RGD Reference Report - Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis. - Rat Genome Database

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Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis.

Authors: Pham, H  Doerrbecker, J  Ramp, AA  D'Souza, CS  Gorasia, DG  Purcell, AW  Ayers, MM  Orian, JM 
Citation: Pham H, etal., J Neuroimmunol. 2011 Mar;232(1-2):51-62. Epub 2010 Nov 6.
RGD ID: 5148015
Pubmed: PMID:21056916   (View Abstract at PubMed)
DOI: DOI:10.1016/j.jneuroim.2010.10.006   (Journal Full-text)

The C57Bl/6 mouse is the preferred host for the maintenance of gene deletion mutants and holds a unique place in investigations of cytokine/chemokine networks in neuroinflammation. It is also susceptible to experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis (MS)-like disease commonly used to assess potential MS therapies. Investigations of glial reactivity in EAE have revealed hitherto undescribed astroglial responses in this model, characterized by progressively diminishing glial fibrillary acidic protein and aquaporin-4 immunostaining, from early disease. These observations show that astrocyte responses vary with the EAE paradigm and are an important pathological criterion for disease mapping and therapy evaluation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
AQP4HumanExperimental Autoimmune Encephalomyelitis disease_progressionISOAqp4 (Mus musculus) RGD 
Aqp4RatExperimental Autoimmune Encephalomyelitis disease_progressionISOAqp4 (Mus musculus) RGD 
Aqp4MouseExperimental Autoimmune Encephalomyelitis disease_progressionIEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp4  (aquaporin 4)

Genes (Mus musculus)
Aqp4  (aquaporin 4)

Genes (Homo sapiens)
AQP4  (aquaporin 4)


Additional Information