RGD Reference Report - IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. - Rat Genome Database

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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.

Authors: Lennon, VA  Kryzer, TJ  Pittock, SJ  Verkman, AS  Hinson, SR 
Citation: Lennon VA, etal., J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8.
RGD ID: 5148024
Pubmed: PMID:16087714   (View Abstract at PubMed)
PMCID: PMC2212860   (View Article at PubMed Central)
DOI: DOI:10.1084/jem.20050304   (Journal Full-text)

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AQP4Humanneuromyelitis optica  IDA  RGD 
Aqp4Ratneuromyelitis optica  ISOAQP4 (Homo sapiens) RGD 
Aqp4Mouseneuromyelitis optica  ISOAQP4 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information