RGD Reference Report - IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. - Rat Genome Database

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IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.

Authors: Lennon, VA  Kryzer, TJ  Pittock, SJ  Verkman, AS  Hinson, SR 
Citation: Lennon VA, etal., J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8.
RGD ID: 5148024
Pubmed: PMID:16087714   (View Abstract at PubMed)
PMCID: PMC2212860   (View Article at PubMed Central)
DOI: DOI:10.1084/jem.20050304   (Journal Full-text)

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. NMO may represent the first example of a novel class of autoimmune channelopathy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuromyelitis optica  IDA 5148024 RGD 
neuromyelitis optica  ISOAQP4 (Homo sapiens)5148024; 5148024 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information