RGD Reference Report - MAPKAP kinases - MKs - two's company, three's a crowd. - Rat Genome Database

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MAPKAP kinases - MKs - two's company, three's a crowd.

Authors: Gaestel, M 
Citation: Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
RGD ID: 2315047
Pubmed: PMID:16421520   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm1834   (Journal Full-text)

Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.



RGD Manual Annotations

1 to 20 of 45 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
MAPKAPK2Humanp38 MAPK signaling pathway   TAS  RGD 
MAPKAPK3Humanp38 MAPK signaling pathway   TAS  RGD 
MAPKAPK5Humanp38 MAPK signaling pathway   TAS  RGD 
MKNK1Humanp38 MAPK signaling pathway   TAS  RGD 
MKNK2Humanp38 MAPK signaling pathway   TAS  RGD 
Mapkapk2Ratp38 MAPK signaling pathway   ISOMAPKAPK2 (Homo sapiens) RGD 
Mapkapk2Mousep38 MAPK signaling pathway   ISOMAPKAPK2 (Homo sapiens) RGD 
Mapkapk3Ratp38 MAPK signaling pathway   ISOMAPKAPK3 (Homo sapiens) RGD 
Mapkapk3Mousep38 MAPK signaling pathway   ISOMAPKAPK3 (Homo sapiens) RGD 
Mapkapk5Mousep38 MAPK signaling pathway   ISOMAPKAPK5 (Homo sapiens) RGD 
Mapkapk5Ratp38 MAPK signaling pathway   ISOMAPKAPK5 (Homo sapiens) RGD 
Mknk1Ratp38 MAPK signaling pathway   ISOMKNK1 (Homo sapiens) RGD 
Mknk1Mousep38 MAPK signaling pathway   ISOMKNK1 (Homo sapiens) RGD 
Mknk2Mousep38 MAPK signaling pathway   ISOMKNK2 (Homo sapiens) RGD 
Mknk2Ratp38 MAPK signaling pathway   ISOMKNK2 (Homo sapiens) RGD 
RPS6KA4Humanp38 MAPK signaling pathway   TAS  RGD 
RPS6KA5Humanp38 MAPK signaling pathway   TAS  RGD 
Rps6ka4Mousep38 MAPK signaling pathway   ISORPS6KA4 (Homo sapiens) RGD 
Rps6ka4Ratp38 MAPK signaling pathway   ISORPS6KA4 (Homo sapiens) RGD 
Rps6ka5Ratp38 MAPK signaling pathway   ISORPS6KA5 (Homo sapiens) RGD 
1 to 20 of 45 rows

Genes (Rattus norvegicus)
Mapkapk2  (MAPK activated protein kinase 2) Mapkapk3  (MAPK activated protein kinase 3) Mapkapk5  (MAPK activated protein kinase 5)
Mknk1  (MAPK interacting serine/threonine kinase 1) Mknk2  (MAPK interacting serine/threonine kinase 2) Rps6ka1  (ribosomal protein S6 kinase A1)
Rps6ka2  (ribosomal protein S6 kinase A2) Rps6ka3  (ribosomal protein S6 kinase A3) Rps6ka4  (ribosomal protein S6 kinase A4)
Rps6ka5  (ribosomal protein S6 kinase A5) Rps6ka6  (ribosomal protein S6 kinase A6)

Genes (Mus musculus)
Mapkapk2  (MAP kinase-activated protein kinase 2) Mapkapk3  (mitogen-activated protein kinase-activated protein kinase 3) Mapkapk5  (MAP kinase-activated protein kinase 5)
Mknk1  (MAP kinase-interacting serine/threonine kinase 1) Mknk2  (MAP kinase-interacting serine/threonine kinase 2) Rps6ka1  (ribosomal protein S6 kinase polypeptide 1)
Rps6ka2  (ribosomal protein S6 kinase, polypeptide 2) Rps6ka3  (ribosomal protein S6 kinase polypeptide 3) Rps6ka4  (ribosomal protein S6 kinase, polypeptide 4)
Rps6ka5  (ribosomal protein S6 kinase, polypeptide 5) Rps6ka6  (ribosomal protein S6 kinase polypeptide 6)

Genes (Homo sapiens)
MAPKAPK2  (MAPK activated protein kinase 2) MAPKAPK3  (MAPK activated protein kinase 3) MAPKAPK5  (MAPK activated protein kinase 5)
MKNK1  (MAPK interacting serine/threonine kinase 1) MKNK2  (MAPK interacting serine/threonine kinase 2) RPS6KA1  (ribosomal protein S6 kinase A1)
RPS6KA2  (ribosomal protein S6 kinase A2) RPS6KA3  (ribosomal protein S6 kinase A3) RPS6KA4  (ribosomal protein S6 kinase A4)
RPS6KA5  (ribosomal protein S6 kinase A5) RPS6KA6  (ribosomal protein S6 kinase A6)