Mapkapk2 (MAPK activated protein kinase 2) - Rat Genome Database

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Gene: Mapkapk2 (MAPK activated protein kinase 2) Rattus norvegicus
Analyze
Symbol: Mapkapk2
Name: MAPK activated protein kinase 2
RGD ID: 631362
Description: Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; protein phosphorylation; and regulation of gene expression. Predicted to act upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2); PARTICIPATES IN interleukin-2 signaling pathway; p38 MAPK signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-nitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP kinase-activated protein kinase 2; mitogen-activated protein kinase-activated protein kinase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21342,513,762 - 42,560,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,120,561 - 45,166,993 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01346,408,685 - 46,455,124 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01343,672,789 - 43,719,216 (-)NCBIRnor_WKY
Rnor_6.01347,785,157 - 47,871,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,865,897 - 52,912,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,994,943 - 44,041,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,008,985 - 44,055,547 (-)NCBI
Celera1342,861,470 - 42,906,683 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-anisomycin  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-nitrotoluene  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromochloroacetic acid  (EXP)
butan-1-ol  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
coniferyl aldehyde  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (EXP)
D-glucitol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fipronil  (EXP)
flurbiprofen  (ISO)
folic acid  (ISO)
geldanamycin  (ISO)
gentamycin  (EXP)
glyphosate  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroxytyrosol  (EXP)
ibuprofen  (ISO)
imidacloprid  (EXP)
indometacin  (ISO)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
methotrexate  (ISO)
methylmercury(1+)  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
potassium dichromate  (ISO)
quercetin  (EXP)
raloxifene  (ISO)
ranitidine  (EXP)
retinyl acetate  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
rottlerin  (ISO)
SB 203580  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
streptozocin  (ISO)
sulfates  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
tetrachloromethane  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA,ISO)
cytoplasm  (IBA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. beta-Amyloid peptide induces formation of actin stress fibers through p38 mitogen-activated protein kinase. Song C, etal., J Neurochem 2002 Nov;83(4):828-36.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:7799959   PMID:8774846   PMID:8846784   PMID:9628873   PMID:10559880   PMID:11741878   PMID:12456657   PMID:14517288   PMID:15014438   PMID:15084475   PMID:15538386   PMID:15850461  
PMID:15856211   PMID:16278218   PMID:17906627   PMID:18440775   PMID:18570454   PMID:20932473   PMID:21139061   PMID:21795542   PMID:24020373   PMID:24927932   PMID:31505169  


Genomics

Comparative Map Data
Mapkapk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21342,513,762 - 42,560,061 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1345,120,561 - 45,166,993 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01346,408,685 - 46,455,124 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01343,672,789 - 43,719,216 (-)NCBIRnor_WKY
Rnor_6.01347,785,157 - 47,871,684 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01352,865,897 - 52,912,481 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41343,994,943 - 44,041,504 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11344,008,985 - 44,055,547 (-)NCBI
Celera1342,861,470 - 42,906,683 (-)NCBICelera
Cytogenetic Map13q13NCBI
MAPKAPK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381206,684,905 - 206,734,281 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1206,684,905 - 206,734,281 (+)EnsemblGRCh38hg38GRCh38
GRCh371206,858,250 - 206,907,626 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,924,912 - 204,974,249 (+)NCBINCBI36Build 36hg18NCBI36
Celera1180,109,718 - 180,159,069 (+)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1177,556,640 - 177,605,949 (+)NCBIHuRef
CHM1_11208,130,566 - 208,179,829 (+)NCBICHM1_1
T2T-CHM13v2.01205,949,085 - 205,998,488 (+)NCBIT2T-CHM13v2.0
Mapkapk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391130,981,437 - 131,025,580 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1130,981,437 - 131,025,563 (-)EnsemblGRCm39 Ensembl
GRCm381131,053,700 - 131,097,871 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,053,700 - 131,097,826 (-)EnsemblGRCm38mm10GRCm38
MGSCv371132,950,281 - 132,994,120 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361132,881,250 - 132,925,089 (-)NCBIMGSCv36mm8
Celera1133,676,280 - 133,720,582 (-)NCBICelera
Cytogenetic Map1E4NCBI
Mapkapk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540642,231,858 - 42,276,477 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540642,231,858 - 42,276,477 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11186,609,836 - 186,615,466 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,608,158 - 186,613,911 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01182,286,854 - 182,336,306 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAPKAPK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.175,873,088 - 5,903,484 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl75,814,201 - 5,902,220 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha75,422,392 - 5,467,592 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.075,547,527 - 5,592,752 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl75,546,052 - 5,590,777 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.175,482,144 - 5,527,321 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.075,583,083 - 5,628,202 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.075,622,716 - 5,667,925 (+)NCBIUU_Cfam_GSD_1.0
Mapkapk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,626,900 - 68,670,925 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365575,867,211 - 5,911,213 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365575,867,182 - 5,911,207 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl967,314,484 - 67,365,059 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1967,314,651 - 67,365,060 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,667,427 - 73,717,087 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,632,180 - 22,681,250 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2522,629,729 - 22,681,373 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605523,329,820 - 23,378,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248074,724,234 - 4,796,143 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248074,726,511 - 4,774,945 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapkapk2
136 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:463
Count of miRNA genes:232
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000061070
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133124133158363171Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134118402245417941Rat

Markers in Region
AA960234  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,513,836 - 42,514,076 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,236 - 47,785,475NCBIRnor6.0
Rnor_5.01352,865,972 - 52,866,211UniSTSRnor5.0
RGSC_v3.41343,995,018 - 43,995,257UniSTSRGSC3.4
Celera1342,861,545 - 42,861,784UniSTS
Cytogenetic Map13q13UniSTS
RH141120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,513,827 - 42,514,008 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,227 - 47,785,407NCBIRnor6.0
Rnor_5.01352,865,963 - 52,866,143UniSTSRnor5.0
RGSC_v3.41343,995,009 - 43,995,189UniSTSRGSC3.4
Celera1342,861,536 - 42,861,716UniSTS
RH 3.4 Map1777.9UniSTS
Cytogenetic Map13q13UniSTS
Mapkapk2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,514,050 - 42,515,053 (+)MAPPERmRatBN7.2
Rnor_6.01347,785,450 - 47,786,452NCBIRnor6.0
Rnor_5.01352,866,186 - 52,867,188UniSTSRnor5.0
RGSC_v3.41343,995,232 - 43,996,234UniSTSRGSC3.4
Celera1342,861,759 - 42,862,761UniSTS
Cytogenetic Map13q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061070   ⟹   ENSRNOP00000057786
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,513,762 - 42,560,457 (-)Ensembl
Rnor_6.0 Ensembl1347,785,161 - 47,831,110 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100098   ⟹   ENSRNOP00000076947
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,513,762 - 42,560,061 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111595   ⟹   ENSRNOP00000085497
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1342,513,762 - 42,523,444 (-)Ensembl
RefSeq Acc Id: NM_178102   ⟹   NP_835203
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,513,762 - 42,560,061 (-)NCBI
Rnor_6.01347,785,161 - 47,871,684 (-)NCBI
Rnor_5.01352,865,897 - 52,912,481 (-)NCBI
RGSC_v3.41343,994,943 - 44,041,504 (-)RGD
Celera1342,861,470 - 42,906,683 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_835203 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH62048 (Get FASTA)   NCBI Sequence Viewer  
  AAO34665 (Get FASTA)   NCBI Sequence Viewer  
  EDM09835 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_835203   ⟸   NM_178102
- UniProtKB: Q80ZF4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000057786   ⟸   ENSRNOT00000061070
RefSeq Acc Id: ENSRNOP00000085497   ⟸   ENSRNOT00000111595
RefSeq Acc Id: ENSRNOP00000076947   ⟸   ENSRNOT00000100098
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M9C0-F1-model_v2 AlphaFold F1M9C0 1-370 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698791
Promoter ID:EPDNEW_R9316
Type:single initiation site
Name:Mapkapk2_1
Description:mitogen-activated protein kinase-activated protein kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01347,831,080 - 47,831,140EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631362 AgrOrtholog
BioCyc Gene G2FUF-18357 BioCyc
Ensembl Genes ENSRNOG00000004726 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000057786.5 UniProtKB/TrEMBL
  ENSRNOP00000076947 ENTREZGENE
  ENSRNOP00000076947.1 UniProtKB/TrEMBL
  ENSRNOP00000085497.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061070.5 UniProtKB/TrEMBL
  ENSRNOT00000100098 ENTREZGENE
  ENSRNOT00000100098.1 UniProtKB/TrEMBL
  ENSRNOT00000111595.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.1170.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598069 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:289014 UniProtKB/TrEMBL
MGC_CLONE MGC:72264 IMAGE-MGC_LOAD
NCBI Gene 289014 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Mapkapk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5ZZC5_RAT UniProtKB/TrEMBL
  F1M9C0_RAT UniProtKB/TrEMBL
  Q80ZF4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mapkapk2  MAPK activated protein kinase 2  Mapkapk2  mitogen-activated protein kinase-activated protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-06 Mapkapk2  mitogen-activated protein kinase-activated protein kinase 2  Mapkapk2  MAP kinase-activated protein kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-11 Mapkapk2  MAP kinase-activated protein kinase 2      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activated by beta-amyloid precursor protein APP-V642I (IAPP) and mutant presenilin-1 L286V (mPS1) 724429