Sardh (sarcosine dehydrogenase) - Rat Genome Database
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Gene: Sardh (sarcosine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Sardh
Name: sarcosine dehydrogenase
RGD ID: 621125
Description: Exhibits flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Involved in tetrahydrofolate interconversion. Localizes to mitochondrial matrix. Orthologous to human SARDH (sarcosine dehydrogenase); PARTICIPATES IN choline metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC366279; sarcosine dehydrogenase, mitochondrial; similar to sarcosine dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Celera35,308,395 - 5,369,033 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,IDA)
mitochondrion  (IBA,IDA,IEA,ISO,ISS)

Molecular Function

References

Additional References at PubMed
PMID:4055729   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Sardh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Celera35,308,395 - 5,369,033 (-)NCBICelera
Cytogenetic Map3p12NCBI
SARDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl9133,663,560 - 133,739,955 (-)EnsemblGRCh38hg38GRCh38
GRCh389133,663,074 - 133,739,958 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh379136,528,682 - 136,605,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,518,503 - 135,594,863 (-)NCBINCBI36hg18NCBI36
Build 349133,558,235 - 133,634,596NCBI
Celera9107,075,562 - 107,151,924 (-)NCBI
Cytogenetic Map9q34.2NCBI
HuRef9106,029,059 - 106,104,804 (-)NCBIHuRef
CHM1_19136,678,641 - 136,754,578 (-)NCBICHM1_1
Sardh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,078,405 - 27,138,344 (-)NCBIGRCm39mm39
GRCm39 Ensembl227,078,405 - 27,138,349 (-)Ensembl
GRCm38227,188,393 - 27,248,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,188,393 - 27,248,337 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,044,902 - 27,102,332 (-)NCBIGRCm37mm9NCBIm37
MGSCv36227,011,391 - 27,068,821 (-)NCBImm8
Celera226,892,296 - 26,949,897 (-)NCBICelera
Cytogenetic Map2A3NCBI
Sardh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,933,918 - 2,976,931 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,933,918 - 2,975,645 (-)NCBIChiLan1.0ChiLan1.0
SARDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.19133,398,806 - 133,473,642 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,398,806 - 133,473,642 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v09104,786,774 - 104,864,480 (-)NCBIMhudiblu_PPA_v0panPan3
SARDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1950,030,397 - 50,093,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Sardh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366693,244,302 - 3,297,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,228,838 - 273,295,104 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,230,357 - 273,295,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,204,192 - 307,268,081 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SARDH
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,397,312 - 4,469,890 (+)NCBI
ChlSab1.1 Ensembl124,397,539 - 4,469,562 (+)Ensembl
Sardh
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247602,030,835 - 2,070,517 (-)NCBI

Position Markers
D3Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.035,775,856 - 5,776,005NCBIRnor6.0
Rnor_5.0311,139,240 - 11,139,389UniSTSRnor5.0
Celera35,345,934 - 5,346,083UniSTS
RH 3.4 Map321.9RGD
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS
RH129217  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.035,737,248 - 5,737,439NCBIRnor6.0
Rnor_5.0311,100,716 - 11,100,907UniSTSRnor5.0
RGSC_v3.436,075,178 - 6,075,369UniSTSRGSC3.4
Celera35,307,407 - 5,307,598UniSTS
Cytogenetic Map3p12UniSTS
RH129462  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.035,737,262 - 5,737,470NCBIRnor6.0
Rnor_5.0311,100,730 - 11,100,938UniSTSRnor5.0
RGSC_v3.436,075,192 - 6,075,400UniSTSRGSC3.4
Celera35,307,421 - 5,307,629UniSTS
Cytogenetic Map3p12UniSTS
BE097994  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.035,768,098 - 5,768,252NCBIRnor6.0
Rnor_5.0311,131,482 - 11,131,636UniSTSRnor5.0
RGSC_v3.436,105,948 - 6,106,102UniSTSRGSC3.4
Celera35,337,989 - 5,338,143UniSTS
RH 3.4 Map314.0UniSTS
Cytogenetic Map3p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3125786001Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3128136884Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3128500807Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3128500807Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3132972944Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3137891710Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3139773425Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3195176874Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35711366000866Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3263142133477544Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3263142148562146Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3328592928136884Rat
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3328592928136884Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)3565463925105730Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000009555
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 41 49 41 1 41 7 35 34 11
Low 3 2 8 18 8 11 67 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000009555   ⟹   ENSRNOP00000009555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)Ensembl
RefSeq Acc Id: NM_053664   ⟹   NP_446116
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,511,586 - 10,573,573 (-)NCBI
Rnor_6.035,738,236 - 5,800,388 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
RGSC_v3.436,076,166 - 6,142,565 (-)RGD
Celera35,308,395 - 5,369,033 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233731   ⟹   XP_006233793
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,510,553 - 10,574,149 (-)NCBI
Rnor_6.035,737,203 - 5,800,956 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233732   ⟹   XP_006233794
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,510,553 - 10,574,095 (-)NCBI
Rnor_6.035,737,203 - 5,800,946 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233733   ⟹   XP_006233795
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.035,737,203 - 5,802,153 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104090   ⟹   XP_038960018
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2310,545,045 - 10,574,095 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_446116   ⟸   NM_053664
- UniProtKB: Q64380 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006233795   ⟸   XM_006233733
- Peptide Label: isoform X1
- UniProtKB: F1LRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233793   ⟸   XM_006233731
- Peptide Label: isoform X1
- UniProtKB: F1LRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233794   ⟸   XM_006233732
- Peptide Label: isoform X1
- UniProtKB: F1LRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009555   ⟸   ENSRNOT00000009555
RefSeq Acc Id: XP_038960018   ⟸   XM_039104090
- Peptide Label: isoform X2
Protein Domains
DAO   FAO_M   GCV_T   GCV_T_C

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691924
Promoter ID:EPDNEW_R2448
Type:single initiation site
Name:Sardh_1
Description:sarcosine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,802,123 - 5,802,183EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621125 AgrOrtholog
Ensembl Genes ENSRNOG00000006916 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000009555 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009555 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1360.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD-dep_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAO_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114123 UniProtKB/Swiss-Prot
NCBI Gene 114123 ENTREZGENE
Pfam DAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAO_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sardh PhenoGen
Superfamily-SCOP SSF101790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt F1LRY5 ENTREZGENE, UniProtKB/TrEMBL
  Q64380 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88499 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Sardh  sarcosine dehydrogenase  LOC366279  similar to sarcosine dehydrogenase  Data Merged 737654 PROVISIONAL
2006-11-19 LOC366279  similar to sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Sardh  sarcosine dehydrogenase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sardh  sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondrial matrix 634034
gene_expression expressed in liver,lung, pancreas, kidney, thymus, and oviduct 634034