AQP4 (aquaporin 4) - Rat Genome Database
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Gene: AQP4 (aquaporin 4) Sus scrofa
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Symbol: AQP4
Name: aquaporin 4
RGD ID: 13904434
Description: ENCODES a protein that exhibits identical protein binding (ortholog); water channel activity (ortholog); INVOLVED IN carbon dioxide transport (ortholog); cell-cell adhesion (ortholog); cellular response to estradiol stimulus (ortholog); PARTICIPATES IN water transport pathway; ASSOCIATED WITH Alpers-Huttenlocher syndrome (ortholog); Alzheimer's disease (ortholog); amyotrophic lateral sclerosis (ortholog); FOUND IN astrocyte end-foot (ortholog); basal plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aquaporin-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,400,794 - 111,422,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:25857369   PMID:26290367  


Genomics

Comparative Map Data
AQP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6111,400,794 - 111,422,042 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26104,387,592 - 104,394,409 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AQP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1826,852,043 - 26,865,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381826,852,038 - 26,865,803 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371824,432,002 - 24,445,767 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361822,686,005 - 22,699,714 (-)NCBINCBI36hg18NCBI36
Build 341822,686,007 - 22,699,714NCBI
Celera1821,242,174 - 21,255,883 (-)NCBI
Cytogenetic Map18q11.2NCBI
HuRef1821,281,696 - 21,295,401 (-)NCBIHuRef
CHM1_11824,359,745 - 24,373,546 (-)NCBICHM1_1
Aqp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391815,522,451 - 15,544,039 (-)NCBIGRCm39mm39
GRCm39 Ensembl1815,522,553 - 15,544,039 (-)Ensembl
GRCm381815,389,394 - 15,410,982 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1815,389,496 - 15,410,982 (-)EnsemblGRCm38mm10GRCm38
MGSCv371815,547,903 - 15,562,193 (-)NCBIGRCm37mm9NCBIm37
MGSCv361815,535,839 - 15,546,671 (-)NCBImm8
Celera1815,609,213 - 15,623,487 (-)NCBICelera
Cytogenetic Map18A1NCBI
cM Map188.74NCBI
Aqp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2186,507,903 - 6,524,558 (-)NCBI
Rnor_6.0 Ensembl186,765,945 - 6,782,996 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0186,766,009 - 6,782,757 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0186,720,759 - 6,737,703 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,626,313 - 6,642,766 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,628,189 - 6,642,700 (-)NCBI
Celera186,530,014 - 6,546,446 (-)NCBICelera
RH 3.4 Map1886.21RGD
RH 3.4 Map1878.3RGD
Cytogenetic Map18p13NCBI
Aqp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049557721,159 - 10,709 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049557721,160 - 10,709 (+)NCBIChiLan1.0ChiLan1.0
AQP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11823,713,141 - 23,726,919 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1823,713,146 - 23,726,919 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01820,108,607 - 20,122,381 (-)NCBIMhudiblu_PPA_v0panPan3
AQP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl761,855,744 - 61,865,089 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1761,855,617 - 61,868,953 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Aqp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365505,931,201 - 5,943,999 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11853,729,143 - 53,742,916 (+)NCBI
ChlSab1.1 Ensembl1853,729,186 - 53,743,156 (+)Ensembl
Aqp4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247705,581,192 - 5,593,470 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system musculoskeletal system nervous system
High
Medium 20
Low 3 2 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000036862   ⟹   ENSSSCP00000036599
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6111,406,381 - 111,422,002 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000042661   ⟹   ENSSSCP00000056358
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6111,407,639 - 111,419,089 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000050372   ⟹   ENSSSCP00000040033
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6111,407,639 - 111,422,042 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000051496   ⟹   ENSSSCP00000047998
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl6111,400,794 - 111,422,002 (-)Ensembl
RefSeq Acc Id: NM_001110423   ⟹   NP_001103893
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,411,832 - 111,418,846 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093187   ⟹   XP_020948846
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,632 - 111,422,169 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093188   ⟹   XP_020948847
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,421,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093189   ⟹   XP_020948848
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,421,092 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093190   ⟹   XP_020948849
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,422,021 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093191   ⟹   XP_020948850
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,420,926 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093192   ⟹   XP_020948851
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,408,253 - 111,421,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093193   ⟹   XP_020948852
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,419,549 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021093195   ⟹   XP_020948854
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.16111,407,642 - 111,421,880 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020948846   ⟸   XM_021093187
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020948849   ⟸   XM_021093190
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948854   ⟸   XM_021093195
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948847   ⟸   XM_021093188
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948848   ⟸   XM_021093189
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948850   ⟸   XM_021093191
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948852   ⟸   XM_021093193
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020948851   ⟸   XM_021093192
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001103893   ⟸   NM_001110423
- UniProtKB: A8V978 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000040033   ⟸   ENSSSCT00000050372
RefSeq Acc Id: ENSSSCP00000047998   ⟸   ENSSSCT00000051496
RefSeq Acc Id: ENSSSCP00000056358   ⟸   ENSSSCT00000042661
RefSeq Acc Id: ENSSSCP00000036599   ⟸   ENSSSCT00000036862


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000035965 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070025319 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000036599 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000040033 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000047998 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000056358 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070042792 UniProtKB/TrEMBL
  ENSSSCP00070042794 UniProtKB/TrEMBL
  ENSSSCP00070042796 UniProtKB/TrEMBL
  ENSSSCP00070042798 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000036862 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042661 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000050372 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000051496 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070050626 UniProtKB/TrEMBL
  ENSSSCT00070050628 UniProtKB/TrEMBL
  ENSSSCT00070050630 UniProtKB/TrEMBL
  ENSSSCT00070050632 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/TrEMBL
  MIP UniProtKB/TrEMBL
  MIP_CS UniProtKB/TrEMBL
KEGG Report ssc:100126277 UniProtKB/TrEMBL
NCBI Gene AQP4 ENTREZGENE
PANTHER PTHR19139 UniProtKB/TrEMBL
Pfam MIP UniProtKB/TrEMBL
PRINTS MINTRINSICP UniProtKB/TrEMBL
PROSITE MIP UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/TrEMBL
UniProt A0A286ZY85_PIG UniProtKB/TrEMBL
  A0A287AVU9_PIG UniProtKB/TrEMBL
  A0A287BJM6_PIG UniProtKB/TrEMBL
  A0A4X1VHA9_PIG UniProtKB/TrEMBL
  A0A4X1VP34_PIG UniProtKB/TrEMBL
  A8V978 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:85432 ENTREZGENE