RGD Reference Report - Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. - Rat Genome Database

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Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.

Authors: Igarashi, H  Huber, VJ  Tsujita, M  Nakada, T 
Citation: Igarashi H, etal., Neurol Sci. 2011 Feb;32(1):113-6. Epub 2010 Oct 6.
RGD ID: 5148022
Pubmed: PMID:20924629   (View Abstract at PubMed)
PMCID: PMC3026762   (View Article at PubMed Central)
DOI: DOI:10.1007/s10072-010-0431-1   (Journal Full-text)

We investigated the in vivo effects of a novel aquaporin 4 (AQP4) inhibitor 2-(nicotinamide)-1,3,4-thiadiazole, TGN-020, in a mouse model of focal cerebral ischemia using 7.0-T magnetic resonance imaging (MRI). Pretreatment with TGN-020 significantly reduced brain edema associated with brain ischemia, as reflected by percentage of brain swelling volume (%BSV), 12.1 +/- 6.3% in the treated group, compared to (20.8 +/- 5.9%) in the control group (p < 0.05), and in the size of cortical infarction as reflected by the percentage of hemispheric lesion volume (%HLV), 20.0 +/- 7.6% in the treated group, compared to 30.0 +/- 9.1% in the control group (p < 0.05). The study indicated the potential pharmacological use of AQP4 inhibition in reducing brain edema associated with focal ischemia.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Reperfusion Injury  ISOAqp4 (Mus musculus)5148022; 5148022 RGD 
Reperfusion Injury  IMP 5148022 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information