Sardh (sarcosine dehydrogenase) - Rat Genome Database

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Gene: Sardh (sarcosine dehydrogenase) Rattus norvegicus
Analyze
Symbol: Sardh
Name: sarcosine dehydrogenase
RGD ID: 621125
Description: Enables flavin adenine dinucleotide binding activity; folic acid binding activity; and sarcosine dehydrogenase activity. Involved in tetrahydrofolate interconversion. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase); PARTICIPATES IN choline metabolic pathway; dihydropyrimidine dehydrogenase deficiency pathway; dimethylglycine dehydrogenase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366279; sarcosine dehydrogenase, mitochondrial; similar to sarcosine dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,908,621 - 30,973,409 (-)NCBIGRCr8
mRatBN7.2310,510,553 - 10,575,342 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,577,541 - 13,639,718 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,162,940 - 22,225,121 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,418,235 - 20,480,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Celera35,308,395 - 5,369,033 (-)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
dextran sulfate  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
ethylparaben  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
formaldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
glyphosate  (EXP)
imidacloprid  (EXP)
indometacin  (EXP)
iodide salt  (EXP)
methapyrilene  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
progesterone  (EXP)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sodium arsenite  (EXP,ISO)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrial matrix  (IBA,IDA)
mitochondrion  (IBA,IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and tissue distribution of rat sarcosine dehydrogenase. Bergeron F, etal., Eur J Biochem 1998 Nov 1;257(3):556-61.
2. Significant Down-Regulation of Urea Cycle Generates Clinically Relevant Proteomic Signature in Hepatocellular Carcinoma Patients with Macrovascular Invasion. Cao Y, etal., J Proteome Res. 2019 May 3;18(5):2032-2044. doi: 10.1021/acs.jproteome.8b00921. Epub 2019 Mar 29.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
13. Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Flavoprotein nature and enzymatic properties of the purified proteins. Wittwer AJ and Wagner C, J Biol Chem. 1981 Apr 25;256(8):4109-15.
Additional References at PubMed
PMID:4055729   PMID:14651853   PMID:18614015  


Genomics

Comparative Map Data
Sardh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8330,908,621 - 30,973,409 (-)NCBIGRCr8
mRatBN7.2310,510,553 - 10,575,342 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx313,577,541 - 13,639,718 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0322,162,940 - 22,225,121 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0320,418,235 - 20,480,397 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.035,737,203 - 5,802,153 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0311,100,670 - 11,164,367 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.436,076,166 - 6,142,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.136,076,465 - 6,142,865 (-)NCBI
Celera35,308,395 - 5,369,033 (-)NCBICelera
Cytogenetic Map3p12NCBI
SARDH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389133,659,418 - 133,739,955 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9133,663,560 - 133,739,955 (-)EnsemblGRCh38hg38GRCh38
GRCh379136,528,682 - 136,605,077 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369135,518,503 - 135,594,863 (-)NCBINCBI36Build 36hg18NCBI36
Build 349133,558,235 - 133,634,596NCBI
Celera9107,075,562 - 107,151,924 (-)NCBICelera
Cytogenetic Map9q34.2NCBI
HuRef9106,029,059 - 106,104,804 (-)NCBIHuRef
CHM1_19136,678,641 - 136,754,578 (-)NCBICHM1_1
T2T-CHM13v2.09145,875,436 - 145,955,389 (-)NCBIT2T-CHM13v2.0
Sardh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39227,078,405 - 27,138,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl227,078,405 - 27,138,349 (-)EnsemblGRCm39 Ensembl
GRCm38227,188,393 - 27,248,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl227,188,393 - 27,248,337 (-)EnsemblGRCm38mm10GRCm38
MGSCv37227,044,902 - 27,102,332 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36227,011,391 - 27,068,821 (-)NCBIMGSCv36mm8
Celera226,892,296 - 26,949,897 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map219.31NCBI
Sardh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555132,933,918 - 2,976,931 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555132,933,918 - 2,975,645 (-)NCBIChiLan1.0ChiLan1.0
SARDH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2115,613,842 - 5,696,750 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan195,616,176 - 5,696,436 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09104,786,774 - 104,864,480 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19133,398,806 - 133,473,642 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9133,398,806 - 133,473,642 (-)Ensemblpanpan1.1panPan2
SARDH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1950,030,397 - 50,093,556 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl950,030,707 - 50,091,553 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha949,310,923 - 49,374,527 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0950,904,459 - 50,967,629 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl950,904,464 - 50,967,596 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1949,665,765 - 49,728,991 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0950,007,753 - 50,071,562 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0950,086,168 - 50,149,420 (-)NCBIUU_Cfam_GSD_1.0
Sardh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947200,077,144 - 200,131,802 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366693,243,762 - 3,297,905 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366693,244,302 - 3,297,906 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SARDH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1273,230,375 - 273,294,621 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11273,230,357 - 273,295,170 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21307,204,192 - 307,268,081 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SARDH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1124,397,312 - 4,469,890 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl124,397,539 - 4,469,562 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666058519,221 - 596,979 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sardh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247602,032,326 - 2,066,584 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247602,030,835 - 2,070,517 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sardh
254 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:71
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000009555
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
D3Mgh17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,549,351 - 10,549,499 (+)MAPPERmRatBN7.2
Rnor_6.035,775,856 - 5,776,005NCBIRnor6.0
Rnor_5.0311,139,240 - 11,139,389UniSTSRnor5.0
Celera35,345,934 - 5,346,083UniSTS
RH 3.4 Map321.9RGD
RH 3.4 Map321.9UniSTS
Cytogenetic Map3p12UniSTS
RH129217  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,510,597 - 10,510,789 (+)MAPPERmRatBN7.2
Rnor_6.035,737,248 - 5,737,439NCBIRnor6.0
Rnor_5.0311,100,716 - 11,100,907UniSTSRnor5.0
RGSC_v3.436,075,178 - 6,075,369UniSTSRGSC3.4
Celera35,307,407 - 5,307,598UniSTS
Cytogenetic Map3p12UniSTS
RH129462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,510,611 - 10,510,820 (+)MAPPERmRatBN7.2
Rnor_6.035,737,262 - 5,737,470NCBIRnor6.0
Rnor_5.0311,100,730 - 11,100,938UniSTSRnor5.0
RGSC_v3.436,075,192 - 6,075,400UniSTSRGSC3.4
Celera35,307,421 - 5,307,629UniSTS
Cytogenetic Map3p12UniSTS
BE097994  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2310,541,407 - 10,541,561 (+)MAPPERmRatBN7.2
Rnor_6.035,768,098 - 5,768,252NCBIRnor6.0
Rnor_5.0311,131,482 - 11,131,636UniSTSRnor5.0
RGSC_v3.436,105,948 - 6,106,102UniSTSRGSC3.4
Celera35,337,989 - 5,338,143UniSTS
RH 3.4 Map314.0UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000009555   ⟹   ENSRNOP00000009555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl310,510,553 - 10,573,874 (-)Ensembl
Rnor_6.0 Ensembl35,737,200 - 5,802,129 (-)Ensembl
RefSeq Acc Id: NM_001423000   ⟹   NP_001409929
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,972,137 (-)NCBI
RefSeq Acc Id: NM_053664   ⟹   NP_446116
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,971,657 (-)NCBI
mRatBN7.2310,511,586 - 10,573,573 (-)NCBI
Rnor_6.035,738,236 - 5,800,388 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
RGSC_v3.436,076,166 - 6,142,565 (-)RGD
Celera35,308,395 - 5,369,033 (-)RGD
Sequence:
RefSeq Acc Id: XM_006233731   ⟹   XP_006233793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,972,216 (-)NCBI
mRatBN7.2310,510,553 - 10,574,149 (-)NCBI
Rnor_6.035,737,203 - 5,800,956 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233733   ⟹   XP_006233795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,908,621 - 30,973,409 (-)NCBI
mRatBN7.2310,510,553 - 10,575,342 (-)NCBI
Rnor_6.035,737,203 - 5,802,153 (-)NCBI
Rnor_5.0311,100,670 - 11,164,367 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039104090   ⟹   XP_038960018
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,943,117 - 30,972,171 (-)NCBI
mRatBN7.2310,545,045 - 10,574,095 (-)NCBI
RefSeq Acc Id: XM_063282992   ⟹   XP_063139062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,943,117 - 30,972,217 (-)NCBI
RefSeq Acc Id: XM_063282993   ⟹   XP_063139063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8330,947,283 - 30,972,161 (-)NCBI
RefSeq Acc Id: NP_446116   ⟸   NM_053664
- UniProtKB: Q64380 (UniProtKB/Swiss-Prot),   O88499 (UniProtKB/Swiss-Prot),   A6JTK8 (UniProtKB/TrEMBL),   F1LRY5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233795   ⟸   XM_006233733
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006233793   ⟸   XM_006233731
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000009555   ⟸   ENSRNOT00000009555
RefSeq Acc Id: XP_038960018   ⟸   XM_039104090
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001409929   ⟸   NM_001423000
- UniProtKB: Q64380 (UniProtKB/Swiss-Prot),   O88499 (UniProtKB/Swiss-Prot),   A6JTK8 (UniProtKB/TrEMBL),   F1LRY5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139062   ⟸   XM_063282992
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063139063   ⟸   XM_063282993
- Peptide Label: isoform X3
Protein Domains
Aminomethyltransferase folate-binding   FAD dependent oxidoreductase   FAD dependent oxidoreductase central   Glycine cleavage T-protein C-terminal barrel

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64380-F1-model_v2 AlphaFold Q64380 1-919 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691924
Promoter ID:EPDNEW_R2448
Type:single initiation site
Name:Sardh_1
Description:sarcosine dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.035,802,123 - 5,802,183EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621125 AgrOrtholog
BioCyc Gene G2FUF-50304 BioCyc
BioCyc Pathway PWY-3661-1 [glycine betaine degradation II (mammalian)] BioCyc
BioCyc Pathway Image PWY-3661-1 BioCyc
Ensembl Genes ENSRNOG00000006916 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009555.8 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/Swiss-Prot
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  Aminomethyltransferase beta-barrel domains UniProtKB/TrEMBL
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FAD-dep_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAO_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GcvT/YgfZ_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TrmE/GcvT_dom1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114123 UniProtKB/Swiss-Prot
NCBI Gene 114123 ENTREZGENE
PANTHER SARCOSINE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SARCOSINE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAO_M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GCV_T_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sardh PhenoGen
RatGTEx ENSRNOG00000006916 RatGTEx
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Folate-binding domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF101790 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JTK8 ENTREZGENE, UniProtKB/TrEMBL
  F1LRY5 ENTREZGENE, UniProtKB/TrEMBL
  O88499 ENTREZGENE
  Q64380 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary O88499 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Sardh  sarcosine dehydrogenase  LOC366279  similar to sarcosine dehydrogenase  Data merged from RGD:1587293 737654 PROVISIONAL
2006-11-19 LOC366279  similar to sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-26 Sardh  sarcosine dehydrogenase      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Sardh  sarcosine dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the mitochondrial matrix 634034
gene_expression expressed in liver,lung, pancreas, kidney, thymus, and oviduct 634034