RPS6KA2 (ribosomal protein S6 kinase A2) - Rat Genome Database

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Gene: RPS6KA2 (ribosomal protein S6 kinase A2) Homo sapiens
Analyze
Symbol: RPS6KA2
Name: ribosomal protein S6 kinase A2
RGD ID: 1348784
HGNC Page HGNC:10431
Description: Enables protein serine/threonine/tyrosine kinase activity. Involved in negative regulation of cell cycle; negative regulation of cell population proliferation; and positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: 90 kDa ribosomal protein S6 kinase 2; HU-2; MAP kinase-activated protein kinase 1c; MAPK-activated protein kinase 1c; MAPKAP kinase 1c; MAPKAPK-1c; MAPKAPK1C; mitogen-activated protein kinase-activated protein kinase 1C; p90-RSK 2; p90-RSK3; p90RSK2; pp90RSK3; ribosomal protein S6 kinase 90kDa polypeptide 2; ribosomal protein S6 kinase alpha 2; ribosomal protein S6 kinase alpha-2; ribosomal protein S6 kinase, 90kDa, polypeptide 2; ribosomal S6 kinase 3; RSK; RSK-3; RSK3; S6K-alpha; S6K-alpha-2; S6K-alpha2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,409,364 - 166,862,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,409,364 - 166,906,451 (-)EnsemblGRCh38hg38GRCh38
GRCh376166,822,852 - 167,276,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,742,844 - 167,195,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 346166,793,264 - 167,011,137NCBI
Celera6167,562,220 - 168,016,996 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,294,243 - 164,748,630 (-)NCBIHuRef
CHM1_16167,086,555 - 167,538,409 (-)NCBICHM1_1
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrolein  (EXP)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
alpha-pinene  (EXP)
ammonium chloride  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cantharidin  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
Cuprizon  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
deoxynivalenol  (ISO)
dorsomorphin  (EXP)
elemental selenium  (EXP)
endosulfan  (ISO)
ethanol  (EXP,ISO)
ferroheme b  (ISO)
fulvestrant  (EXP)
heme b  (ISO)
hydroquinone  (EXP)
lead(0)  (EXP)
Licochalcone B  (EXP)
maneb  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methoxychlor  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-nitrosodiethylamine  (ISO)
nitrogen mustard  (EXP)
Nor-9-carboxy-delta9-THC  (EXP)
obeticholic acid  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentanal  (EXP)
perfluorohexanesulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenylmercury acetate  (EXP)
phosgene  (ISO)
pioglitazone  (EXP)
potassium chromate  (EXP)
propanal  (EXP)
raloxifene  (EXP)
SB 431542  (EXP)
selenium atom  (EXP)
silicon dioxide  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP)
succimer  (ISO)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
taurine  (EXP)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thalidomide  (ISO)
thioacetamide  (ISO)
trovafloxacin  (ISO)
valproic acid  (EXP)
vitamin E  (EXP)
zinc sulfate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,IEA)
cytosol  (TAS)
meiotic spindle  (ISO)
nucleoplasm  (IBA,IDA,TAS)
nucleus  (IDA,IEA,TAS)
ribosome  (IEA)
spindle  (ISO)
synapse  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. MAPKAP kinases - MKs - two's company, three's a crowd. Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7623830   PMID:8141249   PMID:8663493   PMID:8688081   PMID:8756728   PMID:8939914   PMID:9155018   PMID:9381178   PMID:9687510   PMID:9770464   PMID:9829964   PMID:9915826  
PMID:10480933   PMID:10521512   PMID:10837486   PMID:10880354   PMID:10949026   PMID:11160957   PMID:11175347   PMID:11495723   PMID:11698596   PMID:12016217   PMID:12393804   PMID:12477932  
PMID:12832467   PMID:14574404   PMID:14646589   PMID:14702039   PMID:15112576   PMID:15345747   PMID:15489334   PMID:15867353   PMID:15995633   PMID:16217014   PMID:16344560   PMID:16621805  
PMID:16626623   PMID:16751776   PMID:16810323   PMID:16878154   PMID:16895915   PMID:17192257   PMID:20379614   PMID:21035469   PMID:21527514   PMID:21873635   PMID:21988832   PMID:22797923  
PMID:22939624   PMID:22939629   PMID:23128233   PMID:23259602   PMID:23455922   PMID:23564320   PMID:23602568   PMID:23635776   PMID:23727904   PMID:24403857   PMID:24556642   PMID:24722188  
PMID:25189868   PMID:25241761   PMID:25544563   PMID:25852190   PMID:26186194   PMID:26977024   PMID:28319085   PMID:28514442   PMID:28611215   PMID:29117863   PMID:29144123   PMID:29507755  
PMID:29987050   PMID:30126976   PMID:31678930   PMID:31937753   PMID:31980649   PMID:32296183   PMID:32707033   PMID:32814053   PMID:32869517   PMID:33961781   PMID:34550011   PMID:34591642  
PMID:34857952   PMID:35256949   PMID:35271311   PMID:35748872   PMID:36215168   PMID:36736316   PMID:36883564   PMID:36931259   PMID:37067748   PMID:38008756   PMID:38113892  


Genomics

Comparative Map Data
RPS6KA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,409,364 - 166,862,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,409,364 - 166,906,451 (-)EnsemblGRCh38hg38GRCh38
GRCh376166,822,852 - 167,276,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,742,844 - 167,195,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 346166,793,264 - 167,011,137NCBI
Celera6167,562,220 - 168,016,996 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,294,243 - 164,748,630 (-)NCBIHuRef
CHM1_16167,086,555 - 167,538,409 (-)NCBICHM1_1
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBIT2T-CHM13v2.0
Rps6ka2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,356,384 - 7,570,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,437,514 - 7,570,714 (+)EnsemblGRCm39 Ensembl
GRCm38177,088,971 - 7,303,315 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,170,115 - 7,303,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv37177,374,464 - 7,507,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,019,773 - 7,152,973 (+)NCBIMGSCv36mm8
Celera177,033,227 - 7,165,891 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.7NCBI
Rps6ka2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Celera148,533,427 - 48,667,077 (+)NCBICelera
Cytogenetic Map1q12NCBI
Rps6ka2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,332,165 - 15,487,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543915,210,882 - 15,487,305 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,615,281 - 187,112,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,511,214 - 185,009,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,373,829 - 164,829,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,355,114 - 169,806,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,355,136 - 169,806,337 (-)Ensemblpanpan1.1panPan2
RPS6KA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,413,805 - 54,757,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,416,758 - 54,757,067 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,202,572 - 55,547,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,592,807 - 54,938,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,592,818 - 54,938,570 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,489,815 - 54,835,148 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,338,945 - 54,683,764 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,963,546 - 55,308,688 (-)NCBIUU_Cfam_GSD_1.0
Rps6ka2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,203,606 - 2,522,599 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112,203,825 - 2,522,604 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,346,751 - 3,662,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,141,648 - 94,605,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,140,111 - 94,357,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604065,964,531 - 66,420,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478512,657,845 - 12,839,569 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478512,450,686 - 12,839,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in RPS6KA2
40 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6q24.1-27(chr6:141132990-169339571)x3 copy number gain See cases [RCV000050604] Chr6:141132990..169339571 [GRCh38]
Chr6:141454127..169739666 [GRCh37]
Chr6:141495820..169481591 [NCBI36]
Chr6:6q24.1-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170583214)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051902]|See cases [RCV000051902] Chr6:152376338..170583214 [GRCh38]
Chr6:152697473..170892302 [GRCh37]
Chr6:152739166..170734227 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:158664768-170612001)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051904]|See cases [RCV000051904] Chr6:158664768..170612001 [GRCh38]
Chr6:159085800..170921089 [GRCh37]
Chr6:159005788..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154118058-170602152)x1 copy number loss See cases [RCV000052207] Chr6:154118058..170602152 [GRCh38]
Chr6:154439193..170911240 [GRCh37]
Chr6:154480885..170753165 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159454639-170612001)x1 copy number loss See cases [RCV000052209] Chr6:159454639..170612001 [GRCh38]
Chr6:159875671..170921089 [GRCh37]
Chr6:159795661..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159825913-170612001)x1 copy number loss See cases [RCV000052211] Chr6:159825913..170612001 [GRCh38]
Chr6:160246945..170921089 [GRCh37]
Chr6:160166935..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160328288-170612001)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052212]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052212]|See cases [RCV000052212] Chr6:160328288..170612001 [GRCh38]
Chr6:160749320..170921089 [GRCh37]
Chr6:160669310..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160359686-170608818)x1 copy number loss See cases [RCV000052213] Chr6:160359686..170608818 [GRCh38]
Chr6:160780718..170917906 [GRCh37]
Chr6:160700708..170759831 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160422761-170612001)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052214]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052214]|See cases [RCV000052214] Chr6:160422761..170612001 [GRCh38]
Chr6:160843793..170921089 [GRCh37]
Chr6:160763783..170763014 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:161205328-170581161)x1 copy number loss See cases [RCV000052215] Chr6:161205328..170581161 [GRCh38]
Chr6:161626360..170890249 [GRCh37]
Chr6:161546350..170732174 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:162042846-170608818)x1 copy number loss See cases [RCV000052223] Chr6:162042846..170608818 [GRCh38]
Chr6:162463878..170917906 [GRCh37]
Chr6:162383868..170759831 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:162789915-170602152)x1 copy number loss See cases [RCV000052224] Chr6:162789915..170602152 [GRCh38]
Chr6:163210947..170911240 [GRCh37]
Chr6:163130937..170753165 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:163420224-170608818)x1 copy number loss See cases [RCV000052225] Chr6:163420224..170608818 [GRCh38]
Chr6:163841256..170917906 [GRCh37]
Chr6:163761246..170759831 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q27(chr6:165126489-170581161)x1 copy number loss See cases [RCV000052226] Chr6:165126489..170581161 [GRCh38]
Chr6:165539978..170890249 [GRCh37]
Chr6:165459968..170732174 [NCBI36]
Chr6:6q27		 pathogenic
GRCh38/hg38 6q27(chr6:166370159-170602152)x1 copy number loss See cases [RCV000052227] Chr6:166370159..170602152 [GRCh38]
Chr6:166783647..170911240 [GRCh37]
Chr6:166703637..170753165 [NCBI36]
Chr6:6q27		 pathogenic
NM_001006932.1(RPS6KA2):c.955G>A (p.Glu319Lys) single nucleotide variant Malignant melanoma [RCV000067212] Chr6:166469882 [GRCh38]
Chr6:166883370 [GRCh37]
Chr6:166803360 [NCBI36]
Chr6:6q27		 not provided
NM_001006932.1(RPS6KA2):c.123+53076C>A single nucleotide variant Lung cancer [RCV000096696] Chr6:166805124 [GRCh38]
Chr6:167218612 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1696G>A (p.Gly566Arg) single nucleotide variant Autism spectrum disorder [RCV001291500] Chr6:166423303 [GRCh38]
Chr6:166836791 [GRCh37]
Chr6:6q27		 association
GRCh37/hg19 6q26-27(chr6:162865436-170901287)x3 copy number gain See cases [RCV000184080] Chr6:162865436..170901287 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:160484810-170612011)x1 copy number loss See cases [RCV000134021] Chr6:160484810..170612011 [GRCh38]
Chr6:160905842..170921099 [GRCh37]
Chr6:160825832..170763024 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q27(chr6:164790270-170612001)x1 copy number loss See cases [RCV000135415] Chr6:164790270..170612001 [GRCh38]
Chr6:165203779..170921089 [GRCh37]
Chr6:165123769..170763014 [NCBI36]
Chr6:6q27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:154539655-170714507)x1 copy number loss See cases [RCV000137381] Chr6:154539655..170714507 [GRCh38]
Chr6:154860789..171023595 [GRCh37]
Chr6:154902481..170865520 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.3-27(chr6:159915390-170714507)x1 copy number loss See cases [RCV000139636] Chr6:159915390..170714507 [GRCh38]
Chr6:160336422..171023595 [GRCh37]
Chr6:160256412..170865520 [NCBI36]
Chr6:6q25.3-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152793402-170610394)x1 copy number loss See cases [RCV000141880] Chr6:152793402..170610394 [GRCh38]
Chr6:153114537..170919482 [GRCh37]
Chr6:153156230..170761407 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q25.2-27(chr6:152376338-170612001)x3 copy number gain See cases [RCV000142594] Chr6:152376338..170612001 [GRCh38]
Chr6:152697473..170921089 [GRCh37]
Chr6:152739166..170763014 [NCBI36]
Chr6:6q25.2-27		 pathogenic
GRCh38/hg38 6q26-27(chr6:160899898-170610394)x1 copy number loss See cases [RCV000143619] Chr6:160899898..170610394 [GRCh38]
Chr6:161320930..170919482 [GRCh37]
Chr6:161240920..170761407 [NCBI36]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:163731741-167090237)x1 copy number loss See cases [RCV000449040] Chr6:163731741..167090237 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:151214792-170892243)x3 copy number gain See cases [RCV000449011] Chr6:151214792..170892243 [GRCh37]
Chr6:6q25.1-27		 pathogenic
Single allele deletion not provided [RCV000768451] Chr6:162966301..170914973 [GRCh37]
Chr6:6q26-27		 likely pathogenic
GRCh37/hg19 6q27(chr6:165443824-170892302)x1 copy number loss See cases [RCV000239993] Chr6:165443824..170892302 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159121459-170919482) copy number loss Hydrocephalus [RCV002280751] Chr6:159121459..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_021135.6(RPS6KA2):c.2054G>A (p.Arg685Gln) single nucleotide variant Inborn genetic diseases [RCV003245692] Chr6:166413816 [GRCh38]
Chr6:166827304 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:166331006-166984713)x1 copy number loss See cases [RCV000449260] Chr6:166331006..166984713 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:162381975-170919482)x1 copy number loss See cases [RCV000449121] Chr6:162381975..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:165622608-166897295)x3 copy number gain See cases [RCV000445739] Chr6:165622608..166897295 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:167194654-167416922)x1 copy number loss See cases [RCV000445795] Chr6:167194654..167416922 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:164361517-170919482)x1 copy number loss See cases [RCV000446024] Chr6:164361517..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:166571083-167265466)x1 copy number loss See cases [RCV000447812] Chr6:166571083..167265466 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3 copy number gain See cases [RCV000512067] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482) copy number gain See cases [RCV000510595] Chr6:156975..170919482 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q27(chr6:166110423-170919482)x1 copy number loss See cases [RCV000510607] Chr6:166110423..170919482 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:164276935-170919482)x1 copy number loss See cases [RCV000511755] Chr6:164276935..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3 copy number gain not provided [RCV000682734] Chr6:159844762..170919482 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6q27(chr6:165190527-170919482)x1 copy number loss not provided [RCV000682744] Chr6:165190527..170919482 [GRCh37]
Chr6:6q27		 pathogenic
46,XX,der(6)(q25.1,q28)dn.seq[GRCh37/hg19]der(6)(6pter->6q25.2(+)(154768571)::q25.2(+)(154778901),q25.2(+)154778992::q25.2(-)(154774048),q25.2(-)(154768571)::q25.2(-)(154768571),q25.1(-)(~151443183-151443483))dn complex Coffin-Siris syndrome 1 [RCV000714957] Chr6:151443333..171115067 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q27(chr6:166686874-166891466)x3 copy number gain not provided [RCV000682745] Chr6:166686874..166891466 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:167167381-167433823)x1 copy number loss not provided [RCV000682746] Chr6:167167381..167433823 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3 copy number gain not provided [RCV000745400] Chr6:60107..171054786 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3 copy number gain not provided [RCV000745404] Chr6:165632..170919470 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3 copy number gain not provided [RCV000745403] Chr6:108666..170980171 [GRCh37]
Chr6:6p25.3-q27		 pathogenic
GRCh37/hg19 6q25.1-27(chr6:150284435-170919470)x3 copy number gain not provided [RCV000746100] Chr6:150284435..170919470 [GRCh37]
Chr6:6q25.1-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:159155998-171054786)x3 copy number gain not provided [RCV000746132] Chr6:159155998..171054786 [GRCh37]
Chr6:6q25.3-27		 pathogenic
GRCh37/hg19 6q27(chr6:165989942-171054786)x1 copy number loss not provided [RCV000746208] Chr6:165989942..171054786 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q27(chr6:166702780-166873823)x1 copy number loss not provided [RCV000746210] Chr6:166702780..166873823 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166999291-167000131)x1 copy number loss not provided [RCV000746211] Chr6:166999291..167000131 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166999460-167000059)x1 copy number loss not provided [RCV000746212] Chr6:166999460..167000059 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166999676-167000009)x1 copy number loss not provided [RCV000746213] Chr6:166999676..167000009 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166999676-167000059)x1 copy number loss not provided [RCV000746214] Chr6:166999676..167000059 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:166999727-167000059)x1 copy number loss not provided [RCV000746215] Chr6:166999727..167000059 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:167029183-167065170)x3 copy number gain not provided [RCV000746216] Chr6:167029183..167065170 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:167058026-167139479)x3 copy number gain not provided [RCV000746217] Chr6:167058026..167139479 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:167197344-167198027)x0 copy number loss not provided [RCV000746218] Chr6:167197344..167198027 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:167197433-167198027)x0 copy number loss not provided [RCV000746219] Chr6:167197433..167198027 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q27(chr6:167199572-167238612)x3 copy number gain not provided [RCV000746220] Chr6:167199572..167238612 [GRCh37]
Chr6:6q27		 benign
NM_021135.6(RPS6KA2):c.1695C>T (p.Asn565=) single nucleotide variant not provided [RCV000950154] Chr6:166423304 [GRCh38]
Chr6:166836792 [GRCh37]
Chr6:6q27		 benign|likely benign
NM_021135.6(RPS6KA2):c.2187G>C (p.Thr729=) single nucleotide variant not provided [RCV000962189] Chr6:166412777 [GRCh38]
Chr6:166826265 [GRCh37]
Chr6:6q27		 benign
GRCh37/hg19 6q26-27(chr6:162661108-170919482)x1 copy number loss not provided [RCV001005878] Chr6:162661108..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:166517762-170919470) copy number loss not provided [RCV000767664] Chr6:166517762..170919470 [GRCh37]
Chr6:6q27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162452035-170919482)x1 copy number loss not provided [RCV001005874] Chr6:162452035..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:166607593-170919482)x1 copy number loss not provided [RCV000846415] Chr6:166607593..170919482 [GRCh37]
Chr6:6q27		 pathogenic
NM_021135.6(RPS6KA2):c.983G>A (p.Arg328Gln) single nucleotide variant Inborn genetic diseases [RCV003239913] Chr6:166459541 [GRCh38]
Chr6:166873029 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q25.3-27(chr6:159006336-170713678)x3 copy number gain not provided [RCV003312672] Chr6:159006336..170713678 [GRCh37]
Chr6:6q25.3-27		 uncertain significance
NM_021135.6(RPS6KA2):c.1498C>T (p.Arg500Trp) single nucleotide variant Inborn genetic diseases [RCV003272707] Chr6:166430536 [GRCh38]
Chr6:166844024 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:166827923-167156755)x3 copy number gain not provided [RCV001005881] Chr6:166827923..167156755 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:167220089-167305288)x1 copy number loss not provided [RCV001258772] Chr6:167220089..167305288 [GRCh37]
Chr6:6q27		 likely benign
GRCh37/hg19 6q27(chr6:166083476-170919482)x3 copy number gain not provided [RCV001258773] Chr6:166083476..170919482 [GRCh37]
Chr6:6q27		 likely pathogenic
GRCh37/hg19 6q26-27(chr6:161047873-170919482) copy number loss not specified [RCV002053651] Chr6:161047873..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:165622608-166897295) copy number gain not specified [RCV002053656] Chr6:165622608..166897295 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:162212864-170919482) copy number gain not specified [RCV002053652] Chr6:162212864..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:162381975-170919482) copy number loss not specified [RCV002053653] Chr6:162381975..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:163290087-170919482) copy number loss not specified [RCV002053655] Chr6:163290087..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:167263995-167774832)x3 copy number gain not provided [RCV001834343] Chr6:167263995..167774832 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:163836226-170893669)x1 copy number loss not provided [RCV002293168] Chr6:163836226..170893669 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q26-27(chr6:163181847-170919482)x1 copy number loss not provided [RCV002472604] Chr6:163181847..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
NM_021135.6(RPS6KA2):c.1769C>T (p.Ala590Val) single nucleotide variant Inborn genetic diseases [RCV002753973] Chr6:166419933 [GRCh38]
Chr6:166833421 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1499G>A (p.Arg500Gln) single nucleotide variant Inborn genetic diseases [RCV002759270] Chr6:166430535 [GRCh38]
Chr6:166844023 [GRCh37]
Chr6:6q27		 likely benign
NM_021135.6(RPS6KA2):c.1469G>A (p.Arg490His) single nucleotide variant Inborn genetic diseases [RCV002661441] Chr6:166430565 [GRCh38]
Chr6:166844053 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1915G>A (p.Asp639Asn) single nucleotide variant Inborn genetic diseases [RCV002784024] Chr6:166418248 [GRCh38]
Chr6:166831736 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1976A>G (p.Gln659Arg) single nucleotide variant Inborn genetic diseases [RCV002827092] Chr6:166413894 [GRCh38]
Chr6:166827382 [GRCh37]
Chr6:6q27		 uncertain significance
NM_001006932.3(RPS6KA2):c.119A>G (p.Glu40Gly) single nucleotide variant Inborn genetic diseases [RCV002713086] Chr6:166858204 [GRCh38]
Chr6:167271692 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.2182C>A (p.Leu728Ile) single nucleotide variant Inborn genetic diseases [RCV002789227] Chr6:166412782 [GRCh38]
Chr6:166826270 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.538A>G (p.Ile180Val) single nucleotide variant Inborn genetic diseases [RCV002702663] Chr6:166504534 [GRCh38]
Chr6:166918022 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1879G>A (p.Gly627Ser) single nucleotide variant Inborn genetic diseases [RCV002855152] Chr6:166418284 [GRCh38]
Chr6:166831772 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1093C>T (p.Pro365Ser) single nucleotide variant Inborn genetic diseases [RCV002656303] Chr6:166451216 [GRCh38]
Chr6:166864704 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.979T>C (p.Tyr327His) single nucleotide variant Inborn genetic diseases [RCV002652474] Chr6:166459545 [GRCh38]
Chr6:166873033 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1985C>T (p.Thr662Met) single nucleotide variant Inborn genetic diseases [RCV003179219] Chr6:166413885 [GRCh38]
Chr6:166827373 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.1441T>G (p.Phe481Val) single nucleotide variant Inborn genetic diseases [RCV003206958] Chr6:166430593 [GRCh38]
Chr6:166844081 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.151T>C (p.Phe51Leu) single nucleotide variant Inborn genetic diseases [RCV003309975] Chr6:166538733 [GRCh38]
Chr6:166952221 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh38/hg38 6q26-27(chr6:161349282-170584790)x1 copy number loss Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures [RCV003327715] Chr6:161349282..170584790 [GRCh38]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q25.3-27(chr6:160952761-170892276)x1 copy number loss not provided [RCV003334287] Chr6:160952761..170892276 [GRCh37]
Chr6:6q25.3-27		 pathogenic
NM_021135.6(RPS6KA2):c.242G>A (p.Gly81Glu) single nucleotide variant Inborn genetic diseases [RCV003370838] Chr6:166531288 [GRCh38]
Chr6:166944776 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q27(chr6:167047570-167576975)x3 copy number gain not provided [RCV003484659] Chr6:167047570..167576975 [GRCh37]
Chr6:6q27		 uncertain significance
NM_021135.6(RPS6KA2):c.249C>T (p.Asp83=) single nucleotide variant not provided [RCV003432163] Chr6:166531281 [GRCh38]
Chr6:166944769 [GRCh37]
Chr6:6q27		 likely benign
GRCh37/hg19 6q27(chr6:167091844-170919482)x1 copy number loss not provided [RCV003482936] Chr6:167091844..170919482 [GRCh37]
Chr6:6q27		 pathogenic
NM_001006932.3(RPS6KA2):c.123+87310C>T single nucleotide variant not provided [RCV003423476] Chr6:166770890 [GRCh38]
Chr6:167184378 [GRCh37]
Chr6:6q27		 likely benign
NM_021135.6(RPS6KA2):c.1161C>T (p.Pro387=) single nucleotide variant not provided [RCV003423475] Chr6:166451148 [GRCh38]
Chr6:166864636 [GRCh37]
Chr6:6q27		 likely benign
NM_021135.6(RPS6KA2):c.2076+1G>C single nucleotide variant not provided [RCV003494306] Chr6:166413793 [GRCh38]
Chr6:166827281 [GRCh37]
Chr6:6q27		 likely pathogenic
GRCh37/hg19 6q26-27(chr6:162079329-170919482)x1 copy number loss not specified [RCV003986639] Chr6:162079329..170919482 [GRCh37]
Chr6:6q26-27		 pathogenic
GRCh37/hg19 6q27(chr6:167165318-167433823)x1 copy number loss not specified [RCV003986614] Chr6:167165318..167433823 [GRCh37]
Chr6:6q27		 uncertain significance
GRCh37/hg19 6q26-27(chr6:162124972-170893669)x1 copy number loss not provided [RCV003885515] Chr6:162124972..170893669 [GRCh37]
Chr6:6q26-27		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:7006
Count of miRNA genes:1256
Interacting mature miRNAs:1624
Transcripts:ENST00000265678, ENST00000366863, ENST00000366865, ENST00000405189, ENST00000481261, ENST00000491836, ENST00000503859, ENST00000506565, ENST00000507350, ENST00000507371, ENST00000509742, ENST00000510118, ENST00000511034, ENST00000512860
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D6S297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,236,778 - 167,236,995UniSTSGRCh37
Build 366167,156,768 - 167,156,985RGDNCBI36
Celera6167,978,097 - 167,978,308RGD
Cytogenetic Map6q27UniSTS
HuRef6164,709,733 - 164,709,942UniSTS
Marshfield Genetic Map6182.11RGD
Marshfield Genetic Map6182.11UniSTS
Genethon Genetic Map6181.8UniSTS
TNG Radiation Hybrid Map683854.0UniSTS
deCODE Assembly Map6182.75UniSTS
Whitehead-RH Map6859.2UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61672.4UniSTS
D6S1585  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,110,460 - 167,110,643UniSTSGRCh37
Build 366167,030,450 - 167,030,633RGDNCBI36
Celera6167,849,733 - 167,849,916RGD
Cytogenetic Map6q27UniSTS
HuRef6164,582,160 - 164,582,343UniSTS
Marshfield Genetic Map6182.11RGD
Marshfield Genetic Map6182.11UniSTS
Genethon Genetic Map6181.8UniSTS
TNG Radiation Hybrid Map683789.0UniSTS
deCODE Assembly Map6182.42UniSTS
GeneMap99-GB4 RH Map6640.5UniSTS
Whitehead-YAC Contig Map6 UniSTS
NCBI RH Map61672.4UniSTS
RH65049  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371583,658,877 - 83,658,985UniSTSGRCh37
GRCh376166,999,443 - 166,999,551UniSTSGRCh37
Build 366166,919,433 - 166,919,541RGDNCBI36
Celera1560,927,657 - 60,927,765UniSTS
Celera6167,738,748 - 167,738,856RGD
Cytogenetic Map6q27UniSTS
Cytogenetic Map15q25.2UniSTS
HuRef1559,922,357 - 59,922,465UniSTS
HuRef6164,471,109 - 164,471,217UniSTS
RH121975  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,825,961 - 166,826,174UniSTSGRCh37
Build 366166,745,951 - 166,746,164RGDNCBI36
Celera6167,565,326 - 167,565,539RGD
Cytogenetic Map6q27UniSTS
HuRef6164,297,349 - 164,297,562UniSTS
RH121484  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,868,586 - 166,868,931UniSTSGRCh37
Build 366166,788,576 - 166,788,921RGDNCBI36
Celera6167,607,948 - 167,608,293RGD
Cytogenetic Map6q27UniSTS
HuRef6164,340,298 - 164,340,643UniSTS
RH123785  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,265,459 - 167,265,777UniSTSGRCh37
Build 366167,185,449 - 167,185,767RGDNCBI36
Celera6168,006,743 - 168,007,061RGD
Cytogenetic Map6q27UniSTS
HuRef6164,738,368 - 164,738,686UniSTS
TNG Radiation Hybrid Map683877.0UniSTS
SHGC-107446  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,918,623 - 166,918,959UniSTSGRCh37
Build 366166,838,613 - 166,838,949RGDNCBI36
Celera6167,657,981 - 167,658,317RGD
Cytogenetic Map6q27UniSTS
HuRef6164,390,338 - 164,390,674UniSTS
A002B12  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,824,769 - 166,824,933UniSTSGRCh37
Build 366166,744,759 - 166,744,923RGDNCBI36
Celera6167,564,134 - 167,564,298RGD
Cytogenetic Map6q27UniSTS
HuRef6164,296,157 - 164,296,321UniSTS
GeneMap99-GB4 RH Map6633.87UniSTS
NCBI RH Map61662.8UniSTS
AL023487  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,917,607 - 166,917,741UniSTSGRCh37
Build 366166,837,597 - 166,837,731RGDNCBI36
Celera6167,656,965 - 167,657,099RGD
Cytogenetic Map6q27UniSTS
HuRef6164,389,322 - 164,389,456UniSTS
STS-W96228  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,822,909 - 166,823,153UniSTSGRCh37
Build 366166,742,899 - 166,743,143RGDNCBI36
Celera6167,562,275 - 167,562,519RGD
Cytogenetic Map6q27UniSTS
HuRef6164,294,298 - 164,294,542UniSTS
GeneMap99-GB4 RH Map6638.08UniSTS
D6S1169E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,824,737 - 166,824,825UniSTSGRCh37
Build 366166,744,727 - 166,744,815RGDNCBI36
Celera6167,564,102 - 167,564,190RGD
Cytogenetic Map6q27UniSTS
HuRef6164,296,125 - 164,296,213UniSTS
GeneMap99-GB4 RH Map6630.13UniSTS
NCBI RH Map61662.8UniSTS
AL023486  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,065,990 - 167,066,109UniSTSGRCh37
Build 366166,985,980 - 166,986,099RGDNCBI36
Celera6167,805,264 - 167,805,383RGD
Cytogenetic Map6q27UniSTS
HuRef6164,537,632 - 164,537,751UniSTS
SHGC-57104  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,962,660 - 166,962,897UniSTSGRCh37
Build 366166,882,650 - 166,882,887RGDNCBI36
Celera6167,701,976 - 167,702,213RGD
Cytogenetic Map6q27UniSTS
HuRef6164,434,335 - 164,434,572UniSTS
WI-17352  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,823,302 - 166,823,451UniSTSGRCh37
Build 366166,743,292 - 166,743,441RGDNCBI36
Celera6167,562,668 - 167,562,817RGD
Cytogenetic Map6q27UniSTS
HuRef6164,294,691 - 164,294,840UniSTS
GeneMap99-GB4 RH Map6636.52UniSTS
Whitehead-RH Map6848.4UniSTS
NCBI RH Map61672.4UniSTS
AL022447  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376167,195,234 - 167,195,402UniSTSGRCh37
Build 366167,115,224 - 167,115,392RGDNCBI36
Celera6167,937,043 - 167,937,211RGD
Cytogenetic Map6q27UniSTS
HuRef6164,668,171 - 164,668,339UniSTS
RH45609  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,823,015 - 166,823,179UniSTSGRCh37
Build 366166,743,005 - 166,743,169RGDNCBI36
Celera6167,562,381 - 167,562,545RGD
Cytogenetic Map6q27UniSTS
HuRef6164,294,404 - 164,294,568UniSTS
GeneMap99-GB4 RH Map6635.23UniSTS
NCBI RH Map61672.4UniSTS
RPS6KA2__5527  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh376166,824,662 - 166,825,343UniSTSGRCh37
Build 366166,744,652 - 166,745,333RGDNCBI36
Celera6167,564,027 - 167,564,708RGD
HuRef6164,296,050 - 164,296,731UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2040 1889 1108 151 540 27 3314 1410 3491 235 1013 1476 131 1185 2046 1
Low 386 1015 602 461 1255 426 1034 777 238 177 432 113 41 1 19 742 1 2
Below cutoff 10 85 12 8 134 8 5 4 2 6 11 20 3 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001006932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001318938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006715549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047419235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356190 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054356191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA588877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB073884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB209116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF140710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK027727 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL023775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL159163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX019387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF205134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF339000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI836819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ029058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU160797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU617697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA320139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA328327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC402728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ585489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HY150133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ534936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ535080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KJ535087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L07598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X85106 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z98049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000265678   ⟹   ENSP00000265678
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,409,364 - 166,627,251 (-)Ensembl
RefSeq Acc Id: ENST00000366865
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,475,726 - 166,510,310 (-)Ensembl
RefSeq Acc Id: ENST00000405189   ⟹   ENSP00000386050
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,412,748 - 166,542,450 (-)Ensembl
RefSeq Acc Id: ENST00000481261   ⟹   ENSP00000422484
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,412,659 - 166,544,690 (-)Ensembl
RefSeq Acc Id: ENST00000491836
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,439,889 - 166,459,551 (-)Ensembl
RefSeq Acc Id: ENST00000503859   ⟹   ENSP00000427015
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,411,232 - 166,862,551 (-)Ensembl
RefSeq Acc Id: ENST00000506565   ⟹   ENSP00000425148
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,508,223 - 166,862,670 (-)Ensembl
RefSeq Acc Id: ENST00000507350   ⟹   ENSP00000422197
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,498,611 - 166,627,522 (-)Ensembl
RefSeq Acc Id: ENST00000507371   ⟹   ENSP00000423114
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,504,599 - 166,757,911 (-)Ensembl
RefSeq Acc Id: ENST00000509742
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,412,296 - 166,423,984 (-)Ensembl
RefSeq Acc Id: ENST00000510118   ⟹   ENSP00000422435
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,409,388 - 166,862,511 (-)Ensembl
RefSeq Acc Id: ENST00000511034   ⟹   ENSP00000425458
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,510,280 - 166,627,972 (-)Ensembl
RefSeq Acc Id: ENST00000512860   ⟹   ENSP00000427605
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl6166,504,515 - 166,906,451 (-)Ensembl
RefSeq Acc Id: NM_001006932   ⟹   NP_001006933
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,862,525 (-)NCBI
GRCh376166,822,854 - 167,275,948 (-)NCBI
Build 366166,742,844 - 167,195,761 (-)NCBI Archive
HuRef6164,294,243 - 164,748,630 (-)ENTREZGENE
CHM1_16167,086,553 - 167,538,677 (-)NCBI
T2T-CHM13v2.06167,786,324 - 168,245,301 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318936   ⟹   NP_001305865
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,862,525 (-)NCBI
CHM1_16167,086,553 - 167,538,677 (-)NCBI
T2T-CHM13v2.06167,786,324 - 168,245,301 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318937   ⟹   NP_001305866
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,862,525 (-)NCBI
CHM1_16167,086,553 - 167,538,677 (-)NCBI
T2T-CHM13v2.06167,786,324 - 168,245,301 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001318938   ⟹   NP_001305867
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,544,690 (-)NCBI
CHM1_16167,086,553 - 167,221,861 (-)NCBI
T2T-CHM13v2.06167,786,324 - 167,922,173 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021135   ⟹   NP_066958
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,627,251 (-)NCBI
GRCh376166,822,854 - 167,275,948 (-)NCBI
Build 366166,742,844 - 166,960,716 (-)NCBI Archive
HuRef6164,294,243 - 164,748,630 (-)ENTREZGENE
CHM1_16167,086,553 - 167,304,409 (-)NCBI
T2T-CHM13v2.06167,786,324 - 168,005,391 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006715549   ⟹   XP_006715612
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,627,251 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047419233   ⟹   XP_047275189
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,771,111 (-)NCBI
RefSeq Acc Id: XM_047419234   ⟹   XP_047275190
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,757,906 (-)NCBI
RefSeq Acc Id: XM_047419235   ⟹   XP_047275191
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,409,364 - 166,862,773 (-)NCBI
RefSeq Acc Id: XM_054356188   ⟹   XP_054212163
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.06167,786,324 - 168,005,391 (-)NCBI
RefSeq Acc Id: XM_054356189   ⟹   XP_054212164
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.06167,786,324 - 168,153,898 (-)NCBI
RefSeq Acc Id: XM_054356190   ⟹   XP_054212165
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.06167,786,324 - 168,140,711 (-)NCBI
RefSeq Acc Id: XM_054356191   ⟹   XP_054212166
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001006933 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305865 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305866 (Get FASTA)   NCBI Sequence Viewer  
  NP_001305867 (Get FASTA)   NCBI Sequence Viewer  
  NP_066958 (Get FASTA)   NCBI Sequence Viewer  
  XP_006715612 (Get FASTA)   NCBI Sequence Viewer  
  XP_047275189 (Get FASTA)   NCBI Sequence Viewer  
  XP_047275190 (Get FASTA)   NCBI Sequence Viewer  
  XP_047275191 (Get FASTA)   NCBI Sequence Viewer  
  XP_054212163 (Get FASTA)   NCBI Sequence Viewer  
  XP_054212164 (Get FASTA)   NCBI Sequence Viewer  
  XP_054212165 (Get FASTA)   NCBI Sequence Viewer  
  XP_054212166 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC82496 (Get FASTA)   NCBI Sequence Viewer  
  AAH02363 (Get FASTA)   NCBI Sequence Viewer  
  AHW56576 (Get FASTA)   NCBI Sequence Viewer  
  AHW56719 (Get FASTA)   NCBI Sequence Viewer  
  AHW56726 (Get FASTA)   NCBI Sequence Viewer  
  BAD92353 (Get FASTA)   NCBI Sequence Viewer  
  BAG53121 (Get FASTA)   NCBI Sequence Viewer  
  BAH12151 (Get FASTA)   NCBI Sequence Viewer  
  CAA59427 (Get FASTA)   NCBI Sequence Viewer  
  CAC07738 (Get FASTA)   NCBI Sequence Viewer  
  EAW47522 (Get FASTA)   NCBI Sequence Viewer  
  EAW47523 (Get FASTA)   NCBI Sequence Viewer  
  EAW47524 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000265678
  ENSP00000265678.4
  ENSP00000386050.3
  ENSP00000422197.1
  ENSP00000422435
  ENSP00000422435.1
  ENSP00000422484
  ENSP00000422484.1
  ENSP00000423114.1
  ENSP00000425148.1
  ENSP00000425458.1
  ENSP00000427015
  ENSP00000427015.1
  ENSP00000427605.1
GenBank Protein Q15349 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001006933   ⟸   NM_001006932
- Peptide Label: isoform b
- Sequence:
RefSeq Acc Id: NP_066958   ⟸   NM_021135
- Peptide Label: isoform a
- UniProtKB: Q96J38 (UniProtKB/Swiss-Prot),   Q5TI68 (UniProtKB/Swiss-Prot),   Q59GJ3 (UniProtKB/Swiss-Prot),   Q15419 (UniProtKB/Swiss-Prot),   B3KTK9 (UniProtKB/Swiss-Prot),   Q9UJN5 (UniProtKB/Swiss-Prot),   Q15349 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006715612   ⟸   XM_006715549
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001305866   ⟸   NM_001318937
- Peptide Label: isoform d
- UniProtKB: Q15349 (UniProtKB/Swiss-Prot),   X5D337 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305865   ⟸   NM_001318936
- Peptide Label: isoform c
- UniProtKB: F2Z2J1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001305867   ⟸   NM_001318938
- Peptide Label: isoform e
- UniProtKB: B7Z3B5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000427015   ⟸   ENST00000503859
RefSeq Acc Id: ENSP00000425148   ⟸   ENST00000506565
RefSeq Acc Id: ENSP00000422197   ⟸   ENST00000507350
RefSeq Acc Id: ENSP00000423114   ⟸   ENST00000507371
RefSeq Acc Id: ENSP00000422484   ⟸   ENST00000481261
RefSeq Acc Id: ENSP00000386050   ⟸   ENST00000405189
RefSeq Acc Id: ENSP00000422435   ⟸   ENST00000510118
RefSeq Acc Id: ENSP00000425458   ⟸   ENST00000511034
RefSeq Acc Id: ENSP00000427605   ⟸   ENST00000512860
RefSeq Acc Id: ENSP00000265678   ⟸   ENST00000265678
RefSeq Acc Id: XP_047275191   ⟸   XM_047419235
- Peptide Label: isoform X4
- UniProtKB: B7Z3B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_047275189   ⟸   XM_047419233
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047275190   ⟸   XM_047419234
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054212166   ⟸   XM_054356191
- Peptide Label: isoform X4
- UniProtKB: B7Z3B5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054212164   ⟸   XM_054356189
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054212165   ⟸   XM_054356190
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054212163   ⟸   XM_054356188
- Peptide Label: isoform X1
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q15349-F1-model_v2 AlphaFold Q15349 1-733 view protein structure

Promoters
RGD ID:7209641
Promoter ID:EPDNEW_H10567
Type:multiple initiation site
Name:RPS6KA2_2
Description:ribosomal protein S6 kinase A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10568  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,423,984 - 166,424,044EPDNEW
RGD ID:7209645
Promoter ID:EPDNEW_H10568
Type:initiation region
Name:RPS6KA2_1
Description:ribosomal protein S6 kinase A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H10567  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh386166,627,251 - 166,627,311EPDNEW
RGD ID:6803995
Promoter ID:HG_KWN:55760
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000366863,   OTTHUMT00000043075
Position:
Human AssemblyChrPosition (strand)Source
Build 366166,960,566 - 166,961,217 (-)MPROMDB
RGD ID:6804749
Promoter ID:HG_KWN:55762
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid
Transcripts:NM_001006932,   OTTHUMT00000043077,   UC003QVD.1
Position:
Human AssemblyChrPosition (strand)Source
Build 366167,195,666 - 167,196,166 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:10431 AgrOrtholog
COSMIC RPS6KA2 COSMIC
Ensembl Genes ENSG00000071242 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000265678 ENTREZGENE
  ENST00000265678.9 UniProtKB/Swiss-Prot
  ENST00000405189.7 UniProtKB/TrEMBL
  ENST00000481261 ENTREZGENE
  ENST00000481261.6 UniProtKB/TrEMBL
  ENST00000503859 ENTREZGENE
  ENST00000503859.5 UniProtKB/Swiss-Prot
  ENST00000506565.1 UniProtKB/TrEMBL
  ENST00000507350.5 UniProtKB/TrEMBL
  ENST00000507371.5 UniProtKB/TrEMBL
  ENST00000510118 ENTREZGENE
  ENST00000510118.5 UniProtKB/TrEMBL
  ENST00000511034.1 UniProtKB/TrEMBL
  ENST00000512860.5 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000071242 GTEx
HGNC ID HGNC:10431 ENTREZGENE
Human Proteome Map RPS6KA2 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSK3_STKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RSK_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:6196 UniProtKB/Swiss-Prot
NCBI Gene 6196 ENTREZGENE
OMIM 601685 OMIM
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE A4 UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA34846 PharmGKB
PIRSF Ribsml_S6_kin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B3KTK9 ENTREZGENE
  B7Z3B5 ENTREZGENE, UniProtKB/TrEMBL
  D6R910_HUMAN UniProtKB/TrEMBL
  D6RA62_HUMAN UniProtKB/TrEMBL
  D6RD75_HUMAN UniProtKB/TrEMBL
  D6RE03_HUMAN UniProtKB/TrEMBL
  D6RHW7_HUMAN UniProtKB/TrEMBL
  F2Z2J1 ENTREZGENE, UniProtKB/TrEMBL
  KS6A2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q15419 ENTREZGENE
  Q59GJ3 ENTREZGENE
  Q5TI68 ENTREZGENE
  Q96J38 ENTREZGENE
  Q9UJN5 ENTREZGENE
  X5D337 ENTREZGENE, UniProtKB/TrEMBL
  X5DNZ1_HUMAN UniProtKB/TrEMBL
  X5DPB4_HUMAN UniProtKB/TrEMBL
UniProt Secondary B3KTK9 UniProtKB/Swiss-Prot
  Q15419 UniProtKB/Swiss-Prot
  Q59GJ3 UniProtKB/Swiss-Prot
  Q5TI68 UniProtKB/Swiss-Prot
  Q96J38 UniProtKB/Swiss-Prot
  Q9UJN5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-07 RPS6KA2  ribosomal protein S6 kinase A2  RPS6KA2  ribosomal protein S6 kinase, 90kDa, polypeptide 2  Symbol and/or name change 5135510 APPROVED