Rps6ka2 (ribosomal protein S6 kinase A2) - Rat Genome Database

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Gene: Rps6ka2 (ribosomal protein S6 kinase A2) Ictidomys tridecemlineatus
Analyze
Symbol: Rps6ka2
Name: ribosomal protein S6 kinase A2
RGD ID: 12716835
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); INVOLVED IN brain renin-angiotensin system (ortholog); cardiac muscle cell apoptotic process (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); bipolar disorder (ortholog); genetic disease (ortholog); FOUND IN meiotic spindle (ortholog); spindle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC110597773; ribosomal protein S6 kinase alpha-2; uncharacterized LOC110597773
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
meiotic spindle  (ISO)
nucleoplasm  (IEA)
nucleus  (IEA)
spindle  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Rps6ka2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386166,409,364 - 166,862,773 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6166,409,364 - 166,906,451 (-)EnsemblGRCh38hg38GRCh38
GRCh376166,822,852 - 167,276,013 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366166,742,844 - 167,195,761 (-)NCBINCBI36Build 36hg18NCBI36
Build 346166,793,264 - 167,011,137NCBI
Celera6167,562,220 - 168,016,996 (-)NCBICelera
Cytogenetic Map6q27NCBI
HuRef6164,294,243 - 164,748,630 (-)NCBIHuRef
CHM1_16167,086,555 - 167,538,409 (-)NCBICHM1_1
T2T-CHM13v2.06167,786,324 - 168,245,548 (-)NCBIT2T-CHM13v2.0
Rps6ka2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,356,384 - 7,570,714 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,437,514 - 7,570,714 (+)EnsemblGRCm39 Ensembl
GRCm38177,088,971 - 7,303,315 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,170,115 - 7,303,315 (+)EnsemblGRCm38mm10GRCm38
MGSCv37177,374,464 - 7,507,664 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,019,773 - 7,152,973 (+)NCBIMGSCv36mm8
Celera177,033,227 - 7,165,891 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map174.7NCBI
Rps6ka2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8155,178,988 - 55,454,271 (+)NCBIGRCr8
mRatBN7.2152,631,582 - 52,906,739 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl152,631,736 - 52,906,739 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx153,478,991 - 53,614,454 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0159,464,385 - 59,599,587 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0153,554,603 - 53,690,056 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0153,219,346 - 53,499,445 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl153,360,157 - 53,499,445 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0154,469,155 - 54,747,731 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4147,424,106 - 47,560,373 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1147,535,295 - 47,553,857 (+)NCBI
Celera148,533,427 - 48,667,077 (+)NCBICelera
Cytogenetic Map1q12NCBI
Rps6ka2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543915,332,165 - 15,487,305 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543915,210,882 - 15,487,305 (+)NCBIChiLan1.0ChiLan1.0
RPS6KA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25186,615,281 - 187,112,903 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16184,511,214 - 185,009,053 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06164,373,829 - 164,829,195 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16169,355,114 - 169,806,718 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6169,355,136 - 169,806,337 (-)Ensemblpanpan1.1panPan2
RPS6KA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1154,413,805 - 54,757,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl154,416,758 - 54,757,067 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha155,202,572 - 55,547,248 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0154,592,807 - 54,938,176 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl154,592,818 - 54,938,570 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1154,489,815 - 54,835,148 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0154,338,945 - 54,683,764 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0154,963,546 - 55,308,688 (-)NCBIUU_Cfam_GSD_1.0
RPS6KA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12,203,606 - 2,522,599 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112,203,825 - 2,522,604 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213,346,751 - 3,662,181 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11394,141,648 - 94,605,750 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1394,140,111 - 94,357,688 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604065,964,531 - 66,420,530 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6ka2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478512,657,845 - 12,839,569 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478512,450,686 - 12,839,563 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000005342   ⟹   ENSSTOP00000004787
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648916,214,871 - 16,355,388 (-)Ensembl
RefSeq Acc Id: ENSSTOT00000039697   ⟹   ENSSTOP00000031455
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_00493648916,217,553 - 16,355,157 (-)Ensembl
RefSeq Acc Id: XM_005321437   ⟹   XP_005321494
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,103,379 (-)NCBI
SpeTri2.0NW_00493648916,214,790 - 16,355,372 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040283560   ⟹   XP_040139494
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBI
RefSeq Acc Id: XM_040283561   ⟹   XP_040139495
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBI
RefSeq Acc Id: XM_040283562   ⟹   XP_040139496
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,261,569 (-)NCBI
RefSeq Acc Id: XM_040283563   ⟹   XP_040139497
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,261,887 (-)NCBI
RefSeq Acc Id: XM_040283564   ⟹   XP_040139498
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,261,886 (-)NCBI
RefSeq Acc Id: XM_040283565   ⟹   XP_040139499
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404946148,959,493 - 149,157,006 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_005321494   ⟸   XM_005321437
- Peptide Label: isoform X3
- UniProtKB: I3M5X2 (UniProtKB/TrEMBL),   A0A287DD05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040139497   ⟸   XM_040283563
- Peptide Label: isoform X1
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139495   ⟸   XM_040283561
- Peptide Label: isoform X1
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139494   ⟸   XM_040283560
- Peptide Label: isoform X1
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139498   ⟸   XM_040283564
- Peptide Label: isoform X2
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139496   ⟸   XM_040283562
- Peptide Label: isoform X1
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040139499   ⟸   XM_040283565
- Peptide Label: isoform X4
- UniProtKB: A0A287DD05 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000031455   ⟸   ENSSTOT00000039697
RefSeq Acc Id: ENSSTOP00000004787   ⟸   ENSSTOT00000005342
Protein Domains
AGC-kinase C-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005318 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005342.3 UniProtKB/TrEMBL
  ENSSTOT00000039697.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase_II UniProtKB/TrEMBL
  RSK3_STKc UniProtKB/TrEMBL
  RSK_N UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Rps6ka2 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  RIBOSOMAL PROTEIN S6 KINASE ALPHA-2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_2 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287DD05 ENTREZGENE, UniProtKB/TrEMBL
  I3M5X2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-25 Rps6ka2  ribosomal protein S6 kinase A2  LOC110597773  uncharacterized LOC110597773  Data merged from RGD:12961164 737654 PROVISIONAL