Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) - Rat Genome Database

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Gene: Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) Mus musculus
Analyze
Symbol: Abcb11
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11
RGD ID: 730945
MGI Page MGI
Description: Enables canalicular bile acid transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; lipid homeostasis; and regulation of lipid metabolic process. Located in apical part of cell; intercellular canaliculus; and plasma membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ABC1; ABC16; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; Bs; Bsep; Lit; Lith1; PFI; PFIC2; PGY; PGY4; sister of P-glycoprotein; SPGP
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,960 (-)EnsemblGRCm39 Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBIMGSCv36mm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-colchicine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]-2-(4-chlorophenoxy)ethanone  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-estradiol 3-glucosiduronic acid  (ISO)
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
8-Br-cAMP  (ISO)
8-Epidiosbulbin E acetate  (EXP)
acadesine  (EXP,ISO)
acetamide  (ISO)
aflatoxin B1  (EXP,ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (EXP)
alpha-linolenic acid  (ISO)
amiodarone  (ISO)
amitriptyline  (ISO)
amprenavir  (ISO)
angelicin  (ISO)
ANTIMYCIN  (ISO)
arachidonic acid  (ISO)
astemizole  (ISO)
atazanavir sulfate  (ISO)
atenolol  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
atropine  (ISO)
Augmentin  (ISO)
azathioprine  (ISO)
benzbromarone  (ISO)
benziodarone  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-hexachlorocyclohexane  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Boldine  (ISO)
bosentan  (ISO)
bromfenac  (ISO)
bucladesine  (ISO)
budesonide  (ISO)
buta-1,3-diene  (EXP)
cadmium dichloride  (ISO)
calcein am  (EXP)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (EXP)
cefaclor  (ISO)
cefalotin  (EXP)
celecoxib  (ISO)
cerivastatin  (ISO)
cetirizine  (EXP)
cetrorelix  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chlordiazepoxide  (ISO)
chloroform  (ISO)
chlorpromazine  (ISO)
cholate  (ISO)
cholesterol  (EXP)
cholic acid  (EXP,ISO)
choline  (EXP)
chrysophanol  (ISO)
ciglitazone  (ISO)
cinnarizine  (ISO)
ciprofibrate  (EXP)
cisapride  (ISO)
clarithromycin  (ISO)
clavulanic acid  (ISO)
clofazimine  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clotrimazole  (ISO)
cloxacillin  (ISO)
clozapine  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (ISO)
danazol  (ISO)
DDE  (EXP,ISO)
dehydroepiandrosterone sulfate  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP)
diclofenac  (ISO)
dicloxacillin  (ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dihydroergotamine  (ISO)
dioscin  (ISO)
dioxygen  (EXP)
dipyridamole  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dobutamine  (ISO)
dorsomorphin  (EXP,ISO)
doxycycline  (ISO)
drospirenone  (ISO)
drotaverine  (ISO)
efavirenz  (ISO)
emodin  (EXP,ISO)
enilconazole  (EXP)
epoxiconazole  (ISO)
ergocristine  (ISO)
erythromycin A  (ISO)
erythromycin estolate  (ISO)
ethanol  (ISO)
etoricoxib  (ISO)
everolimus  (ISO)
ezetimibe  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (EXP,ISO)
finasteride  (ISO)
flucloxacillin  (ISO)
flutamide  (ISO)
fluvastatin  (ISO)
fluvoxamine  (ISO)
folic acid  (EXP)
fulvestrant  (ISO)
furan  (EXP,ISO)
fusidic acid  (ISO)
gallocatechin  (ISO)
gefitinib  (ISO)
gentamycin  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (EXP,ISO)
glafenine  (ISO)
glimepiride  (ISO)
glipizide  (ISO)
glyburide  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
Goe 6976  (ISO)
guggulsterone  (EXP,ISO)
GW 4064  (EXP,ISO)
Heliotrine  (ISO)
ibuprofen  (EXP)
iloperidone  (ISO)
imipenem hydrate  (EXP)
indinavir  (ISO)
indocyanine green  (ISO)
indometacin  (ISO)
irbesartan  (ISO)
isoniazide  (ISO)
Isradipine  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
kynurenic acid  (ISO)
L-methionine  (EXP)
lapatinib  (ISO)
Lasiocarpine  (ISO)
latanoprost  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (EXP,ISO)
lopinavir  (ISO)
loratadine  (ISO)
losartan  (ISO)
lovastatin  (ISO)
Maprotiline  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methimazole  (ISO)
methoxsalen  (ISO)
methylisothiazolinone  (ISO)
methyltestosterone  (ISO)
Mibefradil  (ISO)
midazolam  (ISO)
Midecamycin  (ISO)
mifepristone  (EXP,ISO)
MK 571  (ISO)
morin  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-amino-6-[(4-fluorophenyl)methylamino]-3-pyridinyl]carbamic acid ethyl ester  (ISO)
N-nitrosodiethylamine  (ISO)
naproxen  (ISO)
nefazodone  (ISO)
nelfinavir  (ISO)
neomycin  (EXP)
neratinib  (ISO)
nicardipine  (ISO)
nifedipine  (ISO)
nitrendipine  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
O-methyleugenol  (ISO)
obeticholic acid  (EXP,ISO)
ochratoxin A  (ISO)
octreotide  (ISO)
ofloxacin  (ISO)
olanzapine  (ISO)
oleanolic acid  (EXP)
oleic acid  (ISO)
olmesartan  (ISO)
Olmesartan medoxomil  (ISO)
oltipraz  (ISO)
omeprazole  (ISO)
oxybutynin  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parathion  (EXP)
pazopanib  (ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (ISO)
phalloidin  (ISO)
phenobarbital  (EXP,ISO)
phosphatidylcholine  (EXP)
physcion  (ISO)
Picroside ii  (EXP)
Pilsicainide hydrochloride  (ISO)
pimecrolimus  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
pitavastatin  (ISO)
pitavastatin(1-)  (ISO)
posaconazole  (ISO)
potassium dichromate  (EXP)
pravastatin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
primaquine  (ISO)
primidone  (ISO)
prochloraz  (ISO)
progesterone  (ISO)
psoralen  (ISO)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
ranolazine  (ISO)
Repaglinide  (ISO)
reserpine  (ISO)
rifabutin  (ISO)
rifampicin  (ISO)
rifamycin SV  (EXP)
rifapentine  (ISO)
ritonavir  (ISO)
rosuvastatin calcium  (ISO)
Salidroside  (EXP)
saquinavir  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silibinin  (ISO)
simvastatin  (ISO)
simvastatin hydroxy acid  (ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium dichromate  (ISO)
sorafenib  (ISO)
soybean oil  (ISO)
spironolactone  (ISO)
staurosporine  (ISO)
stigmasterol  (EXP)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfinpyrazone  (ISO)
Sunset Yellow FCF  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tasosartan  (ISO)
taurine  (ISO)
tauro-beta-muricholic acid  (ISO)
taurochenodeoxycholic acid  (EXP,ISO)
taurocholic acid  (EXP,ISO)
taurodeoxycholic acid  (EXP,ISO)
taurolithocholic acid  (ISO)
tauroursodeoxycholic acid  (ISO)
telithromycin  (ISO)
telmisartan  (ISO)
Temsirolimus  (ISO)
Terfenadine  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (ISO)
ticlopidine  (ISO)
tinidazole  (ISO)
tipranavir  (ISO)
tolcapone  (ISO)
tolvaptan  (ISO)
trichloroethene  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
triptonide  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valinomycin  (ISO)
valproic acid  (EXP,ISO)
valrubicin  (ISO)
vancomycin  (EXP)
vincaleukoblastine  (EXP,ISO)
vitamin E  (ISO)
wortmannin  (ISO)
Yangonin  (EXP)
zafirlukast  (ISO)
zidovudine  (ISO)
zinc acetate  (EXP)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Diagnosis of cirrhosis in patients with chronic hepatitis C genotype 4: Role of ABCB11 genotype polymorphism and plasma bile acid levels. Besheer T, etal., Turk J Gastroenterol. 2018 May;29(3):299-307. doi: 10.5152/tjg.2018.17570.
2. Role of polymorphic bile salt export pump (BSEP, ABCB11) transporters in anti-tuberculosis drug-induced liver injury in a Chinese cohort. Chen R, etal., Sci Rep. 2016 Jun 13;6:27750. doi: 10.1038/srep27750.
3. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. Crocenzi FA, etal., Am J Physiol Gastrointest Liver Physiol. 2003 Aug;285(2):G449-59. Epub 2003 Apr 17.
4. Influence of ABCB11 and HNF4α genes on daclatasvir plasma concentration: preliminary pharmacogenetic data from the Kineti-C study. Cusato J, etal., J Antimicrob Chemother. 2017 Oct 1;72(10):2846-2849. doi: 10.1093/jac/dkx237.
5. Metabolic preconditioning protects BSEP/ABCB11-/- mice against cholestatic liver injury. Fuchs CD, etal., J Hepatol. 2017 Jan;66(1):95-101. doi: 10.1016/j.jhep.2016.08.017. Epub 2016 Sep 1.
6. Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice. Henkel AS, etal., Gastroenterology. 2011 Oct;141(4):1404-11, 1411.e1-2. doi: 10.1053/j.gastro.2011.06.062. Epub 2011 Jul 2.
7. Bile salt export pump (BSEP/ABCB11) can transport a nonbile acid substrate, pravastatin. Hirano M, etal., J Pharmacol Exp Ther. 2005 Aug;314(2):876-82. Epub 2005 May 18.
8. Role of AMP-activated protein kinase α1 in 17α-ethinylestradiol-induced cholestasis in rats. Li X, etal., Arch Toxicol. 2017 Jan;91(1):481-494. doi: 10.1007/s00204-016-1697-8. Epub 2016 Apr 18.
9. Adenovirus-mediated human aquaporin-1 expression in hepatocytes improves lipopolysaccharide-induced cholestasis. Marrone J, etal., IUBMB Life. 2017 Dec;69(12):978-984. doi: 10.1002/iub.1689. Epub 2017 Oct 31.
10. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
11. MGDs mouse GO annotations MGD data from the GO Consortium
12. MGD IEA MGD IEA
13. Changes in the expression of genes related to bile acid synthesis and transport by the rat liver during hepatocarcinogenesis. Monte MJ, etal., Clin Sci (Lond). 2005 Aug;109(2):199-207.
14. A frequent variant in the human bile salt export pump gene ABCB11 is associated with hepatitis C virus infection, but not liver stiffness in a German population. Müllenbach R, etal., BMC Gastroenterol. 2012 Jun 8;12:63. doi: 10.1186/1471-230X-12-63.
15. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. Differences in presentation and progression between severe FIC1 and BSEP deficiencies. Pawlikowska L, etal., J Hepatol. 2010 Jul;53(1):170-8. doi: 10.1016/j.jhep.2010.01.034. Epub 2010 Apr 13.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. Mouse MP Annotation Import Pipeline RGD automated import pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. A novel mutation within a transmembrane helix of the bile salt export pump (BSEP, ABCB11) with delayed development of cirrhosis. Stindt J, etal., Liver Int. 2013 Nov;33(10):1527-35. doi: 10.1111/liv.12217. Epub 2013 Jun 12.
23. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Strautnieks SS, etal., Nat Genet. 1998 Nov;20(3):233-8.
24. Tsumura-Suzuki obese diabetic mice-derived hepatic tumors closely resemble human hepatocellular carcinomas in metabolism-related genes expression and bile acid accumulation. Takahashi T, etal., Hepatol Int. 2018 May;12(3):254-261. doi: 10.1007/s12072-018-9860-3. Epub 2018 Apr 12.
25. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Vos TA, etal., Hepatology. 1998 Dec;28(6):1637-44.
26. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
27. Abcb11 deficiency induces cholestasis coupled to impaired β-fatty acid oxidation in mice. Zhang Y, etal., J Biol Chem. 2012 Jul 13;287(29):24784-94. doi: 10.1074/jbc.M111.329318. Epub 2012 May 22.
Additional References at PubMed
PMID:10349636   PMID:10556425   PMID:10607905   PMID:10708515   PMID:11042159   PMID:11074014   PMID:11076861   PMID:11172067   PMID:11208732   PMID:11217851   PMID:11279518   PMID:11682476  
PMID:12068294   PMID:12399219   PMID:12562825   PMID:14570929   PMID:14647060   PMID:14672610   PMID:14681479   PMID:14724752   PMID:15040800   PMID:15349890   PMID:16141072   PMID:16141073  
PMID:16156672   PMID:16341669   PMID:16602821   PMID:16612327   PMID:17897632   PMID:18551070   PMID:19047482   PMID:19228692   PMID:19497955   PMID:19650158   PMID:20398791   PMID:21195347  
PMID:21267068   PMID:21873635   PMID:22057277   PMID:22767443   PMID:23139217   PMID:23200860   PMID:23555939   PMID:23747249   PMID:23764895   PMID:24002920   PMID:24399466   PMID:24643070  
PMID:24729004   PMID:25552583   PMID:25886055   PMID:26416771   PMID:26926046   PMID:27626380   PMID:29718219   PMID:29850541   PMID:30416103   PMID:31571363   PMID:32141703   PMID:32785220  
PMID:34410012   PMID:34774795  


Genomics

Comparative Map Data
Abcb11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39269,068,626 - 69,172,960 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl269,068,626 - 69,172,960 (-)EnsemblGRCm39 Ensembl
GRCm38269,238,282 - 69,342,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl269,238,282 - 69,342,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv37269,076,339 - 69,180,673 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36269,039,121 - 69,143,426 (-)NCBIMGSCv36mm8
Celera270,904,503 - 71,008,403 (-)NCBICelera
Cytogenetic Map2C2NCBI
cM Map239.69NCBI
ABCB11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382168,915,390 - 169,031,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2168,915,498 - 169,031,324 (-)EnsemblGRCh38hg38GRCh38
GRCh372169,777,291 - 169,887,834 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362169,487,695 - 169,596,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 342169,604,955 - 169,713,340NCBI
Celera2163,404,770 - 163,513,162 (-)NCBICelera
Cytogenetic Map2q31.1NCBI
HuRef2161,675,981 - 161,784,996 (-)NCBIHuRef
CHM1_12169,785,291 - 169,893,825 (-)NCBICHM1_1
T2T-CHM13v2.02169,395,271 - 169,507,061 (-)NCBIT2T-CHM13v2.0
Abcb11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2354,016,854 - 54,112,797 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl354,017,127 - 54,112,730 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx357,417,556 - 57,512,821 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0366,001,112 - 66,096,389 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0363,763,287 - 63,858,864 (-)NCBIRnor_WKY
Rnor_6.0355,480,024 - 55,587,946 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl355,480,024 - 55,587,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0362,091,490 - 62,092,502 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0362,106,821 - 62,195,528 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera353,579,155 - 53,674,029 (-)NCBICelera
Cytogenetic Map3q21NCBI
Abcb11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554495,412,876 - 5,512,701 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554495,412,958 - 5,511,629 (+)NCBIChiLan1.0ChiLan1.0
ABCB11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B173,664,518 - 173,776,233 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B173,664,518 - 173,776,379 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B56,199,434 - 56,311,773 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ABCB11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13613,742,895 - 13,835,312 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3613,746,964 - 13,834,974 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3613,757,951 - 13,834,638 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03613,859,241 - 13,951,551 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3613,861,592 - 13,951,309 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13613,948,052 - 14,024,630 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03613,935,894 - 14,012,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03614,048,864 - 14,125,753 (-)NCBIUU_Cfam_GSD_1.0
Abcb11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303131,017,599 - 131,107,385 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646910,521,576 - 10,599,005 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCB11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1575,402,396 - 75,486,403 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11575,402,296 - 75,487,092 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21584,505,249 - 84,590,184 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCB11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11054,458,283 - 54,575,943 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1054,459,377 - 54,575,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040144,979,703 - 145,077,569 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcb11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247876,650,772 - 6,733,195 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247876,653,849 - 6,733,058 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D18061  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,238,318 - 69,238,392UniSTSGRCm38
MGSCv37269,076,375 - 69,076,449UniSTSGRCm37
Celera270,904,539 - 70,904,613UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS
Whitehead_YAC2 UniSTS
D2Mit94  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38280,175,610 - 80,175,769UniSTSGRCm38
MGSCv37280,015,767 - 80,015,926UniSTSGRCm37
Celera281,836,072 - 81,836,265UniSTS
cM Map248.1UniSTS
Whitehead Genetic248.1UniSTS
Whitehead/MRC_RH21228.95UniSTS
Whitehead_YAC2 UniSTS
RH125581  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,243,908 - 69,244,056UniSTSGRCm38
MGSCv37269,081,965 - 69,082,113UniSTSGRCm37
Celera270,910,127 - 70,910,275UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS
Abcb11  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38269,238,419 - 69,238,702UniSTSGRCm38
MGSCv37269,076,476 - 69,076,759UniSTSGRCm37
Celera270,904,640 - 70,904,923UniSTS
Cytogenetic Map2C2UniSTS
cM Map238.4UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301769Orgwq2_morgan weight QTL 2 (mouse)Not determined2388712693421651Mouse
1357881Estoq1_membryo survival total QTL 1 (mouse)Not determined220897778118894840Mouse
1357454Kidq1_mkidney weight QTL 1 (mouse)Not determined220897778118894840Mouse
1357436Splq1_mspleen weight QTL 1 (mouse)Not determined220897778118894840Mouse
39128209Lwq14_mliver weight QTL 14 (mouse)220897778118894840Mouse
1558899Egq1_mearly growth QTL 1 (mouse)Not determined220897778118894840Mouse
1558966W10q9_mweight 10 weeks QTL 9 (mouse)Not determined220897778118894840Mouse
1558915W3q1_mweight 3 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1558738W6q1_mweight 6 weeks QTL 1 (mouse)Not determined220897778118894840Mouse
1357681Hrtq1_mheart weight QTL 1 (mouse)Not determined220897778118894840Mouse
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
1300577Capsq1_mcapsaicin sensitivity related QTL 1 (mouse)Not determined22760206084013384Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
4141236Hbnr5_mHeligmosomoides bakeri nematode resistance 5 (mouse)Not determined31214567105143570Mouse
4142447Pbwg1.7_mpostnatal body weight growth 1.7 (mouse)Not determined3579732469797406Mouse
4141186Pbwg1.8_mpostnatal body weight growth 1.8 (mouse)Not determined3579732469797406Mouse
4142133Pbwg1.6_mpostnatal body weight growth 1.6 (mouse)Not determined3579732469797406Mouse
1559001Eae33_mexperimental allergic encephalomyelitis susceptibility 33 (mouse)Not determined23599167971609412Mouse
11038703Ltpr1_mLeishmania tropica response 1 (mouse)23997166573971811Mouse
1301109Dntcs2_mdental caries susceptibility 2 (mouse)Not determined240885493114910165Mouse
1301480Pbwg1_mpostnatal body weight growth 1 (mouse)Not determined24182071975820843Mouse
4141069Pbwg1.5_mpostnatal body weight growth 1.5 (mouse)Not determined4352061277520756Mouse
1300788Cia2_mcollagen induced arthritis QTL 2 (mouse)Not determined24352061277520756Mouse
1300671Cia4_mcollagen induced arthritis QTL 4 (mouse)Not determined24352061277520756Mouse
1301402Ap2q_malcohol preference 2 QTL (mouse)Not determined24352061277520756Mouse
1301411Pitm1_mprion incubation time 1 (mouse)Not determined24352061277520756Mouse
10755532Lymph5_mlymphocyte differential 5 (mouse)24419901778199017Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
11532740Pbwg1.10_mpostnatal body weight growth 1.10 (mouse)24813241282132495Mouse
1558820Moo1_mmodifier of Odc1 (mouse)Not determined174826974682269934Mouse
1301747Eae21_mexperimental allergic encephalomyelitis 21 (mouse)Not determined24826974682269934Mouse
1301235Alcw4_malcohol withdrawal 4 (mouse)Not determined24826974682269934Mouse
1300568Hdl1_mhigh density lipoprotein (HDL) level 1 (mouse)Not determined24826974682269934Mouse
10755526Lymph1_mlymphocyte differential 1 (mouse)25081931484819314Mouse
1300875Taste1_mtaste-saccharin preference 1 (mouse)Not determined25092317584923278Mouse
1300761Lgth1_mbody length 1 (mouse)Not determined25170327685703425Mouse
13464141Hbbcq3_mhemoglobin concentration QTL 3 (mouse)25244801986448136Mouse
13463471Hctq6_mhematocrit QTL 6 (mouse)25244801986448136Mouse
4141406Alpq2_malcohol preference QTL 2 (mouse)Not determined25752411791524288Mouse
12738429Lfibq18_mliver fibrosis QTL 18 (mouse)25791999191919991Mouse
13432184Actdes1_mactivity chamber total difference ethanol/saline 1 (mouse)25939228769292287Mouse
13432174Actres5_mactivity response to ethanol/saline 5 (mouse)25989228769792287Mouse
1357577Trmq3_mT cell ratio modifier QTL 3 (mouse)Not determined260520612119355518Mouse
13432178Actres2_mactivity response to ethanol/saline 2 (mouse)26069228774092287Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
10044002Hdl7_mHDL level 7 (mouse)Not determined26300595497006113Mouse
10053681Lith24_mlithogenic gene 24 (mouse)Not determined26300595497006113Mouse
1301405Etohr_methanol response acute (mouse)Not determined26300595497006113Mouse
1301703Bomd3_mbone mineral density 3 (mouse)Not determined26300595497006113Mouse
1300662Etohila_methanol induced locomotor activity (mouse)Not determined26300595497006113Mouse
1301048Actre2_mactivity response to ethanol 2 (mouse)Not determined26300595497006113Mouse
1301873Hsl1_mhyperoxia susceptibility locus 1 (mouse)Not determined26357015497570301Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
1301059Hrtfm1_mheart failure modifier 1 (mouse)Not determined26759194074964933Mouse
1301660Iba1_minduction of brown adipocytes 1 (mouse)Not determined267647887101648142Mouse
13463482Mchq17_mmean corpuscular hemoglobin QTL 17 (mouse)267647887101648142Mouse
1301882Etohc2_methanol consumption 2 (mouse)Not determined268724269102724407Mouse
1301948Elsgp3_melevated serum gp70 3 (mouse)Not determined268724269102724407Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:954
Count of miRNA genes:271
Interacting mature miRNAs:301
Transcripts:ENSMUST00000102709, ENSMUST00000102710, ENSMUST00000133663, ENSMUST00000180142
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000102709   ⟹   ENSMUSP00000099770
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,068,633 - 69,172,944 (-)Ensembl
GRCm38.p6 Ensembl269,238,289 - 69,342,600 (-)Ensembl
RefSeq Acc Id: ENSMUST00000102710   ⟹   ENSMUSP00000099771
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,068,626 - 69,172,958 (-)Ensembl
GRCm38.p6 Ensembl269,238,282 - 69,342,614 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133663
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,068,654 - 69,069,422 (-)Ensembl
GRCm38.p6 Ensembl269,238,310 - 69,239,078 (-)Ensembl
RefSeq Acc Id: ENSMUST00000180142   ⟹   ENSMUSP00000137017
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl269,068,633 - 69,172,960 (-)Ensembl
GRCm38.p6 Ensembl269,238,289 - 69,342,616 (-)Ensembl
RefSeq Acc Id: NM_001363492   ⟹   NP_001350421
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,626 - 69,172,960 (-)NCBI
GRCm38269,238,282 - 69,342,616 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021022   ⟹   NP_066302
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,626 - 69,172,960 (-)NCBI
GRCm38269,238,282 - 69,342,616 (-)NCBI
MGSCv37269,076,339 - 69,180,673 (-)RGD
Celera270,904,503 - 71,008,403 (-)RGD
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006499670   ⟹   XP_006499733
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39269,068,634 - 69,122,253 (-)NCBI
GRCm38269,238,282 - 69,291,909 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_066302   ⟸   NM_021022
- UniProtKB: Q9QZE8 (UniProtKB/Swiss-Prot),   Q9QY30 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006499733   ⟸   XM_006499670
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001350421   ⟸   NM_001363492
- UniProtKB: Q9QZE8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSMUSP00000099771   ⟸   ENSMUST00000102710
RefSeq Acc Id: ENSMUSP00000099770   ⟸   ENSMUST00000102709
RefSeq Acc Id: ENSMUSP00000137017   ⟸   ENSMUST00000180142
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY30-F1-model_v2 AlphaFold Q9QY30 1-1321 view protein structure

Promoters
RGD ID:6830667
Promoter ID:MM_KWN:29538
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:ENSMUST00000102709,   NM_021022
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36269,180,506 - 69,181,006 (-)MPROMDB
RGD ID:6877494
Promoter ID:EPDNEW_M2197
Type:initiation region
Name:Abcb11_1
Description:Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member11 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38269,342,614 - 69,342,674EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1351619 AgrOrtholog
Ensembl Genes ENSMUSG00000027048 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000099770 UniProtKB/Swiss-Prot
  ENSMUSP00000099771 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000137017 ENTREZGENE
  ENSMUSP00000137017.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000102709 UniProtKB/Swiss-Prot
  ENSMUST00000102710 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000180142 ENTREZGENE
  ENSMUST00000180142.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BSEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:27413 UniProtKB/Swiss-Prot
MGD MGI:1351619 ENTREZGENE
NCBI Gene 27413 ENTREZGENE
PANTHER PTHR24221 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24221:SF165 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCB11 RGD
PhenoGen Abcb11 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt ABCBB_MOUSE UniProtKB/Swiss-Prot
  J3QNY6_MOUSE UniProtKB/TrEMBL
  Q9JL39_MOUSE UniProtKB/TrEMBL
  Q9QY30 ENTREZGENE
  Q9QZE8 ENTREZGENE
UniProt Secondary A2AUN4 UniProtKB/Swiss-Prot
  Q9QZE8 UniProtKB/Swiss-Prot