Aqp4 (aquaporin 4) - Rat Genome Database

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Gene: Aqp4 (aquaporin 4) Mus musculus
Analyze
Symbol: Aqp4
Name: aquaporin 4
RGD ID: 10183
MGI Page MGI
Description: Enables water channel activity. Involved in several processes, including cerebrospinal fluid circulation; cerebrospinal fluid secretion; and intracellular water homeostasis. Acts upstream of or within establishment of localization in cell; renal water absorption; and sensory perception of sound. Located in several cellular components, including astrocyte end-foot; basolateral plasma membrane; and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; exocrine system; metanephros; and sensory organ. Used to study malaria. Human ortholog(s) of this gene implicated in several diseases, including Meniere's disease; megalencephalic leukoencephalopathy with subcortical cysts; optic nerve disease (multiple); temporal lobe epilepsy; and transverse myelitis. Orthologous to human AQP4 (aquaporin 4).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AQP-4; aqua; aquaporin-4; mercurial-insensitive water channel; WCH4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)EnsemblGRCm39 Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBIMGSCv36mm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(S)-nicotine  (EXP)
1,1-dichloroethene  (EXP)
1,2-dichloroethane  (EXP,ISO)
1,3-dinitrobenzene  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
acetic acid  (ISO)
acrylamide  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
alpha-D-galactose  (EXP)
alpha-Zearalanol  (ISO)
ammonia  (ISO)
ammonium chloride  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (EXP)
betamethasone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP,ISO)
calcidiol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP)
choline  (EXP)
clofibrate  (EXP)
Cuprizon  (ISO)
cycloheximide  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
desferrioxamine B  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
diprotium oxide  (EXP,ISO)
diquat  (EXP)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
folic acid  (EXP)
furan  (ISO)
galactose  (EXP)
gentamycin  (EXP,ISO)
glucose  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen chloride  (ISO)
inulin  (EXP)
iron atom  (EXP,ISO)
iron dichloride  (EXP)
iron(0)  (EXP,ISO)
iron(III) citrate  (ISO)
L-methionine  (EXP)
lansoprazole  (EXP)
lead(0)  (ISO)
lidocaine  (ISO)
lipopolysaccharide  (EXP)
lycopene  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nicotine  (EXP)
nitrofen  (ISO)
O-methyleugenol  (ISO)
olanzapine  (ISO)
ozone  (ISO)
palmitoyl ethanolamide  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP)
rifampicin  (ISO)
SB 203580  (EXP)
SB-239063  (ISO)
senecionine  (EXP)
sodium arsenite  (EXP)
Soman  (ISO)
sulforaphane  (EXP)
terbutaline  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thalidomide  (EXP)
thioacetamide  (ISO)
thiourea  (ISO)
titanium dioxide  (EXP)
toluene  (ISO)
triazines  (EXP)
trichloroethene  (ISO)
trichostatin A  (ISO)
Triptolide  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
vinclozolin  (ISO)
vitamin E  (EXP,ISO)
water  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal astrocyte physiology  (IAGP)
abnormal auditory brainstem response waveform shape  (IAGP)
abnormal blood-brain barrier function  (IAGP)
abnormal eye electrophysiology  (IAGP)
abnormal fluid regulation  (IAGP)
abnormal glial cell physiology  (IAGP)
abnormal microglial cell physiology  (IAGP)
abnormal nervous system physiology  (IAGP)
abnormal renal water transport  (IAGP)
abnormal respiratory system physiology  (IAGP)
abnormal uterus physiology  (IAGP)
cerebral edema  (IAGP)
deafness  (IAGP)
decreased corpora lutea number  (IAGP)
decreased litter size  (IAGP)
decreased ovary weight  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased superovulation rate  (IAGP)
decreased susceptibility to induced morbidity/mortality  (IAGP)
decreased susceptibility to ischemic brain injury  (IAGP)
decreased tertiary ovarian follicle number  (IAGP)
decreased urine osmolality  (IAGP)
decreased uterus weight  (IAGP)
decreased vascular permeability  (IAGP)
impaired behavioral response to cocaine  (IAGP)
impaired hearing  (IAGP)
impaired ovarian folliculogenesis  (IAGP)
increased dopamine level  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
increased susceptibility to parasitic infection induced morbidity/mortality  (IAGP)
polyuria  (IAGP)
postnatal growth retardation  (IAGP)
reduced female fertility  (IAGP)
retina ischemia  (IAGP)
small uterus  (IAGP)
thin endometrium  (IAGP)
unilateral deafness  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. Ampawong S, etal., Int J Clin Exp Pathol. 2011 Aug 15;4(6):566-74. Epub 2011 Jul 23.
2. Hypoalgesia in mice lacking aquaporin-4 water channels. Bao F, etal., Brain Res Bull. 2010 Nov 20;83(6):298-303. doi: 10.1016/j.brainresbull.2010.08.015. Epub 2010 Sep 22.
3. Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model. Bataveljic D, etal., Glia. 2012 Dec;60(12):1991-2003. doi: 10.1002/glia.22414. Epub 2012 Sep 14.
4. [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. Cai SN and Zhu SM, Zhonghua Yi Xue Za Zhi. 2010 Jun 15;90(23):1648-51.
5. Molecular analysis of aquaporin genes 1 to 4 in patients with Meniere's disease. Candreia C, etal., Cell Physiol Biochem. 2010;26(4-5):787-92. doi: 10.1159/000322346. Epub 2010 Oct 29.
6. Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. Chan KH, etal., J Neuroimmunol. 2010 Oct 8;227(1-2):178-84. Epub 2010 Aug 21.
7. Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. Chi Y, etal., Aging Cell. 2011 Jun;10(3):368-82. doi: 10.1111/j.1474-9726.2011.00677.x. Epub 2011 Mar 22.
8. Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. Christensen N, etal., Brain Res. 2009 Feb 9;1253:27-34. doi: 10.1016/j.brainres.2008.11.070. Epub 2008 Dec 3.
9. Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory response. Cui B, etal., Exp Eye Res. 2012 May;98:37-43. doi: 10.1016/j.exer.2012.02.013. Epub 2012 Mar 16.
10. Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke. Cui D, etal., Life Sci. 2021 Jan 1;264:118683. doi: 10.1016/j.lfs.2020.118683. Epub 2020 Oct 28.
11. Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases. Dellavance A, etal., Eur J Neurol. 2011 Jul 19. doi: 10.1111/j.1468-1331.2011.03479.x.
12. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
13. Changes in ocular aquaporin expression following optic nerve crush. Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40.
14. Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. Eefsen M, etal., Metab Brain Dis. 2010 Sep;25(3):315-23. Epub 2010 Oct 12.
15. Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. Etemadifar M, etal., Int J Prev Med. 2012 Sep;3(9):612-5.
16. Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11.
17. Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats. Gohara T, etal., J Anesth. 2010 Apr;24(2):225-33. Epub 2010 Jan 29.
18. Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. Guo W, etal., Immunopharmacol Immunotoxicol. 2014 Jun;36(3):211-23. doi: 10.3109/08923973.2014.913616. Epub 2014 Apr 29.
19. Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. Heuser K, etal., Epilepsy Res. 2010 Jan;88(1):55-64. Epub 2009 Oct 28.
20. Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy. Hu H, etal., Mol Vis. 2010 Jul 28;16:1415-28.
21. The relationship between aquaporin-4 expression and blood-brain and spinal cord barrier permeability following experimental autoimmune encephalomyelitis in the rat. Huang XN, etal., Anat Rec (Hoboken). 2011 Jan;294(1):46-54. doi: 10.1002/ar.21286. Epub 2010 Nov 12.
22. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. Igarashi H, etal., Neurol Sci. 2011 Feb;32(1):113-6. Epub 2010 Oct 6.
23. Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. Ishiyama G, etal., Cell Tissue Res. 2010 Jun;340(3):407-19. doi: 10.1007/s00441-010-0975-7. Epub 2010 May 12.
24. Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. Kezuka T, etal., J Neuroophthalmol. 2012 Jun;32(2):107-10. doi: 10.1097/WNO.0b013e31823c9b6c.
25. Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. Kim JE, etal., J Comp Neurol. 2010 Nov 15;518(22):4612-28.
26. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Kimura A, etal., Ann Neurol. 2010 Jun;67(6):794-801.
27. Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies. Kitley J, etal., JAMA Neurol. 2013 Nov;70(11):1375-81. doi: 10.1001/jamaneurol.2013.3890.
28. Aquaporins in the kidney. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
29. Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis. Lee DJ, etal., Exp Neurol. 2012 May;235(1):246-55. doi: 10.1016/j.expneurol.2012.02.002. Epub 2012 Feb 14.
30. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. Lennon VA, etal., J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8.
31. Impaired hearing in mice lacking aquaporin-4 water channels. Li J and Verkman AS, J Biol Chem 2001 Aug 17;276(33):31233-7. Epub 2001 Jun 13.
32. Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels. Li J, etal., Invest Ophthalmol Vis Sci 2002 Feb;43(2):573-9.
33. Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. Li L, etal., BMC Neurosci. 2009 Aug 6;10:94.
34. The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage. Liu E, etal., Front Aging Neurosci. 2021 Jan 26;12:611494. doi: 10.3389/fnagi.2020.611494. eCollection 2020.
35. Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content, and aquaporin-4 expression following experimental stroke. Liu X, etal., Neurocrit Care. 2010 Feb;12(1):124-31.
36. Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. Liu Z, etal., Regul Pept. 2011 Nov 10;171(1-3):19-25. Epub 2011 Jun 28.
37. [The effect of AQP4 gene on the activation of retinal glial cells in chronic high intraocular pressure mice]. Luo SS, etal., Zhonghua Yan Ke Za Zhi. 2012 Jul;48(7):598-603.
38. Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. Ma T, etal., J Biol Chem 1998 Feb 20;273(8):4296-9.
39. Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. Mai W, etal., J Neuroimmunol. 2013 Feb 15;255(1-2):75-80. doi: 10.1016/j.jneuroim.2012.10.004. Epub 2012 Oct 29.
40. Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury. Mao L, etal., Brain Inj. 2011;25(3):300-6. Epub 2011 Jan 31.
41. Aquaporin 4 regulation during acute and long-term experimental Herpes simplex virus encephalitis. Martinez Torres FJ, etal., J Neurovirol. 2007;13(1):38-46.
42. Aquaporin-4 astrocytopathy in Balo's disease. Matsuoka T, etal., Acta Neuropathol. 2010 Nov;120(5):651-60. Epub 2010 Aug 3.
43. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
44. MGDs mouse GO annotations MGD data from the GO Consortium
45. MGD IEA MGD IEA
46. Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. Moftakhar P, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1201-9.
47. Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis. Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10.
48. Transcriptional profiling of spinal cord injury-induced central neuropathic pain. Nesic O, etal., J Neurochem. 2005 Nov;95(4):998-1014. Epub 2005 Oct 10.
49. Aquaporin-4 overexpression in rat ALS model. Nicaise C, etal., Anat Rec (Hoboken). 2009 Feb;292(2):207-13.
50. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
51. Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. Papadopoulos MC and Verkman AS, J Biol Chem. 2005 Apr 8;280(14):13906-12. Epub 2005 Feb 4.
52. Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73.
53. Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis. Pham H, etal., J Neuroimmunol. 2011 Mar;232(1-2):51-62. Epub 2010 Nov 6.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. Evidence of aquaporin involvement in human central pontine myelinolysis. Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40.
56. Loss of AQP4 polarized localization with loss of beta-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage. Qiu GP, etal., Neurosci Lett. 2015 Feb 19;588:42-8. doi: 10.1016/j.neulet.2014.12.053. Epub 2014 Dec 27.
57. Brain aquaporin-4 in experimental acute liver failure. Rama Rao KV, etal., J Neuropathol Exp Neurol. 2010 Sep;69(9):869-79.
58. Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. Ratelade J, etal., Acta Neuropathol. 2013 Nov;126(5):699-709. doi: 10.1007/s00401-013-1172-z. Epub 2013 Aug 31.
59. Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
60. Mouse MP Annotation Import Pipeline RGD automated import pipeline
61. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
62. Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. Saadoun S, etal., Brain. 2010 Feb;133(Pt 2):349-61. Epub 2010 Jan 4.
63. [Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice]. Shi WZ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):145-9.
64. Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations. Takahashi T, etal., J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1075-8. doi: 10.1136/jnnp.2008.145391. Epub 2008 Apr 17.
65. Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. Tanaka K, etal., Mult Scler. 2007 Aug;13(7):850-5. Epub 2007 Apr 27.
66. Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. Tanaka M, etal., J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):990-2.
67. Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Thrane AS, etal., Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. Epub 2010 Dec 27.
68. [Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema]. Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11.
69. Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12.
70. Effect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats. Tomura S, etal., J Neurotrauma. 2011 Feb;28(2):237-43.
71. Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Tradtrantip L, etal., Ann Neurol. 2012 Mar;71(3):314-22. doi: 10.1002/ana.22657. Epub 2012 Jan 23.
72. Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. Wang CC, etal., BMC Pharmacol. 2010 Sep 6;10:11. doi: 10.1186/1471-2210-10-11.
73. 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16.
74. Role of aquaporin-4 in the development of brain oedema in liver failure. Wright G, etal., J Hepatol. 2010 Jul;53(1):91-7. Epub 2010 Apr 1.
75. Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. Wu H, etal., Neurochem Int. 2010 Oct;57(3):248-53. Epub 2010 Jun 10.
76. Myelin oligodendrocyte glycoprotein induces aquaporin-4 autoantibodies in mouse experimental autoimmune encephalomyelitis. Wu X, etal., J Neuroimmunol. 2013 Aug 15;261(1-2):1-6. doi: 10.1016/j.jneuroim.2013.03.008. Epub 2013 May 22.
77. Clinical features and sera anti-aquaporin 4 antibody positivity in patients with demyelinating disorders of the central nervous system from Tianjin, China. Yang CS, etal., CNS Neurosci Ther. 2014 Jan;20(1):32-9. doi: 10.1111/cns.12156. Epub 2013 Jul 27.
78. Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16.
79. Differential Regulations of AQP4 and Kir4.1 by Triamcinolone Acetonide and Dexamethasone in the Healthy and Inflamed Retina. Zhao M, etal., Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6340-7. Print 2011 Sep.
80. Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA. Zhou Y, etal., Neurol Res. 2010 Oct;32(8):801-9. doi: 10.1179/016164110X12644252260556. Epub 2010 May 18.
Additional References at PubMed
PMID:8660998   PMID:8889548   PMID:9143504   PMID:9276712   PMID:9325187   PMID:9427293   PMID:9486146   PMID:9757370   PMID:9822113   PMID:9886922   PMID:10021464   PMID:10232700  
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PMID:12031518   PMID:12034763   PMID:12232046   PMID:12233788   PMID:12359252   PMID:12477932   PMID:12565800   PMID:12578959   PMID:12673830   PMID:14576087   PMID:14597704   PMID:14734638  
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PMID:16602821   PMID:16618389   PMID:16624821   PMID:16797122   PMID:16871401   PMID:16938871   PMID:17074507   PMID:17196551   PMID:17349777   PMID:17353068   PMID:17377981   PMID:17437301  
PMID:17525153   PMID:17611025   PMID:17868659   PMID:17869537   PMID:18057022   PMID:18281883   PMID:18284610   PMID:18286643   PMID:18328627   PMID:18338794   PMID:18375385   PMID:18495879  
PMID:18510734   PMID:18511552   PMID:18572411   PMID:18679005   PMID:18708067   PMID:18718702   PMID:18951529   PMID:18973795   PMID:18976758   PMID:18985050   PMID:19033383   PMID:19046364  
PMID:19203409   PMID:19237298   PMID:19258494   PMID:19303428   PMID:19345723   PMID:19367412   PMID:19373938   PMID:19393298   PMID:19416500   PMID:19428702   PMID:19429174   PMID:19449033  
PMID:19450458   PMID:19743445   PMID:19761816   PMID:19843522   PMID:19855135   PMID:19906978   PMID:20121927   PMID:20132816   PMID:20132873   PMID:20153404   PMID:20364088   PMID:20387009  
PMID:20437101   PMID:20544823   PMID:20818388   PMID:20877385   PMID:20944625   PMID:21151500   PMID:21178974   PMID:21212277   PMID:21256195   PMID:21257712   PMID:21262839   PMID:21264240  
PMID:21267068   PMID:21281561   PMID:21283711   PMID:21285396   PMID:21339176   PMID:21446052   PMID:21491501   PMID:21525279   PMID:21552523   PMID:21677750   PMID:21705333   PMID:21721139  
PMID:21873635   PMID:21939392   PMID:21990350   PMID:22020118   PMID:22069320   PMID:22076159   PMID:22128336   PMID:22131281   PMID:22173850   PMID:22193336   PMID:22233890   PMID:22237799  
PMID:22365952   PMID:22378467   PMID:22394609   PMID:22419561   PMID:22472609   PMID:22473056   PMID:22526022   PMID:22533723   PMID:22590566   PMID:22634625   PMID:22709928   PMID:22718347  
PMID:22777185   PMID:22820194   PMID:22896675   PMID:22991445   PMID:23032072   PMID:23051665   PMID:23126383   PMID:23132680   PMID:23180003   PMID:23277579   PMID:23346911   PMID:23428384  
PMID:23443171   PMID:23485789   PMID:23520529   PMID:23563310   PMID:23611872   PMID:23805198   PMID:23935196   PMID:24014171   PMID:24154525   PMID:24165567   PMID:24174672   PMID:24186965  
PMID:24231830   PMID:24321433   PMID:24355496   PMID:24368741   PMID:24390474   PMID:24422972   PMID:24515349   PMID:24717641   PMID:24744149   PMID:24792367   PMID:24904084   PMID:24915007  
PMID:24952082   PMID:24952961   PMID:24978642   PMID:25013167   PMID:25100404   PMID:25124666   PMID:25128605   PMID:25160756   PMID:25174305   PMID:25359421   PMID:25382142   PMID:25449874  
PMID:25471560   PMID:25604731   PMID:25790314   PMID:25944186   PMID:25990016   PMID:26039099   PMID:26120030   PMID:26126866   PMID:26287441   PMID:26413835   PMID:26424896   PMID:26489685  
PMID:26526066   PMID:26748031   PMID:26760501   PMID:26774050   PMID:26847765   PMID:26884844   PMID:26946517   PMID:27018215   PMID:27038751   PMID:27155358   PMID:27373674   PMID:27581370  
PMID:27629271   PMID:27751903   PMID:27789520   PMID:27837334   PMID:27931262   PMID:27940915   PMID:28039592   PMID:28058717   PMID:28078912   PMID:28215940   PMID:28222512   PMID:28317216  
PMID:28365776   PMID:28402976   PMID:28427055   PMID:28461494   PMID:28551776   PMID:28627708   PMID:28639721   PMID:28645746   PMID:28735099   PMID:28822114   PMID:28826498   PMID:28906027  
PMID:28929580   PMID:28940930   PMID:28979186   PMID:29055082   PMID:29106906   PMID:29125630   PMID:29153303   PMID:29154923   PMID:29237740   PMID:29238290   PMID:29565042   PMID:29600800  
PMID:29608911   PMID:29793504   PMID:29869011   PMID:29956748   PMID:30293570   PMID:30347264   PMID:30557661   PMID:30561329   PMID:30607477   PMID:30628716   PMID:30635555   PMID:30650354  
PMID:30680924   PMID:30738082   PMID:30791140   PMID:30809535   PMID:30813473   PMID:30877104   PMID:30889310   PMID:30935410   PMID:31034776   PMID:31078684   PMID:31092872   PMID:31097598  
PMID:31190144   PMID:31220136   PMID:31364823   PMID:31644276   PMID:31648394   PMID:31709761   PMID:31814527   PMID:31927062   PMID:32001524   PMID:32033173   PMID:32046059   PMID:32102323  
PMID:32133736   PMID:32138732   PMID:32178707   PMID:32213628   PMID:32325033   PMID:32398151   PMID:32484924   PMID:32613467   PMID:32623691   PMID:32681852   PMID:32783141   PMID:32790044  
PMID:32976770   PMID:32998402   PMID:33130678   PMID:33167342   PMID:33316302   PMID:33432186   PMID:33474763   PMID:33510137   PMID:33529207   PMID:33599736   PMID:33624776   PMID:33651262  
PMID:33692105   PMID:33772424   PMID:33872576   PMID:34002021   PMID:34038017   PMID:34494549   PMID:34540996   PMID:34562144   PMID:34575909   PMID:34617156   PMID:34674769   PMID:35013307  
PMID:35134442   PMID:35172268   PMID:35212707   PMID:35442708   PMID:35473943   PMID:35536323   PMID:35858542   PMID:36001414   PMID:36100398   PMID:36127549   PMID:36196585   PMID:36417873  
PMID:36450771   PMID:36568889   PMID:36596395   PMID:36653878   PMID:36675000   PMID:36694941   PMID:36757363   PMID:36769371   PMID:36805947   PMID:36918517   PMID:36922751   PMID:36934970  
PMID:36990365   PMID:37074591   PMID:37142655   PMID:37210799   PMID:37282785   PMID:37351177   PMID:37436602   PMID:37439315   PMID:37463205   PMID:37533646   PMID:37546949   PMID:37554272  
PMID:37936982   PMID:38077948   PMID:38163739   PMID:38187761   PMID:38383779   PMID:38507412   PMID:38532513   PMID:38616731   PMID:38735619   PMID:38771571   PMID:38802114   PMID:38802927  
PMID:38924526   PMID:38950712   PMID:38956598   PMID:39125902   PMID:39196941   PMID:39366945   PMID:39385254   PMID:39444081  


Genomics

Comparative Map Data
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)EnsemblGRCm39 Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBIMGSCv36mm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36Build 36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBICelera
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,750 - 24,373,454 (-)NCBICHM1_1
T2T-CHM13v2.01827,046,091 - 27,059,856 (-)NCBIT2T-CHM13v2.0
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8186,782,389 - 6,799,034 (-)NCBIGRCr8
mRatBN7.2186,507,903 - 6,524,558 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl186,507,903 - 6,524,856 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx186,733,660 - 6,750,099 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0187,521,314 - 7,537,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,792,881 - 6,809,322 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1878.3RGD
RH 3.4 Map1886.21RGD
Cytogenetic Map18p13NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21744,280,877 - 44,294,636 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11829,973,472 - 29,987,231 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha761,290,817 - 61,304,150 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0761,906,422 - 61,919,761 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl761,906,451 - 61,926,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1761,579,168 - 61,592,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0761,591,530 - 61,604,873 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0761,894,861 - 61,908,198 (+)NCBIUU_Cfam_GSD_1.0
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494457,872,160 - 57,884,958 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365505,931,194 - 5,941,354 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,407,639 - 111,422,109 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605028,456,973 - 28,470,756 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aqp4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247705,580,808 - 5,594,628 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aqp4
666 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1051
Count of miRNA genes:614
Interacting mature miRNAs:735
Transcripts:ENSMUST00000079081
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11354953Mom21_mmodifier of Min 21 (mouse)18128893823Mouse
13207585Mwmlpt3_mMorris water maze latency to platform, training, 3 (mouse)18133547739Mouse
13207589Mwmlpa3_mMorris water maze latency to platform, all, 3 (mouse)18133547739Mouse
1558873Hrtfm7_mheart failure modifier 7 (mouse)Not determined18808696442087106Mouse
4142127Rafaril_mRafar interacting locus (mouse)Not determined18123108555Mouse
14928307Manh83_mmandible shape 83 (mouse)18126902168Mouse
13432188Actrse3_mactivity response to saline/ethanol 3 (mouse)181237454818574548Mouse
12801458Intmrm3_mintima/media ratio modifier 3 (mouse)18131720756Mouse
13432190Actrse5_mactivity response to saline/ethanol 5 (mouse)181217454817574548Mouse
13504732Cath6_mcarotid atherosclerosis 6 (mouse)181363712647637126Mouse
12801462Intim3_mintima modifier 3 (mouse)18131720756Mouse
4142250Idd21.3_minsulin dependent diabetes susceptibility 21.3 (mouse)Not determined18610840421646477Mouse
1558849W3q15_mweight 3 weeks QTL 15 (mouse)Not determined18504111961272643Mouse
1357603Mom3_mmodifier of Min 3 (mouse)Not determined181403002367098962Mouse
27226723Tibw9_mtibia width 9, proximal, 16 week (mouse)18320000060933072Mouse

Markers in Region
Aqp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381815,399,594 - 15,399,824UniSTSGRCm38
MGSCv371815,558,103 - 15,558,333UniSTSGRCm37
Celera1815,619,401 - 15,619,631UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
cM Map186.0UniSTS
Aqp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381815,392,844 - 15,393,397UniSTSGRCm38
MGSCv371815,551,353 - 15,551,906UniSTSGRCm37
Celera1815,612,663 - 15,613,216UniSTS
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
Aqp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS
Aqp4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map18A1UniSTS
cM Map186.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001317729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_009700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC133525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF219992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF469168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF469169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK039777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK052907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK079614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY484964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY484965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY484966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY728055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY803942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY803943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY803944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB195919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB628835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BB750519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX633380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD803766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT010362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U48400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U88623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000079081   ⟹   ENSMUSP00000078088
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,522,553 - 15,536,815 (-)Ensembl
GRCm38.p6 Ensembl1815,389,496 - 15,403,758 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234053   ⟹   ENSMUSP00000157337
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,448 - 15,544,039 (-)Ensembl
GRCm38.p6 Ensembl1815,393,391 - 15,410,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234140
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,530,250 - 15,533,059 (-)Ensembl
GRCm38.p6 Ensembl1815,397,193 - 15,400,002 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234391   ⟹   ENSMUSP00000157347
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,447 - 15,544,039 (-)Ensembl
GRCm38.p6 Ensembl1815,393,390 - 15,410,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234466   ⟹   ENSMUSP00000157324
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,447 - 15,541,145 (-)Ensembl
GRCm38.p6 Ensembl1815,393,390 - 15,408,088 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234473   ⟹   ENSMUSP00000157152
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,448 - 15,544,039 (-)Ensembl
GRCm38.p6 Ensembl1815,393,391 - 15,410,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234518   ⟹   ENSMUSP00000157239
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,447 - 15,544,039 (-)Ensembl
GRCm38.p6 Ensembl1815,393,390 - 15,410,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234533   ⟹   ENSMUSP00000157261
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,527 - 15,543,986 (-)Ensembl
GRCm38.p6 Ensembl1815,393,470 - 15,410,929 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234624
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,447 - 15,542,551 (-)Ensembl
GRCm38.p6 Ensembl1815,393,390 - 15,409,494 (-)Ensembl
Ensembl Acc Id: ENSMUST00000234643   ⟹   ENSMUSP00000157060
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,501 - 15,536,056 (-)Ensembl
GRCm38.p6 Ensembl1815,393,444 - 15,402,999 (-)Ensembl
Ensembl Acc Id: ENSMUST00000235044   ⟹   ENSMUSP00000157000
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,526,447 - 15,544,039 (-)Ensembl
GRCm38.p6 Ensembl1815,393,390 - 15,410,982 (-)Ensembl
Ensembl Acc Id: ENSMUST00000238946   ⟹   ENSMUSP00000159185
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1815,522,553 - 15,533,059 (-)Ensembl
GRCm38.p6 Ensembl1815,389,496 - 15,400,002 (-)Ensembl
RefSeq Acc Id: NM_001308641   ⟹   NP_001295570
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308642   ⟹   NP_001295571
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308643   ⟹   NP_001295572
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308644   ⟹   NP_001295573
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308645   ⟹   NP_001295574
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308646   ⟹   NP_001295575
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,544,039 (-)NCBI
GRCm381815,389,394 - 15,410,982 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308647   ⟹   NP_001295576
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,536,056 (-)NCBI
GRCm381815,389,394 - 15,402,999 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001317729   ⟹   NP_001304658
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,536,815 (-)NCBI
GRCm381815,389,394 - 15,403,758 (-)NCBI
Sequence:
RefSeq Acc Id: NM_009700   ⟹   NP_033830
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391815,522,451 - 15,536,815 (-)NCBI
GRCm381815,389,394 - 15,403,758 (-)NCBI
MGSCv371815,547,903 - 15,562,193 (-)RGD
Celera1815,609,213 - 15,623,487 (-)RGD
cM Map18 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_001295570 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295571 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295572 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295573 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295574 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295575 (Get FASTA)   NCBI Sequence Viewer  
  NP_001295576 (Get FASTA)   NCBI Sequence Viewer  
  NP_001304658 (Get FASTA)   NCBI Sequence Viewer  
  NP_033830 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA84923 (Get FASTA)   NCBI Sequence Viewer  
  AAB41568 (Get FASTA)   NCBI Sequence Viewer  
  AAB41569 (Get FASTA)   NCBI Sequence Viewer  
  AAB41570 (Get FASTA)   NCBI Sequence Viewer  
  AAB41571 (Get FASTA)   NCBI Sequence Viewer  
  AAC53155 (Get FASTA)   NCBI Sequence Viewer  
  AAG44243 (Get FASTA)   NCBI Sequence Viewer  
  AAH24526 (Get FASTA)   NCBI Sequence Viewer  
  AAL73545 (Get FASTA)   NCBI Sequence Viewer  
  AAL73546 (Get FASTA)   NCBI Sequence Viewer  
  AAM81576 (Get FASTA)   NCBI Sequence Viewer  
  AAS21131 (Get FASTA)   NCBI Sequence Viewer  
  AAS21132 (Get FASTA)   NCBI Sequence Viewer  
  AAS21133 (Get FASTA)   NCBI Sequence Viewer  
  AAX07194 (Get FASTA)   NCBI Sequence Viewer  
  AAX07195 (Get FASTA)   NCBI Sequence Viewer  
  AAX07196 (Get FASTA)   NCBI Sequence Viewer  
  AAX31139 (Get FASTA)   NCBI Sequence Viewer  
  AAX31140 (Get FASTA)   NCBI Sequence Viewer  
  AAX31141 (Get FASTA)   NCBI Sequence Viewer  
  BAC32325 (Get FASTA)   NCBI Sequence Viewer  
  BAE43321 (Get FASTA)   NCBI Sequence Viewer  
  CAJ18569 (Get FASTA)   NCBI Sequence Viewer  
  EDL01600 (Get FASTA)   NCBI Sequence Viewer  
  EDL01601 (Get FASTA)   NCBI Sequence Viewer  
  EDL01602 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000078088
  ENSMUSP00000078088.7
  ENSMUSP00000157000
  ENSMUSP00000157000.2
  ENSMUSP00000157060
  ENSMUSP00000157060.2
  ENSMUSP00000157152
  ENSMUSP00000157152.2
  ENSMUSP00000157239
  ENSMUSP00000157239.2
  ENSMUSP00000157261.2
  ENSMUSP00000157324.2
  ENSMUSP00000157337
  ENSMUSP00000157337.2
  ENSMUSP00000157347
  ENSMUSP00000157347.2
  ENSMUSP00000159185
  ENSMUSP00000159185.2
GenBank Protein P55088 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_033830   ⟸   NM_009700
- Peptide Label: isoform M1
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   A0A0R4J0Z3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295570   ⟸   NM_001308641
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295571   ⟸   NM_001308642
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295573   ⟸   NM_001308644
- Peptide Label: isoform M23
- UniProtKB: Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295572   ⟸   NM_001308643
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295574   ⟸   NM_001308645
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295575   ⟸   NM_001308646
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001304658   ⟸   NM_001317729
- Peptide Label: isoform M1x
- UniProtKB: A0A5F8MQ17 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295576   ⟸   NM_001308647
- Peptide Label: isoform M23
- UniProtKB: Q9EQI3 (UniProtKB/Swiss-Prot),   Q8VHE5 (UniProtKB/Swiss-Prot),   Q8VHE4 (UniProtKB/Swiss-Prot),   Q61132 (UniProtKB/Swiss-Prot),   Q61131 (UniProtKB/Swiss-Prot),   Q4FJP1 (UniProtKB/Swiss-Prot),   P97818 (UniProtKB/Swiss-Prot),   P55088 (UniProtKB/Swiss-Prot),   Q50H70 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000078088   ⟸   ENSMUST00000079081
Ensembl Acc Id: ENSMUSP00000159185   ⟸   ENSMUST00000238946
Ensembl Acc Id: ENSMUSP00000157000   ⟸   ENSMUST00000235044
Ensembl Acc Id: ENSMUSP00000157347   ⟸   ENSMUST00000234391
Ensembl Acc Id: ENSMUSP00000157152   ⟸   ENSMUST00000234473
Ensembl Acc Id: ENSMUSP00000157324   ⟸   ENSMUST00000234466
Ensembl Acc Id: ENSMUSP00000157060   ⟸   ENSMUST00000234643
Ensembl Acc Id: ENSMUSP00000157261   ⟸   ENSMUST00000234533
Ensembl Acc Id: ENSMUSP00000157239   ⟸   ENSMUST00000234518
Ensembl Acc Id: ENSMUSP00000157337   ⟸   ENSMUST00000234053

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55088-F1-model_v2 AlphaFold P55088 1-323 view protein structure

Promoters
RGD ID:13677168
Promoter ID:EPDNEW_M22733
Type:initiation region
Name:Aqp4_1
Description:Mus musculus aquaporin 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22734  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381815,403,649 - 15,403,709EPDNEW
RGD ID:13677170
Promoter ID:EPDNEW_M22734
Type:single initiation site
Name:Aqp4_2
Description:Mus musculus aquaporin 4 , transcript variant 3, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22733  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381815,409,412 - 15,409,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107387 AgrOrtholog
Ensembl Genes ENSMUSG00000024411 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000079081 ENTREZGENE
  ENSMUST00000079081.8 UniProtKB/TrEMBL
  ENSMUST00000234053 ENTREZGENE
  ENSMUST00000234053.2 UniProtKB/Swiss-Prot
  ENSMUST00000234391 ENTREZGENE
  ENSMUST00000234391.2 UniProtKB/Swiss-Prot
  ENSMUST00000234466.2 UniProtKB/Swiss-Prot
  ENSMUST00000234473 ENTREZGENE
  ENSMUST00000234473.2 UniProtKB/Swiss-Prot
  ENSMUST00000234518 ENTREZGENE
  ENSMUST00000234518.2 UniProtKB/Swiss-Prot
  ENSMUST00000234533.2 UniProtKB/TrEMBL
  ENSMUST00000234643 ENTREZGENE
  ENSMUST00000234643.2 UniProtKB/Swiss-Prot
  ENSMUST00000235044 ENTREZGENE
  ENSMUST00000235044.2 UniProtKB/Swiss-Prot
  ENSMUST00000238946 ENTREZGENE
  ENSMUST00000238946.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11829 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107387 ENTREZGENE
NCBI Gene 11829 ENTREZGENE
PANTHER AQUAPORIN-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp4 PhenoGen
PRINTS AQUAPORIN4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0R4J0Z3 ENTREZGENE, UniProtKB/TrEMBL
  A0A3Q4EI78_MOUSE UniProtKB/TrEMBL
  A0A5F8MQ17 ENTREZGENE, UniProtKB/TrEMBL
  AQP4_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  P97818 ENTREZGENE
  Q4FJP1 ENTREZGENE
  Q50H70 ENTREZGENE, UniProtKB/TrEMBL
  Q61131 ENTREZGENE
  Q61132 ENTREZGENE
  Q8BR89_MOUSE UniProtKB/TrEMBL
  Q8VHE4 ENTREZGENE
  Q8VHE5 ENTREZGENE
  Q9EQI3 ENTREZGENE
UniProt Secondary P97818 UniProtKB/Swiss-Prot
  Q4FJP1 UniProtKB/Swiss-Prot
  Q61131 UniProtKB/Swiss-Prot
  Q61132 UniProtKB/Swiss-Prot
  Q8VHE4 UniProtKB/Swiss-Prot
  Q8VHE5 UniProtKB/Swiss-Prot
  Q9EQI3 UniProtKB/Swiss-Prot