Mknk2 (MAPK interacting serine/threonine kinase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Mknk2 (MAPK interacting serine/threonine kinase 2) Rattus norvegicus
Analyze
Symbol: Mknk2
Name: MAPK interacting serine/threonine kinase 2
RGD ID: 1305728
Description: Predicted to enable ATP binding activity; calmodulin binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to arsenic-containing substance; intracellular signal transduction; and protein phosphorylation. Predicted to act upstream of or within extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and nucleus. Orthologous to human MKNK2 (MAPK interacting serine/threonine kinase 2); PARTICIPATES IN p38 MAPK signaling pathway; the extracellular signal-regulated Raf/Mek/Erk signaling pathway; insulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC299618; MAP kinase signal-integrating kinase 2; MAP kinase-interacting serine/threonine kinase 2; MAP kinase-interacting serine/threonine-protein kinase 2; MAPK signal-integrating kinase 2; mnk2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,690,385 - 9,701,527 (+)NCBIGRCr8
mRatBN7.279,039,771 - 9,050,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,039,728 - 9,050,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,918,241 - 11,929,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,793,754 - 13,804,776 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,659,834 - 11,670,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,908,107 - 11,919,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,908,107 - 11,919,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,075,381 - 12,086,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,550,040 - 10,561,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,550,039 - 10,561,095 (+)NCBI
Celera77,222,443 - 7,233,496 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
amitrole  (EXP)
amosite asbestos  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bromobenzene  (EXP)
cadmium dichloride  (EXP)
camptothecin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
diclofenac  (ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
FR900359  (ISO)
furan  (EXP)
genistein  (ISO)
glyphosate  (ISO)
isoprenaline  (ISO)
lead diacetate  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methapyrilene  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
orphenadrine  (EXP)
oxytocin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
progesterone  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
streptozocin  (EXP)
sunitinib  (ISO)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
nuclear body  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA)
PML body  (IEA)

References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9155017   PMID:11463832   PMID:12477932   PMID:15489334   PMID:17903173   PMID:18299328   PMID:21149447  


Genomics

Comparative Map Data
Mknk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr879,690,385 - 9,701,527 (+)NCBIGRCr8
mRatBN7.279,039,771 - 9,050,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl79,039,728 - 9,050,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,918,241 - 11,929,263 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,793,754 - 13,804,776 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0711,659,834 - 11,670,885 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,908,107 - 11,919,161 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,908,107 - 11,919,156 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0712,075,381 - 12,086,471 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4710,550,040 - 10,561,100 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1710,550,039 - 10,561,095 (+)NCBI
Celera77,222,443 - 7,233,496 (+)NCBICelera
Cytogenetic Map7q11NCBI
MKNK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38192,037,471 - 2,051,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl192,037,465 - 2,051,244 (-)EnsemblGRCh38hg38GRCh38
GRCh37192,037,470 - 2,051,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36191,988,470 - 2,002,243 (-)NCBINCBI36Build 36hg18NCBI36
Build 34191,988,469 - 2,002,233NCBI
Celera191,972,223 - 1,985,996 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef191,809,368 - 1,822,963 (-)NCBIHuRef
CHM1_1192,037,373 - 2,051,145 (-)NCBICHM1_1
T2T-CHM13v2.0192,010,542 - 2,024,317 (-)NCBIT2T-CHM13v2.0
Mknk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391080,501,152 - 80,512,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1080,501,161 - 80,513,946 (-)EnsemblGRCm39 Ensembl
GRCm381080,665,318 - 80,676,293 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1080,665,327 - 80,678,112 (-)EnsemblGRCm38mm10GRCm38
MGSCv371080,128,072 - 80,134,721 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,068,456 - 80,075,105 (-)NCBIMGSCv36mm8
Celera1081,683,709 - 81,690,357 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Mknk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554956,048,128 - 6,062,913 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554956,048,346 - 6,061,579 (+)NCBIChiLan1.0ChiLan1.0
MKNK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2206,417,727 - 6,431,445 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1195,648,480 - 5,662,190 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0191,045,316 - 1,059,023 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1192,018,822 - 2,032,429 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl192,018,822 - 2,032,429 (-)Ensemblpanpan1.1panPan2
MKNK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12056,966,656 - 56,978,414 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2056,965,800 - 56,974,073 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2056,761,516 - 56,773,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02057,699,409 - 57,711,005 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2057,698,709 - 57,709,803 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12056,756,543 - 56,768,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02057,236,165 - 57,247,743 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02057,436,941 - 57,448,534 (+)NCBIUU_Cfam_GSD_1.0
Mknk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118216,645,852 - 216,657,922 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,178,890 - 1,188,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,176,861 - 1,188,931 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MKNK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl276,510,303 - 76,522,883 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1276,510,302 - 76,522,885 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2277,245,674 - 77,254,490 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MKNK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.161,836,009 - 1,851,325 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl61,835,993 - 1,851,039 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660816,889,976 - 6,905,278 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mknk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248286,788,069 - 6,801,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mknk2
32 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:705
Count of miRNA genes:275
Interacting mature miRNAs:347
Transcripts:ENSRNOT00000041106
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
RH128320  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,050,402 - 9,050,656 (+)MAPPERmRatBN7.2
mRatBN7.279,050,437 - 9,050,656 (+)MAPPERmRatBN7.2
Rnor_6.0711,918,767 - 11,918,985NCBIRnor6.0
Rnor_6.0711,918,732 - 11,918,985NCBIRnor6.0
Rnor_5.0712,086,075 - 12,086,293UniSTSRnor5.0
Rnor_5.0712,086,040 - 12,086,293UniSTSRnor5.0
RGSC_v3.4710,560,706 - 10,560,924UniSTSRGSC3.4
RGSC_v3.4710,560,671 - 10,560,924UniSTSRGSC3.4
Celera77,233,067 - 7,233,320UniSTS
Celera77,233,102 - 7,233,320UniSTS
Cytogenetic Map7q11UniSTS
BE097229  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.279,050,188 - 9,050,374 (+)MAPPERmRatBN7.2
Rnor_6.0711,918,518 - 11,918,703NCBIRnor6.0
Rnor_5.0712,085,826 - 12,086,011UniSTSRnor5.0
RGSC_v3.4710,560,457 - 10,560,642UniSTSRGSC3.4
Celera77,232,853 - 7,233,038UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000041106   ⟹   ENSRNOP00000039672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,039,728 - 9,050,827 (+)Ensembl
Rnor_6.0 Ensembl711,908,107 - 11,919,156 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105676   ⟹   ENSRNOP00000088086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl79,043,620 - 9,048,939 (+)Ensembl
RefSeq Acc Id: NM_001011985   ⟹   NP_001011985
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,690,465 - 9,701,525 (+)NCBI
mRatBN7.279,039,771 - 9,050,832 (+)NCBI
Rnor_6.0711,908,107 - 11,919,161 (+)NCBI
Rnor_5.0712,075,381 - 12,086,471 (+)NCBI
RGSC_v3.4710,550,040 - 10,561,100 (+)RGD
Celera77,222,443 - 7,233,496 (+)RGD
Sequence:
RefSeq Acc Id: XM_063263174   ⟹   XP_063119244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,690,385 - 9,701,527 (+)NCBI
RefSeq Acc Id: XM_063263175   ⟹   XP_063119245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr879,690,710 - 9,701,527 (+)NCBI
RefSeq Acc Id: NP_001011985   ⟸   NM_001011985
- UniProtKB: Q5U2N4 (UniProtKB/Swiss-Prot),   A6K8I1 (UniProtKB/TrEMBL),   A0A8I6AI16 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039672   ⟸   ENSRNOT00000041106
Ensembl Acc Id: ENSRNOP00000088086   ⟸   ENSRNOT00000105676
RefSeq Acc Id: XP_063119244   ⟸   XM_063263174
- Peptide Label: isoform X1
- UniProtKB: Q5U2N4 (UniProtKB/Swiss-Prot),   A0A8I6AI16 (UniProtKB/TrEMBL),   A6K8I1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119245   ⟸   XM_063263175
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AI16 (UniProtKB/TrEMBL)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2N4-F1-model_v2 AlphaFold Q5U2N4 1-459 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695010
Promoter ID:EPDNEW_R5535
Type:single initiation site
Name:Mknk2_1
Description:MAP kinase-interacting serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,908,063 - 11,908,123EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305728 AgrOrtholog
BioCyc Gene G2FUF-34958 BioCyc
Ensembl Genes ENSRNOG00000029028 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000041106 ENTREZGENE
  ENSRNOT00000041106.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105676.1 UniProtKB/TrEMBL
  ENSRNOT00000140938 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124839 IMAGE-MGC_LOAD
InterPro CDPK_Ser/Thr_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299618 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:95066 IMAGE-MGC_LOAD
NCBI Gene 299618 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mknk2 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029028 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AI16 ENTREZGENE, UniProtKB/TrEMBL
  A6K8I1 ENTREZGENE, UniProtKB/TrEMBL
  MKNK2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mknk2  MAPK interacting serine/threonine kinase 2  Mknk2  MAP kinase-interacting serine/threonine kinase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mknk2  MAP kinase-interacting serine/threonine kinase 2  Mknk2_predicted  MAP kinase-interacting serine/threonine kinase 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mknk2_predicted  MAP kinase-interacting serine/threonine kinase 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED