Aqp4 (aquaporin 4) - Rat Genome Database

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Gene: Aqp4 (aquaporin 4) Rattus norvegicus
Analyze
Symbol: Aqp4
Name: aquaporin 4
RGD ID: 2143
Description: Enables identical protein binding activity and water channel activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to estradiol stimulus; and regulation of cytokine production. Located in several cellular components, including T-tubule; astrocyte end-foot; and basolateral plasma membrane. Part of protein-containing complex. Used to study diabetic retinopathy and status epilepticus. Biomarker of several diseases, including brain edema; cerebrovascular disease (multiple); eye disease (multiple); hydrocephalus; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in Meniere's disease; blindness; optic nerve disease (multiple); temporal lobe epilepsy; and transverse myelitis. Orthologous to human AQP4 (aquaporin 4); PARTICIPATES IN water transport pathway; bile acid transport pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (+)-pilocarpine; 1,2-dichloroethane; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AQP-4; AQP4.M23; aquaporin 4.M23; aquaporin-4; mercurial-insensitive water channel; Miwc; MIWC2; WCH4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Aqp4em1Hrt  
Genetic Models: SD-Aqp4em1Hrt
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,733,660 - 6,750,099 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0187,521,314 - 7,537,753 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,792,881 - 6,809,322 (-)NCBIRnor_WKY
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP)
acetic acid  (EXP)
acrylamide  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
arsenous acid  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
betamethasone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
calcidiol  (EXP)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
choline  (ISO)
clofibrate  (ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
D-glucose  (EXP)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (EXP)
Diallyl sulfide  (ISO)
diarsenic trioxide  (ISO)
diprotium oxide  (EXP,ISO)
doxorubicin  (EXP)
ethanol  (EXP,ISO)
folic acid  (ISO)
furan  (EXP)
galactose  (ISO)
gentamycin  (EXP,ISO)
glucose  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen chloride  (EXP)
iron atom  (EXP,ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
mercury dichloride  (EXP)
methylmercury chloride  (EXP,ISO)
morphine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
olanzapine  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenobarbital  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
rac-lactic acid  (EXP)
reactive oxygen species  (ISO)
rifampicin  (ISO)
SB 203580  (ISO)
SB-239063  (EXP)
senecionine  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
terbutaline  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiourea  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
Triptolide  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (EXP,ISO)
water  (EXP,ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. Ampawong S, etal., Int J Clin Exp Pathol. 2011 Aug 15;4(6):566-74. Epub 2011 Jul 23.
2. Hypoalgesia in mice lacking aquaporin-4 water channels. Bao F, etal., Brain Res Bull. 2010 Nov 20;83(6):298-303. doi: 10.1016/j.brainresbull.2010.08.015. Epub 2010 Sep 22.
3. Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model. Bataveljic D, etal., Glia. 2012 Dec;60(12):1991-2003. doi: 10.1002/glia.22414. Epub 2012 Sep 14.
4. An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. Benfenati V, etal., Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8. doi: 10.1073/pnas.1012867108. Epub 2011 Jan 24.
5. Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. Cadnapaphornchai MA, etal., J Am Soc Nephrol 2003 Mar;14(3):566-74.
6. [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. Cai SN and Zhu SM, Zhonghua Yi Xue Za Zhi. 2010 Jun 15;90(23):1648-51.
7. Molecular analysis of aquaporin genes 1 to 4 in patients with Meniere's disease. Candreia C, etal., Cell Physiol Biochem. 2010;26(4-5):787-92. doi: 10.1159/000322346. Epub 2010 Oct 29.
8. Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. Chan KH, etal., J Neuroimmunol. 2010 Oct 8;227(1-2):178-84. Epub 2010 Aug 21.
9. Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. Chi Y, etal., Aging Cell. 2011 Jun;10(3):368-82. doi: 10.1111/j.1474-9726.2011.00677.x. Epub 2011 Mar 22.
10. Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. Christensen N, etal., Brain Res. 2009 Feb 9;1253:27-34. doi: 10.1016/j.brainres.2008.11.070. Epub 2008 Dec 3.
11. Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory response. Cui B, etal., Exp Eye Res. 2012 May;98:37-43. doi: 10.1016/j.exer.2012.02.013. Epub 2012 Mar 16.
12. Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke. Cui D, etal., Life Sci. 2021 Jan 1;264:118683. doi: 10.1016/j.lfs.2020.118683. Epub 2020 Oct 28.
13. Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases. Dellavance A, etal., Eur J Neurol. 2011 Jul 19. doi: 10.1111/j.1468-1331.2011.03479.x.
14. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
15. Changes in ocular aquaporin expression following optic nerve crush. Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40.
16. Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. Eefsen M, etal., Metab Brain Dis. 2010 Sep;25(3):315-23. Epub 2010 Oct 12.
17. Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. Etemadifar M, etal., Int J Prev Med. 2012 Sep;3(9):612-5.
18. Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats. Gohara T, etal., J Anesth. 2010 Apr;24(2):225-33. Epub 2010 Jan 29.
22. Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. Gorelick DA, etal., BMC Biochem. 2006 May 1;7:14.
23. Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. Guo W, etal., Immunopharmacol Immunotoxicol. 2014 Jun;36(3):211-23. doi: 10.3109/08923973.2014.913616. Epub 2014 Apr 29.
24. Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. Hasegawa H, etal., J Biol Chem 1994 Feb 25;269(8):5497-500.
25. Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Heuser K, etal., Epilepsy Res. 2010 Jan;88(1):55-64. Epub 2009 Oct 28.
26. Implications of the aquaporin-4 structure on array formation and cell adhesion. Hiroaki Y, etal., J Mol Biol. 2006 Jan 27;355(4):628-39. doi: 10.1016/j.jmb.2005.10.081. Epub 2005 Nov 17.
27. Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy. Hu H, etal., Mol Vis. 2010 Jul 28;16:1415-28.
28. The relationship between aquaporin-4 expression and blood-brain and spinal cord barrier permeability following experimental autoimmune encephalomyelitis in the rat. Huang XN, etal., Anat Rec (Hoboken). 2011 Jan;294(1):46-54. doi: 10.1002/ar.21286. Epub 2010 Nov 12.
29. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Igarashi H, etal., Neurol Sci. 2011 Feb;32(1):113-6. Epub 2010 Oct 6.
30. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. Ishiyama G, etal., Cell Tissue Res. 2010 Jun;340(3):407-19. doi: 10.1007/s00441-010-0975-7. Epub 2010 May 12.
31. Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. Jung JS, etal., Proc Natl Acad Sci U S A 1994 Dec 20;91(26):13052-6.
32. Aquaporin-4 water channel oligomers are associated with the transverse tubules of skeletal myofibers. Kaakinen M, etal., Exp Cell Res. 2011 Jan 1;317(1):20-8. Epub 2010 Sep 21.
33. Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. Kezuka T, etal., J Neuroophthalmol. 2012 Jun;32(2):107-10. doi: 10.1097/WNO.0b013e31823c9b6c.
34. Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats. Kiening KL, etal., Neurosci Lett 2002 May 17;324(2):105-8.
35. Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. Kim JE, etal., J Comp Neurol. 2010 Nov 15;518(22):4612-28.
36. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Kimura A, etal., Ann Neurol. 2010 Jun;67(6):794-801.
37. Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies. Kitley J, etal., JAMA Neurol. 2013 Nov;70(11):1375-81. doi: 10.1001/jamaneurol.2013.3890.
38. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
39. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
40. Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis. Lee DJ, etal., Exp Neurol. 2012 May;235(1):246-55. doi: 10.1016/j.expneurol.2012.02.002. Epub 2012 Feb 14.
41. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. Lennon VA, etal., J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8.
42. Downregulation of renal aquaporins in response to unilateral ureteral obstruction. Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79.
43. Impaired hearing in mice lacking aquaporin-4 water channels. Li J and Verkman AS, J Biol Chem 2001 Aug 17;276(33):31233-7. Epub 2001 Jun 13.
44. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. Li L, etal., BMC Neurosci. 2009 Aug 6;10:94.
45. [A aquaporin 4 expression and effects in rat hippocampus after microwave radiation]. Li X, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Sep;27(9):534-8.
46. The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage. Liu E, etal., Front Aging Neurosci. 2021 Jan 26;12:611494. doi: 10.3389/fnagi.2020.611494. eCollection 2020.
47. Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content, and aquaporin-4 expression following experimental stroke. Liu X, etal., Neurocrit Care. 2010 Feb;12(1):124-31.
48. Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. Liu Z, etal., Regul Pept. 2011 Nov 10;171(1-3):19-25. Epub 2011 Jun 28.
49. [The effect of AQP4 gene on the activation of retinal glial cells in chronic high intraocular pressure mice]. Luo SS, etal., Zhonghua Yan Ke Za Zhi. 2012 Jul;48(7):598-603.
50. Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. Mai W, etal., J Neuroimmunol. 2013 Feb 15;255(1-2):75-80. doi: 10.1016/j.jneuroim.2012.10.004. Epub 2012 Oct 29.
51. Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury. Mao L, etal., Brain Inj. 2011;25(3):300-6. Epub 2011 Jan 31.
52. Aquaporin 4 regulation during acute and long-term experimental Herpes simplex virus encephalitis. Martinez Torres FJ, etal., J Neurovirol. 2007;13(1):38-46.
53. Aquaporin-4 astrocytopathy in Balo's disease. Matsuoka T, etal., Acta Neuropathol. 2010 Nov;120(5):651-60. Epub 2010 Aug 3.
54. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
55. Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. Moftakhar P, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1201-9.
56. Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis. Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10.
57. Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. Musa-Aziz R, etal., Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5406-11. doi: 10.1073/pnas.0813231106. Epub 2009 Mar 9.
58. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
59. Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26.
60. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516.
61. Transcriptional profiling of spinal cord injury-induced central neuropathic pain. Nesic O, etal., J Neurochem. 2005 Nov;95(4):998-1014. Epub 2005 Oct 10.
62. Aquaporin 1 - a novel player in spinal cord injury. Nesic O, etal., J Neurochem. 2008 May;105(3):628-40. Epub 2008 Jan 28.
63. Aquaporin-4 overexpression in rat ALS model. Nicaise C, etal., Anat Rec (Hoboken). 2009 Feb;292(2):207-13.
64. Higher order structure of aquaporin-4. Nicchia GP, etal., Neuroscience. 2010 Jul 28;168(4):903-14. Epub 2010 Feb 11.
65. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. Papadopoulos MC and Verkman AS, J Biol Chem. 2005 Apr 8;280(14):13906-12. Epub 2005 Feb 4.
66. Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73.
67. Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis. Pham H, etal., J Neuroimmunol. 2011 Mar;232(1-2):51-62. Epub 2010 Nov 6.
68. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
69. Evidence of aquaporin involvement in human central pontine myelinolysis. Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40.
70. Loss of AQP4 polarized localization with loss of beta-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage. Qiu GP, etal., Neurosci Lett. 2015 Feb 19;588:42-8. doi: 10.1016/j.neulet.2014.12.053. Epub 2014 Dec 27.
71. Brain aquaporin-4 in experimental acute liver failure. Rama Rao KV, etal., J Neuropathol Exp Neurol. 2010 Sep;69(9):869-79.
72. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Ratelade J, etal., Acta Neuropathol. 2013 Nov;126(5):699-709. doi: 10.1007/s00401-013-1172-z. Epub 2013 Aug 31.
73. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
74. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
75. Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica. Rosito S, etal., J Cell Mol Med. 2018 Feb;22(2):1236-1246. doi: 10.1111/jcmm.13401. Epub 2017 Oct 20.
76. Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. Rutkowsky JM, etal., Am J Physiol Cell Physiol. 2011 Jul;301(1):C204-12. Epub 2011 Apr 6.
77. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Saadoun S, etal., Brain. 2010 Feb;133(Pt 2):349-61. Epub 2010 Jan 4.
78. [Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice]. Shi WZ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):145-9.
79. Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus. Speake T, etal., Biochim Biophys Acta 2003 Jan 10;1609(1):80-6.
80. Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations. Takahashi T, etal., J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1075-8. doi: 10.1136/jnnp.2008.145391. Epub 2008 Apr 17.
81. Select types of supporting cell in the inner ear express aquaporin-4 water channel protein. Takumi Y, etal., Eur J Neurosci. 1998 Dec;10(12):3584-95.
82. Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Tanaka K, etal., Mult Scler. 2007 Aug;13(7):850-5. Epub 2007 Apr 27.
83. Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. Tanaka M, etal., J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):990-2.
84. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Thrane AS, etal., Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. Epub 2010 Dec 27.
85. [Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema]. Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11.
86. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12.
87. Effect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats. Tomura S, etal., J Neurotrauma. 2011 Feb;28(2):237-43.
88. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Tradtrantip L, etal., Ann Neurol. 2012 Mar;71(3):314-22. doi: 10.1002/ana.22657. Epub 2012 Jan 23.
89. Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. Wang CC, etal., BMC Pharmacol. 2010 Sep 6;10:11. doi: 10.1186/1471-2210-10-11.
90. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16.
91. Regional expression of aquaporin 1, 4, and 9 in the brain during pregnancy. Wiegman MJ, etal., Reprod Sci. 2008 May;15(5):506-16.
92. Role of aquaporin-4 in the development of brain oedema in liver failure. Wright G, etal., J Hepatol. 2010 Jul;53(1):91-7. Epub 2010 Apr 1.
93. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Wu H, etal., Neurochem Int. 2010 Oct;57(3):248-53. Epub 2010 Jun 10.
94. Myelin oligodendrocyte glycoprotein induces aquaporin-4 autoantibodies in mouse experimental autoimmune encephalomyelitis. Wu X, etal., J Neuroimmunol. 2013 Aug 15;261(1-2):1-6. doi: 10.1016/j.jneuroim.2013.03.008. Epub 2013 May 22.
95. Water permeability and characterization of aquaporin-11. Yakata K, etal., J Struct Biol. 2011 May;174(2):315-20. doi: 10.1016/j.jsb.2011.01.003. Epub 2011 Jan 18.
96. Clinical features and sera anti-aquaporin 4 antibody positivity in patients with demyelinating disorders of the central nervous system from Tianjin, China. Yang CS, etal., CNS Neurosci Ther. 2014 Jan;20(1):32-9. doi: 10.1111/cns.12156. Epub 2013 Jul 27.
97. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
98. Differential Regulations of AQP4 and Kir4.1 by Triamcinolone Acetonide and Dexamethasone in the Healthy and Inflamed Retina. Zhao M, etal., Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6340-7. Print 2011 Sep.
99. Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA. Zhou Y, etal., Neurol Res. 2010 Oct;32(8):801-9. doi: 10.1179/016164110X12644252260556. Epub 2010 May 18.
Additional References at PubMed
PMID:1373524   PMID:1510932   PMID:7530250   PMID:8601457   PMID:8660998   PMID:9369468   PMID:9405233   PMID:9806845   PMID:9829975   PMID:10021464   PMID:10318966   PMID:10510269  
PMID:10564231   PMID:10613915   PMID:10662735   PMID:10795927   PMID:11001937   PMID:11034202   PMID:11076974   PMID:11573934   PMID:11717465   PMID:11726686   PMID:12034763   PMID:12081649  
PMID:12084581   PMID:12359252   PMID:12504879   PMID:12650429   PMID:12673830   PMID:12692561   PMID:12944406   PMID:14627352   PMID:14663195   PMID:14701836   PMID:14752829   PMID:14753448  
PMID:15010203   PMID:15090052   PMID:15149973   PMID:15466140   PMID:15488478   PMID:15948717   PMID:16103109   PMID:16461188   PMID:16582023   PMID:16596446   PMID:16641100   PMID:16646408  
PMID:16814974   PMID:16895520   PMID:16987239   PMID:16997459   PMID:17178220   PMID:17184078   PMID:17266129   PMID:17356517   PMID:17416972   PMID:17566653   PMID:17593398   PMID:17622964  
PMID:17645239   PMID:17970725   PMID:18179769   PMID:18202181   PMID:18206860   PMID:18255256   PMID:18284610   PMID:18286643   PMID:18392839   PMID:18487486   PMID:18501347   PMID:18510734  
PMID:18511455   PMID:18572411   PMID:18649401   PMID:18718702   PMID:18762715   PMID:18951883   PMID:19114109   PMID:19170255   PMID:19229993   PMID:19236167   PMID:19240114   PMID:19285541  
PMID:19297454   PMID:19383790   PMID:19406128   PMID:19429018   PMID:19451651   PMID:19596320   PMID:19705963   PMID:19800950   PMID:19831719   PMID:19843522   PMID:19843787   PMID:19928950  
PMID:19948131   PMID:19962432   PMID:20017335   PMID:20026178   PMID:20071343   PMID:20109536   PMID:20461024   PMID:20484841   PMID:20617879   PMID:20625331   PMID:20709083   PMID:20806048  
PMID:20877385   PMID:21178974   PMID:21204635   PMID:21208160   PMID:21212277   PMID:21468722   PMID:21519634   PMID:21621589   PMID:21682559   PMID:21700703   PMID:21705333   PMID:21713710  
PMID:21850708   PMID:22011386   PMID:22069320   PMID:22146847   PMID:22322923   PMID:22381744   PMID:22420318   PMID:22528459   PMID:22554469   PMID:22590566   PMID:22610042   PMID:22676888  
PMID:22718347   PMID:22728101   PMID:22802001   PMID:22871113   PMID:22896675   PMID:22902770   PMID:22903516   PMID:22922737   PMID:22967487   PMID:23022607   PMID:23040263   PMID:23142737  
PMID:23180003   PMID:23199918   PMID:23357720   PMID:23441695   PMID:23505074   PMID:23510922   PMID:23520529   PMID:23592763   PMID:23616425   PMID:23622727   PMID:23651078   PMID:24238521  
PMID:24282821   PMID:24657265   PMID:24817288   PMID:24828425   PMID:24912027   PMID:25013167   PMID:25146699   PMID:25223087   PMID:25231107   PMID:25373717   PMID:25441658   PMID:25479407  
PMID:25770057   PMID:25800444   PMID:25907740   PMID:26013827   PMID:26385393   PMID:26459070   PMID:26583111   PMID:26617791   PMID:26724742   PMID:27181510   PMID:27188736   PMID:27236300  
PMID:27435677   PMID:27525904   PMID:27706789   PMID:27726111   PMID:27751903   PMID:27788222   PMID:27886057   PMID:27930615   PMID:28206694   PMID:28303331   PMID:28341892   PMID:28461494  
PMID:28549966   PMID:28567523   PMID:28572712   PMID:28826498   PMID:28978666   PMID:29057271   PMID:29066483   PMID:29178911   PMID:29351212   PMID:29520011   PMID:29921834   PMID:29956781  
PMID:30293570   PMID:30628716   PMID:30919512   PMID:31063681   PMID:31218751   PMID:31242419   PMID:31407064   PMID:31454080   PMID:31556577   PMID:31626131   PMID:32131375   PMID:32450187  
PMID:32664509   PMID:32726124   PMID:32920036   PMID:32985231   PMID:33373887   PMID:33862142   PMID:33978309   PMID:33991463   PMID:34099798   PMID:34232129   PMID:34657253   PMID:35189787  
PMID:35961528   PMID:36036510   PMID:36195691   PMID:36293145  


Genomics

Comparative Map Data
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,733,660 - 6,750,099 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0187,521,314 - 7,537,753 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0186,792,881 - 6,809,322 (-)NCBIRnor_WKY
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36Build 36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,750 - 24,373,454 (-)NCBICHM1_1
T2T-CHM13v2.01827,046,091 - 27,059,856 (-)NCBIT2T-CHM13v2.0
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)EnsemblGRCm39 Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBIMGSCv36mm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBIUU_Cfam_GSD_1.0
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,941,354 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,407,639 - 111,422,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605028,456,973 - 28,470,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247705,580,808 - 5,594,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aqp4
26 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir100rno-miR-100-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir30arno-miR-30a-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830
Mir99brno-miR-99b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:2166
Count of miRNA genes:336
Interacting mature miRNAs:452
Transcripts:ENSRNOT00000048109, ENSRNOT00000068150
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)18224947722066430Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat

Markers in Region
RH94727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,511,451 - 6,511,594 (+)MAPPERmRatBN7.2
Rnor_6.0186,769,558 - 6,769,700NCBIRnor6.0
Rnor_5.0186,724,308 - 6,724,450UniSTSRnor5.0
RGSC_v3.4186,629,862 - 6,630,004UniSTSRGSC3.4
Celera186,533,563 - 6,533,705UniSTS
Cytogenetic Map18p13UniSTS
RH142179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,511,345 - 6,511,537 (+)MAPPERmRatBN7.2
Rnor_6.0186,769,452 - 6,769,643NCBIRnor6.0
Rnor_5.0186,724,202 - 6,724,393UniSTSRnor5.0
RGSC_v3.4186,629,756 - 6,629,947UniSTSRGSC3.4
Celera186,533,457 - 6,533,648UniSTS
RH 3.4 Map1886.21UniSTS
Cytogenetic Map18p13UniSTS
RH138222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,510,718 - 6,510,850 (+)MAPPERmRatBN7.2
Rnor_6.0186,768,825 - 6,768,956NCBIRnor6.0
Rnor_5.0186,723,575 - 6,723,706UniSTSRnor5.0
RGSC_v3.4186,629,129 - 6,629,260UniSTSRGSC3.4
Celera186,532,830 - 6,532,961UniSTS
RH 3.4 Map1878.1UniSTS
Cytogenetic Map18p13UniSTS
Aqp4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2186,520,499 - 6,520,730 (+)MAPPERmRatBN7.2
Rnor_6.0186,778,901 - 6,779,131NCBIRnor6.0
Rnor_5.0186,733,651 - 6,733,881UniSTSRnor5.0
Celera186,542,590 - 6,542,820UniSTS
Cytogenetic Map18p13UniSTS


Genetic Models
This gene Aqp4 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 8 10 40 30 1 11 8
Low 2 24 28 18 10 18 1 18 5 18
Below cutoff 14 28 22 8 22 16 18

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001317749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017600857 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096586 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039096587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF541968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO395028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO395446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO397165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO405518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV717820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DV728051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243422 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EV243423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L27588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000048109   ⟹   ENSRNOP00000050942
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,507,903 - 6,523,442 (-)Ensembl
Rnor_6.0 Ensembl186,766,009 - 6,781,841 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000068150   ⟹   ENSRNOP00000063720
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,507,903 - 6,523,682 (-)Ensembl
Rnor_6.0 Ensembl186,766,009 - 6,782,757 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077606   ⟹   ENSRNOP00000073052
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)Ensembl
Rnor_6.0 Ensembl186,766,009 - 6,781,841 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090320   ⟹   ENSRNOP00000072488
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,509,837 - 6,524,856 (-)Ensembl
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105907   ⟹   ENSRNOP00000084924
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl186,511,807 - 6,524,856 (-)Ensembl
RefSeq Acc Id: NM_001142366   ⟹   NP_001135838
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,442 (-)NCBI
Rnor_6.0186,766,009 - 6,781,841 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
RGSC_v3.4186,626,313 - 6,642,766 (-)RGD
Celera186,530,014 - 6,545,530 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270558   ⟹   NP_001257487
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270559   ⟹   NP_001257488
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,442 (-)NCBI
Rnor_6.0186,766,009 - 6,781,841 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
Celera186,530,014 - 6,545,530 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317749   ⟹   NP_001304678
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: NM_012825   ⟹   NP_036957
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,358 (-)NCBI
Rnor_6.0186,766,009 - 6,782,757 (-)NCBI
Rnor_5.0186,720,759 - 6,737,703 (-)NCBI
RGSC_v3.4186,626,313 - 6,642,766 (-)RGD
Celera186,530,014 - 6,546,446 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039096581   ⟹   XP_038952509
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,537 (-)NCBI
RefSeq Acc Id: XM_039096582   ⟹   XP_038952510
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,056 - 6,524,547 (-)NCBI
RefSeq Acc Id: XM_039096583   ⟹   XP_038952511
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,524,545 (-)NCBI
RefSeq Acc Id: XM_039096584   ⟹   XP_038952512
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,431 (-)NCBI
RefSeq Acc Id: XM_039096585   ⟹   XP_038952513
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,283 - 6,524,542 (-)NCBI
RefSeq Acc Id: XM_039096586   ⟹   XP_038952514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,518,056 - 6,524,558 (-)NCBI
RefSeq Acc Id: XM_039096587   ⟹   XP_038952515
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2186,507,903 - 6,523,493 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_036957   ⟸   NM_012825
- Peptide Label: isoform M1
- UniProtKB: Q8CIY8 (UniProtKB/Swiss-Prot),   P47863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001135838   ⟸   NM_001142366
- Peptide Label: isoform M23
- UniProtKB: A0A0G2K4I1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257487   ⟸   NM_001270558
- Peptide Label: isoform 3
- UniProtKB: P47863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257488   ⟸   NM_001270559
- Peptide Label: isoform 4
- UniProtKB: A0A0H2UHZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304678   ⟸   NM_001317749
- Peptide Label: isoform M1x
- Sequence:
RefSeq Acc Id: ENSRNOP00000050942   ⟸   ENSRNOT00000048109
RefSeq Acc Id: ENSRNOP00000073052   ⟸   ENSRNOT00000077606
RefSeq Acc Id: ENSRNOP00000072488   ⟸   ENSRNOT00000090320
RefSeq Acc Id: ENSRNOP00000063720   ⟸   ENSRNOT00000068150
RefSeq Acc Id: XP_038952511   ⟸   XM_039096583
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038952509   ⟸   XM_039096581
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952515   ⟸   XM_039096587
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952512   ⟸   XM_039096584
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038952514   ⟸   XM_039096586
- Peptide Label: isoform X6
RefSeq Acc Id: XP_038952510   ⟸   XM_039096582
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038952513   ⟸   XM_039096585
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000084924   ⟸   ENSRNOT00000105907

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47863-F1-model_v2 AlphaFold P47863 1-323 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700648
Promoter ID:EPDNEW_R11172
Type:initiation region
Name:Aqp4_1
Description:aquaporin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0186,782,709 - 6,782,769EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2143 AgrOrtholog
BioCyc Gene G2FUF-8281 BioCyc
Ensembl Genes ENSRNOG00000016043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000050942 ENTREZGENE
  ENSRNOP00000050942.3 UniProtKB/TrEMBL
  ENSRNOP00000063720.2 UniProtKB/TrEMBL
  ENSRNOP00000072488 ENTREZGENE
  ENSRNOP00000072488.1 UniProtKB/TrEMBL
  ENSRNOP00000073052 ENTREZGENE
  ENSRNOP00000073052.2 UniProtKB/TrEMBL
  ENSRNOP00000084924.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048109 ENTREZGENE
  ENSRNOT00000048109.4 UniProtKB/TrEMBL
  ENSRNOT00000068150.4 UniProtKB/TrEMBL
  ENSRNOT00000077606 ENTREZGENE
  ENSRNOT00000077606.2 UniProtKB/TrEMBL
  ENSRNOT00000090320 ENTREZGENE
  ENSRNOT00000090320.2 UniProtKB/TrEMBL
  ENSRNOT00000105907.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25293 UniProtKB/Swiss-Prot
NCBI Gene 25293 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp4 PhenoGen
PRINTS MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K336_RAT UniProtKB/TrEMBL
  A0A0G2K4I1 ENTREZGENE
  A0A0H2UHZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZY68_RAT UniProtKB/TrEMBL
  A0A8L2R6N8_RAT UniProtKB/TrEMBL
  A0A8L2UNG3_RAT UniProtKB/TrEMBL
  AQP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8CIY8 ENTREZGENE
UniProt Secondary A0A0G2K4I1 UniProtKB/Swiss-Prot
  Q8CIY8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Aqp4  aquaporin 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to hypothyroidism 704374
gene_expression expressed in kidney collecting duct principal cells 70240
gene_expression expressed in inner medullary 67997
gene_function water channel protein 67997
gene_function water channel protein 70240
gene_process mediates water transport across the basolateral plasma membrane of collecting duct principal cells 67997
gene_process mediates water transport across the basolateral plasma membrane of collecting duct principal cells 70240
gene_process regulates water homeostasis and flow in the CNS 730277
gene_process may participate in brain edema formation following trauma 1298579
gene_process does not appear to contribute to the diabetes mellitus model 67997