Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: A2m (alpha-2-macroglobulin) Rattus norvegicus
Analyze
Symbol: A2m
Name: alpha-2-macroglobulin
Description: Exhibits endopeptidase inhibitor activity; identical protein binding activity; and neurotrophin binding activity. Involved in several processes, including acute inflammatory response; embryonic liver development; and response to prostaglandin E. Localizes to extracellular space. Used to study hemolytic anemia and toxic shock syndrome. Biomarker of several diseases, including liver disease (multiple); membranous glomerulonephritis; osteonecrosis; peritonitis; and trypanosomiasis. Human ortholog(s) of this gene implicated in background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; Alzheimer's disease pathway; immune response pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; (S)-amphetamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: A2m1; A2maa; A2MAC1; A2mb; AI893533; alpha-2-M; alpha-2-macroglobulin-P; Mam; MGC114358; RATA2MAC1
Orthologs:
Homo sapiens (human) : A2M (alpha-2-macroglobulin)  HGNC  Alliance
Mus musculus (house mouse) : A2m (alpha-2-macroglobulin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102021956 (alpha-2-macroglobulin)
Canis lupus familiaris (dog) : LOC477699 (alpha-2-macroglobulin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : A2m (alpha-2-macroglobulin)
Sus scrofa (pig) : A2M (alpha-2-macroglobulin)
more info ...
Is Marker For: QTLs:   Plsm2  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04154,309,426 - 154,359,138 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4154,309,426 - 154,359,137 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04221,393,233 - 221,442,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44158,103,711 - 158,153,423 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14158,348,624 - 158,398,358 (+)NCBI
Celera4143,730,195 - 143,781,190 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on A2m
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2004
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.