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Gene: Lamp2 (lysosomal-associated membrane protein 2) Rattus norvegicus
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Symbol: Lamp2
Name: lysosomal-associated membrane protein 2
Description: Predicted to have enzyme binding activity and protein domain specific binding activity. Involved in protein targeting to lysosome involved in chaperone-mediated autophagy. Localizes to the endosome; lysosomal matrix; and lysosomal membrane. Colocalizes with the membrane raft. Used to study Danon disease; cholestasis; chronic conjunctivitis; cognitive disorder; and hypertrophic cardiomyopathy. Biomarker of myocardial infarction and sciatic neuropathy. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2); PARTICIPATES IN autophagy pathway; chaperone mediated autophagy pathway; phagocytosis pathway; INTERACTS WITH (+)-pilocarpine; (RS)-amphetamine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CD107 antigen-like family member B; LAMP-2; LGP-110; LGP-96; LGP-B; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2
Orthologs:
Homo sapiens (human) : LAMP2 (lysosomal associated membrane protein 2)  HGNC  Alliance
Mus musculus (house mouse) : Lamp2 (lysosomal-associated membrane protein 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lamp2 (lysosomal associated membrane protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMP2 (lysosomal associated membrane protein 2)
Canis lupus familiaris (dog) : LAMP2 (lysosomal associated membrane protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lamp2 (lysosomal associated membrane protein 2)
Sus scrofa (pig) : LAMP2 (lysosomal associated membrane protein 2)
more info ...
Allele / Splice: Lamp2em1  
Genetic Models: SD-Lamp2em1
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X124,722,628 - 124,766,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX124,722,628 - 124,766,044 (-)Ensembl
Rnor_5.0X124,809,053 - 124,852,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X6,908,285 - 6,951,772 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X6,913,840 - 6,957,328 (+)NCBI
CeleraX116,392,499 - 116,436,287 (-)NCBICelera
Cytogenetic MapXq35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Lamp2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2990
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-10-22
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.