RGD Reference Report - Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases. - Rat Genome Database

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Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases.

Authors: Dellavance, A  Alvarenga, RR  Rodrigues, SH  Kok, F  De Souza, AW  Andrade, LE 
Citation: Dellavance A, etal., Eur J Neurol. 2011 Jul 19. doi: 10.1111/j.1468-1331.2011.03479.x.
RGD ID: 5148008
Pubmed: PMID:21771203   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1468-1331.2011.03479.x   (Journal Full-text)

Background and purposes: Anti-aquaporin 4 antibodies are specific markers for Devic's disease. This study aimed to test if this high specificity holds in the context of a large spectrum of systemic autoimmune and non-autoimmune diseases. Methods: Anti-aquaporin-4 antibodies (NMO-IgG) were determined by indirect immunofluorescence (IIF) on mouse cerebellum in 673 samples, as follows: group I (clinically defined Devic's disease, n = 47); group II [inflammatory/demyelinating central nervous system (CNS) diseases, n = 41]; group III (systemic and organ-specific autoimmune diseases, n = 250); group IV (chronic or acute viral diseases, n = 35); and group V (randomly selected samples from a general clinical laboratory, n = 300). Results: MNO-IgG was present in 40/47 patients with classic Devic's disease (85.1% sensitivity) and in 13/22 (59.1%) patients with disorders related to Devic's disease. The latter 13 positive samples had diagnosis of longitudinally extensive transverse myelitis (n = 10) and isolated idiopathic optic neuritis (n = 3). One patient with multiple sclerosis and none of the remaining 602 samples with autoimmune and miscellaneous diseases presented NMO-IgG (99.8% specificity). The autoimmune disease subset included five systemic lupus erythematosus individuals with isolated or combined optic neuritis and myelitis and four primary Sjogren's syndrome (SS) patients with cranial/peripheral neuropathy. Conclusions: The available data clearly point to the high specificity of anti-aquaporin-4 antibodies for Devic's disease and related syndromes also in the context of miscellaneous non-neurologic autoimmune and non-autoimmune disorders.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
transverse myelitis  IDA 5148008 RGD 
transverse myelitis  ISOAQP4 (Homo sapiens)5148008; 5148008 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information