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Gene: Gcsh (glycine cleavage system protein H) Rattus norvegicus
Symbol: Gcsh
Name: glycine cleavage system protein H
RGD ID: 619946
Description: Exhibits aminomethyltransferase activity and enzyme binding activity. Involved in glycine decarboxylation via glycine cleavage system. Localizes to mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human GCSH (glycine cleavage system protein H); PARTICIPATES IN folate cycle metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: glycine cleavage system H protein, mitochondrial; glycine cleavage system protein H (aminomethyl carrier); MGC108603
Homo sapiens (human) : GCSH (glycine cleavage system protein H)  HGNC  Alliance
Mus musculus (house mouse) : Gcsh (glycine cleavage system protein H (aminomethyl carrier))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gcsh (glycine cleavage system protein H)
Pan paniscus (bonobo/pygmy chimpanzee) : GCSH (glycine cleavage system protein H)
Canis lupus familiaris (dog) : GCSH (glycine cleavage system protein H)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gcsh (glycine cleavage system protein H)
Sus scrofa (pig) : GCSH (glycine cleavage system protein H)
Chlorocebus sabaeus (African green monkey) : GCSH (glycine cleavage system protein H)
Heterocephalus glaber (naked mole-rat) : Gcsh (glycine cleavage system protein H)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01949,522,054 - 49,532,811 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1949,522,054 - 49,532,811 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01960,313,300 - 60,324,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41947,091,226 - 47,101,983 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11947,096,114 - 47,106,831 (-)NCBI
Celera1944,309,198 - 44,319,954 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Gcsh
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619946
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.