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Gene: Lamp2 (lysosomal-associated membrane protein 2) Mus musculus
Symbol: Lamp2
Name: lysosomal-associated membrane protein 2
RGD ID: 10857
Description: Exhibits protein domain specific binding activity. Involved in several processes, including muscle cell cellular homeostasis; protein stabilization; and protein targeting to lysosome involved in chaperone-mediated autophagy. Localizes to bounding membrane of organelle. Predicted to colocalize with membrane raft. Is expressed in central nervous system; lung; retina; and yolk sac endoderm. Used to study Danon disease. Human ortholog(s) of this gene implicated in Danon disease and hypertrophic cardiomyopathy. Orthologous to human LAMP2 (lysosomal associated membrane protein 2); PARTICIPATES IN chaperone mediated autophagy pathway; autophagy pathway; tuberculosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CD107 antigen-like family member B; CD107b; Lam; Lamp; Lamp II; Lamp-2; Lamp-2a; Lamp-2b; Lamp-2c; LGP-B; lysosomal membrane glycoprotein 2; lysosomal membrane glycoprotein type B; lysosome-associated membrane glycoprotein 2; lysosome-associated membrane protein 2; lysosome-associated membrane protein-2; Mac; Mac3
Homo sapiens (human) : LAMP2 (lysosomal associated membrane protein 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lamp2 (lysosomal-associated membrane protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lamp2 (lysosomal associated membrane protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : LAMP2 (lysosomal associated membrane protein 2)
Canis lupus familiaris (dog) : LAMP2 (lysosomal associated membrane protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lamp2 (lysosomal associated membrane protein 2)
Sus scrofa (pig) : LAMP2 (lysosomal associated membrane protein 2)
Chlorocebus sabaeus (African green monkey) : LAMP2 (lysosomal associated membrane protein 2)
Heterocephalus glaber (naked mole-rat) : Lamp2 (lysosomal associated membrane protein 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 EnsemblX38,401,357 - 38,456,454 (-)EnsemblGRCm38mm10GRCm38
GRCm38X38,399,647 - 38,456,460 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X35,758,241 - 35,809,632 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X34,649,691 - 34,701,082 (-)NCBImm8
CeleraX26,051,798 - 26,103,095 (-)NCBICelera
Cytogenetic MapXA3.3NCBI
cM MapX22.67NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lamp2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10857
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.