Aqp4 (aquaporin 4) - Rat Genome Database

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Gene: Aqp4 (aquaporin 4) Rattus norvegicus
Analyze
Symbol: Aqp4
Name: aquaporin 4
RGD ID: 2143
Description: Exhibits identical protein binding activity and water channel activity. Involved in several processes, including cellular chemical homeostasis; cellular response to cytokine stimulus; and regulation of cytokine production. Localizes to several cellular components, including T-tubule; astrocyte end-foot; and basolateral plasma membrane. Used to study diabetic retinopathy and status epilepticus. Biomarker of several diseases, including brain edema; cerebrovascular disease (multiple); eye disease (multiple); hydrocephalus; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in Meniere's disease; blindness; optic nerve disease (multiple); temporal lobe epilepsy; and transverse myelitis. Orthologous to human AQP4 (aquaporin 4); PARTICIPATES IN water transport pathway; bile acid transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-4; AQP4.M23; aquaporin 4.M23; aquaporin-4; mercurial-insensitive water channel; Miwc; MIWC2; WCH4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBI
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
acetic acid  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
betamethasone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcidiol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
clofibrate  (ISO)
cycloheximide  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diprotium oxide  (EXP,ISO)
doxorubicin  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
gentamycin  (EXP,ISO)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen chloride  (EXP)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dichloride  (EXP)
methylmercury chloride  (EXP,ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (EXP)
reactive oxygen species  (ISO)
rifampicin  (ISO)
SB 203580  (ISO)
SB-239063  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triazines  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
water  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:8601457   PMID:8660998   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10021464   PMID:10318966   PMID:10510269  
PMID:10564231   PMID:10613915   PMID:10662735   PMID:10795927   PMID:11001937   PMID:11034202   PMID:11076974   PMID:11573934   PMID:11717465   PMID:11726686   PMID:12034763   PMID:12081649  
PMID:12084581   PMID:12359252   PMID:12504879   PMID:12650429   PMID:12673830   PMID:12692561   PMID:12944406   PMID:14627352   PMID:14663195   PMID:14701836   PMID:14752829   PMID:14753448  
PMID:15010203   PMID:15090052   PMID:15149973   PMID:15466140   PMID:15488478   PMID:15948717   PMID:16103109   PMID:16461188   PMID:16582023   PMID:16596446   PMID:16641100   PMID:16646408  
PMID:16814974   PMID:16895520   PMID:16987239   PMID:16997459   PMID:17178220   PMID:17184078   PMID:17266129   PMID:17356517   PMID:17416972   PMID:17566653   PMID:17593398   PMID:17622964  
PMID:17645239   PMID:17970725   PMID:18179769   PMID:18202181   PMID:18206860   PMID:18255256   PMID:18284610   PMID:18286643   PMID:18392839   PMID:18487486   PMID:18501347   PMID:18510734  
PMID:18511455   PMID:18572411   PMID:18649401   PMID:18718702   PMID:18762715   PMID:18951883   PMID:19114109   PMID:19170255   PMID:19229993   PMID:19236167   PMID:19240114   PMID:19285541  
PMID:19297454   PMID:19383790   PMID:19406128   PMID:19429018   PMID:19451651   PMID:19596320   PMID:19705963   PMID:19800950   PMID:19831719   PMID:19843522   PMID:19843787   PMID:19928950  
PMID:19948131   PMID:19962432   PMID:20017335   PMID:20026178   PMID:20071343   PMID:20109536   PMID:20461024   PMID:20484841   PMID:20617879   PMID:20625331   PMID:20709083   PMID:20806048  
PMID:20877385   PMID:21178974   PMID:21204635   PMID:21208160   PMID:21212277   PMID:21468722   PMID:21519634   PMID:21621589   PMID:21682559   PMID:21700703   PMID:21705333   PMID:21713710  
PMID:21850708   PMID:22011386   PMID:22069320   PMID:22146847   PMID:22322923   PMID:22381744   PMID:22420318   PMID:22528459   PMID:22554469   PMID:22590566   PMID:22610042   PMID:22676888  
PMID:22718347   PMID:22728101   PMID:22802001   PMID:22871113   PMID:22896675   PMID:22902770   PMID:22903516   PMID:22922737   PMID:22967487   PMID:23022607   PMID:23040263   PMID:23142737  
PMID:23180003   PMID:23199918   PMID:23357720   PMID:23441695   PMID:23505074   PMID:23510922   PMID:23520529   PMID:23592763   PMID:23616425   PMID:23622727   PMID:23651078   PMID:24238521  
PMID:24282821   PMID:24657265   PMID:24817288   PMID:24828425   PMID:24912027   PMID:25013167   PMID:25146699   PMID:25223087   PMID:25231107   PMID:25373717   PMID:25441658   PMID:25479407  
PMID:25770057   PMID:25800444   PMID:25907740   PMID:26013827   PMID:26385393   PMID:26459070   PMID:26583111   PMID:26617791   PMID:26724742   PMID:27181510   PMID:27188736   PMID:27236300  
PMID:27435677   PMID:27525904   PMID:27706789   PMID:27726111   PMID:27751903   PMID:27788222   PMID:27886057   PMID:27930615   PMID:28206694   PMID:28303331   PMID:28341892   PMID:28461494  
PMID:28549966   PMID:28567523   PMID:28572712   PMID:28826498   PMID:28978666   PMID:29057271   PMID:29066483   PMID:29178911   PMID:29351212   PMID:29520011   PMID:29921834   PMID:29956781  
PMID:30293570   PMID:30628716   PMID:30919512   PMID:31063681   PMID:31218751   PMID:31242419   PMID:31407064   PMID:31556577   PMID:31626131   PMID:32664509   PMID:32726124  


Genomics

Comparative Map Data
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBI
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,745 - 24,373,546 (-)NCBICHM1_1
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBImm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0panPan3
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBI
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBI
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBI
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBI
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBI
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBI
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,400,794 - 111,422,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBI
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)Ensembl
Aqp4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBI

Position Markers
RH94727  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0186,769,558 - 6,769,700NCBIRnor6.0
Rnor_5.0186,724,308 - 6,724,450UniSTSRnor5.0
RGSC_v3.4186,629,862 - 6,630,004UniSTSRGSC3.4
Celera186,533,563 - 6,533,705UniSTS
Cytogenetic Map18p13UniSTS
RH142179  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0186,769,452 - 6,769,643NCBIRnor6.0
Rnor_5.0186,724,202 - 6,724,393UniSTSRnor5.0
RGSC_v3.4186,629,756 - 6,629,947UniSTSRGSC3.4
Celera186,533,457 - 6,533,648UniSTS
RH 3.4 Map1886.21UniSTS
Cytogenetic Map18p13UniSTS
RH138222  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0186,768,825 - 6,768,956NCBIRnor6.0
Rnor_5.0186,723,575 - 6,723,706UniSTSRnor5.0
RGSC_v3.4186,629,129 - 6,629,260UniSTSRGSC3.4
Celera186,532,830 - 6,532,961UniSTS
RH 3.4 Map1878.1UniSTS
Cytogenetic Map18p13UniSTS
Aqp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0186,778,901 - 6,779,131NCBIRnor6.0
Rnor_5.0186,733,651 - 6,733,881UniSTSRnor5.0
Celera186,542,590 - 6,542,820UniSTS
Cytogenetic Map18p13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125999214Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125999214Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135097280Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18138195967Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18138195967Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18138753381Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18247709623184414Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18247709623184414Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18371954732487870Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18440751362570466Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18543013441781619Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir100rno-miR-100-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir30arno-miR-30a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir99brno-miR-99b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:2166
Count of miRNA genes:336
Interacting mature miRNAs:452
Transcripts:ENSRNOT00000048109, ENSRNOT00000068150
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 8 10 40 30 1 11 8
Low 2 24 28 18 10 18 1 18 5 18
Below cutoff 14 28 22 8 22 16 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001317749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF541968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO395028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO395446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO397165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO405518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV717820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV728051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000048109   ⟹   ENSRNOP00000050942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl186,766,009 - 6,781,841 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068150   ⟹   ENSRNOP00000063720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl186,766,009 - 6,782,757 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077606   ⟹   ENSRNOP00000073052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl186,766,009 - 6,781,841 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090320   ⟹   ENSRNOP00000072488
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)Ensembl
RefSeq Acc Id: NM_001142366   ⟹   NP_001135838
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,442 (-)NCBI
Rnor_6.0186,766,009 - 6,781,841 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
RGSC_v3.4186,626,313 - 6,642,766 (-)RGD
Celera186,530,014 - 6,545,530 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270558   ⟹   NP_001257487
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270559   ⟹   NP_001257488
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,442 (-)NCBI
Rnor_6.0186,766,009 - 6,781,841 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
Celera186,530,014 - 6,545,530 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317749   ⟹   NP_001304678
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012825   ⟹   NP_036957
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
RGSC_v3.4186,626,313 - 6,642,766 (-)RGD
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017600857   ⟹   XP_017456346
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,766,009 - 6,781,720 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096581   ⟹   XP_038952509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,537 (-)NCBI
RefSeq Acc Id: XM_039096582   ⟹   XP_038952510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,056 - 6,524,547 (-)NCBI
RefSeq Acc Id: XM_039096583   ⟹   XP_038952511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,545 (-)NCBI
RefSeq Acc Id: XM_039096584   ⟹   XP_038952512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,431 (-)NCBI
RefSeq Acc Id: XM_039096585   ⟹   XP_038952513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,283 - 6,524,542 (-)NCBI
RefSeq Acc Id: XM_039096586   ⟹   XP_038952514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,056 - 6,524,558 (-)NCBI
RefSeq Acc Id: XM_039096587   ⟹   XP_038952515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,493 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036957   ⟸   NM_012825
- Peptide Label: isoform M1
- UniProtKB: P47863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001135838   ⟸   NM_001142366
- Peptide Label: isoform M23
- UniProtKB: A0A0G2K4I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257487   ⟸   NM_001270558
- Peptide Label: isoform 3
- UniProtKB: P47863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257488   ⟸   NM_001270559
- Peptide Label: isoform 4
- UniProtKB: A0A0H2UHZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304678   ⟸   NM_001317749
- Peptide Label: isoform M1x
- Sequence:
RefSeq Acc Id: XP_017456346   ⟸   XM_017600857
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000050942   ⟸   ENSRNOT00000048109
RefSeq Acc Id: ENSRNOP00000073052   ⟸   ENSRNOT00000077606
RefSeq Acc Id: ENSRNOP00000072488   ⟸   ENSRNOT00000090320
RefSeq Acc Id: ENSRNOP00000063720   ⟸   ENSRNOT00000068150
RefSeq Acc Id: XP_038952511   ⟸   XM_039096583
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952509   ⟸   XM_039096581
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952515   ⟸   XM_039096587
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952512   ⟸   XM_039096584
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952514   ⟸   XM_039096586
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038952510   ⟸   XM_039096582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952513   ⟸   XM_039096585
- Peptide Label: isoform X5

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700648
Promoter ID:EPDNEW_R11172
Type:initiation region
Name:Aqp4_1
Description:aquaporin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,782,709 - 6,782,769EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2143 AgrOrtholog
Ensembl Genes ENSRNOG00000016043 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050942 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000063720 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000072488 UniProtKB/TrEMBL
  ENSRNOP00000073052 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048109 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000068150 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077606 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000090320 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25293 UniProtKB/Swiss-Prot
NCBI Gene 25293 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp4 PhenoGen
PRINTS MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K336_RAT UniProtKB/TrEMBL
  A0A0G2K4I1 ENTREZGENE
  A0A0H2UHZ1 ENTREZGENE, UniProtKB/TrEMBL
  AQP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K4I1 UniProtKB/Swiss-Prot
  Q8CIY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp4  aquaporin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to hypothyroidism 704374
gene_expression expressed in kidney collecting duct principal cells 70240
gene_expression expressed in inner medullary 67997
gene_function water channel protein 67997
gene_function water channel protein 70240
gene_process mediates water transport across the basolateral plasma membrane of collecting duct principal cells 67997
gene_process mediates water transport across the basolateral plasma membrane of collecting duct principal cells 70240
gene_process regulates water homeostasis and flow in the CNS 730277
gene_process may participate in brain edema formation following trauma 1298579
gene_process does not appear to contribute to the diabetes mellitus model 67997