Gene: Aqp4 (aquaporin 4) Rattus norvegicus
Symbol: Aqp4
Name: aquaporin 4
Description: ENCODES a protein that exhibits porin activity; water channel activity; identical protein binding (ortholog); INVOLVED IN carbon dioxide transport; cellular response to estradiol stimulus; cellular response to glucose stimulus; PARTICIPATES IN water transport pathway; bile acid transport pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH amyotrophic lateral sclerosis; brain edema; Brain Injuries; FOUND IN basal plasma membrane; basolateral plasma membrane; cell projection membrane; INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-4; AQP4.M23; aquaporin 4.M23; aquaporin-4; mercurial-insensitive water channel; Miwc; MIWC2; WCH4
Homo sapiens (human) : AQP4 (aquaporin 4)  HGNC  Alliance
Mus musculus (house mouse) : Aqp4 (aquaporin 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp4 (aquaporin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP4 (aquaporin 4)
Canis lupus familiaris (dog) : AQP4 (aquaporin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp4 (aquaporin 4)
Sus scrofa (pig) : AQP4 (aquaporin 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
Cytogenetic Map18p13NCBI
RH 3.4 Map1878.3RGD
RH 3.4 Map1886.21RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aqp4
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2143
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE