashi T, etal., Hepatol Int. 2018 May;12(3):254-261. doi: 10.1007/s12072-018-9860-3. Epub 2018 Apr 12.
25. Vos TA, etal., Hepatology. 1998 Dec;28(6):1637-44.
26. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
27. Zhang Y, etal., J Biol Chem. 2012 Jul 13;287(29):24784-94. doi: 10.1074/jbc.M111.329318. Epub 2012 May 22.
Additional References at PubMed
PMID:10349636   PMID:10556425   PMID:10607905   PMID:10708515   PMID:11042159   PMID:11074014   PMID:11076861   PMID:11172067   PMID:11208732   PMID:11217851   PMID:11279518   PMID:11682476  
PMID:12068294   PMID:12399219   PMID:12562825   PMID:14570929   PMID:14647060   PMID:14672610   PMID:14681479   PMID:14724752   PMID:15040800   PMID:15349890   PMID:16141072   PMID:16141073  
PMID:16156672   PMID:16341669   PMID:16602821   PMID:16612327   PMID:17897632   PMID:18551070   PMID:19047482   PMID:19228692   PMID:19497955   PMID:19650158   PMID:20398791   PMID:21195347  
PMID:21267068   PMID:21873635   PMID:22057277   PMID:22767443   PMID:23139217   PMID:23200860   PMID:23555939   PMID:23747249   PMID:23764895   PMID:24002920   PMID:24399466   PMID:24643070  
PMID:24729004   PMID:25552583   PMID:25886055   PMID:26416771   PMID:27626380   PMID:29718219   PMID:29850541   PMID:30416103   PMID:31571363   PMID:32785220  


Genomics

Comparative Map Data
Abcb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,960 (-)Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBImm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
ABCB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2168,915,498 - 169,031,324 (-)EnsemblGRCh38hg38GRCh38
GRCh382168,915,468 - 169,031,396 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372169,777,291 - 169,887,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,487,695 - 169,596,079 (-)NCBINCBI36hg18NCBI36
Build 342169,604,955 - 169,713,340NCBI
Celera2163,404,770 - 163,513,162 (-)NCBI
Cytogenetic Map2q31.1NCBI
HuRef2161,675,981 - 161,784,996 (-)NCBIHuRef
CHM1_12169,785,291 - 169,893,825 (-)NCBICHM1_1
Abcb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,016,854 - 54,112,797 (-)NCBI
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
Abcb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,412,876 - 5,512,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,412,958 - 5,511,629 (+)NCBIChiLan1.0ChiLan1.0
ABCB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B173,664,518 - 173,776,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,664,518 - 173,776,379 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,199,434 - 56,311,773 (-)NCBIMhudiblu_PPA_v0panPan3
ABCB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,742,895 - 13,835,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBI
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBI
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBI
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBI
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBI
Abcb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,017,599 - 131,107,385 (-)NCBI
SpeTri2.0NW_00493646910,521,576 - 10,599,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,400,766 - 75,486,403 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,402,296 - 75,487,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,505,249 - 84,590,184 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,458,283 - 54,575,943 (-)NCBI
ChlSab1.1 Ensembl1054,459,377 - 54,575,059 (-)Ensembl
Abcb11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247876,653,849 - 6,733,058 (-)NCBI

Position Markers
D18061  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,238,318 - 69,238,392UniSTSGRCm38
MGSCv37269,076,375 - 69,076,449UniSTSGRCm37
Celera270,904,539 - 70,904,613UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS
Whitehead_YAC2 UniSTS
D2Mit94  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38280,175,610 - 80,175,769UniSTSGRCm38
MGSCv37280,015,767 - 80,015,926UniSTSGRCm37
Celera281,836,072 - 81,836,265UniSTS
cM Map248.1UniSTS
Whitehead Genetic248.1UniSTS
Whitehead/MRC_RH21228.95UniSTS
Whitehead_YAC2 UniSTS
RH125581  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,243,908 - 69,244,056UniSTSGRCm38
MGSCv37269,081,965 - 69,082,113UniSTSGRCm37
Celera270,910,127 - 70,910,275UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS
Abcb11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,238,419 - 69,238,702UniSTSGRCm38
MGSCv37269,076,476 - 69,076,759UniSTSGRCm37
Celera270,904,640 - 70,904,923UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388608993591306Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357829Lvrq1_mliver weight QTL 1 (mouse)Not determined220892967119064359Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220892967119064359Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220892967119064359Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220892967119064359Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220892967119064359Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220892967119064359Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220892967119064359Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22771204884183040Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31324555105313225Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3590731269907394Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3590731269907394Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3590731269907394Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23610166771779068Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)24008165374081799Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240995481115079684Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24193070775930831Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24369026877690412Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4369026877690412Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24369026877690412Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24369026877690412Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24369026877690412Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24436867378368673Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
4141809Pbwg1.1_mpostnatal body weight growth 1.1 (mouse)Not determined4830206882302151Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24830206882302151Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24843940282439590Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24843940282439590Mouse
1302085Mobe1_mmodifier of obesity 1 (mouse)Not determined24843940282439590Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24843940282439590Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174843940282439590Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25098897084988970Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25109283185092934Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25187293285873081Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25261767586617792Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25261767586617792Mouse
4142299Pbwg1.4_mpostnatal body weight growth 1.4 (mouse)Not determined5562407289624172Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25769377391693944Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25808964792089647Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260690268119525037Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26317561097175769Mouse
1301405Etohr_methanol response acute (mouse)Not determined26317561097175769Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26317561097175769Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26317561097175769Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26317561097175769Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26317561097175769Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26373981097739957Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26776159675134589Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267817543101817798Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267817543101817798Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268893925102894063Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268893925102894063Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:954
Count of miRNA genes:271
Interacting mature miRNAs:301
Transcripts:ENSMUST00000102709, ENSMUST00000102710, ENSMUST00000133663, ENSMUST00000180142
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000102709   ⟹   ENSMUSP00000099770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl269,238,289 - 69,342,600 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102710   ⟹   ENSMUSP00000099771
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl269,238,282 - 69,342,614 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl269,238,310 - 69,239,078 (-)Ensembl
RefSeq Acc Id: ENSMUST00000180142   ⟹   ENSMUSP00000137017
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl269,238,289 - 69,342,616 (-)Ensembl
RefSeq Acc Id: NM_001363492   ⟹   NP_001350421
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,626 - 69,172,960 (-)NCBI
GRCm38269,238,282 - 69,342,616 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021022   ⟹   NP_066302
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,626 - 69,172,960 (-)NCBI
GRCm38269,238,282 - 69,342,616 (-)NCBI
MGSCv37269,076,339 - 69,180,673 (-)RGD
Celera270,904,503 - 71,008,403 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499670   ⟹   XP_006499733
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,634 - 69,122,253 (-)NCBI
GRCm38269,238,282 - 69,291,909 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_066302   ⟸   NM_021022
- UniProtKB: Q9QY30 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499733   ⟸   XM_006499670
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001350421   ⟸   NM_001363492
RefSeq Acc Id: ENSMUSP00000099771   ⟸   ENSMUST00000102710
RefSeq Acc Id: ENSMUSP00000099770   ⟸   ENSMUST00000102709
RefSeq Acc Id: ENSMUSP00000137017   ⟸   ENSMUST00000180142
Promoters
RGD ID:6830667
Promoter ID:MM_KWN:29538
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000102709,   NM_021022
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,180,506 - 69,181,006 (-)MPROMDB
RGD ID:6877494
Promoter ID:EPDNEW_M2197
Type:initiation region
Name:Abcb11_1
Description:Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38269,342,614 - 69,342,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351619 AgrOrtholog
Ensembl Genes ENSMUSG00000027048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000099770 UniProtKB/Swiss-Prot
  ENSMUSP00000099771 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000137017 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102709 UniProtKB/Swiss-Prot
  ENSMUST00000102710 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000180142 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BSEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27413 UniProtKB/Swiss-Prot
MGD MGI:1351619 ENTREZGENE
NCBI Gene 27413 ENTREZGENE
PANTHER PTHR24221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24221:SF165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCB11 RGD
PhenoGen Abcb11 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ABCBB_MOUSE UniProtKB/Swiss-Prot
  J3QNY6_MOUSE UniProtKB/TrEMBL
  Q9JL39_MOUSE UniProtKB/TrEMBL
  Q9QY30 ENTREZGENE
UniProt Secondary A2AUN4 UniProtKB/Swiss-Prot
  Q9QZE8 UniProtKB/Swiss-Prot