AQP4 (aquaporin 4) - Rat Genome Database
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Gene: AQP4 (aquaporin 4) Pan paniscus
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Symbol: AQP4
Name: aquaporin 4
RGD ID: 11702858
Description: ENCODES a protein that exhibits identical protein binding (ortholog); water channel activity (ortholog); INVOLVED IN carbon dioxide transport (ortholog); cell-cell adhesion (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN water transport pathway; ASSOCIATED WITH Alpers-Huttenlocher syndrome (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN astrocyte end-foot (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: aquaporin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0panPan3
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,745 - 24,373,546 (-)NCBICHM1_1
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBImm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBI
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,400,794 - 111,422,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBI
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)Ensembl
Aqp4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040284   ⟹   ENSPPAP00000017576
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040289   ⟹   ENSPPAP00000017581
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1823,717,314 - 23,726,790 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040290   ⟹   ENSPPAP00000017582
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1823,717,314 - 23,723,663 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000040292   ⟹   ENSPPAP00000017584
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1823,717,314 - 23,723,472 (-)Ensembl
RefSeq Acc Id: XM_003830269   ⟹   XP_003830317
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11823,713,141 - 23,726,919 (-)NCBI
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034943753   ⟹   XP_034799644
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01820,108,607 - 20,119,695 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003830317 (Get FASTA)   NCBI Sequence Viewer  
  XP_034799644 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003830317   ⟸   XM_003830269
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034799644   ⟸   XM_034943753
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000017581   ⟸   ENSPPAT00000040289
RefSeq Acc Id: ENSPPAP00000017576   ⟸   ENSPPAT00000040284
RefSeq Acc Id: ENSPPAP00000017582   ⟸   ENSPPAT00000040290
RefSeq Acc Id: ENSPPAP00000017584   ⟸   ENSPPAT00000040292


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031870 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000017576 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000017581 UniProtKB/TrEMBL
  ENSPPAP00000017582 UniProtKB/TrEMBL
  ENSPPAP00000017584 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040284 UniProtKB/TrEMBL
  ENSPPAT00000040289 UniProtKB/TrEMBL
  ENSPPAT00000040290 UniProtKB/TrEMBL
  ENSPPAT00000040292 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
  MIP_CS UniProtKB/TrEMBL
KEGG Report pps:100969962 UniProtKB/TrEMBL
NCBI Gene AQP4 ENTREZGENE
PANTHER PTHR19139 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PRINTS MINTRINSICP UniProtKB/TrEMBL
PROSITE MIP UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/TrEMBL
UniProt A0A2R9AJM5_PANPA UniProtKB/TrEMBL
  A0A2R9AJM9_PANPA UniProtKB/TrEMBL
  A0A2R9AJN0_PANPA UniProtKB/TrEMBL
  A0A2R9ARU0_PANPA UniProtKB/TrEMBL