Fgfr1 (Fibroblast growth factor receptor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Fgfr1 (Fibroblast growth factor receptor 1) Rattus norvegicus
Analyze
Symbol: Fgfr1
Name: Fibroblast growth factor receptor 1
RGD ID: 620713
Description: Exhibits cell adhesion molecule binding activity and signaling receptor binding activity. Involved in several processes, including cellular response to histamine; neuron development; and positive regulation of cell population proliferation. Localizes to nucleus; perinuclear region of cytoplasm; and plasma membrane. Used to study pulmonary hypertension. Biomarker of several diseases, including ischemia (multiple); mesangial proliferative glomerulonephritis; sciatic neuropathy; vascular dementia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Jackson-Weiss syndrome; bone disease (multiple); cleft lip; hematologic cancer (multiple); and hypogonadotropic hypogonadism (multiple). Orthologous to human FGFR1 (fibroblast growth factor receptor 1); PARTICIPATES IN cerium oxide nanoparticle response pathway; fibroblast growth factor signaling pathway; glypican signaling pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3,3',5-triiodo-L-thyronine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: basic fibroblast growth factor receptor 1; bFGF-R; bFGF-R-1; c-fgr; FGF receptor-1; FGFR-1; MFR; proto-oncogene c-Fgr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Fgfr1-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21666,492,445 - 66,546,731 (-)NCBI
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Celera1664,402,647 - 64,442,189 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acrocephalosyndactylia  (ISO)
Acute Lymphoblastic Leukemia, with Lymphomatous Features  (ISO)
acute myeloid leukemia  (ISO)
Alzheimer's disease  (ISO)
atypical chronic myeloid leukemia  (ISO)
Breast Neoplasms  (ISO)
Burns  (IEP)
cerebellar hypoplasia  (ISO)
cleft lip  (ISO)
cleft palate  (ISO)
Congenital Foot Deformities  (ISO)
Craniofacial Abnormalities  (ISO)
craniosynostosis  (ISO)
Craniosynostosis Syndrome, Autosomal Recessive  (ISO)
Delayed Puberty  (ISO)
demyelinating disease  (ISO)
disease of cellular proliferation  (ISO)
Encephalocraniocutaneous Lipomatosis  (ISO)
Experimental Arthritis  (ISO)
Experimental Leukemia  (ISO)
Experimental Liver Cirrhosis  (IMP)
fatty liver disease  (ISO)
Femoral Fractures  (IEP)
fibrolamellar carcinoma  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Head Injuries, Penetrating  (IEP)
heart valve disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
holoprosencephaly  (ISO)
Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip/Palate  (ISO)
Hypoglossal Nerve Injuries  (IEP)
hypogonadotropic hypogonadism 2 with or without anosmia  (ISO)
hypogonadotropic hypogonadism 7 with or without anosmia  (ISO)
Hypogonadotropic Hypogonadism and Anosmia, Autosomal Dominant  (ISO)
infertility  (ISO)
Jackson-Weiss syndrome  (ISO)
Kallmann syndrome  (ISO)
Limb Ischemia  (IEP)
Liver Metastasis  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
malignant astrocytoma  (ISO)
medulloblastoma  (ISO)
mental depression  (ISO)
mesangial proliferative glomerulonephritis  (IEP)
mouth disease  (IEP)
myeloid leukemia  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Neointima  (IDA)
Neoplasm Metastasis  (ISO)
neuroblastoma  (ISO)
non-alcoholic fatty liver disease  (ISO)
Nonsyndromic Trigonocephaly  (ISO)
obesity  (IEP,ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteoglophonic dysplasia  (ISO)
otitis media  (ISS)
Pfeiffer syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
pulmonary hypertension  (IMP)
renal cell carcinoma  (ISO)
retinal detachment  (IEP)
schizophrenia  (ISO)
sciatic neuropathy  (IEP)
squamous cell carcinoma  (ISO)
Stargardt Disease 3  (ISO)
T-Cell Lymphoma  (ISO)
transient cerebral ischemia  (IEP)
transitional cell carcinoma  (ISO)
Trigonocephaly 1  (ISO)
Tympanic Membrane Perforation  (IMP)
type 2 diabetes mellitus  (ISO)
umbilical hernia  (ISO)
vascular dementia  (IEP)
visual epilepsy  (IEP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-amphetamine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (EXP)
aflatoxin B2  (ISO)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
AP20187  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
capsaicin  (EXP)
carbamazepine  (ISO)
chlorpromazine  (ISO)
choline  (ISO)
cisplatin  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
coumestrol  (ISO)
crizotinib  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dieldrin  (EXP)
dimethylarsinous acid  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ellagic acid  (ISO)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (EXP,ISO)
ethyl trans-caffeate  (ISO)
fenamidone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
heparan sulfate  (ISO)
heparin  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isotretinoin  (ISO)
kainic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
lenalidomide  (ISO)
malathion  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
orantinib  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraoxon  (ISO)
PD-166866  (EXP,ISO)
PD173074  (ISO)
peroxynitrous acid  (EXP)
piperine  (ISO)
pirinixic acid  (EXP)
pomalidomide  (ISO)
ponatinib  (ISO)
resveratrol  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
titanium dioxide  (ISO)
tocopherol  (ISO)
topotecan  (EXP)
triptonide  (ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc protoporphyrin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
auditory receptor cell development  (ISO)
blood vessel morphogenesis  (ISO)
brain development  (ISO)
branching involved in salivary gland morphogenesis  (ISO)
cell maturation  (ISO)
cellular response to histamine  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to nerve growth factor stimulus  (IEP)
central nervous system neuron development  (IMP)
chondrocyte differentiation  (ISO)
ear development  (ISO)
embryonic limb morphogenesis  (ISO)
epithelial to mesenchymal transition  (IEA,ISO)
female pregnancy  (IEP)
fibroblast growth factor receptor signaling pathway  (IEA,ISO,ISS)
fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development  (ISO)
generation of neurons  (ISO)
in utero embryonic development  (ISO)
inner ear morphogenesis  (ISO)
lung development  (ISO)
lung-associated mesenchyme development  (ISO)
mesenchymal cell differentiation  (ISO)
midbrain development  (ISO)
middle ear morphogenesis  (ISO)
motogenic signaling involved in postnatal olfactory bulb interneuron migration  (IMP)
multicellular organism development  (IBA)
negative regulation of fibroblast growth factor production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of osteoblast differentiation  (IMP)
negative regulation of transcription by RNA polymerase II  (ISO)
neuron projection development  (IDA)
orbitofrontal cortex development  (ISO)
organ induction  (ISO)
outer ear morphogenesis  (ISO)
paraxial mesoderm development  (ISO)
peptidyl-tyrosine phosphorylation  (IEA,ISO,ISS)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IMP,ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell differentiation  (IBA)
positive regulation of cell population proliferation  (IEA,ISO,ISS)
positive regulation of endothelial cell chemotaxis to fibroblast growth factor  (IEA,ISO)
positive regulation of fibroblast migration  (IMP)
positive regulation of hepatic stellate cell activation  (IMP)
positive regulation of inflammatory response  (IMP)
positive regulation of kinase activity  (IBA)
positive regulation of MAP kinase activity  (IEA,ISO,ISS)
positive regulation of MAPK cascade  (ISO)
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of mesenchymal cell proliferation  (IMP,ISO)
positive regulation of mitotic cell cycle DNA replication  (ISO)
positive regulation of neuron differentiation  (IEA,ISO,ISS)
positive regulation of neuron projection development  (IDA,IMP,ISO)
positive regulation of parathyroid hormone secretion  (ISO)
positive regulation of phospholipase C activity  (IEA,ISO,ISS)
positive regulation of protein kinase B signaling  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IMP)
positive regulation of vascular endothelial cell proliferation  (IEA,ISO)
protein autophosphorylation  (IEA,ISO,ISS)
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling  (ISO)
regulation of cell population proliferation  (IDA,ISO)
regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
regulation of gene expression  (ISO)
regulation of lateral mesodermal cell fate specification  (ISO)
regulation of phosphate transport  (ISO)
regulation of phosphorus metabolic process  (ISO)
regulation of sensory perception of pain  (IMP)
regulation of stem cell proliferation  (IMP)
response to ischemia  (IEP)
response to nutrient levels  (IEP)
salivary gland morphogenesis  (ISO)
sensory perception of sound  (ISO)
stem cell population maintenance  (IMP)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
ureteric bud development  (ISO)
ventricular zone neuroblast division  (ISO)
vitamin D3 metabolic process  (ISO)
wound healing  (IEP)

Cellular Component

References

References - curated
1. Acevedo VD, etal., Cancer Cell. 2007 Dec;12(6):559-71.
2. Bae JH, etal., Cell. 2009 Aug 7;138(3):514-24. doi: 10.1016/j.cell.2009.05.028.
3. Bessenyei B, etal., Am J Med Genet A. 2014 Dec;164A(12):3176-9. doi: 10.1002/ajmg.a.36774. Epub 2014 Sep 23.
4. Borroto-Escuela DO, etal., Biochem Biophys Res Commun. 2015 Jan 2;456(1):489-93. doi: 10.1016/j.bbrc.2014.11.112. Epub 2014 Dec 6.
5. Borroto-Escuela DO, etal., Biol Psychiatry. 2012 Jan 1;71(1):84-91. doi: 10.1016/j.biopsych.2011.09.012. Epub 2011 Oct 27.
6. Borroto-Escuela DO, etal., J Neurosci. 2012 May 2;32(18):6295-303. doi: 10.1523/JNEUROSCI.4203-11.2012.
7. Chen J, etal., Proc Natl Acad Sci U S A. 2004 Oct 5;101(40):14479-84. Epub 2004 Sep 24.
8. Chen PY, etal., J Biol Chem. 2009 Jun 5;284(23):15980-92. Epub 2009 Apr 1.
9. Cras-Meneur C and Scharfmann R, Mech Dev 2002 Aug;116(1-2):205-8.
10. Dombrowski C, etal., Stem Cells Dev. 2009 May;18(4):661-70.
11. Garcia-Gonzalez D, etal., Exp Neurol. 2010 Apr;222(2):285-95. Epub 2010 Jan 18.
12. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. GOA data from the GO Consortium
14. Grothe C, etal., Neuroscience. 1997 Jan;76(1):123-35.
15. Guasch G, etal., Blood. 2004 Jan 1;103(1):309-12. Epub 2003 Sep 11.
16. Guillonneau X, etal., Mol Biol Cell 1998 Oct;9(10):2785-802.
17. Hadziselimovic NO, etal., Urol Int. 2010;84(3):353-61. doi: 10.1159/000288242. Epub 2010 Apr 13.
18. Ho TH, etal., BMC Cancer. 2015 Apr 18;15:304. doi: 10.1186/s12885-015-1302-1.
19. Hu Y, etal., J Biol Chem. 2004 Jul 9;279(28):29325-35. Epub 2004 Apr 26.
20. Hu Y, etal., JHEP Rep. 2020 Feb 18;2(2):100093. doi: 10.1016/j.jhepr.2020.100093. eCollection 2020 Apr.
21. Huang X, etal., Cancer Res. 2006 Feb 1;66(3):1481-90. doi: 10.1158/0008-5472.CAN-05-2412.
22. Huber K, etal., J Comp Neurol. 1997 Jun 2;382(2):189-98.
23. Irshad S, etal., Sci Transl Med. 2013 Sep 11;5(202):202ra122. doi: 10.1126/scitranslmed.3006408.
24. Izikki M, etal., J Clin Invest. 2009 Mar;119(3):512-23. doi: 10.1172/JCI35070. Epub 2009 Feb 9.
25. Jiao H, etal., J Clin Endocrinol Metab. 2011 Jun;96(6):E962-6. doi: 10.1210/jc.2010-2639. Epub 2011 Mar 23.
26. Jiao J, etal., Arch Biochem Biophys 2003 Feb 15;410(2):187-200.
27. Jyo-Oshiro Y, etal., Virchows Arch. 1999 Nov;435(5):501-8.
28. Kaftan H, etal., Eur Arch Otorhinolaryngol. 2012 Jan;269(1):87-92. doi: 10.1007/s00405-011-1627-6. Epub 2011 May 18.
29. Kentsis A, etal., Nat Med. 2012 Jul;18(7):1118-22. doi: 10.1038/nm.2819.
30. Kirschbaum K, etal., J Biol Chem. 2009 Oct 16;284(42):28533-42. Epub 2009 Aug 7.
31. Kiselyov VV, etal., Structure (Camb) 2003 Jun;11(6):691-701.
32. Kuny S, etal., Invest Ophthalmol Vis Sci. 2012 Feb 13;53(2):664-75. doi: 10.1167/iovs.11-8418.
33. Kuo CH, etal., Cardiovasc Res. 2015 Jan 1;105(1):107-17. doi: 10.1093/cvr/cvu239. Epub 2014 Nov 10.
34. Laitinen EM, etal., Fertil Steril. 2010 Apr;93(6):2074.e13-6. doi: 10.1016/j.fertnstert.2009.11.013. Epub 2010 Jan 15.
35. Li G, etal., Circulation. 2002 Aug 13;106(7):854-9.
36. Lin N, etal., Am J Physiol Cell Physiol. 2011 Aug;301(2):C469-77. doi: 10.1152/ajpcell.00452.2010. Epub 2011 May 4.
37. Liu X and Zhu XZ, Brain Res Mol Brain Res. 1999 Aug 25;71(2):171-7.
38. Lou D, etal., Exp Ther Med. 2018 Oct;16(4):2909-2916. doi: 10.3892/etm.2018.6586. Epub 2018 Aug 7.
39. Lu R, etal., J Lipid Res. 2009 Jun;50(6):1156-64. doi: 10.1194/jlr.M800594-JLR200. Epub 2009 Feb 19.
40. Luo W, etal., Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1081-6. Epub 2004 Apr 8.
41. Ma DK, etal., Mol Brain. 2009 Jun 8;2(1):16.
42. Maric D, etal., J Neurosci. 2007 Feb 21;27(8):1836-52.
43. Masumura M, etal., Neurosci Lett. 1996 Aug 2;213(2):119-22.
44. Meisinger C, etal., Brain Res Mol Brain Res. 1996 Feb;36(1):70-8.
45. Messersmith DJ, etal., J Neurosci Res. 2000 Oct 15;62(2):241-56.
46. MGD data from the GO Consortium
47. Molina-Hernandez A, etal., Neural Dev. 2013 Mar 7;8:4. doi: 10.1186/1749-8104-8-4.
48. Muenke M, etal., Nat Genet. 1994 Nov;8(3):269-74.
49. Nakajima A, etal., Bone. 2001 Nov;29(5):458-66.
50. NCBI rat LocusLink and RefSeq merged data July 26, 2002
51. Nichol PF, etal., J Pediatr Surg. 2011 Jan;46(1):90-6. doi: 10.1016/j.jpedsurg.2010.09.066.
52. O'Reilly BF, etal., Otol Neurotol. 2004 Sep;25(5):791-6.
53. Oda Y, etal., J Oral Maxillofac Surg. 2004 Jan;62(1):73-80.
54. OMIM Disease Annotation Pipeline
55. Online Mendelian Inheritance in Man, OMIM (TM).
56. Orfanidou T, etal., Exp Biol Med (Maywood). 2012 Mar;237(3):241-53. doi: 10.1258/ebm.2011.011301. Epub 2012 Mar 5.
57. Owczarek S, etal., FASEB J. 2010 Apr;24(4):1139-50. Epub 2009 Dec 1.
58. Ozaki S, etal., Invest Ophthalmol Vis Sci. 2000 Feb;41(2):568-79.
59. Pipeline to import KEGG annotations from KEGG into RGD
60. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
61. Pitteloud N, etal., J Clin Invest. 2007 Feb;117(2):457-63. Epub 2007 Jan 18.
62. Pitteloud N, etal., Mol Cell Endocrinol. 2006 Jul 25;254-255:60-9. Epub 2006 Jun 9.
63. Pitteloud N, etal., Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6281-6. Epub 2006 Apr 10.
64. Purushothaman R, etal., Birth Defects Res A Clin Mol Teratol. 2011 Jul;91(7):603-9. doi: 10.1002/bdra.20811. Epub 2011 Apr 28.
65. Rafiqdoost Z, etal., Int J Pediatr Otorhinolaryngol. 2014 May;78(5):731-6. doi: 10.1016/j.ijporl.2014.01.024. Epub 2014 Jan 27.
66. Ren M, etal., Blood. 2009 Aug 20;114(8):1576-84. doi: 10.1182/blood-2009-03-212704. Epub 2009 Jun 8.
67. Ren M, etal., Blood. 2013 Aug 8;122(6):1007-16. doi: 10.1182/blood-2013-03-489823. Epub 2013 Jun 18.
68. Ren M, etal., Int J Cancer. 2016 Aug 15;139(4):836-40. doi: 10.1002/ijc.30100. Epub 2016 May 4.
69. Ren M, etal., Leukemia. 2013 Jan;27(1):32-40. doi: 10.1038/leu.2012.188. Epub 2012 Jul 11.
70. RGD automated data pipeline
71. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
72. RGD automated import pipeline for gene-chemical interactions
73. Rider V, etal., Endocrinology. 1995 Jul;136(7):3137-45.
74. Riehle KJ, etal., Mod Pathol. 2015 Jan;28(1):103-10. doi: 10.1038/modpathol.2014.78. Epub 2014 Jun 13.
75. Roumiantsev S, etal., Cancer Cell. 2004 Mar;5(3):287-98.
76. Sasaki S, etal., PLoS One. 2011 May 9;6(5):e19618. doi: 10.1371/journal.pone.0019618.
77. Sato N, etal., Hum Reprod. 2005 Aug;20(8):2173-8. Epub 2005 Apr 21.
78. Sato T, etal., Oncol Rep. 2009 Jan;21(1):211-6.
79. Seyed M and Dimario JX, J Mol Cell Cardiol. 2008 Mar;44(3):510-9. doi: 10.1016/j.yjmcc.2007.12.008. Epub 2008 Jan 17.
80. Smith C, etal., Eur J Neurosci. 2001 Feb;13(3):443-56.
81. Takami K, etal., Brain Res. 1998 Aug 17;802(1-2):89-97.
82. Takenaka H, etal., J Invest Dermatol. 1997 Jul;109(1):108-12.
83. Ting SR, etal., Biomaterials. 2013 Jun;34(17):4377-86. doi: 10.1016/j.biomaterials.2013.02.042. Epub 2013 Mar 7.
84. Tran TN, etal., Lung Cancer. 2013 Sep;81(3):462-467. doi: 10.1016/j.lungcan.2013.05.015. Epub 2013 Jun 24.
85. Trarbach EB, etal., J Clin Endocrinol Metab. 2006 Oct;91(10):4006-12. Epub 2006 Aug 1.
86. Trokovic R, etal., EMBO J 2003 Apr 15;22(8):1811-23.
87. Van Der Wal EA, etal., Neuroscience. 1994 May;60(2):311-23.
88. Villanueva C, etal., Genet Med. 2015 Aug;17(8):651-9. doi: 10.1038/gim.2014.166. Epub 2014 Nov 13.
89. Wang P, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Jan;32(1):97-101.
90. Wang XH, etal., Chin Med J (Engl). 2007 Mar 20;120(6):485-90.
91. Weng T, etal., Arthritis Rheum. 2012 Dec;64(12):3982-92. doi: 10.1002/art.34645.
92. White KE, etal., Am J Hum Genet. 2005 Feb;76(2):361-7. Epub 2004 Dec 28.
93. Wu AL, etal., Sci Transl Med. 2011 Dec 14;3(113):113ra126. doi: 10.1126/scitranslmed.3002669.
94. Xu N, etal., J Clin Endocrinol Metab. 2007 Mar;92(3):1155-8. Epub 2007 Jan 2.
95. Yamanaka H, etal., Neuroscience. 2007 Nov 30;150(1):202-11. Epub 2007 Aug 29.
96. Yang F, etal., Cancer Res. 2013 Jun 15;73(12):3716-24. doi: 10.1158/0008-5472.CAN-12-3274. Epub 2013 Apr 10.
97. Yazaki N, etal., Biochim Biophys Acta 1993 Feb 20;1172(1-2):37-42.
98. Zheng S, etal., J Huazhong Univ Sci Technolog Med Sci. 2010 Feb;30(1):25-8. doi: 10.1007/s11596-010-0105-5. Epub 2010 Feb 14.
99. Zhou YX, etal., Hum Mol Genet. 2000 Aug 12;9(13):2001-8.
Additional References at PubMed
PMID:2161540   PMID:8381605   PMID:8622701   PMID:8663044   PMID:10373225   PMID:10830168   PMID:12194867   PMID:12421715   PMID:15576401   PMID:15621532   PMID:15630379   PMID:15695515  
PMID:15929978   PMID:16172976   PMID:16207751   PMID:16417571   PMID:16442091   PMID:16540513   PMID:16778080   PMID:16943278   PMID:17086194   PMID:17186267   PMID:17255109   PMID:17544391  
PMID:17687036   PMID:18187602   PMID:18191119   PMID:18337405   PMID:18480409   PMID:18533146   PMID:18559345   PMID:18586016   PMID:18799682   PMID:18824081   PMID:19103603   PMID:19185025  
PMID:19307307   PMID:19696444   PMID:20133753   PMID:20410112   PMID:20816673   PMID:21389209   PMID:21392510   PMID:21515689   PMID:21575685   PMID:21885851   PMID:23263626   PMID:23382219  
PMID:23564461   PMID:23828126   PMID:23867734   PMID:23874817   PMID:24072480   PMID:24121132   PMID:24157794   PMID:24259513   PMID:24571920   PMID:25907855   PMID:25957476   PMID:26154243  
PMID:26234751   PMID:26311115   PMID:26451614   PMID:26535780   PMID:27015635   PMID:27815219   PMID:28515153   PMID:28813681  


Genomics

Comparative Map Data
Fgfr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21666,492,445 - 66,546,731 (-)NCBI
Rnor_6.0 Ensembl1671,266,248 - 71,319,449 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01671,265,390 - 71,319,046 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01670,924,716 - 70,977,998 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41670,869,974 - 70,910,045 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11670,870,238 - 70,910,310 (-)NCBI
Celera1664,402,647 - 64,442,189 (-)NCBICelera
Cytogenetic Map16q12.4NCBI
FGFR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl838,400,215 - 38,468,834 (-)EnsemblGRCh38hg38GRCh38
GRCh38838,411,143 - 38,468,635 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37838,268,661 - 38,326,153 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36838,387,813 - 38,445,509 (-)NCBINCBI36hg18NCBI36
Build 34838,389,448 - 38,445,293NCBI
Celera837,221,633 - 37,279,334 (-)NCBI
Cytogenetic Map8p11.23NCBI
HuRef836,802,638 - 36,860,684 (-)NCBIHuRef
CHM1_1838,470,562 - 38,528,261 (-)NCBICHM1_1
Fgfr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39826,008,775 - 26,065,734 (+)NCBIGRCm39mm39
GRCm39 Ensembl826,003,670 - 26,065,734 (+)Ensembl
GRCm38825,518,759 - 25,575,718 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl825,513,654 - 25,575,718 (+)EnsemblGRCm38mm10GRCm38
MGSCv37826,629,244 - 26,686,186 (+)NCBIGRCm37mm9NCBIm37
MGSCv36826,997,826 - 27,039,466 (+)NCBImm8
Celera826,986,822 - 27,044,074 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map814.12NCBI
Fgfr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546314,013,247 - 14,064,111 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546314,013,247 - 14,064,354 (-)NCBIChiLan1.0ChiLan1.0
FGFR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1834,890,147 - 34,948,904 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl834,890,147 - 34,948,904 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0837,713,133 - 37,773,098 (-)NCBIMhudiblu_PPA_v0panPan3
FGFR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11627,029,902 - 27,080,514 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1627,031,588 - 27,078,261 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1627,547,259 - 27,597,845 (+)NCBI
ROS_Cfam_1.01628,928,146 - 28,978,790 (+)NCBI
UMICH_Zoey_3.11627,151,667 - 27,202,222 (+)NCBI
UNSW_CanFamBas_1.01627,728,739 - 27,779,306 (+)NCBI
UU_Cfam_GSD_1.01627,767,626 - 27,818,261 (+)NCBI
Fgfr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494349,645,976 - 49,698,868 (+)NCBI
SpeTri2.0NW_0049367101,760,365 - 1,815,269 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGFR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1548,053,340 - 48,106,746 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11548,053,895 - 48,106,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21555,216,111 - 55,269,152 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FGFR1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1836,426,116 - 36,485,683 (-)NCBI
ChlSab1.1 Ensembl836,427,110 - 36,485,508 (-)Ensembl
Vero_WHO_p1.0NW_0236660525,502,205 - 5,561,763 (+)NCBI
Fgfr1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247805,161,245 - 5,212,641 (+)NCBI

Position Markers
D16Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,275,197 - 71,275,327NCBIRnor6.0
Rnor_5.01670,934,523 - 70,934,653UniSTSRnor5.0
RGSC_v3.41670,878,893 - 70,879,023UniSTSRGSC3.4
Celera1664,411,568 - 64,411,698UniSTS
Cytogenetic Map16q12.4UniSTS
D16Wox23  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,274,886 - 71,275,086NCBIRnor6.0
Rnor_5.01670,934,212 - 70,934,412UniSTSRnor5.0
RGSC_v3.41670,878,582 - 70,878,782UniSTSRGSC3.4
Celera1664,411,255 - 64,411,457UniSTS
Cytogenetic Map16q12.4UniSTS
BF400869  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,303,253 - 71,303,444NCBIRnor6.0
Rnor_5.01670,962,205 - 70,962,396UniSTSRnor5.0
RGSC_v3.41670,906,999 - 70,907,190UniSTSRGSC3.4
Celera1664,439,143 - 64,439,334UniSTS
RH 3.4 Map16623.8UniSTS
Cytogenetic Map16q12.4UniSTS
AU047379  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,275,181 - 71,275,327NCBIRnor6.0
Rnor_5.01670,934,507 - 70,934,653UniSTSRnor5.0
RGSC_v3.41670,878,877 - 70,879,023UniSTSRGSC3.4
Celera1664,411,552 - 64,411,698UniSTS
Cytogenetic Map16q12.4UniSTS
Fgfr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,266,354 - 71,266,602NCBIRnor6.0
Rnor_5.01670,925,680 - 70,925,928UniSTSRnor5.0
RGSC_v3.41670,870,050 - 70,870,298UniSTSRGSC3.4
Celera1664,402,723 - 64,402,971UniSTS
Cytogenetic Map16q12.4UniSTS
PMC154461P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,272,065 - 71,272,630NCBIRnor6.0
Rnor_5.01670,931,391 - 70,931,956UniSTSRnor5.0
RGSC_v3.41670,875,761 - 70,876,326UniSTSRGSC3.4
Celera1664,408,434 - 64,408,999UniSTS
Cytogenetic Map16q12.4UniSTS
Fgfr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01671,266,599 - 71,267,397NCBIRnor6.0
Rnor_5.01670,925,925 - 70,926,723UniSTSRnor5.0
Celera1664,402,968 - 64,403,766UniSTS
Cytogenetic Map16q12.4UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)16109005486162972Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)162075555680316424Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162751998072519980Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162834031573340315Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163900002184000021Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)164151271086512710Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)164151271086512710Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164655818890668790Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165781635790668790Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165781635790668790Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165781635790668790Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165928577589248943Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:54
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000029284, ENSRNOT00000050980
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 17 6 10 6 6 9 74 35 34 11 6
Low 40 35 9 35 2 2 7 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039094851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF000144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D12498 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S54008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U95164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000029284   ⟹   ENSRNOP00000036885
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1671,266,745 - 71,319,449 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000050980   ⟹   ENSRNOP00000043459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1671,266,248 - 71,319,052 (-)Ensembl
RefSeq Acc Id: NM_024146   ⟹   NP_077060
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,494,072 - 66,533,600 (-)NCBI
Rnor_6.01671,266,278 - 71,306,299 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
RGSC_v3.41670,869,974 - 70,910,045 (-)RGD
Celera1664,402,647 - 64,442,189 (-)RGD
Sequence:
RefSeq Acc Id: XM_006253323   ⟹   XP_006253385
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Rnor_6.01671,265,531 - 71,318,932 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253324   ⟹   XP_006253386
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,153 (-)NCBI
Rnor_6.01671,265,531 - 71,318,448 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253326   ⟹   XP_006253388
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Rnor_6.01671,265,531 - 71,318,932 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006253327   ⟹   XP_006253389
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,731 (-)NCBI
Rnor_6.01671,265,531 - 71,319,046 (-)NCBI
Rnor_5.01670,924,716 - 70,977,998 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600251   ⟹   XP_017455740
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,492,445 - 66,546,664 (-)NCBI
Rnor_6.01671,265,390 - 71,318,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600252   ⟹   XP_017455741
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,545,926 (-)NCBI
Rnor_6.01671,265,531 - 71,318,294 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600253   ⟹   XP_017455742
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Rnor_6.01671,265,531 - 71,318,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600254   ⟹   XP_017455743
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Rnor_6.01671,265,531 - 71,318,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600255   ⟹   XP_017455744
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,153 (-)NCBI
Rnor_6.01671,265,531 - 71,318,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039094850   ⟹   XP_038950778
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,360 (-)NCBI
RefSeq Acc Id: XM_039094851   ⟹   XP_038950779
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21666,493,325 - 66,546,664 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_077060   ⟸   NM_024146
- Peptide Label: precursor
- UniProtKB: Q04589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006253389   ⟸   XM_006253327
- Peptide Label: isoform X7
- UniProtKB: Q63827 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253386   ⟸   XM_006253324
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006253388   ⟸   XM_006253326
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_006253385   ⟸   XM_006253323
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017455740   ⟸   XM_017600251
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455743   ⟸   XM_017600254
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017455742   ⟸   XM_017600253
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017455744   ⟸   XM_017600255
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017455741   ⟸   XM_017600252
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000036885   ⟸   ENSRNOT00000029284
RefSeq Acc Id: ENSRNOP00000043459   ⟸   ENSRNOT00000050980
RefSeq Acc Id: XP_038950779   ⟸   XM_039094851
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038950778   ⟸   XM_039094850
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700176
Promoter ID:EPDNEW_R10695
Type:initiation region
Name:Fgfr1_1
Description:Fibroblast growth factor receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01671,319,476 - 71,319,536EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620713 AgrOrtholog
Ensembl Genes ENSRNOG00000016050 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000036885 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000043459 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000029284 UniProtKB/TrEMBL
  ENSRNOT00000050980 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FGF_rcpt_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FGF_rcpt_fam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FGFR_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:79114 UniProtKB/Swiss-Prot
NCBI Gene 79114 ENTREZGENE
Pfam FGFR3_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fgfr1 PhenoGen
PIRSF FGFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LM54_RAT UniProtKB/TrEMBL
  FGFR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q63827 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPM6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Fgfr1  Fibroblast growth factor receptor 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Fgfr1        Symbol and Name status set to provisional 70820 PROVISIONAL