Eml4 (EMAP like 4) - Rat Genome Database

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Gene: Eml4 (EMAP like 4) Rattus norvegicus
Analyze
Symbol: Eml4
Name: EMAP like 4
RGD ID: 1304690
Description: Predicted to have alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including attachment of spindle microtubules to kinetochore; mitotic metaphase plate congression; and negative regulation of microtubule depolymerization. Predicted to colocalize with mitotic spindle. Orthologous to human EML4 (EMAP like 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',5,5'-tetrabromobisphenol A; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: echinoderm microtubule associated protein like 4; echinoderm microtubule-associated protein-like 4; LOC313861
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
Rnor_6.0 Ensembl66,619,076 - 6,674,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.066,618,370 - 6,674,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.066,573,560 - 6,629,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.466,754,664 - 6,813,231 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.166,694,898 - 6,811,133 (+)NCBI
Celera610,924,478 - 10,979,707 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
aflatoxin B1  (EXP,ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
chloroprene  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crizotinib  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
folic acid  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
irinotecan  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP)
Mecamylamine  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
ochratoxin A  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
tubocurarine  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:17196341   PMID:19946888   PMID:24625528  


Genomics

Comparative Map Data
Eml4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
Rnor_6.0 Ensembl66,619,076 - 6,674,554 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.066,618,370 - 6,674,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.066,573,560 - 6,629,053 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.466,754,664 - 6,813,231 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.166,694,898 - 6,811,133 (+)NCBI
Celera610,924,478 - 10,979,707 (-)NCBICelera
Cytogenetic Map6q12NCBI
EML4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl242,169,353 - 42,332,548 (+)EnsemblGRCh38hg38GRCh38
GRCh38242,169,353 - 42,332,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37242,396,493 - 42,559,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36242,250,020 - 42,413,192 (+)NCBINCBI36hg18NCBI36
Build 34242,308,166 - 42,471,337NCBI
Celera242,236,800 - 42,399,970 (+)NCBI
Cytogenetic Map2p21NCBI
HuRef242,130,861 - 42,294,053 (+)NCBIHuRef
CHM1_1242,326,032 - 42,489,120 (+)NCBICHM1_1
Eml4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391783,658,341 - 83,787,790 (+)NCBIGRCm39mm39
GRCm39 Ensembl1783,658,360 - 83,787,790 (+)Ensembl
GRCm381783,350,930 - 83,480,361 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1783,350,931 - 83,480,361 (+)EnsemblGRCm38mm10GRCm38
MGSCv371783,750,271 - 83,879,701 (+)NCBIGRCm37mm9NCBIm37
MGSCv361783,259,308 - 83,388,687 (+)NCBImm8
Celera1787,692,800 - 87,822,185 (+)NCBICelera
Cytogenetic Map17E4NCBI
Eml4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554419,640,899 - 9,713,596 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554419,633,906 - 9,715,866 (+)NCBIChiLan1.0ChiLan1.0
EML4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A43,119,984 - 43,281,825 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A43,119,984 - 43,281,825 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A42,267,435 - 42,430,231 (+)NCBIMhudiblu_PPA_v0panPan3
EML4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11733,774,478 - 33,935,478 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1733,774,140 - 33,934,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1733,544,396 - 33,704,779 (+)NCBI
ROS_Cfam_1.01734,541,313 - 34,702,667 (+)NCBI
UMICH_Zoey_3.11733,666,618 - 33,827,461 (+)NCBI
UNSW_CanFamBas_1.01733,729,208 - 33,890,080 (+)NCBI
UU_Cfam_GSD_1.01733,946,661 - 34,107,545 (+)NCBI
Eml4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629237,875,039 - 38,018,878 (-)NCBI
SpeTri2.0NW_0049365089,303,639 - 9,447,478 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EML4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl398,005,811 - 98,155,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1398,005,809 - 98,155,876 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23104,141,153 - 104,291,245 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EML4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11464,927,288 - 65,090,904 (-)NCBI
ChlSab1.1 Ensembl1464,929,617 - 65,090,861 (-)Ensembl
Eml4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473823,887,822 - 24,045,864 (+)NCBI

Position Markers
AI644019  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2611,219,742 - 11,219,843 (-)MAPPER
Rnor_6.066,674,252 - 6,674,352NCBIRnor6.0
Rnor_5.066,628,755 - 6,628,855UniSTSRnor5.0
RGSC_v3.466,812,954 - 6,813,054UniSTSRGSC3.4
Celera610,924,655 - 10,924,755UniSTS
Cytogenetic Map6q12UniSTS
RH138441  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2611,220,511 - 11,220,740 (-)MAPPER
Rnor_6.066,673,355 - 6,673,583NCBIRnor6.0
Rnor_5.066,627,858 - 6,628,086UniSTSRnor5.0
RGSC_v3.466,812,057 - 6,812,285UniSTSRGSC3.4
Celera610,925,424 - 10,925,652UniSTS
RH 3.4 Map1529.4UniSTS
Cytogenetic Map6q12UniSTS
RH140067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2611,269,489 - 11,269,639 (-)MAPPER
Rnor_6.066,624,460 - 6,624,609NCBIRnor6.0
Rnor_5.066,578,963 - 6,579,112UniSTSRnor5.0
RGSC_v3.466,760,048 - 6,760,197UniSTSRGSC3.4
Celera610,974,174 - 10,974,323UniSTS
Cytogenetic Map6q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6123620518Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6125048718Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
8693645Alc31Alcohol consumption QTL 313.70.038drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)613505323600274Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:241
Count of miRNA genes:175
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000042307
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 57 41 19 41 1 1 74 33 38 11 1
Low 14 7 9 2 3 7
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001108008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006239682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC112092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000042307   ⟹   ENSRNOP00000050319
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl66,619,076 - 6,674,529 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080013   ⟹   ENSRNOP00000072435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl66,619,081 - 6,674,554 (+)Ensembl
RefSeq Acc Id: NM_001108008   ⟹   NP_001101478
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,566 - 11,275,023 (-)NCBI
Rnor_6.066,619,076 - 6,674,529 (+)NCBI
Rnor_5.066,573,560 - 6,629,053 (+)NCBI
RGSC_v3.466,754,664 - 6,813,231 (+)RGD
Celera610,924,478 - 10,979,707 (-)RGD
Sequence:
RefSeq Acc Id: XM_006239681   ⟹   XP_006239743
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.066,618,370 - 6,674,550 (+)NCBI
Rnor_5.066,573,560 - 6,629,053 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006239682   ⟹   XP_006239744
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.066,618,370 - 6,674,550 (+)NCBI
Rnor_5.066,573,560 - 6,629,053 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594117   ⟹   XP_017449606
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.066,618,370 - 6,674,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594118   ⟹   XP_017449607
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.066,618,370 - 6,674,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594119   ⟹   XP_017449608
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.066,618,370 - 6,674,550 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112148   ⟹   XP_038968076
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
RefSeq Acc Id: XM_039112149   ⟹   XP_038968077
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
RefSeq Acc Id: XM_039112150   ⟹   XP_038968078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
RefSeq Acc Id: XM_039112151   ⟹   XP_038968079
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,824 (-)NCBI
RefSeq Acc Id: XM_039112152   ⟹   XP_038968080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,823 (-)NCBI
RefSeq Acc Id: XM_039112153   ⟹   XP_038968081
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,334,823 (-)NCBI
RefSeq Acc Id: XM_039112154   ⟹   XP_038968082
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2611,219,545 - 11,256,654 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101478   ⟸   NM_001108008
- UniProtKB: F1LT71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006239743   ⟸   XM_006239681
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006239744   ⟸   XM_006239682
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449606   ⟸   XM_017594117
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017449607   ⟸   XM_017594118
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017449608   ⟸   XM_017594119
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000072435   ⟸   ENSRNOT00000080013
RefSeq Acc Id: ENSRNOP00000050319   ⟸   ENSRNOT00000042307
RefSeq Acc Id: XP_038968079   ⟸   XM_039112151
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038968078   ⟸   XM_039112150
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038968077   ⟸   XM_039112149
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038968076   ⟸   XM_039112148
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038968081   ⟸   XM_039112153
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038968080   ⟸   XM_039112152
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038968082   ⟸   XM_039112154
- Peptide Label: isoform X7
Protein Domains
WD_REPEATS_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304690 AgrOrtholog
Ensembl Genes ENSRNOG00000030294 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050319 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000072435 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042307 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000080013 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro HELP UniProtKB/TrEMBL
  Quinonprotein_ADH-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/TrEMBL
  WD40_repeat_dom UniProtKB/TrEMBL
KEGG Report rno:313861 UniProtKB/TrEMBL
NCBI Gene 313861 ENTREZGENE
Pfam HELP UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PhenoGen Eml4 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP Quin_alc_DH_like UniProtKB/TrEMBL
UniProt A0A0G2K2Z0_RAT UniProtKB/TrEMBL
  F1LT71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-12-04 Eml4  EMAP like 4  Eml4  echinoderm microtubule associated protein like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Eml4  echinoderm microtubule associated protein like 4   Eml4_predicted  echinoderm microtubule associated protein like 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eml4_predicted  echinoderm microtubule associated protein like 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED