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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3681
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc10a1
Name: solute carrier family 10 member 1
Acc ID: CHEBI:76607
Term: macitentan
Definition: A member of the class of sulfamides in which the two amino groups of sulfonamide are substituted by 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl and propyl groups. An orphan drug used for the treatment of pulmonary arterial hypertension.
Chemical ID: MESH:C533860
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc10a1decreases expressionISORGD:7371746480464CTDmacitentan results in decreased expression of SLC10A1 mRNAPMID:28369585
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