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Gene: Aqp4 (aquaporin 4) Mus musculus
Symbol: Aqp4
Name: aquaporin 4
Description: Exhibits water channel activity. Involved in several processes, including cerebrospinal fluid circulation; cerebrospinal fluid secretion; and water homeostasis. Localizes to several cellular components, including astrocyte end-foot; basolateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; mammary gland; metanephros; and nasal cavity. Used to study malaria. Human ortholog(s) of this gene implicated in Meniere's disease; blindness; neuromyelitis optica; optic neuritis; and temporal lobe epilepsy. Orthologous to human AQP4 (aquaporin 4).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AQP-4; aquaporin-4; mercurial-insensitive water channel; WCH4
Homo sapiens (human) : AQP4 (aquaporin 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aqp4 (aquaporin 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aqp4 (aquaporin 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AQP4 (aquaporin 4)
Canis lupus familiaris (dog) : AQP4 (aquaporin 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aqp4 (aquaporin 4)
Sus scrofa (pig) : AQP4 (aquaporin 4)
Chlorocebus sabaeus (African green monkey) : AQP4 (aquaporin 4)
Heterocephalus glaber (naked mole-rat) : Aqp4 (aquaporin 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBImm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aqp4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10183
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.