Rps6ka2 (ribosomal protein S6 kinase A2) - Rat Genome Database

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Gene: Rps6ka2 (ribosomal protein S6 kinase A2) Rattus norvegicus
Analyze
Symbol: Rps6ka2
Name: ribosomal protein S6 kinase A2
RGD ID: 620676
Description: Predicted to enable protein serine/threonine/tyrosine kinase activity and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including TORC1 signaling; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Predicted to act upstream of or within several processes, including cardiac muscle cell apoptotic process; oocyte maturation; and regulation of gene expression. Predicted to be located in meiotic spindle and nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA2 (ribosomal protein S6 kinase A2); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; long term potentiation; mitogen activated protein kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase polypeptide 2; ribosomal protein S6 kinase, 90kD, polypeptide 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Celera148,533,427 - 48,667,077 (+)NCBICelera
Cytogenetic Map1q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ferroheme b  (ISO)
fulvestrant  (ISO)
heme b  (ISO)
hydroquinone  (ISO)
lead(0)  (ISO)
Licochalcone B  (ISO)
maneb  (ISO)
metformin  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-nitrosodiethylamine  (EXP)
nitrogen mustard  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
obeticholic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pioglitazone  (ISO)
potassium chromate  (ISO)
propanal  (ISO)
raloxifene  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
meiotic spindle  (ISO)
nucleoplasm  (IBA,ISO)
nucleus  (ISO)
spindle  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Fingar DC, etal., Genes Dev 2002 Jun 15;16(12):1472-87.
2. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Kim YB, etal., Biochem Biophys Res Commun 1999 Jan 27;254(3):720-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7508917   PMID:10635333   PMID:11684016   PMID:15509711   PMID:15526037   PMID:16585392   PMID:16878154   PMID:19418583   PMID:21891976   PMID:22797923   PMID:22997248  


Genomics

Comparative Map Data
Rps6ka2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Celera148,533,427 - 48,667,077 (+)NCBICelera
Cytogenetic Map1q12NCBI
RPS6KA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,409,364 - 166,862,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,409,364 - 166,906,451 (-)EnsemblGRCh38hg38GRCh38
GRCh376166,822,852 - 167,276,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,742,844 - 167,195,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 346166,793,264 - 167,011,137NCBI
Celera6167,562,220 - 168,016,996 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,294,243 - 164,748,630 (-)NCBIHuRef
CHM1_16167,086,555 - 167,538,409 (-)NCBICHM1_1
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBIT2T-CHM13v2.0
Rps6ka2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,356,384 - 7,570,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,292,942 - 7,570,726 (+)EnsemblGRCm39 Ensembl
GRCm38177,088,971 - 7,303,315 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,170,115 - 7,303,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv37177,374,464 - 7,507,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,019,773 - 7,152,973 (+)NCBIMGSCv36mm8
Celera177,033,227 - 7,165,891 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.7NCBI
Rps6ka2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,332,165 - 15,487,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543915,210,882 - 15,487,305 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,615,281 - 187,112,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,511,214 - 185,009,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,373,829 - 164,829,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,355,114 - 169,806,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,355,136 - 169,806,337 (-)Ensemblpanpan1.1panPan2
RPS6KA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,413,805 - 54,757,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,416,758 - 54,757,067 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,202,572 - 55,547,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,592,807 - 54,938,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,592,818 - 54,938,570 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,489,815 - 54,835,148 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,338,945 - 54,683,764 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,963,546 - 55,308,688 (-)NCBIUU_Cfam_GSD_1.0
Rps6ka2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,203,606 - 2,522,599 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112,203,825 - 2,522,604 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,346,751 - 3,662,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,141,648 - 94,605,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,140,111 - 94,357,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604065,964,531 - 66,420,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478512,657,845 - 12,839,569 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478512,450,686 - 12,839,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rps6ka2
1706 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:332
Count of miRNA genes:203
Interacting mature miRNAs:237
Transcripts:ENSRNOT00000017809
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14936146582174945Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat

Markers in Region
D1Rat489  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,712,762 - 52,713,019 (+)MAPPERmRatBN7.2
Rnor_6.0153,301,737 - 53,301,995NCBIRnor6.0
Rnor_5.0154,551,265 - 54,551,523UniSTSRnor5.0
RGSC_v3.4147,364,593 - 47,364,852RGDRGSC3.4
RGSC_v3.4147,364,594 - 47,364,852UniSTSRGSC3.4
RGSC_v3.1147,367,538 - 47,367,797RGD
Celera148,475,189 - 48,475,447UniSTS
FHH x ACI Map129.09UniSTS
FHH x ACI Map129.09RGD
Cytogenetic Map1q11UniSTS
RH127829  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,906,396 - 52,906,609 (+)MAPPERmRatBN7.2
Rnor_6.0153,499,103 - 53,499,315NCBIRnor6.0
Rnor_5.0154,747,389 - 54,747,601UniSTSRnor5.0
RGSC_v3.4147,560,031 - 47,560,243UniSTSRGSC3.4
Celera148,666,735 - 48,666,947UniSTS
RH 3.4 Map1627.0UniSTS
Cytogenetic Map1q11UniSTS
BF386574  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,724,859 - 52,725,038 (+)MAPPERmRatBN7.2
Rnor_6.0153,313,830 - 53,314,008NCBIRnor6.0
Rnor_5.0154,563,358 - 54,563,536UniSTSRnor5.0
RGSC_v3.4147,376,693 - 47,376,871UniSTSRGSC3.4
Celera148,487,288 - 48,487,466UniSTS
RH 3.4 Map1624.3UniSTS
Cytogenetic Map1q11UniSTS
BE096506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2152,789,815 - 52,790,003 (+)MAPPERmRatBN7.2
Rnor_6.0153,378,554 - 53,378,741NCBIRnor6.0
Rnor_5.0154,628,022 - 54,628,209UniSTSRnor5.0
RGSC_v3.4147,443,145 - 47,443,332UniSTSRGSC3.4
Celera148,552,001 - 48,552,188UniSTS
RH 3.4 Map1624.4UniSTS
Cytogenetic Map1q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017809   ⟹   ENSRNOP00000017809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,771,260 - 52,906,739 (+)Ensembl
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094462   ⟹   ENSRNOP00000086785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,825,976 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095647   ⟹   ENSRNOP00000088182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,741,017 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103591   ⟹   ENSRNOP00000097579
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107274   ⟹   ENSRNOP00000084178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,684,153 - 52,906,739 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000112387   ⟹   ENSRNOP00000076821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl152,704,915 - 52,906,739 (+)Ensembl
RefSeq Acc Id: NM_057128   ⟹   NP_476469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,318,811 - 55,454,271 (+)NCBI
mRatBN7.2152,771,260 - 52,906,739 (+)NCBI
Rnor_6.0153,360,157 - 53,499,445 (+)NCBI
Rnor_5.0154,469,155 - 54,747,731 (+)NCBI
RGSC_v3.4147,424,106 - 47,560,373 (+)RGD
Celera148,533,427 - 48,667,077 (+)RGD
Sequence:
RefSeq Acc Id: XM_039078975   ⟹   XP_038934903
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,178,988 - 55,454,271 (+)NCBI
mRatBN7.2152,631,582 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079021   ⟹   XP_038934949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,231,696 - 55,454,271 (+)NCBI
mRatBN7.2152,684,170 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079056   ⟹   XP_038934984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,288,449 - 55,454,271 (+)NCBI
mRatBN7.2152,740,903 - 52,906,739 (+)NCBI
RefSeq Acc Id: XM_039079122   ⟹   XP_038935050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8155,288,833 - 55,454,271 (+)NCBI
mRatBN7.2152,741,284 - 52,906,739 (+)NCBI
RefSeq Acc Id: NP_476469   ⟸   NM_057128
- UniProtKB: F1M7N7 (UniProtKB/TrEMBL),   A6KK46 (UniProtKB/TrEMBL),   A0A8I6GEE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017809   ⟸   ENSRNOT00000017809
RefSeq Acc Id: XP_038934903   ⟸   XM_039078975
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AWJ2 (UniProtKB/TrEMBL),   A0A8I5Y0U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934949   ⟸   XM_039079021
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZYL5 (UniProtKB/TrEMBL),   A0A8I5Y0U0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038934984   ⟸   XM_039079056
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A7B5 (UniProtKB/TrEMBL),   A0A8I6GEE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935050   ⟸   XM_039079122
- Peptide Label: isoform X4
- UniProtKB: A0A8I5Y0U0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000088182   ⟸   ENSRNOT00000095647
Ensembl Acc Id: ENSRNOP00000097579   ⟸   ENSRNOT00000103591
Ensembl Acc Id: ENSRNOP00000076821   ⟸   ENSRNOT00000112387
Ensembl Acc Id: ENSRNOP00000084178   ⟸   ENSRNOT00000107274
Ensembl Acc Id: ENSRNOP00000086785   ⟸   ENSRNOT00000094462
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M7N7-F1-model_v2 AlphaFold F1M7N7 1-733 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689633
Promoter ID:EPDNEW_R157
Type:initiation region
Name:Rps6ka2_1
Description:ribosomal protein S6 kinase A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0153,360,166 - 53,360,226EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620676 AgrOrtholog
BioCyc Gene G2FUF-61506 BioCyc
Ensembl Genes ENSRNOG00000013194 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017809.6 UniProtKB/TrEMBL
  ENSRNOT00000094462.1 UniProtKB/TrEMBL
  ENSRNOT00000095647.1 UniProtKB/TrEMBL
  ENSRNOT00000103591.1 UniProtKB/TrEMBL
  ENSRNOT00000107274.1 UniProtKB/TrEMBL
  ENSRNOT00000112387.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RSK3_STKc UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:117269 UniProtKB/TrEMBL
NCBI Gene 117269 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PhenoGen Rps6ka2 PhenoGen
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013194 RatGTEx
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A8I5Y0U0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZYL5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7B5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AWJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GEE6 ENTREZGENE, UniProtKB/TrEMBL
  A6KK46 ENTREZGENE, UniProtKB/TrEMBL
  F1M7N7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-11-29 Rps6ka2  ribosomal protein S6 kinase A2  Rps6ka2  ribosomal protein S6 kinase polypeptide 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rps6ka2  ribosomal protein S6 kinase, polypeptide 2    ribosomal protein S6 kinase, 90kD, polypeptide 2  Name updated 1299863 APPROVED
2002-08-07 Rps6ka2  ribosomal protein S6 kinase, 90kD, polypeptide 2      Symbol and Name status set to provisional 70820 PROVISIONAL