Mapkapk3 (MAPK activated protein kinase 3) - Rat Genome Database

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Gene: Mapkapk3 (MAPK activated protein kinase 3) Rattus norvegicus
Analyze
Symbol: Mapkapk3
Name: MAPK activated protein kinase 3
RGD ID: 1304980
Description: Predicted to enable calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; peptidyl-serine phosphorylation; and response to lipopolysaccharide. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315994; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; mitogen-activated protein kinase-activated protein kinase 3; MK-3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,808,429 - 116,842,228 (-)NCBIGRCr8
mRatBN7.28107,929,754 - 107,963,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,556,431 - 113,590,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,755,606 - 111,789,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,598,393 - 109,631,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,012,126 - 116,046,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,368,430 - 115,402,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,497,626 - 112,531,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,517,080 - 112,551,233 (-)NCBI
Celera8107,239,457 - 107,273,298 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
C60 fullerene  (EXP)
cadmium atom  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chenodeoxycholic acid  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
endosulfan  (EXP)
fenamidone  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glyphosate  (EXP)
ibuprofen  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
lipopolysaccharide  (ISO)
methoxyacetic acid  (EXP)
methylmercury chloride  (ISO)
mitomycin C  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
tartrazine  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
triphenyl phosphate  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
nucleoplasm  (IEA,ISO)
nucleus  (IBA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7799959   PMID:8774846   PMID:12477932   PMID:15489334   PMID:15850461   PMID:17906627  


Genomics

Comparative Map Data
Mapkapk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,808,429 - 116,842,228 (-)NCBIGRCr8
mRatBN7.28107,929,754 - 107,963,638 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8113,556,431 - 113,590,016 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08111,755,606 - 111,789,192 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08109,598,393 - 109,631,978 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08116,012,126 - 116,046,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,368,430 - 115,402,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,497,626 - 112,531,778 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18112,517,080 - 112,551,233 (-)NCBI
Celera8107,239,457 - 107,273,298 (-)NCBICelera
Cytogenetic Map8q32NCBI
MAPKAPK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38350,611,520 - 50,649,291 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl350,611,520 - 50,649,291 (+)EnsemblGRCh38hg38GRCh38
GRCh37350,649,308 - 50,686,722 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,629,605 - 50,661,723 (+)NCBINCBI36Build 36hg18NCBI36
Build 34350,629,604 - 50,661,723NCBI
Celera350,627,403 - 50,659,525 (+)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef350,705,224 - 50,742,794 (+)NCBIHuRef
CHM1_1350,601,533 - 50,638,951 (+)NCBICHM1_1
T2T-CHM13v2.0350,641,158 - 50,679,247 (+)NCBIT2T-CHM13v2.0
Mapkapk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,132,125 - 107,167,082 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9107,132,126 - 107,167,076 (-)EnsemblGRCm39 Ensembl
GRCm389107,254,927 - 107,289,877 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,254,927 - 107,289,877 (-)EnsemblGRCm38mm10GRCm38
MGSCv379107,157,258 - 107,192,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369107,113,028 - 107,147,978 (-)NCBIMGSCv36mm8
Celera9106,860,944 - 106,896,004 (-)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.98NCBI
Mapkapk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,392,539 - 2,420,604 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,392,539 - 2,419,219 (+)NCBIChiLan1.0ChiLan1.0
MAPKAPK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2250,597,068 - 50,629,342 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1350,601,850 - 50,634,117 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0350,542,547 - 50,574,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1351,779,906 - 51,812,124 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,779,912 - 51,812,124 (+)Ensemblpanpan1.1panPan2
MAPKAPK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12038,731,492 - 38,759,000 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2038,732,397 - 38,758,494 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,649,808 - 38,677,437 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02039,084,740 - 39,112,355 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2039,084,740 - 39,112,232 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12038,452,657 - 38,480,274 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02038,856,269 - 38,883,882 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02039,136,177 - 39,163,793 (-)NCBIUU_Cfam_GSD_1.0
Mapkapk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,369,894 - 65,399,362 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365292,130,252 - 2,160,313 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365292,130,421 - 2,159,859 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPKAPK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1333,097,393 - 33,125,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11333,097,329 - 33,125,820 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,318,931 - 36,348,176 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPKAPK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,998,774 - 12,036,477 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041154,949,436 - 154,982,394 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapkapk3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247304,446,850 - 4,476,630 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247304,446,815 - 4,492,753 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mapkapk3
131 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:401
Count of miRNA genes:191
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000020065
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH128348  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,929,828 - 107,930,012 (+)MAPPERmRatBN7.2
Rnor_6.08116,012,201 - 116,012,384NCBIRnor6.0
Rnor_5.08115,368,502 - 115,368,685UniSTSRnor5.0
RGSC_v3.48112,497,693 - 112,497,876UniSTSRGSC3.4
Celera8107,239,524 - 107,239,707UniSTS
RH 3.4 Map81139.5UniSTS
Cytogenetic Map8q32UniSTS
AI874665  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28107,929,959 - 107,930,083 (+)MAPPERmRatBN7.2
Rnor_6.08116,012,332 - 116,012,455NCBIRnor6.0
Rnor_5.08115,368,633 - 115,368,756UniSTSRnor5.0
RGSC_v3.48112,497,824 - 112,497,947UniSTSRGSC3.4
Celera8107,239,655 - 107,239,778UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000020065   ⟹   ENSRNOP00000020065
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)Ensembl
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094925   ⟹   ENSRNOP00000091496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100521   ⟹   ENSRNOP00000096910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,929,762 - 107,963,568 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114765   ⟹   ENSRNOP00000088134
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,929,762 - 107,939,239 (-)Ensembl
RefSeq Acc Id: NM_001012127   ⟹   NP_001012127
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,808,429 - 116,842,228 (-)NCBI
mRatBN7.28107,929,762 - 107,963,568 (-)NCBI
Rnor_6.08116,012,134 - 116,045,926 (-)NCBI
Rnor_5.08115,368,430 - 115,402,297 (-)NCBI
RGSC_v3.48112,497,626 - 112,531,778 (-)RGD
Celera8107,239,457 - 107,273,298 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766531   ⟹   XP_008764753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,808,430 - 116,842,126 (-)NCBI
mRatBN7.28107,929,754 - 107,963,638 (-)NCBI
Rnor_6.08116,012,126 - 116,046,012 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001012127   ⟸   NM_001012127
- UniProtKB: Q66H84 (UniProtKB/Swiss-Prot),   A6I2W4 (UniProtKB/TrEMBL),   A0A8I6AVR4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764753   ⟸   XM_008766531
- Peptide Label: isoform X1
- UniProtKB: Q66H84 (UniProtKB/Swiss-Prot),   A6I2W4 (UniProtKB/TrEMBL),   A0A8I6AVR4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000020065   ⟸   ENSRNOT00000020065
Ensembl Acc Id: ENSRNOP00000088134   ⟸   ENSRNOT00000114765
Ensembl Acc Id: ENSRNOP00000096910   ⟸   ENSRNOT00000100521
Ensembl Acc Id: ENSRNOP00000091496   ⟸   ENSRNOT00000094925
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H84-F1-model_v2 AlphaFold Q66H84 1-384 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696263
Promoter ID:EPDNEW_R6788
Type:initiation region
Name:Mapkapk3_1
Description:mitogen-activated protein kinase-activated protein kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08116,045,945 - 116,046,005EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304980 AgrOrtholog
BioCyc Gene G2FUF-29212 BioCyc
Ensembl Genes ENSRNOG00000014832 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055012357 UniProtKB/Swiss-Prot
  ENSRNOG00060024691 UniProtKB/Swiss-Prot
  ENSRNOG00065008167 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020065.6 UniProtKB/Swiss-Prot
  ENSRNOT00000094925.1 UniProtKB/TrEMBL
  ENSRNOT00000100521.1 UniProtKB/TrEMBL
  ENSRNOT00000114765.1 UniProtKB/TrEMBL
  ENSRNOT00055021044 UniProtKB/Swiss-Prot
  ENSRNOT00060042850 UniProtKB/Swiss-Prot
  ENSRNOT00065012942 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1170.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126359 IMAGE-MGC_LOAD
InterPro CDPK_Ser/Thr_kinases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MAPKAPK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:315994 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94118 IMAGE-MGC_LOAD
NCBI Gene 315994 ENTREZGENE
PANTHER MAP KINASE-ACTIVATED PROTEIN KINASE 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mapkapk3 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014832 RatGTEx
  ENSRNOG00055012357 RatGTEx
  ENSRNOG00060024691 RatGTEx
  ENSRNOG00065008167 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A779_RAT UniProtKB/TrEMBL
  A0A8I6ABR6_RAT UniProtKB/TrEMBL
  A0A8I6AVR4 ENTREZGENE, UniProtKB/TrEMBL
  A6I2W4 ENTREZGENE, UniProtKB/TrEMBL
  MAPK3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-08 Mapkapk3  MAPK activated protein kinase 3  Mapkapk3  mitogen-activated protein kinase-activated protein kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mapkapk3  mitogen-activated protein kinase-activated protein kinase 3  Mapkapk3_predicted  mitogen-activated protein kinase-activated protein kinase 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mapkapk3_predicted  mitogen-activated protein kinase-activated protein kinase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED