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MAPKAP kinases - MKs - two's company, three's a crowd.

Authors: Gaestel, M 
Citation: Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
Pubmed: (View Article at PubMed) PMID:16421520
DOI: Full-text: DOI:10.1038/nrm1834

Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets. Although there is no known common function for all three MKs, these kinases are involved in important processes: MKs regulate gene expression at the transcriptional and post-transcriptional level, control cytoskeletal architecture and cell-cycle progression, and are implicated in inflammation and cancer.


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RGD Object Information
RGD ID: 2315047
Created: 2009-12-15
Species: All species
Last Modified: 2009-12-15
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.