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Gene: Slc10a1 (solute carrier family 10 member 1) Rattus norvegicus
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Symbol: Slc10a1
Name: solute carrier family 10 member 1
RGD ID: 3681
Description: Exhibits bile acid:sodium symporter activity. Involved in several processes, including bile acid and bile salt transport; regulation of bile acid secretion; and response to 17alpha-ethynylestradiol. Localizes to basolateral plasma membrane. Biomarker of alcoholic hepatitis; cholestasis; and obesity. Orthologous to human SLC10A1 (solute carrier family 10 member 1); PARTICIPATES IN bile acid signaling pathway; bile acid transport pathway; INTERACTS WITH (+)-schisandrin B; (-)-epigallocatechin 3-gallate; 1-benzylpiperazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; NA-dependent cholate transporting protein; Ntcp; Ntcp1; SBACT; sodium-dependent bile acid cotransporter; sodium-dependent taurocholate cotransporting polypeptide; sodium/bile acid cotransporter; sodium/taurocholate cotransporting polypeptide; solute carrier family 10 (sodium/bile acid cotransporter family) member 1; Solute carrier family 10 (sodium/bile acid cotransporter family), member 1; solute carrier family 10 (sodium/bile acid cotransporter), member 1; solute carrier family 10, member 1
Orthologs:
Homo sapiens (human) : SLC10A1 (solute carrier family 10 member 1)  HGNC  Alliance
Mus musculus (house mouse) : Slc10a1 (solute carrier family 10 (sodium/bile acid cotransporter family), member 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc10a1 (solute carrier family 10 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC10A1 (solute carrier family 10 member 1)
Canis lupus familiaris (dog) : SLC10A1 (solute carrier family 10 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc10a1 (solute carrier family 10 member 1)
Sus scrofa (pig) : SLC10A1 (solute carrier family 10 member 1)
Chlorocebus sabaeus (African green monkey) : SLC10A1 (solute carrier family 10 member 1)
Heterocephalus glaber (naked mole-rat) : Slc10a1 (solute carrier family 10 member 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.06104,617,730 - 104,631,355 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6104,617,730 - 104,631,355 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06112,782,934 - 112,796,559 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46104,735,839 - 104,749,464 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.16104,739,294 - 104,752,920 (-)NCBI
Celera698,468,708 - 98,482,340 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Slc10a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3681
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.