No known orthologs.
Symbol:
Slco1a1
Name:
solute carrier organic anion transporter family, member 1a1
RGD ID:
3700
Description:
Enables organic anion transmembrane transporter activity. Involved in organic anion transport and response to testosterone. Located in membrane. Biomarker of Dubin-Johnson syndrome and primary biliary cholangitis. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2); INTERACTS WITH testosterone.
Type:
protein-coding
RefSeq Status:
VALIDATED
Previously known as:
OATP-1; Oatp1; organic anion-transporting polypeptide 1; Slc21a1; Slc21a3; sodium-independent organic anion transporter 1; solute carrier family (organic anion transporter) member 1; solute carrier family (organic anion transporter) member 3; solute carrier family 21 member 1; solute carrier family 21, member 1; solute carrier organic anion transporter family member 1A1; solute carrier organic anion transporter family member 1A1-like
RGD Orthologs
Alliance Orthologs
More Info
homologs ...
More Info
Latest Assembly:
GRCr8 - GRCr8 Assembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCr8 4 176,606,924 - 176,682,027 (-) NCBI GRCr8 mRatBN7.2 4 174,877,045 - 174,950,900 (-) NCBI mRatBN7.2 mRatBN7.2 mRatBN7.2 Ensembl 4 174,876,593 - 174,950,873 (-) Ensembl mRatBN7.2 Ensembl UTH_Rnor_SHR_Utx 4 181,171,932 - 181,245,799 (-) NCBI Rnor_SHR UTH_Rnor_SHR_Utx UTH_Rnor_SHRSP_BbbUtx_1.0 4 176,956,227 - 177,030,092 (-) NCBI Rnor_SHRSP UTH_Rnor_SHRSP_BbbUtx_1.0 UTH_Rnor_WKY_Bbb_1.0 4 175,576,756 - 175,650,620 (-) NCBI Rnor_WKY UTH_Rnor_WKY_Bbb_1.0 Rnor_6.0 4 176,158,174 - 176,231,331 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 4 176,158,640 - 176,231,344 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 4 240,374,352 - 240,447,509 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.1 4 179,739,781 - 179,773,529 (-) NCBI Celera 4 163,412,182 - 163,485,720 (-) NCBI Celera Cytogenetic Map 4 q44 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
1.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.
Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.
Gender difference in the Oatp1-mediated tubular reabsorption of estradiol 17beta-D-glucuronide in rats.
Gotoh Y, etal., Am J Physiol Endocrinol Metab 2002 Jun;282(6):E1245-54.
3.
Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina.
Ito A, etal., Invest Ophthalmol Vis Sci 2002 Mar;43(3):858-63.
4.
Expression cloning of a rat liver Na(+)-independent organic anion transporter.
Jacquemin E, etal., Proc Natl Acad Sci U S A 1994 Jan 4;91(1):133-7.
5.
Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats.
Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
6.
Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters.
Leuthold S, etal., Am J Physiol Cell Physiol. 2009 Mar;296(3):C570-82. doi: 10.1152/ajpcell.00436.2008. Epub 2009 Jan 7.
7.
Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2.
Meng LJ, etal., Hepatology 2002 May;35(5):1031-40.
8.
Rat ISS GO annotations from MGI mouse gene data--August 2006
MGD data from the GO Consortium
9.
Electronic Transfer of LocusLink and RefSeq Data
NCBI rat LocusLink and RefSeq merged data July 26, 2002
10.
Magnetic resonance imaging with hepatospecific contrast agents in cirrhotic rat livers.
Planchamp C, etal., Invest Radiol. 2005 Apr;40(4):187-94.
11.
GOA pipeline
RGD automated data pipeline
12.
ClinVar Automated Import and Annotation Pipeline
RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.
Data Import for Chemical-Gene Interactions
RGD automated import pipeline for gene-chemical interactions
14.
Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models.
Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
.
Predicted Target Of
Count of predictions: 59 Count of miRNA genes: 54 Interacting mature miRNAs: 55 Transcripts: ENSRNOT00000049154 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
6478754 Anxrr43 Anxiety related response QTL 43 0.14035 locomotor behavior trait (VT:0001392) distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493) 4 144639524 182687754 Rat 1576316 Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 3.8 pituitary gland mass (VT:0010496) pituitary gland wet weight (CMO:0000853) 4 83428419 177635233 Rat 2303623 Vencon2 Ventilatory control QTL 2 3.8 respiration trait (VT:0001943) minute ventilation (CMO:0000132) 4 135204660 180204660 Rat 724558 Plsm2 Polydactyly-luxate syndrome (PLS) morphotypes QTL 2 0.0003 hindlimb integrity trait (VT:0010563) hind foot phalanges count (CMO:0001949) 4 132422778 177422778 Rat 6478693 Anxrr32 Anxiety related response QTL 32 0.00092 locomotor behavior trait (VT:0001392) measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957) 4 144639524 182687754 Rat 1578674 Bmd12 Bone mineral density QTL 12 3.8 femur mineral mass (VT:0010011) compact volumetric bone mineral density (CMO:0001730) 4 135699135 180699135 Rat 1331738 Bp209 Blood pressure QTL 209 2.979 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 4 138503169 179293946 Rat 6478700 Anxrr33 Anxiety related response QTL 33 0.00896 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 4 144639524 182687754 Rat 634342 Cia24 Collagen induced arthritis QTL 24 4.5 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 4 146565735 175236377 Rat 10053718 Scort25 Serum corticosterone level QTL 25 2.15 0.0097 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 4 155561574 182687754 Rat 1549827 Scl46 Serum cholesterol level QTL 46 3.5 blood cholesterol amount (VT:0000180) serum total cholesterol level (CMO:0000363) 4 132396220 177396220 Rat 2293659 Bmd35 Bone mineral density QTL 35 4.5 0.0001 femur strength trait (VT:0010010) femoral neck ultimate force (CMO:0001703) 4 137755016 181392681 Rat 10401796 Kidm48 Kidney mass QTL 48 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 4 145568712 182687754 Rat 6478718 Anxrr34 Anxiety related response QTL 34 0.00896 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 4 144639524 182687754 Rat 2316958 Gluco58 Glucose level QTL 58 10 blood glucose amount (VT:0000188) blood glucose level (CMO:0000046) 4 11320076 180699135 Rat 6478748 Anxrr42 Anxiety related response QTL 42 0.28008 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 4 144639524 182687754 Rat 1300109 Rf13 Renal function QTL 13 3.91 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 4 157710145 182687754 Rat
D4Rat288
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 4 175,181,600 - 175,181,807 (+) MAPPER mRatBN7.2 Rnor_6.0 4 176,455,129 - 176,455,335 NCBI Rnor6.0 Rnor_5.0 4 240,670,233 - 240,670,439 UniSTS Rnor5.0 RGSC_v3.4 4 179,799,414 - 179,799,620 UniSTS RGSC3.4 Celera 4 163,714,632 - 163,714,838 UniSTS FHH x ACI Map 4 111.32 UniSTS FHH x ACI Map 4 111.32 RGD Cytogenetic Map 4 q44 UniSTS
PMC19316P1
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 4 174,877,453 - 174,877,836 (+) MAPPER mRatBN7.2 mRatBN7.2 4 175,072,367 - 175,072,751 (+) MAPPER mRatBN7.2 Rnor_6.0 4 176,345,896 - 176,346,279 NCBI Rnor6.0 Rnor_6.0 4 176,158,583 - 176,158,965 NCBI Rnor6.0 Rnor_5.0 4 240,560,748 - 240,561,131 UniSTS Rnor5.0 Rnor_5.0 4 240,374,761 - 240,375,143 UniSTS Rnor5.0 RGSC_v3.4 4 179,431,605 - 179,431,987 UniSTS RGSC3.4 RGSC_v3.4 4 179,688,414 - 179,688,797 UniSTS RGSC3.4 Celera 4 163,606,297 - 163,606,680 UniSTS Celera 4 163,412,591 - 163,412,973 UniSTS Cytogenetic Map 4 q44 UniSTS
RH139685
Rat Assembly Chr Position (strand) Source JBrowse mRatBN7.2 4 174,975,217 - 174,975,415 (+) MAPPER mRatBN7.2 Rnor_6.0 4 176,255,699 - 176,255,896 NCBI Rnor6.0 Rnor_5.0 4 240,471,877 - 240,472,074 UniSTS Rnor5.0 RGSC_v3.4 4 179,552,760 - 179,552,957 UniSTS RGSC3.4 Celera 4 163,510,075 - 163,510,272 UniSTS RH 3.4 Map 4 1043.4 UniSTS Cytogenetic Map 4 q44 UniSTS
Click on a value in the shaded box below the category label to view a detailed expression data table for that system.
alimentary part of gastrointestinal system
6
7
8
45
77
76
47
16
47
6
141
44
25
37
34
29
Too many to show, limit is 500. Download them if you would like to view them all.
Ensembl Acc Id:
ENSRNOT00000049154 ⟹ ENSRNOP00000040752
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 4 174,879,496 - 174,950,873 (-) Ensembl Rnor_6.0 Ensembl 4 176,158,640 - 176,231,344 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000102966 ⟹ ENSRNOP00000078030
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 4 174,876,593 - 174,950,873 (-) Ensembl
Ensembl Acc Id:
ENSRNOT00000114721 ⟹ ENSRNOP00000084066
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source mRatBN7.2 Ensembl 4 174,876,593 - 174,928,079 (-) Ensembl
RefSeq Acc Id:
NM_017111 ⟹ NP_058807
RefSeq Status:
VALIDATED
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 4 176,608,139 - 176,681,992 (-) NCBI mRatBN7.2 4 174,877,045 - 174,950,900 (-) NCBI Rnor_6.0 4 176,158,174 - 176,231,331 (-) NCBI Rnor_5.0 4 240,374,352 - 240,447,509 (-) NCBI Celera 4 163,412,182 - 163,485,720 (-) RGD
Sequence:
CATGAGTGTACTTCTCTCTTGGCTAAGAAAGACAGCAAAGCAAAGACTTTTAAAGCGAAGAAGCTGGAAACAATCAGAAGAACACCATGGAAGAAACAGAGAAAAAGATTGCAACACAAGAGGGTAGA
hide sequence
RefSeq Acc Id:
XM_063286619 ⟹ XP_063142689
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 4 176,606,924 - 176,682,027 (-) NCBI
RefSeq Acc Id:
XM_063286620 ⟹ XP_063142690
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 4 176,611,644 - 176,682,008 (-) NCBI
RefSeq Acc Id:
XM_063286621 ⟹ XP_063142691
Type:
CODING
Position:
Rat Assembly Chr Position (strand) Source GRCr8 4 176,608,839 - 176,682,008 (-) NCBI
RefSeq Acc Id:
NP_058807 ⟸ NM_017111
- UniProtKB:
P46720 (UniProtKB/Swiss-Prot), A6IMP9 (UniProtKB/TrEMBL), A0A8I5ZY22 (UniProtKB/TrEMBL)
- Sequence:
MEETEKKIATQEGRLFSKMKVFLLSLTCACLTKSLSGVYMNSMLTQIERQFDISTSVAGLINGSFEIGNLFFIVFVSYFGTKLHRPVVIGIGCVIMGLGCLLMSLPHFFMGRYEYETTISPTGNLSSN
hide sequence
Ensembl Acc Id:
ENSRNOP00000040752 ⟸ ENSRNOT00000049154
Ensembl Acc Id:
ENSRNOP00000078030 ⟸ ENSRNOT00000102966
Ensembl Acc Id:
ENSRNOP00000084066 ⟸ ENSRNOT00000114721
RefSeq Acc Id:
XP_063142689 ⟸ XM_063286619
- Peptide Label:
isoform X1
- UniProtKB:
P46720 (UniProtKB/Swiss-Prot), A6IMP9 (UniProtKB/TrEMBL), A0A8I5ZY22 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063142691 ⟸ XM_063286621
- Peptide Label:
isoform X3
- UniProtKB:
A0A8L2QM78 (UniProtKB/TrEMBL)
RefSeq Acc Id:
XP_063142690 ⟸ XM_063286620
- Peptide Label:
isoform X2
- UniProtKB:
A0A8L2QM78 (UniProtKB/TrEMBL)
RGD ID: 13693482 Promoter ID: EPDNEW_R4005 Type: initiation region Name: Slco1a1_1 Description: solute carrier organic anion transporter family, member 1a1 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/ ) Experiment Methods: Single-end sequencing. Position: Rat Assembly Chr Position (strand) Source Rnor_6.0 4 176,231,361 - 176,231,421 EPDNEW
Date
Current Symbol
Current Name
Previous Symbol
Previous Name
Description
Reference
Status
2006-10-28
Slco1a1
solute carrier organic anion transporter family, member 1a1
Slc21a1
solute carrier family 21, member 1
Symbol and Name updated to reflect Human and Mouse nomenclature
1299863 APPROVED
2002-06-10
Slc21a1
solute carrier family 21, member 1
Name updated
70584 APPROVED
Note Type
Note
Reference
gene_cellular_localization
localized at the sinusoidal plasma membrane of the liver and at the apical plasma membrane of the kidney in the S3 segment of the proximal tubule of the outer medulla
625763
gene_expression
expression altered in response to certain types of liver damage
70249
gene_expression
expressed in the retina
70527
gene_expression
expressed in kidney with the expression level 20% (one-fifth) less in female than in male rats
625763
gene_process
involved in tubular reabsorption (urinary clearance) of estradiol 17b-D-glucuronide which is 250-fold higher in females compared with males
625763
gene_regulation
expression is mediated by the level of testosterone
625763
