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Gene: Mapkapk3 (MAPK activated protein kinase 3) Rattus norvegicus
Symbol: Mapkapk3
Name: MAPK activated protein kinase 3
RGD ID: 1304980
Description: Predicted to have calmodulin binding activity; mitogen-activated protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including macropinocytosis; protein phosphorylation; and response to lipopolysaccharide. Predicted to localize to cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in patterned macular dystrophy 3. Orthologous to human MAPKAPK3 (MAPK activated protein kinase 3); PARTICIPATES IN p38 MAPK signaling pathway; mitogen activated protein kinase signaling pathway; vascular endothelial growth factor signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
Also known as: LOC315994; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP-K3; MAPKAPK-3; mitogen-activated protein kinase-activated protein kinase 3; MK-3
Homo sapiens (human) : MAPKAPK3 (MAPK activated protein kinase 3)  HGNC  Alliance
Mus musculus (house mouse) : Mapkapk3 (mitogen-activated protein kinase-activated protein kinase 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mapkapk3 (MAPK activated protein kinase 3)
Pan paniscus (bonobo/pygmy chimpanzee) : MAPKAPK3 (MAPK activated protein kinase 3)
Canis lupus familiaris (dog) : MAPKAPK3 (MAPK activated protein kinase 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mapkapk3 (MAPK activated protein kinase 3)
Sus scrofa (pig) : MAPKAPK3 (MAPK activated protein kinase 3)
Chlorocebus sabaeus (African green monkey) : MAPKAPK3 (MAPK activated protein kinase 3)
Heterocephalus glaber (naked mole-rat) : Mapkapk3 (MAPK activated protein kinase 3)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.08116,012,126 - 116,046,012 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,012,121 - 116,045,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,368,430 - 115,402,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,497,626 - 112,531,778 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,517,080 - 112,551,233 (-)NCBI
Celera8107,239,457 - 107,273,298 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Mapkapk3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1304980
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.