Gene: Aqp4 (aquaporin 4) Rattus norvegicus
Symbol: Aqp4
Name: aquaporin 4
Description: ENCODES a protein that exhibits porin activity; water channel activity; identical protein binding (ortholog); INVOLVED IN carbon dioxide transport; cellular response to estradiol stimulus; cellular response to glucose stimulus; PARTICIPATES IN water transport pathway; bile acid transport pathway; vasopressin signaling pathway via receptor type 2; ASSOCIATED WITH Amyotrophic Lateral Sclerosis; Brain Edema; Brain Injuries; FOUND IN basal plasma membrane; basolateral plasma membrane; cell projection membrane; INTERACTS WITH (+)-pilocarpine; 1,3-dinitrobenzene; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-4; AQP4.M23; aquaporin 4.M23; aquaporin-4; mercurial-insensitive water channel; Miwc; MIWC2; WCH4
Homo sapiens (human) : AQP4 (aquaporin 4)  HGNC  AGR
Mus musculus (house mouse) : Aqp4 (aquaporin 4)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Aqp4 (aquaporin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP4 (aquaporin 4)
Canis lupus familiaris (dog) : AQP4 (aquaporin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp4 (aquaporin 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
Cytogenetic Map18p13NCBI
RH 3.4 Map1878.3RGD
RH 3.4 Map1886.21RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Aqp4
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2143
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2017-12-26
Status: ACTIVE