RGD Reference Report - A receptor for the selective uptake and degradation of proteins by lysosomes. - Rat Genome Database

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A receptor for the selective uptake and degradation of proteins by lysosomes.

Authors: Cuervo, AM  Dice, JF 
Citation: Cuervo AM and Dice JF, Science. 1996 Jul 26;273(5274):501-3.
RGD ID: 10412302
Pubmed: PMID:8662539   (View Abstract at PubMed)

Multiple pathways of protein degradation operate within cells. A selective protein import pathway exists for the uptake and degradation of particular cytosolic proteins by lysosomes. Here, the lysosomal membrane glycoprotein LGP96 was identified as a receptor for the selective import and degradation of proteins within lysosomes. Specific substrates of this proteolytic pathway bound to the cytosolic tail of a 96-kilodalton lysosomal membrane protein in two different binding assays. Overexpression of human LGP96 in Chinese hamster ovary cells increased the activity of the selective lysosomal proteolytic pathway in vivo and in vitro.



Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Lamp2Ratlysosomal membrane located_inIDA PMID:8662539ParkinsonsUK-UCL 

Objects Annotated

Genes (Rattus norvegicus)
Lamp2  (lysosomal-associated membrane protein 2)


Additional Information