GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcb11 | increases expression | EXP | | 6480464 | CTD | Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA; Chenodeoxycholic Acid results in increased expression of ABCB11 protein | PMID:27743861 | Abcb11 | multiple interactions | EXP | | 6480464 | CTD | Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]] | PMID:27743861 | Abcb11 | decreases expression | ISO | Abcb11 (Mus musculus) | 6480464 | CTD | Chenodeoxycholic Acid results in decreased expression of ABCB11 mRNA | PMID:25582706 | Abcb11 | increases expression | ISO | ABCB11 (Homo sapiens) | 6480464 | CTD | Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA; Chenodeoxycholic Acid results in increased expression of ABCB11 protein | PMID:12519787 PMID:12525500 PMID:14684751 PMID:16423920 PMID:19072826 PMID:22178739 PMID:22291955 PMID:25055961 PMID:26241054 PMID:27174168 PMID:32294204 | Abcb11 | increases expression | ISO | Abcb11 (Mus musculus) | 6480464 | CTD | Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA | PMID:22961653 | Abcb11 | multiple interactions | ISO | ABCB11 (Homo sapiens) | 6480464 | CTD | 7-hydroxytheonellasterol inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]; [Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of ABCB11 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Acetaminophen] results in decreased expression of ABCB11 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid co-treated with Triclosan] results in increased expression of ABCB11 mRNA; [Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in increased expression of ABCB11 mRNA; [pregna-4,17-diene-3,16-dione co-treated with Chenodeoxycholic Acid] results in increased expression of ABCB11 mRNA; Copper Sulfate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]; epigallocatechin gallate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]; LG 100268 inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]; Zinc Sulfate inhibits the reaction [Copper Sulfate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]] | PMID:12519787 PMID:12525500 PMID:17963371 PMID:22178739 PMID:22291955 PMID:26241054 PMID:32152650 PMID:33819548 | Abcb11 | multiple interactions | ISO | Abcb11 (Mus musculus) | 6480464 | CTD | Chenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 mRNA]; Chenodeoxycholic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCB11 protein]; Chenodeoxycholic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of ABCB11 mRNA]; epiallopregnanolone sulfate inhibits the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA]; NR1H4 protein promotes the reaction [Chenodeoxycholic Acid results in increased expression of ABCB11 mRNA] | PMID:22961653 PMID:25747392 PMID:32976922 | |
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