A2m (alpha-2-macroglobulin) - Rat Genome Database

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Gene: A2m (alpha-2-macroglobulin) Rattus norvegicus
Analyze
Symbol: A2m
Name: alpha-2-macroglobulin
RGD ID: 2004
Description: Exhibits endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and luteinization. Localizes to extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A2m1; A2maa; A2MAC1; A2mb; AI893533; alpha-2-M; alpha-2-macroglobulin-like; alpha-2-macroglobulin-P; LOC100911545; Mam; MGC114358; RATA2MAC1
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   Plsm2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24154,897,770 - 154,947,787 (+)NCBI
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
(S)-amphetamine  (EXP)
1-methylphenanthrene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-aminohexanoate  (ISO)
6-aminohexanoic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
7-NITROINDAZOLE  (EXP)
Actein  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antimony(0)  (ISO)
apigenin  (EXP)
arsenous acid  (ISO)
bacitracin  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
carbonyl sulfide  (EXP)
chlorohydrocarbon  (EXP)
cholate  (EXP)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
furan  (EXP)
gemcitabine  (ISO)
genistein  (ISO)
glafenine  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
irinotecan  (EXP)
isoniazide  (EXP)
isoprenaline  (ISO)
isotretinoin  (ISO)
ketoconazole  (EXP)
lead diacetate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
melamine  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (EXP)
N(6),N(6)-dimethyladenine  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP,ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
olanzapine  (ISO)
orphenadrine  (EXP)
ouabain  (ISO)
paracetamol  (EXP)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
pirinixic acid  (EXP,ISO)
potassium bromate  (ISO)
prednisone  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrogallol  (ISO)
rac-lactic acid  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sirolimus  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
streptozocin  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
tauroursodeoxycholic acid  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
vinclozolin  (EXP)
XL147  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

References

References - curated
1. Anbalagan K and Sadique J, Biochem Med. 1984 Apr;31(2):236-45.
2. Andrejko KM, etal., Am J Physiol. 1998 Dec;275(6 Pt 1):G1423-9.
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4. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
5. Bhanushali AA, etal., Eur J Haematol 2002 Jan;68(1):42-8.
6. Blacker D, etal., Nat Genet 1998 Aug;19(4):357-60.
7. Budovsky A, etal., J Vector Borne Dis. 2007 Jun;44(2):128-36.
8. Chen D, etal., J Neurol Sci. 2004 Jan 15;217(1):13-5.
9. Dasu MR, etal., Gene. 2004 Feb 18;327(1):51-60.
10. Dow DJ, etal., Nat Genet 1999 May;22(1):16-7; author reply 21-2.
11. Fletcher S, etal., Eur J Biochem. 1988 Feb 1;171(3):703-9.
12. Gaddy-Kurten D, etal., Endocrinology. 1989 Dec;125(6):2985-95.
13. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Gebicke-Haerter PJ, etal., J Neurochem. 1987 Oct;49(4):1139-45.
15. Gehring MR, etal., J Biol Chem 1987 Jan 5;262(1):446-54.
16. GOA data from the GO Consortium
17. Gori AM, etal., J Cereb Blood Flow Metab. 2017 Sep;37(9):3253-3261. doi: 10.1177/0271678X17695572. Epub 2017 Mar 7.
18. Hirschelmann R, etal., Agents Actions. 1980 Nov;10(5):431-4.
19. Hsieh YC, etal., Shock. 2004 Jun;21(6):549-55.
20. Hunter N, etal., Immunology. 1991 May;73(1):58-63.
21. KEGG
22. Kendrick JE, etal., Gynecol Oncol. 2008 Mar;108(3):591-7. Epub 2008 Jan 4.
23. Kerachian MA, etal., Arthritis Res Ther. 2010;12(3):R124. doi: 10.1186/ar3062. Epub 2010 Jun 25.
24. Kurokawa S, etal., Cell Struct Funct. 1987 Feb;12(1):35-42.
25. Laulederkind SJ, etal., Database (Oxford). 2012 Mar 20;2012:bas016. Print 2012.
26. Lyoumi S, etal., J Nutr. 1998 Feb;128(2):166-74.
27. MGD data from the GO Consortium
28. Moreau ME, etal., J Pharmacol Sci. 2005 Sep;99(1):6-38.
29. NCBI rat LocusLink and RefSeq merged data July 26, 2002
30. Nieuwenhuizen W, etal., Biochim Biophys Acta. 1979 Sep 29;580(1):129-39.
31. Northemann W, etal., Biochemistry 1988 Dec 27;27(26):9194-203.
32. Northemann W, etal., J Biol Chem 1985 May 25;260(10):6200-5.
33. OMIM Disease Annotation Pipeline
34. Petri V, etal., Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011.
35. Pipeline to import KEGG annotations from KEGG into RGD
36. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. Poller W, etal., Hum Genet 1989 Aug;83(1):93-6.
38. Qiu Z, etal., J Biol Chem 2002 Apr 26;277(17):14458-66.
39. Rajan S, etal., Basic Res Cardiol 2003 Feb;98(1):39-49.
40. Ramlall V, etal., Nat Med. 2020 Aug 3. pii: 10.1038/s41591-020-1021-2. doi: 10.1038/s41591-020-1021-2.
41. RGD automated data pipeline
42. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
43. RGD automated import pipeline for gene-chemical interactions
44. RGD comprehensive gene curation
45. Saunders AJ, etal., Hum Mol Genet. 2003 Nov 1;12(21):2765-76. Epub 2003 Sep 9.
46. Schweer D, etal., J Neuroimmunol 2001 Aug 30;118(2):300-3.
47. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
48. Shibata N, etal., Neurosci Lett. 2000 Aug 25;290(2):154-6.
49. Shimizu M, etal., Exp Anim. 2002 Jul;51(4):361-5.
50. Skornicka EL, etal., J Neurosci Res. 2002 Feb 1;67(3):346-53.
51. Soman S, etal., Exp Toxicol Pathol. 2013 Jan;65(1-2):91-5. doi: 10.1016/j.etp.2011.06.005. Epub 2011 Jul 13.
52. Spiridonov VK and Tolochko ZS, Bull Exp Biol Med. 2008 Sep;146(3):375-8.
53. Stevenson FT, etal., Kidney Int. 1998 Jan;53(1):67-75.
54. Subbiah R, etal., Heart Lung Circ. 2010 Feb;19(2):93-5. doi: 10.1016/j.hlc.2009.10.005. Epub 2009 Dec 11.
55. Sukata T, etal., Am J Pathol 2004 Nov;165(5):1479-88.
56. Tang G, etal., Neurosci Lett. 2002 Aug 9;328(2):195-7.
57. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
58. Tsuchiya Y, etal., Gene 1987;57(1):73-80.
59. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
60. van Vugt H, etal., Br J Exp Pathol. 1986 Jun;67(3):313-9.
61. van Vugt H, etal., Br J Exp Pathol. 1988 Aug;69(4):577-88.
62. van Westrhenen R, etal., Perit Dial Int. 2006 Jan-Feb;26(1):101-7.
63. Widder RA, etal., Transfus Sci. 1999 Dec;21(3):201-6.
Additional References at PubMed
PMID:1725450   PMID:2414291   PMID:2466233   PMID:2473946   PMID:9398211   PMID:9714181   PMID:10880251   PMID:11435418   PMID:12223092   PMID:12477932   PMID:12538697   PMID:15226301  
PMID:15272003   PMID:15489334   PMID:17071617   PMID:17487688   PMID:17565389   PMID:18485748   PMID:18701465   PMID:19796622   PMID:20458337   PMID:20848291   PMID:21188621   PMID:21362503  
PMID:21642630   PMID:21669904   PMID:22516433   PMID:23376485   PMID:23533145   PMID:26746007   PMID:26895739   PMID:27301375   PMID:29476059  


Genomics

Candidate Gene Status
A2m is a candidate Gene for QTL Plsm2
A2m is a candidate Gene for QTL Bp353
Comparative Map Data
A2m
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24154,897,770 - 154,947,787 (+)NCBI
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
A2M
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl129,067,664 - 9,116,229 (-)EnsemblGRCh38hg38GRCh38
GRCh38129,067,708 - 9,116,229 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37129,220,304 - 9,268,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36129,111,571 - 9,159,825 (-)NCBINCBI36hg18NCBI36
Build 34129,111,576 - 9,159,754NCBI
Celera1210,757,430 - 10,805,676 (-)NCBI
Cytogenetic Map12p13.31NCBI
HuRef129,000,837 - 9,049,088 (-)NCBIHuRef
CHM1_1129,189,284 - 9,237,532 (-)NCBICHM1_1
A2m
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396121,612,920 - 121,656,197 (+)NCBIGRCm39mm39
GRCm39 Ensembl6121,612,335 - 121,656,186 (+)Ensembl
GRCm386121,636,165 - 121,679,238 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6121,635,376 - 121,679,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv376121,586,191 - 121,629,256 (+)NCBIGRCm37mm9NCBIm37
MGSCv366121,593,574 - 121,644,846 (+)NCBImm8
MGSCv366122,445,338 - 122,497,328 (+)NCBImm8
Celera6123,474,284 - 123,517,770 (+)NCBICelera
Cytogenetic Map6F1NCBI
cM Map657.49NCBI
LOC102021956
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554136,019,082 - 6,062,529 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554136,019,457 - 6,062,366 (+)NCBIChiLan1.0ChiLan1.0
LOC477699
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12736,654,328 - 36,695,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha279,920,641 - 9,962,291 (-)NCBI
ROS_Cfam_1.02737,002,478 - 37,044,674 (+)NCBI
UMICH_Zoey_3.12736,883,699 - 36,925,608 (+)NCBI
UNSW_CanFamBas_1.02736,918,717 - 36,960,000 (+)NCBI
UU_Cfam_GSD_1.0279,452,043 - 9,493,920 (-)NCBI
LOC101959212
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494598,303,198 - 98,346,620 (+)NCBI
SpeTri2.0NW_004936870424,832 - 468,303 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
A2M
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl562,438,017 - 62,485,537 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1562,406,928 - 62,483,690 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2565,274,903 - 65,320,342 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Position Markers
D4Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,902,669 - 154,902,892 (+)MAPPER
Rnor_6.04154,314,020 - 154,314,242NCBIRnor6.0
Rnor_6.04154,427,762 - 154,427,984NCBIRnor6.0
Rnor_5.04221,510,881 - 221,511,103UniSTSRnor5.0
Rnor_5.04221,397,827 - 221,398,049UniSTSRnor5.0
RGSC_v3.44158,108,304 - 158,108,528RGDRGSC3.4
RGSC_v3.44158,108,305 - 158,108,527UniSTSRGSC3.4
RGSC_v3.14158,353,240 - 158,353,464RGD
Celera4143,736,074 - 143,736,296UniSTS
Celera4143,734,692 - 143,736,296UniSTS
RH 3.4 Map4997.54RGD
RH 3.4 Map4997.54UniSTS
RH 2.0 Map41012.9RGD
Cytogenetic Map4q42UniSTS
D4Wox16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,896,195 - 154,896,338 (+)MAPPER
Rnor_6.04154,421,288 - 154,421,430NCBIRnor6.0
Rnor_6.04154,307,546 - 154,307,688NCBIRnor6.0
Rnor_5.04221,504,407 - 221,504,549UniSTSRnor5.0
Rnor_5.04221,391,353 - 221,391,495UniSTSRnor5.0
RGSC_v3.44158,101,830 - 158,101,973RGDRGSC3.4
RGSC_v3.44158,101,831 - 158,101,973UniSTSRGSC3.4
RGSC_v3.14158,346,766 - 158,346,909RGD
Celera4143,728,315 - 143,728,457UniSTS
RH 3.4 Map4997.91UniSTS
RH 3.4 Map4997.91RGD
Cytogenetic Map4q42UniSTS
D4Arb15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24154,896,113 - 154,896,328 (+)MAPPER
Rnor_6.04154,307,464 - 154,307,678NCBIRnor6.0
Rnor_6.04154,421,206 - 154,421,420NCBIRnor6.0
Rnor_5.04221,391,271 - 221,391,485UniSTSRnor5.0
Rnor_5.04221,504,325 - 221,504,539UniSTSRnor5.0
RGSC_v3.44158,101,748 - 158,101,963RGDRGSC3.4
RGSC_v3.44158,101,749 - 158,101,963UniSTSRGSC3.4
RGSC_v3.14158,346,684 - 158,346,899RGD
Celera4143,728,233 - 143,728,447UniSTS
RH 3.4 Map4997.5UniSTS
RH 3.4 Map4997.5RGD
RH 2.0 Map4989.4RGD
SHRSP x BN Map475.9499RGD
Cytogenetic Map4q42UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61446Coreg2Compensatory renal growth QTL 23.5kidney mass (VT:0002707)compensatory renal growth score (CMO:0001894)4147274055157294090Rat
61451Ciaa4CIA Autoantibody QTL 43.1blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)4125884464168047091Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4117926139162926139Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4131834282176834282Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4136351734180689124Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4108876717169215811Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4105971071168047091Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)463537179157286626Rat
631683Bp116Blood pressure QTL 1160.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4123111827168111827Rat
737978Pia23Pristane induced arthritis QTL 235.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4116726724157291438Rat
1582237Kidm34Kidney mass QTL 3440.0001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)4146942075168998263Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)458640017154427984Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)458640017154427984Rat
631511Pia7Pristane induced arthritis QTL 74.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4131532269168047091Rat
1581574Eae20Experimental allergic encephalomyelitis QTL 207.8nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)4152482121158564471Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4136908430182878540Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494893247168046938Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4145373934176509907Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123478354168478354Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)443414605155469929Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)484475257178931073Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)4137171018182171018Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)47850904182171018Rat
1358364Sradr4Stress Responsive Adrenal Weight QTL 44.92adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)4128602727173602727Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486438317168047091Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4134917642179917642Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4131864442176864442Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109636356154636356Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4136351734174694858Rat
61422Cia13Collagen induced arthritis QTL 134.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4132455408168047091Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4145547014184226339Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110702761155702761Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4123587009168587009Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4145547014184226339Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4145547014184226339Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4124442168169442168Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109636356154636356Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4146497452184226339Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)423850384169318094Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4112807675157807675Rat
12798525Anxrr57Anxiety related response QTL 573.210.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4146086918168047091Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:27
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000019346
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 22 22 1
Low 2 11 10 1 10 23 29
Below cutoff 15 6 13 6 1 1 51 15 11 4 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039106995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH002120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002202 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY887133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY919611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY921651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211201 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M27045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000019346   ⟹   ENSRNOP00000019346
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075799   ⟹   ENSRNOP00000066130
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl4154,423,209 - 154,472,924 (+)Ensembl
RefSeq Acc Id: NM_012488   ⟹   NP_036620
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24154,898,076 - 154,947,787 (+)NCBI
Rnor_6.04154,309,426 - 154,359,138 (+)NCBI
Rnor_5.04221,393,233 - 221,442,945 (+)NCBI
RGSC_v3.44158,103,711 - 158,153,423 (+)RGD
Celera4143,730,195 - 143,781,190 (+)RGD
Sequence:
RefSeq Acc Id: XM_039106994   ⟹   XP_038962922
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24154,897,770 - 154,934,050 (+)NCBI
RefSeq Acc Id: XM_039106995   ⟹   XP_038962923
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24154,897,770 - 154,924,475 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036620   ⟸   NM_012488
- Peptide Label: precursor
- UniProtKB: P06238 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019346   ⟸   ENSRNOT00000019346
RefSeq Acc Id: XP_038962922   ⟸   XM_039106994
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038962923   ⟸   XM_039106995
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000066130   ⟸   ENSRNOT00000075799

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2004 AgrOrtholog
  RGD:6492449 AgrOrtholog
Ensembl Genes ENSRNOG00000028896 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000045772 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000019346 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000066130 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019346 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000075799 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  2.60.40.690 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7458629 IMAGE-MGC_LOAD
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot
  A2M_N_BRD UniProtKB/Swiss-Prot
  A2M_TED UniProtKB/Swiss-Prot
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  Macroglobln_a2 UniProtKB/Swiss-Prot
  MacrogloblnA2_CS UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot
KEGG Report rno:100911545 UniProtKB/Swiss-Prot
  rno:24153 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114358 IMAGE-MGC_LOAD
NCBI Gene 24153 ENTREZGENE
Pfam A2M UniProtKB/Swiss-Prot
  A2M_BRD UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
  MG2 UniProtKB/Swiss-Prot
  MG3 UniProtKB/Swiss-Prot
  MG4 UniProtKB/Swiss-Prot
  TED_complement UniProtKB/Swiss-Prot
PhenoGen A2m PhenoGen
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot
SMART A2M UniProtKB/Swiss-Prot
  A2M_N_2 UniProtKB/Swiss-Prot
  A2M_recep UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48239 UniProtKB/Swiss-Prot
  SSF49410 UniProtKB/Swiss-Prot
  SSF81296 UniProtKB/Swiss-Prot
TIGR TC229016
  TC239648
UniProt A2MG_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q4FZY3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 A2m  alpha-2-macroglobulin  LOC100911545  alpha-2-macroglobulin-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100911545  alpha-2-macroglobulin-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-16 A2m    A2m1  alpha-2-macroglobulin  Symbol updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2002-06-10 A2m  alpha-2-macroglobulin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression may be induced during the regeneration of hepatocytes after liver damage 67925
gene_expression may be induced during the regeneration of hepatocytes after liver damage 70249
gene_process has a role in the acute-phase response to tissue damage and infection 67925
gene_process has a role in the acute-phase response to tissue damage and infection 70249
gene_process inhibits proteinases 67925
gene_process inhibits proteinases 70249