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Gene: RPS6KA3 (ribosomal protein S6 kinase A3) Homo sapiens
Symbol: RPS6KA3
Name: ribosomal protein S6 kinase A3
Description: Exhibits cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process and positive regulation of transcription by RNA polymerase II. Predicted to localize to the cytoplasm and nucleus. Implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 90 kDa ribosomal protein S6 kinase 3; CLS; Coffin-Lowry syndrome; HU-3; insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; MAPKAPK1B; mental retardation, X-linked 19; MRX19; p90-RSK 3; p90-RSK2; p90RSK3; pp90RSK2; ribosomal protein S6 kinase alpha-3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; ribosomal S6 kinase 2; RSK; RSK-2; RSK2; S6K-alpha-3; S6K-alpha3
Mus musculus (house mouse) : Rps6ka3 (ribosomal protein S6 kinase polypeptide 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6ka3 (ribosomal protein S6 kinase A3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6ka3 (ribosomal protein S6 kinase A3)
Pan paniscus (bonobo/pygmy chimpanzee) : RPS6KA3 (ribosomal protein S6 kinase A3)
Canis lupus familiaris (dog) : RPS6KA3 (ribosomal protein S6 kinase A3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6ka3 (ribosomal protein S6 kinase A3)
Sus scrofa (pig) : RPS6KA3 (ribosomal protein S6 kinase A3)
Chlorocebus sabaeus (African green monkey) : RPS6KA3 (ribosomal protein S6 kinase A3)
Heterocephalus glaber (naked mole-rat) : Rps6ka3 (ribosomal protein S6 kinase A3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX20,149,911 - 20,267,519 (-)Ensembl
GRCh38X20,149,911 - 20,267,514 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X20,168,029 - 20,285,523 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X20,077,950 - 20,194,671 (-)NCBINCBI36hg18NCBI36
Build 34X19,927,686 - 20,044,407NCBI
CeleraX24,292,410 - 24,377,495 (-)NCBI
Cytogenetic MapXp22.12NCBI
HuRefX17,910,375 - 17,994,979 (-)NCBIHuRef
CHM1_1X20,198,431 - 20,315,161 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on RPS6KA3
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1354498
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.