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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3681
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc10a1
Name: solute carrier family 10 member 1
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc10a1decreases expressionEXP 6480464CTDEmodin results in decreased expression of SLC10A1 mRNA; Emodin results in decreased expression of SLC10A1 proteinPMID:28161596
Slc10a1multiple interactionsISOSlc10a1 (Mus musculus)6480464CTDEmodin inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of SLC10A1 mRNA]PMID:30517764
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