Abcb1b (ATP-binding cassette, sub-family B member 1B) - Rat Genome Database

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Gene: Abcb1b (ATP-binding cassette, sub-family B member 1B) Rattus norvegicus
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Symbol: Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
RGD ID: 3318
Description: Predicted to enable ATPase-coupled transmembrane transporter activity; phosphatidylcholine floppase activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including Sertoli cell barrier remodeling; cellular response to external biotic stimulus; and establishment of endothelial blood-brain barrier. Located in Golgi membrane and external side of apical plasma membrane. Used to study colorectal adenocarcinoma; end stage renal disease; epilepsy (multiple); high grade glioma; and human immunodeficiency virus infectious disease. Biomarker of brain disease (multiple); cholestasis; human immunodeficiency virus infectious disease; metabolic dysfunction-associated steatotic liver disease; and obstructive sleep apnea. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (+)-pilocarpine; (+)-schisandrin B; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abcb1; ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, subfamily B (MDR/TAP), member 1B; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; Mdr1; mdr1b; multidrug resistance protein 1; P-glycoprotein 1; P-glycoprotein 2/ multidrug resistance 1b; P-glycoprotein/multidrug resistance 1; Pgy1; Pgy2; phospholipid transporter ABCB1
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Allele / Splice: Abcb1bem2Mcwi  
Genetic Models: SS-Abcb1bem2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,197,706 - 26,280,156 (-)NCBIGRCr8
mRatBN7.2425,242,761 - 25,325,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,242,798 - 25,325,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,241,677 - 30,323,456 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,167,915 - 26,249,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,554,567 - 24,629,857 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,225,123 - 22,307,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,161,597 - 22,244,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,829,489 - 21,912,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,829,488 - 21,912,239 (+)NCBI
Celera420,736,092 - 20,817,649 (-)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,9-dideoxyforskolin  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-diaminotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (EXP)
Azoxymethane  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
berberine  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bis-4-nitrophenyl phosphate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
BMY-25067  (EXP)
bromocriptine  (EXP)
cadmium acetate  (EXP)
cadmium dichloride  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloroform  (EXP)
chlorpromazine  (EXP)
cholic acid  (ISO)
choline  (EXP,ISO)
chromium(6+)  (EXP,ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (EXP)
coptisine  (EXP)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (EXP)
cyproconazole  (EXP)
DDE  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextropropoxyphene  (ISO)
dibenz[a,h]anthracene  (ISO)
dichlorine  (EXP)
diclofenac  (EXP)
digoxin  (ISO)
dioxygen  (ISO)
diquat  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
emodin  (EXP)
epinastine  (ISO)
epoxiconazole  (EXP,ISO)
eticlopride(1+)  (EXP)
everolimus  (ISO)
fipronil  (EXP)
fluoxetine  (EXP)
fluvoxamine  (ISO)
folic acid  (ISO)
fulvestrant  (EXP)
furan  (EXP)
genistein  (EXP,ISO)
gentamycin  (EXP)
Heliotrine  (EXP)
hydrogen peroxide  (EXP)
indole-3-methanol  (EXP)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
kainic acid  (EXP)
L-methionine  (EXP,ISO)
Lasiocarpine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (ISO)
loperamide  (ISO)
loratadine  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mercury atom  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (EXP)
methadone  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
metoclopramide  (ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-dimethylformamide  (EXP)
N-hydroxy-2-acetamidofluorene  (EXP)
N-hydroxy-PhIP  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP)
okadaic acid  (EXP)
olanzapine  (EXP)
oltipraz  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
paclitaxel  (ISO)
paliperidone palmitate  (ISO)
palmatine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenytoin  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP,ISO)
prazosin  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (ISO)
progesterone  (EXP)
quinidine  (EXP,ISO)
quinine  (EXP)
quinpirole  (EXP)
reactive oxygen species  (EXP)
resveratrol  (ISO)
risperidone  (ISO)
rotenone  (EXP)
saquinavir  (ISO)
SDZ PSC 833  (EXP)
Selamectin  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
soybean oil  (EXP)
spiperone  (EXP)
streptozocin  (ISO)
tamoxifen  (EXP)
Technetium tc 99m sestamibi  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
toluene  (EXP)
trabectedin  (EXP,ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (EXP)
tunicamycin  (ISO)
vancomycin  (ISO)
verapamil  (EXP,ISO)
vincaleukoblastine  (EXP)
vincristine  (EXP)
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Brain erythropoietin receptor expression in Alzheimer disease and mild cognitive impairment. Assaraf MI, etal., J Neuropathol Exp Neurol. 2007 May;66(5):389-98.
2. The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy. Brandt C, etal., Neurobiol Dis. 2006 Oct;24(1):202-11. Epub 2006 Aug 22.
3. Acute exposure to doxorubicin results in increased cardiac P-glycoprotein expression. Budde T, etal., J Pharm Sci. 2011 Sep;100(9):3951-8. doi: 10.1002/jps.22622. Epub 2011 May 17.
4. Identification of genes responsive to gamma radiation in rat hepatocytes and rat liver by cDNA array gene expression analysis. Christiansen H, etal., Radiat Res. 2006 Mar;165(3):318-25.
5. Development of a P-glycoprotein knockout model in rodents to define species differences in its functional effect at the blood-brain barrier. Cutler L, etal., J Pharm Sci. 2006 Sep;95(9):1944-53.
6. Increased intestinal P-glycoprotein expression and activity with progression of diabetes and its modulation by epigallocatechin-3-gallate: Evidence from pharmacokinetic studies. Dash RP, etal., Eur J Pharmacol. 2015 Nov 15;767:67-76. doi: 10.1016/j.ejphar.2015.10.009. Epub 2015 Oct 10.
7. Identification of distinct P-glycoprotein gene sequences in rat. Deuchars KL, etal., Biochim Biophys Acta 1992 Mar 24;1130(2):157-65.
8. Hepatobiliary damage and changes in hepatic gene expression caused by the antitumor drug ecteinascidin-743 (ET-743) in the female rat. Donald S, etal., Cancer Res 2002 Aug 1;62(15):4256-62.
9. Influence of intermittent hypoxia on myocardial and hepatic P-glycoprotein expression in a rodent model. Dopp JM, etal., Pharmacotherapy. 2009 Apr;29(4):365-72.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids. Gilchrist SE and Alcorn J, Fundam Clin Pharmacol. 2009 Aug 21.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. Hardwick RN, etal., Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23.
14. Nitric oxide differentially regulates renal ATP-binding cassette transporters during endotoxemia. Heemskerk S, etal., Pflugers Arch. 2007 May;454(2):321-34. Epub 2007 Feb 7.
15. Phospholipid alterations in hepatocyte membranes and transporter protein changes in cholestatic rat model. Hyogo H, etal., Dig Dis Sci. 2001 Oct;46(10):2089-97.
16. In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment. Jones S, etal., Biol Reprod. 2015 Oct;93(4):92. doi: 10.1095/biolreprod.115.129098. Epub 2015 Aug 26.
17. PSC 833, an inhibitor of P-glycoprotein inhibits 1,2-dimethylhydrazine-induced colorectal carcinogenesis in male Fischer F344 rats. Kankesan J, etal., Anticancer Res. 2006 Mar-Apr;26(2A):995-9.
18. Newly synthesized canalicular ABC transporters are directly targeted from the Golgi to the hepatocyte apical domain in rat liver. Kipp H and Arias IM, J Biol Chem. 2000 May 26;275(21):15917-25.
19. Chronic exposure to methylated arsenicals stimulates arsenic excretion pathways and induces arsenic tolerance in rat liver cells. Kojima C, etal., Toxicol Sci. 2006 May;91(1):70-81. Epub 2006 Jan 25.
20. Neonatal exposure to zearalenone induces long term modulation of ABC transporter expression in testis. Koraichi F, etal., Toxicology. 2013 Aug 9;310:29-38. doi: 10.1016/j.tox.2013.05.002. Epub 2013 May 22.
21. Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival. Kuo TC, etal., J Pharmacol Exp Ther. 2009 Sep;330(3):736-44. Epub 2009 Jun 23.
22. Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition. Lamprecht A and Benoit JP, J Control Release. 2006 May 15;112(2):208-13. Epub 2006 Feb 28.
23. Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats. Liu H, etal., Brain Res. 2006 Dec 6;1123(1):245-52. Epub 2006 Oct 30.
24. Functional induction of P-glycoprotein in the blood-brain barrier of streptozotocin-induced diabetic rats: evidence for the involvement of nuclear factor-kappaB, a nitrosative stress-sensitive transcription factor, in the regulation. Maeng HJ, etal., Drug Metab Dispos. 2007 Nov;35(11):1996-2005. Epub 2007 Jul 30.
25. P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes. Mercier C, etal., J Neurochem. 2003 Nov;87(4):820-30.
26. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
27. Development of multidrug resistance due to multiple factors including P-glycoprotein overexpression under K-selection after MYC and HRAS oncogene activation. Nakamura Y, etal., Int J Cancer. 2006 May 15;118(10):2448-54.
28. Down-regulation of intestinal drug transporters in chronic renal failure in rats. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
29. P-glycoprotein expression and distribution in the rat placenta during pregnancy. Novotna M, etal., Reprod Toxicol. 2004 Aug-Sep;18(6):785-92.
30. Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells. Ortiz DF, etal., J Biol Chem 2004 Jul 30;279(31):32761-70. Epub 2004 May 24.
31. Moderate increase in Mdr1a/1b expression causes in vivo resistance to doxorubicin in a mouse model for hereditary breast cancer. Pajic M, etal., Cancer Res. 2009 Aug 15;69(16):6396-404. Epub 2009 Aug 4.
32. Regulation of MDR-1 (P-glycoprotein) by cyclooxygenase-2. Patel VA, etal., J Biol Chem 2002 Oct 11;277(41):38915-20.
33. Examination of the functional activity of P-glycoprotein in the rat placental barrier using rhodamine 123. Pavek P, etal., J Pharmacol Exp Ther. 2003 Jun;305(3):1239-50. Epub 2003 Mar 6.
34. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
35. Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis. Potocnik U, etal., Genes Immun. 2004 Nov;5(7):530-9.
36. Transient expression of MDR-1/P-glycoprotein in a model of partial cortical devascularization. Ramos AJ, etal., Cell Mol Neurobiol. 2004 Feb;24(1):101-7.
37. GOA pipeline RGD automated data pipeline
38. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
39. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
40. Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model. Robillard KR, etal., Biochem Biophys Res Commun. 2014 Feb 21;444(4):531-6. doi: 10.1016/j.bbrc.2014.01.092. Epub 2014 Jan 25.
41. HIV-1 viral envelope glycoprotein gp120 triggers an inflammatory response in cultured rat astrocytes and regulates the functional expression of P-glycoprotein. Ronaldson PT and Bendayan R, Mol Pharmacol. 2006 Sep;70(3):1087-98. Epub 2006 Jun 21.
42. Cloning and characterization of a member of the rat multidrug resistance (mdr) gene family. Silverman JA, etal., Gene 1991 Oct 15;106(2):229-36.
43. Ontogeny of ABC and SLC transporters in the microvessels of developing rat brain. Soares RV, etal., Fundam Clin Pharmacol. 2016 Apr;30(2):107-116. doi: 10.1111/fcp.12175. Epub 2016 Feb 4.
44. Abcb1a and Abcb1b genes function differentially in blood-testis barrier dynamics in the rat. Su L, etal., Cell Death Dis. 2017 Sep 7;8(9):e3038. doi: 10.1038/cddis.2017.435.
45. Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats. Suzuki T, etal., Life Sci. 2006 Jun 27;79(5):455-61. Epub 2006 Feb 17.
46. Changes in CNS cells in hyperammonemic portal hypertensive rats. Tallis S, etal., J Neurochem. 2014 Feb;128(3):431-44. doi: 10.1111/jnc.12458. Epub 2013 Oct 24.
47. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Teeter LD, etal., Mol Carcinog. 1993;8(2):67-73.
48. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
49. Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. van Vliet E, etal., Epilepsy Res 2004 Jul-Aug;60(2-3):203-13.
50. Up-regulation of the multidrug resistance genes, Mrp1 and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Vos TA, etal., Hepatology. 1998 Dec;28(6):1637-44.
51. Independent amplification of two gene clusters on chromosome 4 in rat endometrial cancer: identification and molecular characterization. Walentinsson A, etal., Cancer Res 2001 Nov 15;61(22):8263-73.
52. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
53. The Alterations in the Expression and Function of P-Glycoprotein in Vitamin A-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Wang Y, etal., Molecules. 2015 Dec 29;21(1). pii: E46. doi: 10.3390/molecules21010046.
54. Cloning and characterization of the rat multidrug resistance-associated protein 1. Yang Z, etal., AAPS PharmSci 2002;4(3):E15.
55. Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia. Yu C, etal., Cell Physiol Biochem. 2008;22(5-6):745-56. Epub 2008 Dec 9.
Additional References at PubMed
PMID:1385112   PMID:12068294   PMID:12477932   PMID:14551217   PMID:14757850   PMID:15049512   PMID:15262198   PMID:15327746   PMID:15328029   PMID:15744753   PMID:16252067   PMID:16255849  
PMID:16728344   PMID:16946557   PMID:17028260   PMID:17326770   PMID:17651695   PMID:17669244   PMID:17919779   PMID:17982267   PMID:18057958   PMID:18094072   PMID:18213456   PMID:18290326  
PMID:18346469   PMID:18390207   PMID:18485890   PMID:18538350   PMID:18581211   PMID:18614015   PMID:18619980   PMID:18855017   PMID:19357816   PMID:19570321   PMID:19703566   PMID:19840843  
PMID:19959334   PMID:20197783   PMID:20593167   PMID:20955690   PMID:21075088   PMID:21198435   PMID:21297965   PMID:21351448   PMID:21403895   PMID:21436125   PMID:21618049   PMID:21685928  
PMID:21822614   PMID:22106313   PMID:22339773   PMID:22472606   PMID:22563480   PMID:22579010   PMID:22749978   PMID:22870815   PMID:22925079   PMID:22949658   PMID:23035695   PMID:23306951  
PMID:23940624   PMID:24015255   PMID:24590840   PMID:26045880   PMID:26364927   PMID:26677173   PMID:26727197   PMID:27616577   PMID:27925244   PMID:28045902   PMID:28119480   PMID:28303499  
PMID:33558655   PMID:33984358   PMID:34844996   PMID:34876109   PMID:35226682  


Genomics

Comparative Map Data
Abcb1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,197,706 - 26,280,156 (-)NCBIGRCr8
mRatBN7.2425,242,761 - 25,325,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,242,798 - 25,325,199 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,241,677 - 30,323,456 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,167,915 - 26,249,690 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,554,567 - 24,629,857 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,225,123 - 22,307,577 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,133,521 - 22,425,515 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,161,597 - 22,244,735 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4421,829,489 - 21,912,239 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1421,829,488 - 21,912,239 (+)NCBI
Celera420,736,092 - 20,817,649 (-)NCBICelera
Cytogenetic Map4q12NCBI
Abcb1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3958,848,147 - 8,916,314 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl58,848,147 - 8,916,315 (+)EnsemblGRCm39 Ensembl
GRCm3858,798,147 - 8,866,314 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,798,147 - 8,866,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,798,147 - 8,866,314 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,804,192 - 8,872,314 (+)NCBIMGSCv36mm8
Celera58,717,809 - 8,786,039 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI

Variants

.
Variants in Abcb1b
945 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:26
Interacting mature miRNAs:26
Transcripts:ENSRNOT00000037712, ENSRNOT00000047126
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat


Genetic Models
This gene Abcb1b is modified in the following models/strains:
SS-Abcb1bem2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001435556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001435557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001435558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592469 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ312410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY082609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M81855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X61104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X69027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000037712   ⟹   ENSRNOP00000038721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,242,798 - 25,322,029 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000047126   ⟹   ENSRNOP00000049952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,242,798 - 25,325,153 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109425   ⟹   ENSRNOP00000086483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,243,744 - 25,325,199 (-)Ensembl
RefSeq Acc Id: NM_012623   ⟹   NP_036755
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,198,031 - 26,280,029 (-)NCBI
mRatBN7.2425,243,086 - 25,325,086 (-)NCBI
Rnor_6.0422,225,461 - 22,307,453 (-)NCBI
Rnor_5.0422,161,597 - 22,244,735 (-)NCBI
RGSC_v3.4421,829,489 - 21,912,239 (+)RGD
Celera420,736,092 - 20,817,649 (-)RGD
Sequence:
RefSeq Acc Id: XM_017592469   ⟹   XP_017447958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,197,706 - 26,280,156 (-)NCBI
mRatBN7.2425,242,761 - 25,325,194 (-)NCBI
Rnor_6.0422,225,123 - 22,307,577 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107052   ⟹   XP_038962980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,197,706 - 26,280,156 (-)NCBI
mRatBN7.2425,242,761 - 25,325,194 (-)NCBI
RefSeq Acc Id: XM_039107053   ⟹   XP_038962981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,197,706 - 26,280,141 (-)NCBI
mRatBN7.2425,242,761 - 25,325,169 (-)NCBI
RefSeq Acc Id: NP_036755   ⟸   NM_012623
- UniProtKB: G3V9J6 (UniProtKB/TrEMBL),   A6K234 (UniProtKB/TrEMBL),   Q8R427 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447958   ⟸   XM_017592469
- Peptide Label: isoform X2
- UniProtKB: Q8R427 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038962980   ⟸   XM_039107052
- Peptide Label: isoform X1
- UniProtKB: Q8R427 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038962981   ⟸   XM_039107053
- Peptide Label: isoform X3
- UniProtKB: D4A0Y9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086483   ⟸   ENSRNOT00000109425
Ensembl Acc Id: ENSRNOP00000049952   ⟸   ENSRNOT00000047126
Ensembl Acc Id: ENSRNOP00000038721   ⟸   ENSRNOT00000037712
Protein Domains
ABC transmembrane type-1   ABC transporter

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43245-F1-model_v2 AlphaFold P43245 1-1277 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3318 AgrOrtholog
BioCyc Gene G2FUF-45828 BioCyc
Ensembl Genes ENSRNOG00000008012 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000066042 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011166.6 UniProtKB/TrEMBL
  ENSRNOT00000037712.6 UniProtKB/TrEMBL
  ENSRNOT00000047126.6 UniProtKB/TrEMBL
  ENSRNOT00000096021.1 UniProtKB/TrEMBL
  ENSRNOT00000100110.1 UniProtKB/TrEMBL
  ENSRNOT00000101034.1 UniProtKB/TrEMBL
  ENSRNOT00000109425.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7936890 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Type_I_exporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24646 UniProtKB/TrEMBL
MGC_CLONE MGC:124558 IMAGE-MGC_LOAD
NCBI Gene 24646 ENTREZGENE
PANTHER ABC TRANSPORTER B FAMILY UniProtKB/TrEMBL
  ALPHA-FACTOR-TRANSPORTING ATPASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MYCOBACTIN IMPORT ATP-BINDING/PERMEASE PROTEIN IRTB UniProtKB/TrEMBL
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Abcb1b PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008012 RatGTEx
  ENSRNOG00000066042 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y6F1_RAT UniProtKB/TrEMBL
  A0A8I5ZY39_RAT UniProtKB/TrEMBL
  A0A8I6A8Y5_RAT UniProtKB/TrEMBL
  A0A8I6GMN6_RAT UniProtKB/TrEMBL
  A6K234 ENTREZGENE, UniProtKB/TrEMBL
  D4A0Y9 ENTREZGENE, UniProtKB/TrEMBL
  F7FKA8_RAT UniProtKB/TrEMBL
  G3V9J6 ENTREZGENE, UniProtKB/TrEMBL
  MDR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q3B7L2_RAT UniProtKB/TrEMBL
  Q8R427 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q63426 UniProtKB/Swiss-Prot
  Q63427 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-11-16 Abcb1b  ATP-binding cassette, subfamily B (MDR/TAP), member 1B  Abcb1b  ATP-binding cassette, sub-family B (MDR/TAP), member 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-12-05 Abcb1b  ATP-binding cassette, sub-family B (MDR/TAP), member 1B  Abcb1  ATP-binding cassette, sub-family B (MDR/TAP), member 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2004-09-10 Abcb1  ATP-binding cassette, sub-family B (MDR/TAP), member 1  Pgy1  P-glycoprotein/multidrug resistance 1  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pgy1  P-glycoprotein/multidrug resistance 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease primary cause of multiple drug resistance in tumors 628390
gene_expression expressed in uterus 70249
gene_expression expressed in uterus 70348
gene_expression expressed in uterus 70557
gene_expression expression reduced in response to certain types of liver damage 70249
gene_expression expression reduced in response to certain types of liver damage 70348
gene_expression expression reduced in response to certain types of liver damage 70557
gene_expression expressed in liver and kidney and also in tumors 628390
gene_function exhibits transporter activity 633704
gene_process upregulated in uterine tumors 70249
gene_process upregulated in uterine tumors 70348
gene_process upregulated in uterine tumors 70557
gene_process membrane protein functions in active transportation of lipophilic xenobiotics in normal tissues and as an efflux pump for a wide range of chemotherapeutic agents 628390
gene_protein 1533 amino acids; 190 kDa 633704
gene_regulation transcription and protein levels are directly regulated by the levels of Cox2 transcripts; protein activity induced by higher Cox2 levels in renal mesangial cells 628390